LOCUS       NM_030702               2442 bp    mRNA    linear   ROD 01-OCT-2024
DEFINITION  Mus musculus SUMO/sentrin specific peptidase 3 (Senp3), transcript
            variant 1, mRNA.
ACCESSION   NM_030702
VERSION     NM_030702.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2442)
  AUTHORS   Chen,X., Wang,J., Yang,P., Liu,H.Y., Zhong,S., Lu,C., Gao,M.,
            Liu,D., Zhang,J., Wang,J., Ma,S., Wang,W., Zhu,H., Zhang,X. and
            Liu,Y.
  TITLE     SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of
            FSP1
  JOURNAL   Redox Biol 75, 103267 (2024)
   PUBMED   39025016
  REMARK    GeneRIF: SENP3 sensitizes macrophages to ferroptosis via
            de-SUMOylation of FSP1.
REFERENCE   2  (bases 1 to 2442)
  AUTHORS   Chen,X., Su,Q., Ling,X., Yang,Y., Liu,Y., Zhu,X., He,A., Wu,H. and
            Qi,Y.
  TITLE     SENP3-regulated Nodal signaling plays a potential role in cardiac
            left-right asymmetry development
  JOURNAL   Int J Biol Macromol 274 (Pt 2), 133294 (2024)
   PUBMED   38925188
  REMARK    GeneRIF: SENP3-regulated Nodal signaling plays a potential role in
            cardiac left-right asymmetry development.
REFERENCE   3  (bases 1 to 2442)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2442)
  AUTHORS   Jiang,Y., Liang,M., Chen,L., Wang,J., Huang,Y., Huo,H., Xiao,D.,
            Hu,Y., Wang,Z., Ji,Q., Li,Y., Cai,Z. and He,B.
  TITLE     Myeloid SENP3 deficiency protects mice from diet and age-induced
            obesity via regulation of YAP1 SUMOylation
  JOURNAL   Cell Mol Life Sci 81 (1), 4 (2023)
   PUBMED   38070059
  REMARK    GeneRIF: Myeloid SENP3 deficiency protects mice from diet and
            age-induced obesity via regulation of YAP1 SUMOylation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2442)
  AUTHORS   Xia,Q., Mao,M., Zhan,G., Luo,Z., Zhao,Y. and Li,X.
  TITLE     SENP3-mediated deSUMOylation of c-Jun facilitates microglia-induced
            neuroinflammation after cerebral ischemia and reperfusion injury
  JOURNAL   iScience 26 (6), 106953 (2023)
   PUBMED   37332598
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2442)
  AUTHORS   Huang,C., Han,Y., Wang,Y., Sun,X., Yan,S., Yeh,E.T., Chen,Y.,
            Cang,H., Li,H., Shi,G., Cheng,J., Tang,X. and Yi,J.
  TITLE     SENP3 is responsible for HIF-1 transactivation under mild oxidative
            stress via p300 de-SUMOylation
  JOURNAL   EMBO J 28 (18), 2748-2762 (2009)
   PUBMED   19680224
REFERENCE   7  (bases 1 to 2442)
  AUTHORS   Kuo,M.L., den Besten,W., Thomas,M.C. and Sherr,C.J.
  TITLE     Arf-induced turnover of the nucleolar nucleophosmin-associated
            SUMO-2/3 protease Senp3
  JOURNAL   Cell Cycle 7 (21), 3378-3387 (2008)
   PUBMED   18948745
  REMARK    GeneRIF: The p53-independent tumor suppressive functions of
            p19(Arf) may be mediated by its ability to antagonize Senp3,
            thereby inducing cell cycle arrest by abnormally elevating the
            cellular levels of SUMOylated proteins.
REFERENCE   8  (bases 1 to 2442)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 2442)
  AUTHORS   Nishida,T., Tanaka,H. and Yasuda,H.
