LOCUS       NM_029457               4499 bp    mRNA    linear   ROD 21-MAY-2024
DEFINITION  Mus musculus SUMO/sentrin specific peptidase 2 (Senp2), transcript
            variant 1, mRNA.
ACCESSION   NM_029457
VERSION     NM_029457.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4499)
  AUTHORS   Luo,Y., Zhou,S., Xu,T., Wu,W., Shang,P., Wang,S., Pan,D. and Li,D.
  TITLE     SENP2-mediated SERCA2a deSUMOylation increases calcium overload in
            cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
  JOURNAL   Chin Med J (Engl) 136 (20), 2496-2507 (2023)
   PUBMED   37462038
  REMARK    GeneRIF: SENP2-mediated SERCA2a deSUMOylation increases calcium
            overload in cardiomyocytes to aggravate myocardial
            ischemia/reperfusion injury.
REFERENCE   2  (bases 1 to 4499)
  AUTHORS   Nguyen,M.T.H., Imanishi,M., Li,S., Chau,K., Banerjee,P.,
            Velatooru,L.R., Ko,K.A., Samanthapudi,V.S.K., Gi,Y.J., Lee,L.L.,
            Abe,R.J., McBeath,E., Deswal,A., Lin,S.H., Palaskas,N.L.,
            Dantzer,R., Fujiwara,K., Borchrdt,M.K., Turcios,E.B.,
            Olmsted-Davis,E.A., Kotla,S., Cooke,J.P., Wang,G., Abe,J.I. and
            Le,N.T.
  TITLE     Endothelial activation and fibrotic changes are impeded by laminar
            flow-induced CHK1-SENP2 activity through mechanisms distinct from
            endothelial-to-mesenchymal cell transition
  JOURNAL   Front Cardiovasc Med 10, 1187490 (2023)
   PUBMED   37711550
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4499)
  AUTHORS   Yang,T.T., Chiang,M.F., Chang,C.C., Yang,S.Y., Huang,S.W.,
            Liao,N.S., Shih,H.M., Hsu,W. and Lin,K.I.
  TITLE     SENP2 restrains the generation of pathogenic Th17 cells in mouse
            models of colitis
  JOURNAL   Commun Biol 6 (1), 629 (2023)
   PUBMED   37301920
  REMARK    GeneRIF: SENP2 restrains the generation of pathogenic Th17 cells in
            mouse models of colitis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4499)
  AUTHORS   Kim,P.C., Lee,J.S., Chung,S.S. and Park,K.S.
  TITLE     Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid
            Metabolism in White Adipocytes
  JOURNAL   Diabetes Metab J 47 (3), 382-393 (2023)
   PUBMED   36872063
  REMARK    GeneRIF: Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty
            Acid Metabolism in White Adipocytes.
REFERENCE   5  (bases 1 to 4499)
  AUTHORS   Dufour,D., Dumontet,T., Sahut-Barnola,I., Carusi,A., Onzon,M.,
            Pussard,E., Wilmouth,J.J., Olabe,J., Lucas,C., Levasseur,A.,
            Damon-Soubeyrand,C., Pointud,J.C., Roucher-Boulez,F., Tauveron,I.,
            Bossis,G., Yeh,E.T., Breault,D.T., Val,P., Lefrancois-Martinez,A.M.
            and Martinez,A.
  TITLE     Loss of SUMO-specific protease 2 causes isolated glucocorticoid
            deficiency by blocking adrenal cortex zonal transdifferentiation in
            mice
  JOURNAL   Nat Commun 13 (1), 7858 (2022)
   PUBMED   36543805
  REMARK    GeneRIF: Loss of SUMO-specific protease 2 causes isolated
            glucocorticoid deficiency by blocking adrenal cortex zonal
            transdifferentiation in mice.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4499)
  AUTHORS   Chiu,S.Y., Asai,N., Costantini,F. and Hsu,W.
  TITLE     SUMO-specific protease 2 is essential for modulating p53-Mdm2 in
            development of trophoblast stem cell niches and lineages
  JOURNAL   PLoS Biol 6 (12), e310 (2008)
   PUBMED   19090619
  REMARK    GeneRIF: data reveal a key genetic pathway, SENP2-Mdm2-p53,
            underlying trophoblast lineage development, suggesting its pivotal
            role in cell cycle progression of mitosis and endoreduplication.
