LOCUS       NM_001311110            4976 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus SUMO/sentrin specific peptidase 6 (Senp6), transcript
            variant 1, mRNA.
ACCESSION   NM_001311110 XM_006511013
VERSION     NM_001311110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4976)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 4976)
  AUTHORS   Xia,Q., Mao,M., Zeng,Z., Luo,Z., Zhao,Y., Shi,J. and Li,X.
  TITLE     Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury
            by regulating Annexin-A1 nuclear translocation-associated neuronal
            apoptosis
  JOURNAL   Theranostics 11 (15), 7450-7470 (2021)
   PUBMED   34158860
  REMARK    GeneRIF: Inhibition of SENP6 restrains cerebral
            ischemia-reperfusion injury by regulating Annexin-A1 nuclear
            translocation-associated neuronal apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4976)
  AUTHORS   Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T.
            and Salmona,M.
  TITLE     Neuronal Localization of SENP Proteins with Super Resolution
            Microscopy
  JOURNAL   Brain Sci 10 (11), 778 (2020)
   PUBMED   33113832
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4976)
  AUTHORS   Li,J., Lu,D., Dou,H., Liu,H., Weaver,K., Wang,W., Li,J.,
            Yeh,E.T.H., Williams,B.O., Zheng,L. and Yang,T.
  TITLE     Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by
            suppressing the p53 pathway
  JOURNAL   Nat Commun 9 (1), 143 (2018)
   PUBMED   29321472
  REMARK    GeneRIF: postnatal loss of the desumoylase SUMO1/sentrin-specific
            peptidase 6 (SENP6) causes premature aging. OCP-specific SENP6
            knockout mice exhibit smaller skeletons, with elevated apoptosis
            and cell senescence in OCPs and chondrocytes. SENP6 interacts with,
            desumoylates, and stabilizes TRIM28, suppressing p53 activity.
            Erratum:[Nat Commun. 2018 Feb 8;9(1):646. doi:
            10.1038/s41467-018-03177-0.. PMID: 29422621]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4976)
  AUTHORS   Liu,X., Chen,W., Wang,Q., Li,L. and Wang,C.
  TITLE     Negative regulation of TLR inflammatory signaling by the
            SUMO-deconjugating enzyme SENP6
  JOURNAL   PLoS Pathog 9 (6), e1003480 (2013)
   PUBMED   23825957
  REMARK    GeneRIF: Negative regulation of TLR inflammatory signaling by the
            SUMO-deconjugating enzyme SENP6.
REFERENCE   6  (bases 1 to 4976)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 4976)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053904.1, BC052718.1 and AK083377.1.
            
            On Jul 25, 2015 this sequence version replaced XM_006511013.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.153309.1,
                                           SRR1660811.215049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-196               AK053904.1         1-196
            197-764             BC052718.1         1-568
            765-822             AK083377.1         354-411
            823-4976            BC052718.1         569-4722
FEATURES             Location/Qualifiers
     source          1..4976
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.88 cM"
     gene            1..4976
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /note="SUMO/sentrin specific peptidase 6"
                     /db_xref="GeneID:215351"
                     /db_xref="MGI:MGI:1922075"
     exon            1..670
