LOCUS       NM_025483               4908 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus SUMO1/sentrin specific peptidase 7 (Senp7), transcript
            variant 1, mRNA.
ACCESSION   NM_025483
VERSION     NM_025483.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4908)
  AUTHORS   Pei,J., Zou,D., Li,L., Kang,L., Sun,M., Li,X., Chen,Q., Chen,D.,
            Qu,B., Gao,X. and Lin,Z.
  TITLE     Senp7 deficiency impairs lipid droplets maturation in white adipose
            tissues via Plin4 deSUMOylation
  JOURNAL   J Biol Chem 300 (6), 107319 (2024)
   PUBMED   38677512
  REMARK    GeneRIF: Senp7 deficiency impairs lipid droplets maturation in
            white adipose tissues via Plin4 deSUMOylation.
REFERENCE   2  (bases 1 to 4908)
  AUTHORS   Wu,Z., Huang,H., Han,Q., Hu,Z., Teng,X.L., Ding,R., Ye,Y., Yu,X.,
            Zhao,R., Wang,Z. and Zou,Q.
  TITLE     SENP7 senses oxidative stress to sustain metabolic fitness and
            antitumor functions of CD8+ T cells
  JOURNAL   J Clin Invest 132 (7) (2022)
   PUBMED   35143421
REFERENCE   3  (bases 1 to 4908)
  AUTHORS   Zhang,X., Wang,C., Zhao,D., Chen,X., Zhang,C., Zheng,J. and Liu,X.
  TITLE     Zinc deficiency induces abnormal development of the myocardium by
            promoting SENP5 overexpression
  JOURNAL   PLoS One 15 (11), e0242606 (2020)
   PUBMED   33211757
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4908)
  AUTHORS   Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T.
            and Salmona,M.
  TITLE     Neuronal Localization of SENP Proteins with Super Resolution
            Microscopy
  JOURNAL   Brain Sci 10 (11), 778 (2020)
   PUBMED   33113832
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4908)
  AUTHORS   Suhail,A., Rizvi,Z.A., Mujagond,P., Ali,S.A., Gaur,P., Singh,M.,
            Ahuja,V., Awasthi,A. and Srikanth,C.V.
  TITLE     DeSUMOylase SENP7-Mediated Epithelial Signaling Triggers Intestinal
            Inflammation via Expansion of Gamma-Delta T Cells
  JOURNAL   Cell Rep 29 (11), 3522-3538 (2019)
   PUBMED   31825833
REFERENCE   6  (bases 1 to 4908)
  AUTHORS   Garvin,A.J., Densham,R.M., Blair-Reid,S.A., Pratt,K.M., Stone,H.R.,
            Weekes,D., Lawrence,K.J. and Morris,J.R.
  TITLE     The deSUMOylase SENP7 promotes chromatin relaxation for homologous
            recombination DNA repair
  JOURNAL   EMBO Rep 14 (11), 975-983 (2013)
   PUBMED   24018422
REFERENCE   7  (bases 1 to 4908)
  AUTHORS   Bawa-Khalfe,T., Lu,L.S., Zuo,Y., Huang,C., Dere,R., Lin,F.M. and
            Yeh,E.T.
  TITLE     Differential expression of SUMO-specific protease 7 variants
            regulates epithelial-mesenchymal transition
  JOURNAL   Proc Natl Acad Sci U S A 109 (43), 17466-17471 (2012)
   PUBMED   23045645
REFERENCE   8  (bases 1 to 4908)
  AUTHORS   Maison,C., Romeo,K., Bailly,D., Dubarry,M., Quivy,J.P. and
            Almouzni,G.
  TITLE     The SUMO protease SENP7 is a critical component to ensure HP1
            enrichment at pericentric heterochromatin
  JOURNAL   Nat Struct Mol Biol 19 (4), 458-460 (2012)
   PUBMED   22388734
  REMARK    GeneRIF: Depletion of Senp7 delocalizes HP1 alpha from pericentric
            heterochromatin without affecting H3K9me3 levels.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 4908)
  AUTHORS   Kim,J.H. and Baek,S.H.
  TITLE     Emerging roles of desumoylating enzymes
  JOURNAL   Biochim Biophys Acta 1792 (3), 155-162 (2009)
   PUBMED   19162180
  REMARK    Review article
REFERENCE   10 (bases 1 to 4908)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK040314.1, AK085060.1 and
            AC154275.2.
            
            On Jan 30, 2015 this sequence version replaced NM_025483.3.
