LOCUS       NM_001024911            2189 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus septin 10 (Septin10), transcript variant 2, mRNA.
ACCESSION   NM_001024911
VERSION     NM_001024911.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Keppner,A., Correia,M., Santambrogio,S., Koay,T.W., Maric,D.,
            Osterhof,C., Winter,D.V., Clerc,A., Stumpe,M., Chalmel,F.,
            Dewilde,S., Odermatt,A., Kressler,D., Hankeln,T., Wenger,R.H. and
            Hoogewijs,D.
  TITLE     Androglobin, a chimeric mammalian globin, is required for male
            fertility
  JOURNAL   Elife 11, e72374 (2022)
   PUBMED   35700329
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Yoshida,A., Yamamoto,N., Kinoshita,M., Hiroi,N., Hiramoto,T.,
            Kang,G., Trimble,W.S., Tanigaki,K., Nakagawa,T. and Ito,J.
  TITLE     Localization of septin proteins in the mouse cochlea
  JOURNAL   Hear Res 289 (1-2), 40-51 (2012)
   PUBMED   22575789
REFERENCE   5  (bases 1 to 2189)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC153941.3.
            
            On Mar 19, 2020 this sequence version replaced NM_001024911.2.
            
            Transcript Variant: This variant (2) uses a different segment for
            its 3' coding region and 3' UTR, compared to variant 1. The
            resulting protein (isoform 2) has a shorter and distinct C-terminus
            when it is compared to isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC053752.1, SRR7652917.788728.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               AC153941.3         179293-179402       c
            111-228             AC153941.3         150600-150717       c
            229-424             AC153941.3         150068-150263       c
            425-611             AC153941.3         141427-141613       c
            612-773             AC153941.3         138922-139083       c
            774-870             AC153941.3         136663-136759       c
            871-1039            AC153941.3         134750-134918       c
            1040-1172           AC153941.3         128716-128848       c
            1173-1360           AC153941.3         124406-124593       c
            1361-2189           AC153941.3         122018-122846       c
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 29.48 cM"
     gene            1..2189
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /note="septin 10"
                     /db_xref="GeneID:103080"
                     /db_xref="MGI:MGI:1918110"
     exon            1..110
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1376
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /codon_start=1
                     /product="septin-10 isoform 2"
                     /protein_id="NP_001020082.1"
                     /db_xref="CCDS:CCDS48566.1"
                     /db_xref="GeneID:103080"
                     /db_xref="MGI:MGI:1918110"
                     /translation="MASCDEIKEHPRSLSMCGHVGFESLPDQLVDRSIEQGFCFNILC
                     VGETGIGKSTLINTLFNTNFEELESSHFCPCVRLRAQTYELQESNVRLKLTIVNTVGF
                     GDQINKEDSYQPIVDYIDDQFEAYLQEELKIKRALFNYHDSRIHVCLYFIAPTGHSLR
                     TLDLLTMKSLDNKVNIIPLIAKADTISKSELQKFKMKLMNELVINGVQIYQFPTDDDT
                     TSKINGAMNGHLPFAVVGSMDEIKVGNKMVKGRQYPWGIVQVENENHCDFVKLREMLI
                     CTNMEDLREQTHMRHYELYRRCKLQEMGFVDMGPENKPLSLQETYEAKRHEFYGERQR
                     KEEQMKQMFVQRVKEKEAILKEAERELQAKFEHLKRIHQEERMKLEEKRRMLEEESVA
                     FAKKKATCELFPNQSFLASGSSIRKDKDRKNSNFM"
     exon            111..228
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            229..424