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             622..4041
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /EC_number="3.4.22.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SUMO/sentrin specific protease 6; sentrin-specific
                     protease 6; SUMO-1-specific protease 1;
                     sentrin/SUMO-specific protease SENP6"
                     /codon_start=1
                     /product="sentrin-specific protease 6 isoform 1"
                     /protein_id="NP_001298039.1"
                     /db_xref="CCDS:CCDS81040.1"
                     /db_xref="GeneID:215351"
                     /db_xref="MGI:MGI:1922075"
                     /translation="MAAGKSGGSAGALFLKALDRSESKRDGGFKNNWSFDHEEESEGD
                     ADKDGANLLSVEDEDSEISKGKKLNRRSEIVATSSGDFILKTYVRRSKTDGFKTLKGN
                     PIGLNMLSNNKKLSESTAGTALCSGTVVHGRRFHHAHSQTPGIRTAAQSNQDRKERKE
                     YPPYVHKAENSPVMLSHGQGGDHIMKKTEESESYVESEIKRKVQQKRHCSTYQLSPLS
                     PASKKCLTHLEVSEQREYCPKCGKEKENQTKCQSCGIVFHNDLQRNCRQAVTLNEPTG
                     PLLRTSIHQNSGGQKSQNTGLTAKKFYGNSVDKIPIDILVTCDDSRHNYIQTNGKVIL
                     PGGKIPKLTNPKERKISVSDLNDPIILSSDDDDDDDDRTKRRESTSPKPADSACSSPV
                     PSTGKVEAALNADACRAEQEPRSSPAEPELNTIVIPRKARMKDQLGNSISTPLKRRKV
                     NSHAAFIHPMSLSCQNFESVILNCRSIRVGTLFRLLVEPVIFSLESITIHLDGPESDP
                     VDIILNTSDLTKCEWCNVRKLPVVFLQAIPAVYQKLSMQLQMSKEDKVWNDCKGINRI
                     TSLEEQYIILIFQTGLDHQAEVVFESIITDIGIRNNVPNFFAKILFDEANSRLVACTR
                     SYEESIKGNCAQKENKVKTVSFESKIQLRSKQELQFFDDDEEAGESHTIFIGPVEKLI
                     VYPPPPAKGGISVTNEDLHCLSEGEFLNDVIIDFYLKYLVLEKLKKEDADRIHIFSSF
                     FYKRLNQRERRNPETTNLSIQQKRHGRVKTWTRHVDIFEKDFIFVPLNEAAHWFLAVV
                     CFPGLEKPKYEPNPHYHENAVMQKTPSAEDSCVSSASEMGACSQNSAAKPVIKKMLNR
                     KHCLAVTDSSAAQEESEPCYRRNAYSVKCSMKKKNHAINENEEPSNGESTCQDICDRT
                     QSENGLRDECFSSVHHPDALSKIRLNYGDQSADGGKLLEDELIDFSEDQDDPDDSSDD
                     GLLADENYSSEIGQWHLKPTVCKQPCILLMDSLRGPSRSNVVKILREYLEVEWEVKKG
                     SKRSFSKDVMKGSNPKVPQQNNFSDCGVYVLQYVESFFENPVLNFELPMNLMNWFPPP
                     RMKTKREEIRNIILKLQESQSKDKKLLKDSLAETSLGDGAEQYASASGGSE"
     exon            671..764
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            765..822
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            823..968
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            969..1073
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1074..1094
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1095..1165
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1166..1308
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1696
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1929
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            1930..2094
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2095..2128
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2129..2323
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2324..2550
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..2660
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2661..2777
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2778..2897
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2898..2990
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            2991..3415
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3416..3519
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3520..3608