REFERENCE   7  (bases 1 to 4499)
  AUTHORS   Cheng,J., Kang,X., Zhang,S. and Yeh,E.T.
  TITLE     SUMO-specific protease 1 is essential for stabilization of
            HIF1alpha during hypoxia
  JOURNAL   Cell 131 (3), 584-595 (2007)
   PUBMED   17981124
REFERENCE   8  (bases 1 to 4499)
  AUTHORS   Gomez-del Arco,P., Koipally,J. and Georgopoulos,K.
  TITLE     Ikaros SUMOylation: switching out of repression
  JOURNAL   Mol Cell Biol 25 (7), 2688-2697 (2005)
   PUBMED   15767674
REFERENCE   9  (bases 1 to 4499)
  AUTHORS   Best,J.L., Ganiatsas,S., Agarwal,S., Changou,A., Salomoni,P.,
            Shirihai,O., Meluh,P.B., Pandolfi,P.P. and Zon,L.I.
  TITLE     SUMO-1 protease-1 regulates gene transcription through PML
  JOURNAL   Mol Cell 10 (4), 843-855 (2002)
   PUBMED   12419228
  REMARK    GeneRIF: SUMO-1 protease-1 regulates gene transcription through
            PML.
REFERENCE   10 (bases 1 to 4499)
  AUTHORS   Nishida,T., Kaneko,F., Kitagawa,M. and Yasuda,H.
  TITLE     Characterization of a novel mammalian SUMO-1/Smt3-specific
            isopeptidase, a homologue of rat axam, which is an axin-binding
            protein promoting beta-catenin degradation
  JOURNAL   J Biol Chem 276 (42), 39060-39066 (2001)
   PUBMED   11489887
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ169147.1, AK031030.1, CT030725.15 and CT009567.9.
            
            On Apr 15, 2009 this sequence version replaced NM_029457.2.
            
            Transcript Variant: This variant (1) encodes the functional
            protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031652.1, AK031030.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                CJ169147.1         1-18
            19-2638             AK031030.1         4-2623
            2639-3489           CT030725.15        114363-115213
            3490-4499           CT009567.9         2001-3010
FEATURES             Location/Qualifiers
     source          1..4499
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 12.98 cM"
     gene            1..4499
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /note="SUMO/sentrin specific peptidase 2"
                     /db_xref="GeneID:75826"
                     /db_xref="MGI:MGI:1923076"
     exon            1..259
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1925
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /EC_number="3.4.22.68"
                     /note="isoform 1 is encoded by transcript variant 1;
                     SUMO/sentrin specific protease 2; SUMO-1/Smt3-specific
                     isopeptidase 2; sentrin-specific protease 2; SUMO-1
                     protease-1; axam2; sentrin/SUMO-specific protease SENP2"
                     /codon_start=1
                     /product="sentrin-specific protease 2 isoform 1"
                     /protein_id="NP_083733.1"
                     /db_xref="CCDS:CCDS28065.1"
                     /db_xref="GeneID:75826"
                     /db_xref="MGI:MGI:1923076"
                     /translation="MYRWLAKVLGTILRLCERPAPGARALLKRRRSSSTLFSTAVDTD
                     EIPAKRPRLDCFIHQVKNSLYNAASLFGFPFQLTTKPMVSSACNGTRNVAPSGEVFSN
                     SSSCELMSSGSCSSMLKLGNKSPNGISDYPKIRVTVTRDQPRRVLPSFGFTLKSEGYN
                     RRPSGRRHSKSNPESSLTWKPQEQGVTEMISEEGGKGVRRPHCTVEEGVQKDEREKYR
                     KLLERLKEGAHGSTFPPTVSHHSSQRIQMDTLKTKGWVEEQNHGVRTTHFVPKQYRVV
                     ETRGPLCSMRSEKRYSKGKADTEKVVGLRFEKEGTRGHQMEPDLSEEVSARLRLGSGS
                     NGLLRRKISVLEIKEKNFPSKEKDRRTEDLFEFTEDMEKEISNALGHGPPDEILSSAF
                     KLRITRGDIQTLKNYHWLNDEVINFYMNLLVERSKKQGYPALHAFSTFFYPKLKSGGY
