LOCUS       NP_001298039            1139 aa            linear   ROD 11-FEB-2025
DEFINITION  sentrin-specific protease 6 isoform 1 [Mus musculus].
ACCESSION   NP_001298039 XP_006511076
VERSION     NP_001298039.1
DBSOURCE    REFSEQ: accession NM_001311110.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 1139)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 1139)
  AUTHORS   Xia,Q., Mao,M., Zeng,Z., Luo,Z., Zhao,Y., Shi,J. and Li,X.
  TITLE     Inhibition of SENP6 restrains cerebral ischemia-reperfusion injury
            by regulating Annexin-A1 nuclear translocation-associated neuronal
            apoptosis
  JOURNAL   Theranostics 11 (15), 7450-7470 (2021)
   PUBMED   34158860
  REMARK    GeneRIF: Inhibition of SENP6 restrains cerebral
            ischemia-reperfusion injury by regulating Annexin-A1 nuclear
            translocation-associated neuronal apoptosis.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 1139)
  AUTHORS   Colnaghi,L., Conz,A., Russo,L., Musi,C.A., Fioriti,L., Borsello,T.
            and Salmona,M.
  TITLE     Neuronal Localization of SENP Proteins with Super Resolution
            Microscopy
  JOURNAL   Brain Sci 10 (11), 778 (2020)
   PUBMED   33113832
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 1139)
  AUTHORS   Li,J., Lu,D., Dou,H., Liu,H., Weaver,K., Wang,W., Li,J.,
            Yeh,E.T.H., Williams,B.O., Zheng,L. and Yang,T.
  TITLE     Desumoylase SENP6 maintains osteochondroprogenitor homeostasis by
            suppressing the p53 pathway
  JOURNAL   Nat Commun 9 (1), 143 (2018)
   PUBMED   29321472
  REMARK    GeneRIF: postnatal loss of the desumoylase SUMO1/sentrin-specific
            peptidase 6 (SENP6) causes premature aging. OCP-specific SENP6
            knockout mice exhibit smaller skeletons, with elevated apoptosis
            and cell senescence in OCPs and chondrocytes. SENP6 interacts with,
            desumoylates, and stabilizes TRIM28, suppressing p53 activity.
            Erratum:[Nat Commun. 2018 Feb 8;9(1):646. doi:
            10.1038/s41467-018-03177-0.. PMID: 29422621]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 1139)
  AUTHORS   Liu,X., Chen,W., Wang,Q., Li,L. and Wang,C.
  TITLE     Negative regulation of TLR inflammatory signaling by the
            SUMO-deconjugating enzyme SENP6
  JOURNAL   PLoS Pathog 9 (6), e1003480 (2013)
   PUBMED   23825957
  REMARK    GeneRIF: Negative regulation of TLR inflammatory signaling by the
            SUMO-deconjugating enzyme SENP6.
REFERENCE   6  (residues 1 to 1139)
  AUTHORS   Tamplin,O.J., Kinzel,D., Cox,B.J., Bell,C.E., Rossant,J. and
            Lickert,H.
  TITLE     Microarray analysis of Foxa2 mutant mouse embryos reveals novel
            gene expression and inductive roles for the gastrula organizer and
            its derivatives
  JOURNAL   BMC Genomics 9, 511 (2008)
   PUBMED   18973680
  REMARK    Publication Status: Online-Only
REFERENCE   7  (residues 1 to 1139)
  AUTHORS   Okazaki,N., Kikuno,R., Ohara,R., Inamoto,S., Koseki,H., Hiraoka,S.,
            Saga,Y., Nagase,T., Ohara,O. and Koga,H.
  TITLE     Prediction of the coding sequences of mouse homologues of KIAA
            gene: III. the complete nucleotide sequences of 500 mouse
            KIAA-homologous cDNAs identified by screening of terminal sequences
            of cDNA clones randomly sampled from size-fractionated libraries
  JOURNAL   DNA Res 10 (4), 167-180 (2003)
   PUBMED   14621295
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK053904.1, BC052718.1 and AK083377.1.