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3609..3677
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3678..3828
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     exon            3829..4960
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4328..4333
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /note="hexamer: AATAAA"
     polyA_site      4350
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /note="major polyA site"
     polyA_site      4385
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
     regulatory      4473..4478
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /note="hexamer: AATATA"
     polyA_site      4501
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
ORIGIN      
        1 ggagcggcgg cggggctgct gtggcgaccg acgcgcggcg gtggcggaga cccacccccg
       61 tccacatgga cagtcgccga ggcctgggct gatgctctga cgcctgggcg gggtgggcgg
      121 gcggcggcgg ccactgctgg agcagcgagg ggtcgcgggc gcctcacggt cgcggagccc
      181 tcgctcggct caagccgctg cggccatttt acggcccggg acgtagaagg cgtgtgagcg
      241 ttcgctccgt tctccgtcct ccggagccag cggcggagcg gggcggaggg gagcggaggg
      301 agctcctcag aggccggcgc ggcccggtgg atggggagtc gtgtgccgag gggagccggg
      361 cccgggaagc gccgccgccg ccgctcacgg tccccggtag gcgcctgagg agaagcagcc
      421 caggccgtgg gcctcgccgc ctcccgtcag gcccgctttt gtgtgggggg cccggccggc
      481 ggggagcgcc cctcgcggag gtcgagcccg aggcccgcca ccctgcggct gctaccctcc
      541 cgacgcgcgg cccccattcc ccgccagcac cgcgccggtg tcggccatgg agtaagaagg
      601 aggcggcgtg gaaggaggaa gatggcggcg ggcaagagcg gtggcagcgc tggggctctt
      661 ttcctgaaag ctttggatag atcagaatct aagagggatg gaggctttaa aaataattgg
      721 agctttgatc atgaagaaga aagtgaagga gatgcagaca aagatggggc aaatctactc
      781 agtgtagaag atgaggattc tgaaatctca aaaggaaaaa agttaaatcg gagatctgaa
      841 attgttgcta ctagttctgg tgatttcatc ttgaagactt atgtaaggcg gagcaagact
      901 gacggcttta aaactttgaa aggcaaccca attggactta acatgttaag caacaataag
      961 aaactgagtg aaagcaccgc aggcacagca ttatgttctg gaactgtggt tcatgggagg
     1021 cgcttccatc atgctcactc acagacgcca ggcatcagaa cagcggctca gagcaatcag
     1081 gaccgaaaag aaaggaaaga atacccacct tatgtccaca aagctgaaaa cagccctgta
     1141 atgctaagtc atggccaagg tggagaccat ataatgaaga aaactgaaga gtcagaatca
     1201 tatgtagagt ctgagattaa gaggaaagtc cagcagaagc ggcactgtag cacttaccag
     1261 ctttctcctc tgtcccctgc ctcaaagaag tgtttgaccc atttagaggt ttctgaacag
     1321 cgtgaatatt gcccaaaatg tggaaaagaa aaagaaaatc agaccaaatg ccaaagttgt
     1381 ggtattgttt ttcataatga tttgcaaaga aattgccgac aagccgtaac tttgaatgaa
     1441 cctactggac cattgctaag aacatcaatt catcagaact ctggaggaca gaaatcacaa
     1501 aacacaggac taacagctaa gaaattttat gggaacagtg tggataagat tccaattgat
     1561 attttggtca cctgtgatga tagcagacat aattacatac agacaaatgg gaaagtcatt
     1621 ttacctggag gaaaaatacc taaactcaca aacccaaaag agcgaaagat aagcgtgtca
     1681 gatttaaacg atccaatcat tttgtctagt gatgatgatg acgacgacga cgataggact
     1741 aagagaagag agagcacgtc cccgaagcct gccgactcag catgctcctc accagtacca
     1801 tctacgggaa aagttgaagc tgcactaaat gcagatgcct gtagagcaga gcaggaaccc
     1861 agaagcagtc cagcagagcc tgagttaaat accattgtca taccacgaaa agcaagaatg
     1921 aaggaccagc ttggtaattc catcagcaca cctttaaaac gtcgtaaagt aaacagtcat
     1981 gcagctttta ttcaccctat gtctttaagt tgccaaaact ttgaaagtgt cattttaaac
     2041 tgccgaagta tacgagttgg aacactcttc cgactgttgg tagagcctgt aattttttct
     2101 ttagagtcaa tcacgataca tctagatgga ccagaaagtg atcctgtaga cattatttta
     2161 aatacctctg atctaactaa atgtgaatgg tgtaatgtcc ggaaattacc agtagtgttt
