LOCUS       NM_177103               6352 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SUMO/sentrin specific peptidase 5 (Senp5), transcript
            variant 1, mRNA.
ACCESSION   NM_177103
VERSION     NM_177103.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6352)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 6352)
  AUTHORS   Yamada,S., Sato,A., Ishihara,N., Akiyama,H. and Sakakibara,S.I.
  TITLE     Drp1 SUMO/deSUMOylation by Senp5 isoforms influences ER tubulation
            and mitochondrial dynamics to regulate brain development
  JOURNAL   iScience 24 (12), 103484 (2021)
   PUBMED   34988397
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6352)
  AUTHORS   Rutkowski,T.P., Purcell,R.H., Pollak,R.M., Grewenow,S.M.,
            Gafford,G.M., Malone,T., Khan,U.A., Schroeder,J.P., Epstein,M.P.,
            Bassell,G.J., Warren,S.T., Weinshenker,D., Caspary,T. and
            Mulle,J.G.
  TITLE     Behavioral changes and growth deficits in a CRISPR engineered mouse
            model of the schizophrenia-associated 3q29 deletion
  JOURNAL   Mol Psychiatry 26 (3), 772-783 (2021)
   PUBMED   30976085
REFERENCE   4  (bases 1 to 6352)
  AUTHORS   Zhang,X., Wang,C., Zhao,D., Chen,X., Zhang,C., Zheng,J. and Liu,X.
  TITLE     Zinc deficiency induces abnormal development of the myocardium by
            promoting SENP5 overexpression
  JOURNAL   PLoS One 15 (11), e0242606 (2020)
   PUBMED   33211757
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6352)
  AUTHORS   Akiyama,H., Nakadate,K. and Sakakibara,S.I.
  TITLE     Synaptic localization of the SUMOylation-regulating protease SENP5
            in the adult mouse brain
  JOURNAL   J Comp Neurol 526 (6), 990-1005 (2018)
   PUBMED   29277914
  REMARK    GeneRIF: In the present study demonstrate for the first time that
            SENP5 are ubiquitously distributed in the adult murine brain.
REFERENCE   6  (bases 1 to 6352)
  AUTHORS   Kim,E.Y., Zhang,Y., Beketaev,I., Segura,A.M., Yu,W., Xi,Y.,
            Chang,J. and Wang,J.
  TITLE     SENP5, a SUMO isopeptidase, induces apoptosis and cardiomyopathy
  JOURNAL   J Mol Cell Cardiol 78, 154-164 (2015)
   PUBMED   25128087
REFERENCE   7  (bases 1 to 6352)
  AUTHORS   Nishida,T. and Yamada,Y.
  TITLE     SMT3IP1, a nucleolar SUMO-specific protease, deconjugates SUMO-2
            from nucleolar and cytoplasmic nucleophosmin
  JOURNAL   Biochem Biophys Res Commun 374 (2), 382-387 (2008)
   PUBMED   18639523
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK028177.1, BC067014.1, AC124681.3 and BG146216.1.
            
            On Nov 2, 2007 this sequence version replaced NM_177103.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK043171.1, SRR1660811.62271.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-242               AK028177.1         2-243
            243-2876            BC067014.1         10-2643
            2877-6322           AC124681.3         112367-115812       c
            6323-6352           BG146216.1         388-417
FEATURES             Location/Qualifiers
     source          1..6352
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 22.4 cM"
     gene            1..6352
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /note="SUMO/sentrin specific peptidase 5"
                     /db_xref="GeneID:320213"
                     /db_xref="MGI:MGI:2443596"
     exon            1..296
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            297..1822
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             328..2577
