LOCUS       NM_017461               1465 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus septin 1 (Septin1), mRNA.
ACCESSION   NM_017461
VERSION     NM_017461.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1465)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1465)
  AUTHORS   Ito,H., Morishita,R., Noda,M., Iwamoto,I. and Nagata,K.I.
  TITLE     Biochemical and morphological characterization of SEPT1 in mouse
            brain
  JOURNAL   Med Mol Morphol 53 (4), 221-228 (2020)
   PUBMED   32146512
  REMARK    GeneRIF: Biochemical and morphological characterization of SEPT1 in
            mouse brain.
REFERENCE   3  (bases 1 to 1465)
  AUTHORS   Yoshida,A., Yamamoto,N., Kinoshita,M., Hiroi,N., Hiramoto,T.,
            Kang,G., Trimble,W.S., Tanigaki,K., Nakagawa,T. and Ito,J.
  TITLE     Localization of septin proteins in the mouse cochlea
  JOURNAL   Hear Res 289 (1-2), 40-51 (2012)
   PUBMED   22575789
REFERENCE   4  (bases 1 to 1465)
  AUTHORS   Zhu,J., Qi,S.T., Wang,Y.P., Wang,Z.B., Ouyang,Y.C., Hou,Y.,
            Schatten,H. and Sun,Q.Y.
  TITLE     Septin1 is required for spindle assembly and chromosome congression
            in mouse oocytes
  JOURNAL   Dev Dyn 240 (10), 2281-2289 (2011)
   PUBMED   21932310
  REMARK    GeneRIF: Results show that septin1 is a key player in spindle
            assembly and chromosome congression in mouse meiosis.
REFERENCE   5  (bases 1 to 1465)
  AUTHORS   Tooley,A.J., Gilden,J., Jacobelli,J., Beemiller,P., Trimble,W.S.,
            Kinoshita,M. and Krummel,M.F.
  TITLE     Amoeboid T lymphocytes require the septin cytoskeleton for cortical
            integrity and persistent motility
  JOURNAL   Nat Cell Biol 11 (1), 17-26 (2009)
   PUBMED   19043408
  REMARK    GeneRIF: These data suggest that septins tune actomyosin forces
            during motility and probably regulate lymphocyte trafficking in
            confined tissues.
REFERENCE   6  (bases 1 to 1465)
  AUTHORS   Nottenburg,C., Gallatin,W.M. and St John,T.
  TITLE     Lymphocyte HEV adhesion variants differ in the expression of
            multiple gene sequences
  JOURNAL   Gene 95 (2), 279-284 (1990)
   PUBMED   2174398
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122537.4.
            
            On Jan 10, 2023 this sequence version replaced NM_017461.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC145081.1, SRR13862062.244929.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-51                AC122537.4         193476-193526       c
            52-142              AC122537.4         193210-193300       c
            143-229             AC122537.4         193040-193126       c
            230-353             AC122537.4         192688-192811       c
            354-488             AC122537.4         191970-192104       c
            489-606             AC122537.4         191759-191876       c
            607-708             AC122537.4         190937-191038       c
            709-805             AC122537.4         190728-190824       c
            806-971             AC122537.4         190350-190515       c
            972-1062            AC122537.4         190018-190108       c
            1063-1465           AC122537.4         189511-189913       c
FEATURES             Location/Qualifiers
     source          1..1465
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 69.39 cM"
     gene            1..1465
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /note="septin 1"
                     /db_xref="GeneID:54204"
                     /db_xref="MGI:MGI:1858916"
     exon            1..51
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     CDS             49..1149
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /EC_number="3.1.5.1"
                     /note="protein Diff6; peanut-like protein 3;