     2221 ctccaggcaa taccagcagt ttaccagaag ctgagcatgc agctacagat gagtaaagaa
     2281 gataaagttt ggaatgattg taaaggaata aacaggataa caagtttaga agaacagtac
     2341 attattttaa tttttcaaac tggccttgat catcaggcag aggtggtctt tgaaagtatc
     2401 attactgaca ttggtataag gaataatgtt cccaactttt ttgcaaaaat tctttttgac
     2461 gaagccaata gcagacttgt tgcctgtaca agaagctatg aagagagcat caaaggaaac
     2521 tgcgcgcaaa aagagaacaa agtgaaaact gtgtcgtttg aatctaaaat acaacttaga
     2581 agcaaacaag aattgcagtt ttttgatgat gacgaagaag ctggggagag ccatacaatc
     2641 ttcattggcc ctgtagaaaa attgatagta tacccaccac ctccagctaa gggaggcatt
     2701 tctgttacta atgaggacct gcactgtcta agtgaaggag agtttttaaa tgatgttatt
     2761 atcgactttt atttgaaata cttggtgctt gaaaaactga agaaagaaga cgctgaccga
     2821 attcatatat ttagttcttt tttctataaa cgccttaatc agagagagag gagaaatcct
     2881 gagacaacta atctgtcgat acaacaaaaa cggcatggga gagtaaaaac gtggacacgg
     2941 catgtagata tttttgagaa ggactttatt tttgtacccc ttaatgaagc tgcacattgg
     3001 tttttggctg ttgtttgttt ccctggtttg gaaaaaccaa aatatgaacc taatcctcat
     3061 taccatgaaa atgcagtcat gcaaaaaact ccaagtgcag aggacagttg tgtttcttct
     3121 gccagtgaga tgggtgcttg ttcacagaac tctgctgcca agcctgtgat caagaagatg
     3181 ttaaatagaa aacattgctt agctgtgact gattcgagtg ctgcacagga agaaagtgag
     3241 ccttgttacc ggagaaacgc atacagtgta aagtgtagta tgaaaaaaaa aaatcatgct
     3301 atcaatgaaa atgaagaacc aagtaacgga gaatctacgt gccaggacat ttgtgataga
     3361 acccaaagtg agaatggcct ccgggatgaa tgcttcagtt ctgtacatca tccagatgcc
     3421 ttaagcaaaa tcagactaaa ctacggtgat cagtcagcag acggtgggaa gctgcttgaa
     3481 gatgagctca ttgacttctc agaggatcag gatgacccgg atgatagcag tgatgacgga
     3541 ctccttgctg atgaaaacta cagttcagaa ataggacagt ggcatttaaa gcctactgtc
     3601 tgtaaacaac cttgtatcct ccttatggac tcactcagag gcccttctcg ttcaaatgtt
     3661 gtcaaaattc taagagagta tttagaagtg gaatgggagg tgaaaaaagg aagcaaaaga
     3721 agtttttcca aagatgttat gaaagggtcc aacccaaaag tcccacaaca gaacaacttc
     3781 agtgactgtg gtgtctatgt gctgcagtat gtagagagct tttttgagaa tccagtacta
     3841 aattttgagc tccctatgaa tttgatgaac tggtttcctc cccccagaat gaaaacaaaa
     3901 agagaagaaa tccgaaacat aattttgaag ctacaggaat cacagagtaa agacaagaag
     3961 ctgctgaagg actccttagc agagacgtcc ttaggggacg gagcagagca gtacgccagc
     4021 gccagcggtg gctcagagtg acgaggaggc tgggcctgga aggctccccc ttcccagtga
     4081 cagacacagc atttactctt gggggagact gtaaagagct gaagtgctca ctactcagag
     4141 actggggtga taaagcctgt aaaaatgtca taagtgagtt ccaaaggagt gtgtattaag
     4201 taaaagcctg taaatatgtt aatgaggcca acttttccaa catttataat tatttttttc
     4261 acttttagga agcctttgtt atgtattttc tgttaatagt actaaaactg caacttctaa
     4321 acacaaaaat aaaatattta taggaggaaa tgattaattt gatattcttt agtgaacttg
     4381 cataattcct cagtgtgatt ttatttcatg ggaatagaag tatcttttga tttttttttt
     4441 aacctttgtt ctaaaatact ccacaatgtg aaaatataat tgtcaaagac attttaaact
     4501 acagatgcat ctttatatgc ttgcatagca agaaaaattc atcttttcaa ttcatgctct
     4561 ttcatctgtt caaagaaccc ccaaagtata acaactattc ataattttac acaaatactt
     4621 aaacaccatt aagagcaatc aaagacagtg caccttgact tgtgctagtg aggcgaccct
     4681 gctccagcat acccccagca actcaggtga aggctgtcct ggcaacggca gcttgaatct
     4741 caaatatcca acaggacctt tgcagttcat cttgcagtgt gctgcagcct ggatgacaga
     4801 actagttaag gaacagtttt catctgtgaa cacgggcttt ctttcacata agaatttctt
     4861 ttctgtatct tctgctcttt ttcactattt cgttctcatt gttttgataa agtatcaggc
     4921 tttttgcttg agttttttct gagtaaatta ttttaacctg aaaaaaaaaa aaaaaa
//