  TITLE     A novel mammalian Smt3-specific isopeptidase 1 (SMT3IP1) localized
            in the nucleolus at interphase
  JOURNAL   Eur J Biochem 267 (21), 6423-6427 (2000)
   PUBMED   11029585
REFERENCE   10 (bases 1 to 2442)
  AUTHORS   Yeh,E.T., Gong,L. and Kamitani,T.
  TITLE     Ubiquitin-like proteins: new wines in new bottles
  JOURNAL   Gene 248 (1-2), 1-14 (2000)
   PUBMED   10806345
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY134888.1, AK045071.1 and AY008764.1.
            
            On Jul 31, 2009 this sequence version replaced NM_030702.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY008764.1, AK045071.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-132               BY134888.1         1-132
            133-268             AK045071.1         10-145
            269-2442            AY008764.1         1-2174
FEATURES             Location/Qualifiers
     source          1..2442
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 42.86 cM"
     gene            1..2442
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /note="SUMO/sentrin specific peptidase 3"
                     /db_xref="GeneID:80886"
                     /db_xref="MGI:MGI:2158736"
     exon            1..308
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            309..1016
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     CDS             320..2026
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /EC_number="3.4.22.68"
                     /note="SUMO/sentrin specific protease 3; SUMO-1-specific
                     protease 3; sentrin/SUMO-specific protease SENP3;
                     smt3-specific isopeptidase 1"
                     /codon_start=1
                     /product="sentrin-specific protease 3"
                     /protein_id="NP_109627.3"
                     /db_xref="CCDS:CCDS24905.1"
                     /db_xref="GeneID:80886"
                     /db_xref="MGI:MGI:2158736"
                     /translation="MKETIQGTGSWGPEPPGPGTTYSNPRRERLRWPLPPKPRLKSGG
                     GFGPDPGSGTTVPTRRLPAPRPSFDASASEEEEEEEEEDEEEVAAWRLPPRWGQLGAS
                     QRSRALRPSHRKTCSQRRRRAMRAFQMLLYSKSTSLTFHWKLWGRHRGRRRNLAHPKN
                     HLSPQEGGATPQVPSPCCRFDSPRGLPPPRLGLLGALMAEDGMRGSPPVPSGPPMEED
                     GLRWTPKSPLDPDSGLLSCTLPNGFGGLSGPEGERSLAPPDASILISNVCSIGDHVAQ
                     ELFQSSDLGIAEEADRTGEKAGQHSPLREEHVTCVQSILDEFLQTYGSLIPLSTDEVV
                     EKLEDIFQQEFSTPSRKSLVLQLIQSYQRMPGNAMVRGFRVSYKRHVLTMDDLGTLYG
                     QNWLNDQVMNMYGDLVMDTVPEKVHFFNSFFYDKLRTKGYDGVKRWTKNVDIFNKELL
                     LIPIHLEVHWSLISVDVRRRTITYFDSQRTLNRRCPKHIAKYLQAEAVKKDRLDFHQG
                     WKGYFKMNVARQNNDSDCGAFVLQYCKHLALSQPFSFTQQDMPKLRRQIYKELCHCKL
                     TV"
     exon            1017..1256
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1368
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1516
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1517..1564
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1565..1642
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1780
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1781..1864
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1865..1915
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     exon            1916..2442