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /EC_number="3.4.22.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SUMO/sentrin specific protease 5; sentrin-specific
                     protease 5; SUMO/Smt3-specific isopeptidase 3;
                     sentrin/SUMO-specific protease SENP5"
                     /codon_start=1
                     /product="sentrin-specific protease 5 isoform 1"
                     /protein_id="NP_796077.2"
                     /db_xref="CCDS:CCDS28111.1"
                     /db_xref="GeneID:320213"
                     /db_xref="MGI:MGI:2443596"
                     /translation="MKKQKKILWKKGIHLAFSEKWNAGFGSFKKFYFPQNLCFLKAKL
                     GRPVAWHRQVKHFQCNKGLHIQKTWIQDVPFCSKTKSGLATQNVSTLYPKVKRKDSKH
                     FISSSRSLLKLQADKLLSSAKSLDHKYCREKSLLKAAPGLSANTVLGRANGHEPTTDP
                     QASDFPMKFSGESQSPGDSGKTVVLNKHRKRVCHGCYQGLEHHRNRRPLIPKQFQLNQ
                     HRRVRASLMMYEKLSMIRFRYRIFRSQHFRTKSRVCKLRKAQRSWVQKVTGDHQENLR
                     DNNTEGDNCNPVPSLEPKDPCRCQPYFPDMDSSAVGKGKNCHVPDGHTKENPVLDKEH
                     GLDDTFPDQQNGCVAYNWDQSSSCPKWECTEQIHEIPLMEHPSSDKFSPETERALMAL
                     GQESGTSAVSDDREKLPVSGADKSVSSVDGPVSEEPAQNENFQMEEDGSLKQSILSSK
                     LLDHPYCKSPLDAPLLCSEPKVENQMSGGKSSQTASPVDDEQLSTCLSGFLDEVMKKY
                     GSLVPLSEKDVLGRLKDVFNEDFSNRKPFINREITNYRARHQKCNFRIFYNKHMLDMD
                     DLATLDGQNWLNDQVINMYGELIMDAVPDKVHFFNSFFHRQLVTKGYNGVKRWTKKVD
                     LFKKSLLLIPIHLEVHWSLITVTLSSRIISFYDSQGIHFKFCVENIRKYLLTEAREKN
                     RPEFLQGWQTAVTKCIPQQKNDSDCGVFVLQYCKCLALEQPFQFSQEDMPRVRKRIYK
                     ELCECRLLD"
     exon            1823..1928
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            1929..2067
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2068..2115
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2116..2193
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2194..2331
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2332..2415
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2416..2466
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     exon            2467..6334
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6315..6320
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /note="hexamer: ACTAAA"
     polyA_site      6332
                     /gene="Senp5"
                     /gene_synonym="6230429P13Rik; A730063F07Rik; SMT3IP3"
                     /note="major polyA site"
ORIGIN      
        1 agggacagca gtgcacccag cgcctcgagg ttaacgccct agtcacgctc ttcgcacaag
       61 gcgtgggcgg agcttctggc ggaagggcaa ggaaggaggt gacgcgaaaa gcaggcgctg
      121 gtgtcgcgct gccgctggga ggaagctcgg ccgccttgcc ggccgaaagc aggccggagc
      181 cccggtggct ggcctggctt tccccgggcg tgggcgtggg cgtgggcgaa ggcgaaacag
      241 cggtcccgca gcgtccgtcc aggcagaagc ttaggtgccg ggagcaaaga acgtaggtac
      301 atccagttct cattatgcat cagaaaaatg aaaaaacaga agaaaattct atggaagaaa
      361 ggaattcact tagccttttc tgagaaatgg aatgctgggt ttggaagctt taagaagttc
      421 tactttcccc aaaacttgtg ctttctgaaa gctaagctgg gaaggccagt tgcttggcat
      481 cggcaggtga agcatttcca gtgtaataag ggtcttcaca tccagaaaac atggattcaa
      541 gatgtaccgt tttgttcaaa gacaaagtct ggactggcta ctcaaaatgt tagtactttg
      601 taccccaaag tgaaaagaaa ggacagtaag cacttcattt cctcctcaag gagtctcctg
      661 aaactccaag cagataaatt actgtcttca gcaaagagct tggaccataa atactgcaga
      721 gagaaaagcc ttctgaaggc agctcctggc ttgtcagcaa acactgtttt aggtagagcc