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            425..611
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            612..773
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            774..870
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            871..1039
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            1040..1172
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            1173..1360
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..2189
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2166..2171
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /note="hexamer: AATAAA"
     polyA_site      2189
                     /gene="Septin10"
                     /gene_synonym="4921515A04Rik; 9430099J10Rik; Sept10"
                     /note="major polyA site"
ORIGIN      
        1 agttacgccc agcgggtctc tctctgaagc ggcccgggac ctgtgtttgc gtccagcctg
       61 agaccaccgt ttccctacgt cccaccaggg ctatggcctc atgcgacgag ataaaagagc
      121 atccccgctc cttgtctatg tgtggccatg ttggttttga aagcttacct gatcagctgg
      181 tcgatagatc cattgagcaa ggcttctgtt tcaatattct ctgtgtgggg gagactggaa
      241 ttggaaaatc aacactgatt aacacattgt ttaatactaa ttttgaagaa ctcgaatcct
      301 cacatttttg tccatgtgtt agacttagag ctcagacata tgaactccag gaaagcaatg
      361 ttcgcttgaa actgaccatt gtaaatacag tgggctttgg tgaccaaatc aataaagaag
      421 acagctatca accaatagtt gattacatag atgatcaatt tgaggcctat cttcaggaag
      481 aactgaagat caagcgtgct ctttttaact accatgactc tcgtatccat gtgtgcctct
      541 acttcattgc tccgacaggc cattctctaa ggacacttga cctcttaacc atgaagagcc
      601 tggacaacaa ggtgaacatt ataccactta ttgccaaggc agatacaatt tctaagagtg
      661 aattacagaa gtttaagatg aagctcatga atgaactggt catcaatggt gttcagatat
      721 atcagtttcc aacagatgat gacacgacct ccaagatcaa tggagcaatg aacggccatt
      781 tgccatttgc tgttgttgga agtatggatg agataaaagt tggaaataag atggtgaagg
      841 gtcgtcagta tccttggggt atcgtacaag tggaaaatga aaatcactgt gactttgtaa
      901 agctacggga aatgcttatt tgcacaaaca tggaggatct acgggagcag acacatatga
      961 ggcactatga gctgtacagg cgctgcaaac tgcaggagat gggctttgta gatatgggcc
     1021 cagagaacaa gcccctcagt cttcaagaga cgtatgaagc caaaagacac gagttctatg
     1081 gtgagcgtca gaggaaggaa gagcagatga agcagatgtt tgtgcagcgg gtcaaggaga
     1141 aagaagccat tctgaaggaa gcggaaagag agcttcaggc caaatttgag cacctcaaaa
     1201 gaattcatca ggaagagaga atgaaacttg aagaaaagag aagaatgttg gaggaagaat
     1261 cggttgcttt tgctaagaag aaagctacct gtgagctgtt cccgaaccag tcatttttgg
     1321 cgtcaggtag cagcattagg aaggacaaag accgaaagaa ctccaatttt atgtaacaca
     1381 agagttccag agcacagatg gccatcacag tcaaagctgt ttgtatgcat tgagctcttg
     1441 ctccttttgc cttatcagta actcagttat tatctagcaa agggctaaag ctattcacat
     1501 ttgtagaaaa atattttcac gtataaggct gatctgtcag ccaaggtgca tatttctcac
     1561 acatatactg tcattaggaa tctgtaagtt cctatcttgc tgtggatctt ggtcactttc
     1621 ctgctgccgg atgttatttt actgactgtt actctaagta gcaaaggttc atcgctattg
     1681 agacactaca gaactccttc atattatgca tagctgattg ccattttatt ctagcatgaa
     1741 cctttttttt tttttttttt tgctgtatac taaacagaaa acactggagg catgtatgtt
     1801 ggactgtatt acagagttaa agctaacttt aaactatgta accttttatg actcaatgtg
     1861 ccttattgtg tattgctgtg atatagcaaa atatgcttag aaattaaaac atacatttga
     1921 agcttggtta tgatattatt tttcttataa tatcatatgt atttttttaa aatttgcctt
     1981 tcagggacta aaaaaattga aaaaaaataa agttgaaaat tttattagac catctgaatt
     2041 tgtatttcag gaggtatttg cattcagtgc cttaatagtc ctagagcatt ttaatgtttt
     2101 atcttttcta atggttatag gtatatatgt tttcattctt ttgtatttga atattctgta
     2161 ttctaaataa aattgataat cttgaccaa
//
