LOCUS       NP_780609                392 aa            linear   ROD 02-JUN-2024
DEFINITION  selenide, water dikinase 1 isoform a [Mus musculus].
ACCESSION   NP_780609
VERSION     NP_780609.4
DBSOURCE    REFSEQ: accession NM_175400.6
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 392)
  AUTHORS   Bang,J., Kang,D., Jung,J., Yoo,T.J., Shim,M.S., Gladyshev,V.N.,
            Tsuji,P.A., Hatfield,D.L., Kim,J.H. and Lee,B.J.
  TITLE     SEPHS1: Its evolution, function and roles in development and
            diseases
  JOURNAL   Arch Biochem Biophys 730, 109426 (2022)
   PUBMED   36202216
  REMARK    GeneRIF: SEPHS1: Its evolution, function and roles in development
            and diseases.
REFERENCE   2  (residues 1 to 392)
  AUTHORS   Kang,D., Lee,J., Jung,J., Carlson,B.A., Chang,M.J., Chang,C.B.,
            Kang,S.B., Lee,B.C., Gladyshev,V.N., Hatfield,D.L., Lee,B.J. and
            Kim,J.H.
  TITLE     Selenophosphate synthetase 1 deficiency exacerbates osteoarthritis
            by dysregulating redox homeostasis
  JOURNAL   Nat Commun 13 (1), 779 (2022)
   PUBMED   35140209
  REMARK    GeneRIF: Selenophosphate synthetase 1 deficiency exacerbates
            osteoarthritis by dysregulating redox homeostasis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 392)
  AUTHORS   Qiao,L., Dho,S.H., Kim,J.Y. and Kim,L.K.
  TITLE     SEPHS1 is dispensable for pluripotency maintenance but
            indispensable for cardiac differentiation in mouse embryonic stem
            cells
  JOURNAL   Biochem Biophys Res Commun 590, 125-131 (2022)
   PUBMED   34974300
  REMARK    GeneRIF: SEPHS1 is dispensable for pluripotency maintenance but
            indispensable for cardiac differentiation in mouse embryonic stem
            cells.
REFERENCE   4  (residues 1 to 392)
  AUTHORS   Bang,J., Han,M., Yoo,T.J., Qiao,L., Jung,J., Na,J., Carlson,B.A.,
            Gladyshev,V.N., Hatfield,D.L., Kim,J.H., Kim,L.K. and Lee,B.J.
  TITLE     Identification of Signaling Pathways for Early Embryonic Lethality
            and Developmental Retardation in Sephs1-/- Mice
  JOURNAL   Int J Mol Sci 22 (21), 11647 (2021)
   PUBMED   34769078
  REMARK    GeneRIF: Identification of Signaling Pathways for Early Embryonic
            Lethality and Developmental Retardation in Sephs1(-/-) Mice.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 392)
  AUTHORS   Jung,J., Kim,Y., Na,J., Qiao,L., Bang,J., Kwon,D., Yoo,T.J.,
            Kang,D., Kim,L.K., Carlson,B.A., Hatfield,D.L., Kim,J.H. and
            Lee,B.J.
  TITLE     Constitutive Oxidative Stress by SEPHS1 Deficiency Induces
            Endothelial Cell Dysfunction
  JOURNAL   Int J Mol Sci 22 (21), 11646 (2021)
   PUBMED   34769076
  REMARK    GeneRIF: Constitutive Oxidative Stress by SEPHS1 Deficiency Induces
            Endothelial Cell Dysfunction.
            Publication Status: Online-Only
REFERENCE   6  (residues 1 to 392)
  AUTHORS   Tobe,R., Carlson,B.A., Huh,J.H., Castro,N.P., Xu,X.M., Tsuji,P.A.,
            Lee,S.G., Bang,J., Na,J.W., Kong,Y.Y., Beaglehole,D., Southon,E.,
            Seifried,H., Tessarollo,L., Salomon,D.S., Schweizer,U.,
            Gladyshev,V.N., Hatfield,D.L. and Lee,B.J.