      781 aatggtcacg aacctaccac agacccacaa gcttcagact ttcccatgaa gttcagtggg
      841 gagagccaaa gtccaggtga cagtggcaag actgtggtct tgaacaaaca tagaaagcga
      901 gtttgtcatg gctgctacca agggctagag caccacagga acaggagacc cctgattcca
      961 aagcagttcc agcttaacca acaccgaaga gtcagagcgt ctctgatgat gtatgagaaa
     1021 ctatccatga ttagatttcg gtataggatt ttcagatccc agcacttcag aacgaaaagc
     1081 agagtttgca agctaagaaa ggcccagcga agttgggtac agaaggtcac tggggaccat
     1141 caagagaacc ttagggataa taacactgag ggtgacaatt gcaatccagt cccttcccta
     1201 gaacctaaag atccttgtcg gtgtcagcca tactttccag acatggacag cagtgctgtg
     1261 gggaagggaa aaaactgtca cgtgcctgat ggtcacacta aagaaaaccc tgtattggac
     1321 aaggagcatg gtttagatga cacattccct gaccagcaga atggctgtgt tgcatacaat
     1381 tgggaccagt catcctcttg tcctaagtgg gaatgtacag agcaaattca tgaaatccct
     1441 ttaatggaac atccttctag tgacaagttc tctccagaaa ctgaaagagc acttatggcg
     1501 ctgggtcagg aaagcgggac aagtgctgtc agcgatgaca gagagaaact gccagtgtct
     1561 ggagcagaca aatctgtgag tagtgtagac gggcctgtgt ctgaggagcc tgcccagaat
     1621 gagaacttcc agatggagga ggatgggtct ctgaagcaga gcattcttag ttctaagctg
     1681 ctggaccacc cttactgtaa aagtccactg gatgctccct tgctgtgcag tgaacccaaa
     1741 gtagaaaacc aaatgtcagg tggcaagagc agccagacag cgtctccagt ggatgatgag
     1801 cagctctcaa cctgcctttc tggattccta gatgaggtta tgaaaaagta tggaagtctg
     1861 gtcccactca gtgaaaaaga tgtccttggg agattaaaag atgtctttaa tgaagacttt
     1921 tctaatagaa aaccattcat caatagggaa ataacaaact accgggccag acatcaaaag
     1981 tgtaacttcc gcatcttcta caataagcac atgctggata tggacgatct ggcaactttg
     2041 gatgggcaga actggttgaa tgaccaggtt attaatatgt atggcgagct gataatggat
     2101 gcagtcccag acaaggtcca cttcttcaac agctttttcc atagacagct ggtaaccaaa
     2161 ggctataatg gagttaaaag atggacgaag aaggtggact tgtttaaaaa gagtcttctg
     2221 ttgattccca tccacctgga ggtccactgg tctctcatta ctgtgacact ctccagccgg
     2281 attatttcat tttatgattc ccaaggcatt cattttaaat tctgtgtaga gaatataaga
     2341 aagtatttgc tgactgaagc cagagaaaaa aatagacctg aatttcttca gggttggcag
     2401 actgctgtta caaagtgtat tccacaacag aaaaatgaca gtgactgtgg agtctttgtg
     2461 ctccagtact gcaagtgcct cgccctagag cagcctttcc agttttctca agaagacatg
     2521 cctcgtgtgc ggaagaggat ctataaggag ctgtgtgagt gccggctcct ggactgagac
     2581 tcactcagca gggactccag aaggcgccat gatggagcag atggcttgtt acttgaatct
     2641 ccaaacactt actgaatctt tacagatatt tcagattggt ggtattgggc cacttattgt
     2701 tacctcagat ttatttttgc ccttcattct cttgctatta tgtacttttt tttaatgttc
     2761 aatttagttt catttttaac tttatggatt ccatatgtcc ctcccatatt taatatttat
     2821 tatccaaacg catgcatata gacagagcat gcagtaaaga gtattaaaaa aaaaaagcct
     2881 agtagatttg gtgcagcttt tgaaacatag ttagatgtga actgaataca ggtttaaaag
     2941 ttaaccccag aacctaaaaa tgcaagatgt ttttgataca gcatagctca gagtagatgt
     3001 tccctatggc ataaagggca gctaggagtg ctgtggaaag ccagtcacat tcacttacac
     3061 cagcagtccc gtttgctgat gtccctcagc tgagtctcca gcatgagaca cgttccttct
     3121 gaaggcgagg gggaggggct ggtgtgctta ggggtatgga gcttgctggc acagggctga
     3181 tctgagaaga gttaaggtag gaggaaaaac gggcagcgtc cttgggtgcc agttacctga
     3241 tttttaaaaa ggcaggggga ggggttattt tgttttgttt tgttttgttt tgagacaaag
     3301 tctcactatg tagcccaagc tgtcctggag ctcacagtag ctaggctggc ctcaaactca
     3361 agctaaacct gtctctgtct ccccagtgct ggtaatatag gtacatacca acatactcta
     3421 caataaaatt cccattttgg ttttatgaat tataatatgt aggctaaatc tcataaaggc
     3481 ttttcctgag acatttaatt ttcttggatt tttttttctg ggtttgactt gtgaaaaaaa