                     QAVKRWTKGVNLFEQELVLVPIHRKVHWSLVVMDLRKKCLKYLDSMGQKGHRICEILL
                     QYLQDESKTKRNTDLNLLEWTHYSMKPHEIPQQLNGSDCGMFTCKYADYISRDKPITF
                     TQHQMPLFRKKMVWEILHQQLL"
     exon            260..318
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            319..452
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            453..519
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            520..610
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            611..779
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            780..880
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            881..975
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            976..1027
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1028..1088
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1265
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1266..1397
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1398..1601
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1602..1681
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1682..1766
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1862
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1863..4499
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3085..3090
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /note="hexamer: AATAAA"
     polyA_site      3106
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /note="major polyA site"
     regulatory      4453..4458
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /note="hexamer: AGTAAA"
     regulatory      4468..4473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
                     /note="hexamer: AATACA"
     polyA_site      4473
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
     polyA_site      4499
                     /gene="Senp2"
                     /gene_synonym="2310007L05Rik; 4930538C18Rik; mKIAA1331;
                     Smt3ip2; SuPr-1"
ORIGIN      
        1 aagtccgcgc ctgatcctgg ctacggctga agcggcgaag gcggcagcgg cagcggcagc
       61 ggcagcggcg acggcggcgg cggcggcggc ggcggcggcg acagctctgg ggttcgcgtc
      121 tcggggtgtg tcggccgccg ctgctgctca ggcctggaat gtacagatgg ctggctaagg
      181 ttctcggcac cattcttcgc ttgtgtgagc ggcccgcgcc cggggcccgc gccctactca
      241 agaggcggcg ctccagcagc actctgtttt ctactgcagt ggacactgat gagatcccag
      301 ccaaaaggcc aagattagat tgctttattc accaagtgaa gaacagtctc tacaatgctg
      361 ccagtttatt tggattcccg ttccagctga ccacaaaacc catggtgtct tctgcttgta
      421 atggaacacg gaatgtggcc ccttctggag aggtcttttc gaactcttca tcttgtgagc
      481 tgatgagttc tggatcctgc agcagcatgc tgaaactggg taataaatct cctaatggaa
      541 taagcgacta tccaaagatc agagtgacag tgacccgcga tcagccacgg agagtcctgc
      601 cctcctttgg ttttacgctg aaatcggaag gctataatag aaggccaagt ggtcgtcgcc
      661 atagcaaaag caatccagag agttccttaa catggaagcc tcaggagcaa ggtgtgacag
      721 agatgatttc tgaagagggt ggcaagggtg tgaggcgtcc ccactgcacc gtggaggagg
      781 gtgtccaaaa ggatgaaaga gaaaagtatc gaaagttatt ggagcgactt aaagaaggtg
      841 ctcatggaag cacgttccct cccacggttt cacaccacag ttctcagaga attcagatgg
      901 acacattaaa gaccaaaggc tgggtggagg agcagaatca tggcgtcaga acaacccatt
      961 ttgttccaaa acagtataga gttgttgaaa caagaggacc tctctgttca atgagaagtg
     1021 aaaagaggta ttcaaaaggg aaagctgata cagagaaggt ggtgggactc cgatttgaaa
     1081 aggaaggtac aagaggacac caaatggagc ctgatctgtc agaagaagtg tctgcccgac
     1141 ttcgtctagg aagtggaagc aatggcttac tcagaaggaa aatatcagtg cttgagataa
     1201 aggaaaagaa cttcccgagc aaagagaagg acagaagaac ggaagacctc tttgaattta