            
            On Jul 25, 2015 this sequence version replaced XP_006511076.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660821.153309.1,
                                           SRR1660811.215049.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1139
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 43.88 cM"
     Protein         1..1139
                     /product="sentrin-specific protease 6 isoform 1"
                     /EC_number="3.4.22.68"
                     /note="SUMO/sentrin specific protease 6; sentrin-specific
                     protease 6; SUMO-1-specific protease 1;
                     sentrin/SUMO-specific protease SENP6"
                     /calculated_mol_wt=127741
     Region          23..51
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Site            41
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZR1; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Region          334..395
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Site            362
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Site            363
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0007744|PubMed:21183079; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Site            378
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZR1; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Site            380
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZR1; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Site            443
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZR1; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Region          693..1139
                     /region_name="Protease"
                     /note="propagated from UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Region          707..>819
                     /region_name="Peptidase_C48"
                     /note="Ulp1 protease family, C-terminal catalytic domain;
                     cl23802"
                     /db_xref="CDD:420019"
     Site            945
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZR1; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     Region          <999..1075
                     /region_name="Peptidase_C48"
                     /note="Ulp1 protease family, C-terminal catalytic domain;
                     cl23802"
                     /db_xref="CDD:420019"
     Site            1138
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9GZR1; propagated from
                     UniProtKB/Swiss-Prot (Q6P7W0.3)"
     CDS             1..1139
                     /gene="Senp6"
                     /gene_synonym="2810017C20Rik; E130319N12Rik; mKIAA0797;
                     Susp1"
                     /coded_by="NM_001311110.1:622..4041"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS81040.1"
                     /db_xref="GeneID:215351"
                     /db_xref="MGI:MGI:1922075"
ORIGIN      
        1 maagksggsa galflkaldr seskrdggfk nnwsfdheee segdadkdga nllsvededs
       61 eiskgkklnr rseivatssg dfilktyvrr sktdgfktlk gnpiglnmls nnkklsesta
      121 gtalcsgtvv hgrrfhhahs qtpgirtaaq snqdrkerke yppyvhkaen spvmlshgqg
      181 gdhimkktee sesyveseik rkvqqkrhcs tyqlsplspa skkclthlev seqreycpkc
      241 gkekenqtkc qscgivfhnd lqrncrqavt lneptgpllr tsihqnsggq ksqntgltak
      301 kfygnsvdki pidilvtcdd srhnyiqtng kvilpggkip kltnpkerki svsdlndpii
      361 lssddddddd drtkrrests pkpadsacss pvpstgkvea alnadacrae qeprsspaep
      421 elntiviprk armkdqlgns istplkrrkv nshaafihpm slscqnfesv ilncrsirvg
      481 tlfrllvepv ifslesitih ldgpesdpvd iilntsdltk cewcnvrklp vvflqaipav
      541 yqklsmqlqm skedkvwndc kginritsle eqyiilifqt gldhqaevvf esiitdigir
      601 nnvpnffaki lfdeansrlv actrsyeesi kgncaqkenk vktvsfeski qlrskqelqf
      661 fdddeeages htifigpvek livyppppak ggisvtnedl hclsegefln dviidfylky
      721 lvleklkked adrihifssf fykrlnqrer rnpettnlsi qqkrhgrvkt wtrhvdifek
      781 dfifvplnea ahwflavvcf pglekpkyep nphyhenavm qktpsaedsc vssasemgac
      841 sqnsaakpvi kkmlnrkhcl avtdssaaqe esepcyrrna ysvkcsmkkk nhaineneep
      901 sngestcqdi cdrtqsengl rdecfssvhh pdalskirln ygdqsadggk lledelidfs
      961 edqddpddss ddglladeny sseigqwhlk ptvckqpcil lmdslrgpsr snvvkilrey
     1021 levewevkkg skrsfskdvm kgsnpkvpqq nnfsdcgvyv lqyvesffen pvlnfelpmn
     1081 lmnwfppprm ktkreeirni ilklqesqsk dkkllkdsla etslgdgaeq yasasggse
//