     3541 aaacttagca tccatcaaat tcatagttaa tgagaatttg gcatttcatg gaagtaattt
     3601 gctagttacc gcttctctgt gttgctgcct atgtactcca aggcatttaa gatttactaa
     3661 aaatgttcct atttcaagac atataaaaaa caaaccctca aaagtagaag actgggtatg
     3721 gtcttttgca gatgggggtg ggggggggag gcagcactga ggtctctggg agagcagtgg
     3781 cgagggatgg tctctagtct tctctggtac ctcagcatcc ccaaaggctc ttttggcttc
     3841 cacaggaaca atctgagtcc tgtacttact gaacaggctg taatagtcct gttctctgga
     3901 ttaggatgaa agtggtagag cttgcatatt taatctggcc ttttgtgaca tgtttgaaaa
     3961 gaatataaga tgcatattaa gccaaaccag tttttttctc tcccagaatt ggagggaagc
     4021 attaagaaac ttgtgtagaa aactaccaag tacacgagag agaataactg cctagctagg
     4081 catgagatgt ttgaaaaaca aaaaaggcaa aatggctgag tagggcctac tgcctcggtt
     4141 agggctgagc cacctaggtt cccacgcagg agtctccgca gcagcagaca caggcacagg
     4201 gtggcactct tctctcctca gttagccaga ctgagtccgt agtgtaaagc cgggtcagca
     4261 gtccttgcgc tgaccgaggt ggaggcactt tctgttgctg cagctggagg ttgtatcgac
     4321 cctggggaag atgtcttcat tgcttctgtg gtactgggga tggaacgcag ggcccatttc
     4381 tatgttaggc gagtgctcta ccactgaggt acaaccttag ccctctttat aaaacatttt
     4441 tacattttga gacctggtct tatgatgttg ccgtaggctg gccttgaatt tgctcagtgg
     4501 ctgagcctga tcttctgttt aatactcctg tcacccaagt aactaggatt actggccagg
     4561 ctgcttgaag atcttttagg gaaggggttt ggggaacagg gtctcgtgtg tcagactagc
     4621 ctcaaaggtg ctaggattat aggtctctgt caccatgccc agctaaggat gtagtcttaa
     4681 gactttcaga cataattata ccagcatgag cttcttcaaa atttatgtgc aagatgttac
     4741 tatgggattt tgttggtgtg cctatactga aatagccagt agtaagatga ctgactcaaa
     4801 ggtcttaagg aagtatttca cttccccagt aagagacttc atgcagaagt tacagttgtg
     4861 ttcctttgag attcttattg aaaaagggtc tttgtttagc ccaggctggc ctcatacttg
     4921 cagtcctcct gcctcagcct ccctgatgtg tagattacat gggtgcgtca ttatgtccaa
     4981 tgcctgggag aataatcata acgcccacct ctgcagtctg agaagccgtc ctgtcagctg
     5041 tgagggatgc aggaatgaac actcagctat ccaggtccag ttactctttc ctttctagta
     5101 tgctaggaca ccttcaggtg gactcttcag cttgctttag cctacatgct gggtgtcttc
     5161 agtatgttct acacctgttt cctgtttctg ccattagtga gatctggttt cagcacacag
     5221 ttgttctttc tcttctttat tgtttttgtt tgtttgtttg tttgtttgtt tttcaagaca
     5281 gggtttctct gtagccctgg ctgtcctgga actcactctg cagaccaggc tggcctcaaa
     5341 ctcagaaatc cacctgcctc tgtctcccga gtgctgggat taaaggcgtg caccaccagg
     5401 cctgtcgttc tttttcttct tgtaattaca tgtaaacctc tgtttagcac aatcttttga
     5461 tgtttgcagt aatgctttac tgtcactggc ttggcactga attttgatac ccataaagta
     5521 ctggcagact ttatgtcact gggatgaatg taagccttgc acaaacttag agctattcat
     5581 atatgatgag cctttagcaa gctgcccggt cctcatgggc aaacttaccc ggctgtagtt
     5641 gcttttttcc agtagtagtt ccttttgtta aacctctagc aatcaataaa gatttaattc
     5701 atcttttagt tttcttaaga attatggaga cttaactttc agttggcctc tcaaggaaga
     5761 gaaaagaagt tgctgccaat aacttcacag cacacttttg gctttgcact gtattctgtt
     5821 taccattgaa tatgaataaa tggtcatcgt gagcttatgg ttggaatata ccagtgcaga
     5881 gctaactagg gacacagcca gtacttgtct agtgtgactt gtccctttcc tctgcagttg
     5941 gggctcactg cttcttccct gccttaggag ccattggggg tctgagtggg tcagagacag
     6001 tgagtgaata atgtcaatga aatacactga tgtatctgct gtgcttcatt atgttaagag
     6061 accaaggtaa tcaacaatta taaagtacat cattttgcta tgtgctaggt aggctctgcc
     6121 tcctggccag tagatgtcta agatctgggg aatagcatcc aagaaatgct attgtatttg
     6181 gggattacaa aagcagacct agacaagttg ttcacttgaa tgatacctgt tggtcagatt
     6241 ttattaaaag attatgatca tgtaaaatta gtcagtactc agcccttcta gcaaaatatt
     6301 tttttgaaaa ataaactaaa tacctttata aacaaaaaaa aaaaaaaaaa aa
//