            
            Summary: This gene encodes a SUMO deconjugating enzyme of the
            Sentrin/SUMO-specific protease (SENP) family. The encoded protein
            is a protease that exhibits deSUMOylating activity towards proteins
            involved in chromatin remodeling and promotes chromatin relaxation
            for DNA repair or transcription. Alternative splicing of this gene
            results in multiple transcript variants. [provided by RefSeq, Jan
            2015].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK122542.1, BC058593.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-61                AK040314.1         1-61
            62-3690             AK085060.1         2-3630
            3691-4908           AC154275.2         113848-115065
FEATURES             Location/Qualifiers
     source          1..4908
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 33.82 cM"
     gene            1..4908
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /note="SUMO1/sentrin specific peptidase 7"
                     /db_xref="GeneID:66315"
                     /db_xref="MGI:MGI:1913565"
     exon            1..175
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..3249
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /EC_number="3.4.22.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SUMO1/sentrin specific protease 7; sentrin-specific
                     protease 7; SUMO-1-specific protease 2;
                     sentrin/SUMO-specific protease SENP7"
                     /codon_start=1
                     /product="sentrin-specific protease 7 isoform 1"
                     /protein_id="NP_079759.2"
                     /db_xref="CCDS:CCDS28222.1"
                     /db_xref="GeneID:66315"
                     /db_xref="MGI:MGI:1913565"
                     /translation="MDRARPGRRRASSEIVTEGKRKKSSPADLQKITKLLTVKSEDVL
                     AQSPLSKLRGSECWWTRSLRNKVICLDHKKPKAARGCPPKGLPKRHLRVMLTNVLWTD
                     LGREFRKTLPRKDANLCAPSKVQSDSLPSTSVDSIETCQRLDPLHQSLNLSERTPRVI
                     LTDIRQTELGRKYLKIPPVTEASLSDTANLKSEQLSSSSDGSLESCQSVNHHKSFLSE
                     SGPKPSRTGDVPAKEAACGGQKQGDDGGVTPEMAAPHPKDFNTGNKGCDYLEEGTSNK
                     NTSYSYSEMDHTPVSRKRKKRGRSNFHDSHNSKTSLDKPTEHTKEEENDSSVSRKLEE
                     SGEDSHQDPAPPEGLAPESLESEATNLRSFAAGQEPDASAASGRASSPNKSLESSASS
                     EVSENSSVAVKGEALTLKEASPPGGSSEESQLLISAEPIVVSSDEEGPVEHKNSVILK
                     LQPPHEIMSENQGTSDPQLSELTLGACESVQVTSELFPYNPDVENISCIKSNSEMDLK
                     LDFIFTCVYIGKIKGTPKGCVTFTKKYIKIPFQVSTNEISLTVDTARLKRFGLWESKD
                     EDHSKRSHAILFLWLSSDYLQDIQTQLENPMLSQQSKANEFIFLELNSSISQREELKL
                     KDIMMEISTKNGNLHLSCPLPWVQALPLFQDLSPQEISFLHYYYASASALPTAAGADM
                     KKKSVSQPSNSDTIKPTYTFLHKQSSGCYSLSITSSPEEEWQEVRNTGPVQKLIVYPP
                     PPTKGGLGVTNEDLECLEEGEFLNDVIIDFYLKYLLLEKASDELVERSHIFSSFFYKC
                     LTRKENNLTEDNPDLSVAQRRHRRVRTWTRHINIFNKDYIFVPVNESSHWYLAVICFP
                     WLEEAVYEDCPQTVSQQFQGQQSQHDHKMTDNDPHTTSTVSTSAEDSQSTEVNMSVPK
                     KMCKRPCILILDSLKAASIQNTVQNLREYLEVEWEVKRKTHREFSKTNMVDLCPKVPK
                     QDNSSDCGVYLLQYVESFFQDPIVNFELPIHLEKWFPRHVIKTKREDIRELILKLHLQ
                     QQKGGSC"
     exon            176..228
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            229..309
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            310..401
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            402..599
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            600..791
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            792..907
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            908..1092
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1093..1426