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2416..2421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /note="hexamer: AATAAA"
     polyA_site      2437
                     /gene="Senp3"
                     /gene_synonym="Smt3ip; Smt3ip1"
                     /note="major polyA site"
ORIGIN      
        1 gagccggcgc tgctcgccgg gtgtgacgca ctaattgcgc gccgccatcg gcggtgggcc
       61 tggggctcgc gggaggggaa ggaggaggag gggtggcggc ggtgctggag gtggaggtgg
      121 aggtggaggc tagagccgcg ctagaggcgg ccgcagtggg gcggcacgag cattggcttc
      181 gtgaattgag acggctccgc ctgaggatag caggagtggc ggggtcgccg ccgtccgaaa
      241 gatgagccgg aaagcctaag tcggagacag ccgccttggg gcccgtgtgc ccggcttccc
      301 cgctcctggg tactgaaaga tgaaagagac tatacagggg accgggtctt gggggcctga
      361 gcctccggga cccggcacca cttactcaaa tcccaggcga gagcgtcttc gttggcccct
      421 accccctaag ccccggctca agtccggtgg tggttttggg ccagatcctg ggtctgggac
      481 cacagtgcca actagacgcc tccctgcccc ccggccatct tttgatgcct cagctagtga
      541 agaagaggaa gaggaagagg aggaagatga ggaggaagta gcagcttgga ggctaccccc
      601 taggtggggc caactggggg cctcccagcg ctctcgagct ctccgaccct ctcatagaaa
      661 aacctgctca cagcgccggc gccgagccat gagagccttc cagatgctgc tctactcaaa
      721 aagcacctcg ctgacattcc actggaagct ttgggggcgc caccgaggcc ggcggcggaa
      781 cctcgcgcac cccaagaacc atctctcacc ccaggaaggg ggtgcaacgc cacaggtgcc
      841 atcaccctgc tgtcgttttg actccccccg ggggctaccc ccaccccggc tgggtctgct
      901 aggtgctctc atggcagagg atgggatgag agggtctcca ccagtgccct ctgggccccc
      961 catggaggaa gatggactaa ggtggacccc aaagtctcct ctggaccctg actcgggcct
     1021 cctctcatgt actctaccca atggttttgg gggactgtct ggtcctgaag gggagcgcag
     1081 cctggcaccc cctgatgcca gcatactcat cagtaatgtg tgcagcattg gagaccacgt
     1141 ggctcaggaa ctttttcaga gctctgactt gggcattgca gaagaggcag atcggactgg
     1201 ggagaaagct ggccagcata gcccccttcg ggaggaacat gtgacctgtg tgcagagtat
     1261 cttagatgaa ttccttcaaa cttatggcag cctcatccct ctcagcactg atgaagttgt
     1321 agagaagttg gaggacattt tccagcagga gttctctaca ccctcaagga agagtctggt
     1381 actacagctg atccagtctt atcagcggat gccaggcaac gctatggtaa ggggcttccg
     1441 ggtatcctat aagcgacacg tgctcaccat ggatgacttg ggtaccttat atggacagaa
     1501 ctggctcaat gaccaggtga tgaacatgta tggagatctg gtcatggaca cagtccctga
     1561 aaaggtgcat ttcttcaaca gcttcttcta tgataaactc cgtaccaagg gttatgatgg
     1621 ggtaaagagg tggaccaaaa atgtggacat cttcaataag gaattactgc taatccccat
     1681 ccatctggag gtgcactggt cccttatctc agttgatgta aggcgacgta ccatcaccta
     1741 ttttgactcc cagcgaactc taaatcgccg ctgccctaag catattgcca agtatctaca
     1801 ggcagaggca gtcaaaaaag accgactgga cttccatcag ggctggaaag gttacttcaa
     1861 aatgaatgtg gccaggcaga ataatgacag tgactgtggt gcctttgtat tacagtactg
     1921 caagcacctg gccctgtctc agccattcag cttcacccag caggacatgc ccaaactccg
     1981 tcgtcagatc tacaaggaac tgtgtcactg caaactcact gtgtgagcct cataccccag
     2041 acccttagcc catcagtggg caggggaaag ggagaccctt cccaagaaac tctagttcct
     2101 ttttgtttct ctacccaatt ccctttggat tttcatattt aaatgtttgg tttctgtatt
     2161 ttgttttttt ttgctgcgag tatattgatt tctgatggga agggaatggc cacataaaag
     2221 caagcctctt tctccctcta taggagaatg ttgccttgtg gcctaggtgg agcagccatt
     2281 cctccttcca tgttcagagg gcaggaaaac agtgtggggg tggtggacgc gcaaagggat
     2341 tactgcctgc ccgatcttca aacttttttt tatatatata aatatatata aaaatgccac
     2401 ggtcctgctc tggtcaataa aggatccttt gaagatatgc aa
//