  TITLE     Selenophosphate synthetase 1 is an essential protein with roles in
            regulation of redox homoeostasis in mammals
  JOURNAL   Biochem J 473 (14), 2141-2154 (2016)
   PUBMED   27208177
  REMARK    GeneRIF: Data found that several malignant characteristics of
            SPS1-deficient F9 cells were reversed, suggesting that SPS1 played
            a role in supporting and/or sustaining cancer. Selenophosphate
            synthetase 1 is an essential protein with roles in regulation of
            redox homoeostasis in mammals.
REFERENCE   7  (residues 1 to 392)
  AUTHORS   Saiki,R., Nagata,A., Kainou,T., Matsuda,H. and Kawamukai,M.
  TITLE     Characterization of solanesyl and decaprenyl diphosphate synthases
            in mice and humans
  JOURNAL   FEBS J 272 (21), 5606-5622 (2005)
   PUBMED   16262699
  REMARK    GeneRIF: murine and human solanesyl and decaprenyl diphosphate
            synthases are heterotetramers composed of newly characterized hDPS1
            (mSPS1) and hDLP1 (mDLP1)
REFERENCE   8  (residues 1 to 392)
  AUTHORS   Blackshaw,S., Harpavat,S., Trimarchi,J., Cai,L., Huang,H.,
            Kuo,W.P., Weber,G., Lee,K., Fraioli,R.E., Cho,S.H., Yung,R.,
            Asch,E., Ohno-Machado,L., Wong,W.H. and Cepko,C.L.
  TITLE     Genomic analysis of mouse retinal development
  JOURNAL   PLoS Biol 2 (9), E247 (2004)
   PUBMED   15226823
REFERENCE   9  (residues 1 to 392)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC066037.1 and BC065165.1.
            
            On Sep 1, 2007 this sequence version replaced NP_780609.3.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2, and 3 all encode the same isoform (a).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066037.1, SRR1660817.31012.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..392
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 3.02 cM"
     Protein         1..392
                     /product="selenide, water dikinase 1 isoform a"
                     /EC_number="2.7.9.3"
                     /note="selenide, water dikinase 1; selenium donor protein
                     1; selenophosphate synthase 1"
                     /calculated_mol_wt=42776
     Site            2
                     /site_type="acetylation"
                     /note="N-acetylserine.
                     /evidence=ECO:0000250|UniProtKB:P49903; propagated from
                     UniProtKB/Swiss-Prot (Q8BH69.1)"
     Region          19..333
                     /region_name="selD"
                     /note="selenium donor protein; TIGR00476"
                     /db_xref="CDD:273100"
     Site            32
                     /site_type="other"
                     /note="Important for catalytic activity.
                     /evidence=ECO:0000250|UniProtKB:P16456; propagated from
                     UniProtKB/Swiss-Prot (Q8BH69.1)"
     Site            order(81..84,86,88,110,121,124,127,163,170..171,175,277)
                     /site_type="other"
                     /note="dimerization interface [polypeptide binding]"
                     /db_xref="CDD:100031"
     Site            order(106,110,161..163)
                     /site_type="other"
                     /note="putative ATP binding site [chemical binding]"
                     /db_xref="CDD:100031"
     CDS             1..392
                     /gene="Sephs1"
                     /gene_synonym="1110046B24Rik; SELD; SPS; SPS1"
                     /coded_by="NM_175400.6:379..1557"
                     /note="isoform a is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS15659.1"
                     /db_xref="GeneID:109079"
                     /db_xref="MGI:MGI:1923580"
ORIGIN      
        1 mstresfnpe tyeldksfrl trftelkgtg ckvpqdvlqk lleslqenhf qedeqflgav
       61 mprlgigmdt cviplrhggl slvqttdyiy pivddpymmg riacanvlsd lyamgvtecd
      121 nmlmllgvsn kmtdrerdkv ipliiqgfkd aaeeagtsvt ggqtvlnpwi vlggvattvc
      181 qpnefimpdn avpgdvlvlt kplgtqvava vhqwldipek wnkiklvvtq edvelayqea
      241 mmnmarlnrt aaglmhtfna haatditgfg ilghaqnlak qqrnevsfvi hnlpvlakma
      301 avskacgnmf glmhgtcpet sgglliclpr eqaarfcaei kspkygeghq awiigivekg
      361 nrtariidkp riievapqva tqnvnptpga ts
//