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1427..1578
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1579..1725
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1726..1759
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1760..1939
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1940..2202
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2203..2336
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2337..2453
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2454..2576
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2577..2669
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2794
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2795..2847
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2848..2891
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2892..2960
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            2961..3111
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            3112..4908
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4842..4847
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /note="hexamer: ATTAAA"
     regulatory      4862..4867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      4862
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
                     /note="major polyA site"
     polyA_site      4888
                     /gene="Senp7"
                     /gene_synonym="2410152H17Rik; 2810413I22Rik;
                     2900036C23Rik; 6030449K19Rik"
ORIGIN      
        1 gaggcgacga ctagtgcgca agcgcgaatc tcacttctgg ctttctctct tcccctcccc
       61 ctcccttccc cagcccgagg ggtcctgagg tgacagcgcc tggaagtggg actggaggag
      121 ccggcggagg agaagatgga cagggccagg cctgggcgtc ggcgagcttc atcagagatt
      181 gttacagagg gaaaacggaa aaagtcatca ccagctgatt tacagaagat aacaaagttg
      241 ttaactgtaa agtcagagga tgttcttgct cagtcaccat tgtccaaact cagaggctca
      301 gaatgctggt ggacaagaag cctaagaaat aaagtcatct gtctagacca caaaaaacca
      361 aaagctgccc gtgggtgtcc tcctaaggga ttaccaaaaa ggcatctcag agttatgttg
      421 acgaatgttc tatggacgga cttaggacga gaattcagaa agaccctgcc tagaaaggat
      481 gctaatttat gtgctcccag caaggtgcaa tcagactcat tgccttcgac atctgttgac
      541 agcatagaga catgtcaaag attagatcct cttcaccaaa gccttaattt atccgaaagg
      601 acacccagag ttatactgac ggatatccgg caaacagaat taggaagaaa atatttaaag
      661 atcccacctg taactgaggc cagtttgagt gatacagcca acctgaaatc agagcaactt
      721 tcttcatcat ctgatggcag cttagagtct tgtcagagtg taaatcatca caagagcttt
      781 ttatctgaaa gtggtcccaa accaagtagg acaggtgacg ttcctgcaaa ggaggctgca
      841 tgtgggggac agaagcaggg tgatgatgga ggagtcactc ctgagatggc tgctcctcat
      901 cctaaagact ttaatactgg aaataaaggt tgtgattatc ttgaagaggg gaccagcaac
      961 aagaatactt catattctta ttcggaaatg gaccatactc cagtttccag gaagagaaag
     1021 aaaaggggta gaagtaattt tcatgattct cataattcta agacttcttt ggataagcca
     1081 acagaacata caaaagaaga agaaaatgac tcttcagtct cccgtaagct tgaagagtcc
     1141 ggtgaagact ctcaccagga cccagcacca cccgaaggac tcgcgccaga atctttagag
     1201 agcgaggcca ctaacctgcg ctcattcgct gctggtcagg agccagatgc tagcgctgcc
     1261 tctggaaggg cctcttcacc caacaaaagc ttggagagct ctgcttctag tgaagtgtcg
     1321 gagaattctt ccgtggctgt gaagggtgag gcgttgactc taaaagaagc atcccctccg
     1381 ggtggaagca gtgaagagag ccagttgttg atctcagctg agccaattgt agtttccagt
     1441 gatgaagaag gaccggttga acataagaat tcagtaattc taaaattaca gcctcctcat
     1501 gagattatga gtgaaaatca gggcacttct gacccacagt tgtcagagct gacactcggt
     1561 gcatgtgaat ctgtacaggt aacatctgaa ttatttccat acaatcctga tgtagaaaac
     1621 atttcctgta ttaaatctaa tagtgaaatg gatctgaaat tggatttcat atttacatgt
     1681 gtgtatattg gtaaaataaa aggaactcca aaaggttgtg tcacgttcac aaagaagtat
     1741 attaaaatcc cgtttcaagt gtccacaaat gagatttccc tgacagtgga caccgcacgt
     1801 ttaaagaggt tcgggttatg ggaaagcaag gatgaggacc acagcaagag gagccacgct