                     differentiation protein 6; differentiation 6
                     (deoxyguanosine triphosphate triphosphohydrolase)"
                     /codon_start=1
                     /product="septin-1"
                     /protein_id="NP_059489.2"
                     /db_xref="CCDS:CCDS40141.1"
                     /db_xref="GeneID:54204"
                     /db_xref="MGI:MGI:1858916"
                     /translation="MDKEYVGFAALPNQLHRKSVKKGFDFTLMVAGESGLGKSTLINS
                     LFLTNLYEDRQVPDASARTAQTLTIERRGVEIEEGGIKVKLTLVDTPGFGDSVDCSDC
                     WLPVVRFIEEQFEQYLRDESGLNRKNIQDSRVHCCLYFISPFGRGLRPLDVAFLRAVH
                     EKVNIIPVIGKADALMPRETQALKQKIRDQLKEEEINIYQFPECDSDEDEEFKKQNEE
                     MKENIPFAVVGSCEVVRDGTRPVRGRRYSWGTVEVENPHHCDFLNLRRMLVQTHLQDL
                     KEVTHDLLYEGYRARCLQSLARPGARDRASRSKLSRQSATEIPLPMLPLADTEKLIRE
                     KDEELRRMQEMLEKMQAQMQQSQAQGEQSDVL"
     exon            52..142
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            143..229
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            230..353
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            354..488
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            489..606
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            607..708
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            709..805
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            806..971
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            972..1062
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     exon            1063..1465
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1438..1443
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /note="hexamer: AATAAA"
     polyA_site      1465
                     /gene="Septin1"
                     /gene_synonym="Diff6; Pnutl3; Sept1"
                     /note="major polyA site"
ORIGIN      
        1 agaggaagtg gggagcaaca ccaggtgcaa gcgacaacca gcagagccat ggacaaggaa
       61 tatgtgggct ttgctgccct gcccaaccag ctgcatcgca agtctgtcaa gaaggggttt
      121 gacttcacac tcatggtggc aggggagtca ggcctgggga aatccaccct catcaacagc
      181 ttgttcctca ccaacctcta cgaggatcgg caggtgccag atgccagtgc tcgcacggca
      241 caaactctga ccattgagcg ccggggtgtg gagattgagg agggaggtat caaggtgaag
      301 ttgaccttgg tggacacgcc tggctttggg gactctgtgg actgctcaga ctgctggctg
      361 cctgtggttc gcttcattga ggagcagttt gagcaatacc tcagggatga gagtggcttg
      421 aacaggaaga acatccagga ttccagagtc cattgctgcc tctacttcat ctcacccttt
      481 ggccgagggc tccggcccct agatgtggct ttcctccggg cagtgcacga gaaagtcaat
      541 atcatcccgg tcatcggtaa agcagacgcc ctgatgccta gggagactca ggccctcaag
      601 cagaagatcc gggaccagtt gaaagaggag gagatcaaca tctatcagtt cccagagtgt
      661 gactctgatg aggacgaaga attcaagaag cagaatgaag aaatgaagga aaacatccct
      721 ttcgcagtcg ttgggtcttg tgaagtggtg agggatggaa cccgaccagt gaggggaaga
      781 cgctactcct ggggtaccgt ggaggtggag aacccacatc actgcgattt cctgaacctg
      841 aggcggatgt tggtgcagac ccaccttcag gacttgaaag aggtgaccca cgatctgctc
      901 tacgagggct accgggctcg ctgcctacag agtctggctc gacctggggc ccgggatcga
      961 gccagccgca gcaagctttc ccggcaaagt gccacagaga tcccgctgcc catgttgcct
     1021 ctggctgaca ctgaaaagtt gattcgcgag aaggacgaag agctgcgccg catgcaagaa
     1081 atgctggaga agatgcaagc ccagatgcag cagagccagg ctcagggcga gcaatcagat
     1141 gtgctgtgat attccccaat accgcctgtc ctcgcctctg ctcaccgcta atcggctatc
     1201 ccatccccgc gctggacagc ccagcgccca atccggggat ccagagggta ggcctgccct
     1261 tgcacttaaa ccagatccct ccaatccgga agtttaaggc ccatccgact tcgtcttccg
     1321 cgcggctcta agaggaccgc actccaagaa aagcctcccc accactcctc cccccccccc
     1381 cccaccgctc ttcccgcgtt ccaattgggt tttcctattc ctccaagttc tccatctaat
     1441 aaaaactgct tcccgccttc cccca
//