     1861 atccttttcc tctggctttc ctcagactac cttcaagaca ttcagaccca gctagaaaac
     1921 cccatgctaa gccagcaatc aaaagccaat gaatttattt tccttgagtt aaacagttcc
     1981 atttcacaaa gagaagaatt gaaattgaaa gatattatga tggaaatcag tacaaaaaat
     2041 ggaaatttac acctgtcttg tccattgccc tgggtccagg cacttccttt gtttcaggat
     2101 ctctctccac aagaaatctc ttttcttcac tattactatg cttcagcttc tgctctcccc
     2161 actgctgctg gggcagacat gaagaagaag tcagtgtctc agccctcaaa ttcagacacc
     2221 atcaagccta cttacacctt cctacataaa caaagtagtg gttgctactc gctctctatt
     2281 acttcaagtc cagaggagga atggcaggaa gtcaggaaca cgggacccgt tcagaagttg
     2341 attgtttatc ctccaccacc tactaaggga ggcttgggag taactaatga agatctagag
     2401 tgtttagaag aaggagaatt tcttaacgat gtaatcattg acttttacct taagtatctt
     2461 ctattggaga aggcatcaga tgaacttgtt gaacgaagtc acatttttag tagctttttc
     2521 tataaatgct tgacaagaaa ggaaaataat ttaacagaag ataatccaga tctatcagtg
     2581 gctcagagga gacaccgaag agtgagaaca tggactcgtc atataaacat ttttaataaa
     2641 gactacatct ttgtacctgt taatgaatcg tctcactggt atcttgcagt catttgtttc
     2701 ccatggctag aagaggctgt gtatgaagat tgtccacaaa ctgtgtccca acagttccag
     2761 ggtcagcagt ctcagcatga ccacaaaatg acagataatg atccacatac cacttcaact
     2821 gtgtccacga gtgcagagga ttcccaaagt accgaggtga atatgtcagt accaaagaaa
     2881 atgtgtaagc ggccatgtat tctcatacta gactccctga aagctgcttc tatacaaaac
     2941 acagttcaga acttacgaga gtatttggag gtagagtggg aggtgaaacg aaaaacgcac
     3001 cgtgaattca gtaaaaccaa tatggtcgac ctgtgcccca aagtccctaa gcaggataac
     3061 agcagtgact gtggagtcta tttgttgcag tatgtggaga gctttttcca ggatcccatt
     3121 gttaactttg aacttccaat tcacttggag aaatggtttc ctcgccatgt aataaagacc
     3181 aaacgggaag atattcgaga gctcattttg aaacttcact tacagcaaca gaagggcggc
     3241 agctgctagt taatctgtgc acacacgcac ccgctcccta agtttcctag aaagccgctt
     3301 accagcatct gtgtcagctt acaaagaaga aagcaactcc cagtacatca cagattgttg
     3361 aaatgtacat gcgatcttgt ttgagtcctt gggctctccc agccgaaggt gatgaacaaa
     3421 gtacttataa gatagaaatt aaaatctcaa aaatatgata tttttatgac taaatatgct
     3481 tggattatgc aatagcatat gtaatgtggg aatgttttcc taaataataa gcctatgtga
     3541 tctgtacttc cacatgactg ggtgttgatg ggaggtcggc cctccctggt gccagcccag
     3601 ggcttgtcag gtgtgttgac aagtcacatc atattgtaat tctaatcttt gcagctcaag
     3661 catgcagtat gaatactgtg tatttttttt taaaaataac ttagtatcaa ggcttcagaa
     3721 aatgccattc acggcatctc ttctgtatag tgtgggaaaa aaaaaagaaa tattaaaaaa
     3781 ttaccctttc aaagtgcagc ttattctcca ttactaaatg caactacttt gctctaattt
     3841 ccttctccac ttgtttcaat gtcatatata tagggatctg agaaatgagc tcatctgttc
     3901 atataaaatg tgaaacaaat tttaatacca aataagtttt aaaatactgt gtagctaagc
     3961 tttgtttatt tgatgcatag ctatataaat attcattcct acgttacccc aaaatgtgtg
     4021 tatacagttt ctataaaagg taaaattgat accctcatca ttttagcaaa gaataccttt
     4081 aaacttgtat ttattattta gaaccaaata tgtgattttt atcgtttggt ttacccactg
     4141 ctcatgtgca aagccagatt tttcattgct tttatatttt taagttattg tttttaaagc
     4201 tatatgatcc tctgtggatc tcacatactc agcacttaac atttgattaa atgttcaggt
     4261 aacaattgta ctgaacttgt gtgtcgatga tagcgtcacc taacaaacag tttagagcct
     4321 tatgctctta gaaatgttct gaaggagaca taatcatact gttttctcaa ataatgggtt
     4381 ttagaatatt attttaatca tctcttggat ttacagttat aactgtatgt aaagcacttg
     4441 aagcaaatgt aatttaagat aaaaccaaga agtctgaaag tttcatttcc agtcaagtga
     4501 cttggttgtc agtcagcctc cgcgtcctcg gcttctgcag atcttgactc tctgcgttgt
     4561 ttgaggtacg tggcttttgg agatctcaca tgaaaattgt tattaattgc ataattcatt
     4621 cccaatttat gtgtgttggg gagaattttt ttaaagtggc tgttaattgt gttgtatatc
     4681 taattttgca aagcaggtat gtgagacatc ttgtaatttc tgaactgttt tgtttgtgtg
     4741 tttttcaaag ataccatgat cattcatcat gttttggaga ctgtttaaaa tttgttttcc
     4801 taaattcatg tagaaatgat ttgaggatat caacattttg tattaaacat gttttcaatt
     4861 cattaaattg taattttttt cttaaatatg aaggactgct agcaatgt
//