     1261 cagaggacat ggaaaaggaa atcagtaatg ccctgggcca cggcccacca gatgagattt
     1321 tgagcagcgc tttcaagttg cgaatcaccc gcggagacat ccagacctta aagaactatc
     1381 attggctcaa cgatgaggtc attaattttt atatgaatct tttagtggaa aggagtaaaa
     1441 agcaaggtta tccagcactt catgcattca gtacattctt ctatcctaag ctaaagtctg
     1501 gaggttacca agcagtgaaa agatggacca aaggggtaaa tctcttcgaa caagaacttg
     1561 ttctggtacc tattcatcgg aaggtacatt ggagcctggt ggtgatggac ctaagaaaaa
     1621 agtgtcttaa atatctggat tctatgggac aaaaaggcca caggatctgt gagattcttc
     1681 ttcagtattt acaggatgaa agcaagacca aaagaaatac agatctcaac ctcttagagt
     1741 ggacccacta cagcatgaag ccacatgaga ttcctcagca gttgaatggg agtgactgtg
     1801 gaatgtttac ttgtaaatat gcagattata tttctaggga caaacctatc acattcactc
     1861 agcaccagat gcctctcttc cggaagaaga tggtgtggga gatccttcac cagcagttgc
     1921 tgtgacaatg ccccgcctgg tcttctagct gctggtggtt ctttgatgga tgtttccata
     1981 tacctcatgc attgtgggtt aaaaagtccc cgatcatttc tcttctctca caggtactga
     2041 gctctcaaga gtgcatgaag gcctctccac aatggccctg actagaggtg tggaggggct
     2101 gcttgaaacc ctgtttctaa ggctgtgcct gctcagagcc ctggactatt caccccatac
     2161 aagaacaaat gctaattaat gtgttttgtt ttaaagcgtt atttccatat gaatgtggga
     2221 aatgcaggat ctgttatatg aattgttctg tgtgttcaca cgaattcact ctctcattgg
     2281 gcagtgccct tttcccactg ctcttttata attagctata aataatttgg actatttatt
     2341 tctgaaaaga atgttaatca aactgccact tcctgctgca gagagatatc agcaggggga
     2401 ggaaggaggt gttcgctagc ttctctaatg ctggagtgcg aactgccgac atacagttaa
     2461 ggttctctct tttaaggctt gaaaatgcca gaagaaatga cgatgctctg ttgtaggatc
     2521 tggctgcctt ttagagagtc tgatgctatg acacgggcac agttcgtgga aatgtggcca
     2581 aggaactcga tctgtgcatc ctcagaacgg ggcgtgcgca tcttagagac tttcttttct
     2641 agaaccgaag tagcttggct tcctcttgaa actggattca aagtaactgt gagcatccat
     2701 gttaagtcgt aggtctggtg agtgagtgtg tgagcctcac cagggaaggg ctggcctgag
     2761 ctgtctgctc tgaagatgct cctcaatgga agcctatttt tcctcagagt tttttttttt
     2821 tttaatatat atatatataa agctgaaatt aagttcttgg ctcatcagca tgccccactc
     2881 cagccccact gagcctttgg agagagatta gtacttggct ctgaggttgc caggtttaca
     2941 ggcatctatt ttgcatatga aagtttgtat ttaacttttt tgttcattaa aaatcttaca
     3001 ggtgtggtta tgcattgtca atttcagaaa gttggtcaga gcacattttg caagatctag
     3061 tgcctagtgt tgcttttatg acgtaataaa agactggcag aacctagagt atattctgat
     3121 aatttttcct cttttctctg cctcaacctt ccaaagttgt tctggtacaa aaagagagag
     3181 aaagagagag ataaaattag aaaagctgca cacatgttag atacaaacgt acacgtctgc
     3241 tcttgggacg cctgggcagc tgatcagagg ttgtagctgt tgaaacctgt ttgctctgag
     3301 acttgaaatg accttcgtta tggaagctgg gcctgtgatg gggactgaaa tggctgagcc
     3361 aacccgagac caggtggcct aaacctgaaa gcgagcatgt ggtctaacaa ttcaggggta
     3421 aacggtgttg taacctcctc aaggcagact acacagggac cccttccttt atttagccta
     3481 gacccccccc ccccccaagc actgtgccag tgatgccggg atcaggcagc tggtctaacc
     3541 aaaagagccc agaagttgat cctgtctaca ctactaaaac ctgggtgcta gaattctacc
     3601 tgagaattta tgatcccggc ctatcaaaca aaatagctac ctgaccagag tttgatcccc
     3661 agtgcccaca ctggagggcg aaaactgact ccccaaaatt gtcctcagac ctccatactt
     3721 gcacaaacca acagatggac caaattagta ataagtaaaa aaaaattaaa ggaattttaa
     3781 gggccttgga taggtttgtt tctgttggct cagtcctgct tggatggcga ctttctctcc
     3841 ccaggtgagt gatgctatag ctaatgtggc atttgaaggt gtcctcaagc tcgccacccg
     3901 ggtgtgctta gaacaggaac ctggagagac agatggttgg gtggtgaggc caggattgac
     3961 ttttagtctc agccaggtgt gtctgtaaca agctggatcc ctgctcacat ctgtaatccc
     4021 agttcccagt ggggagaggc agggtcggta gatccttcct gggaggagca ggaagagtga
     4081 tggagaacaa cttccctctc ccatgtctgc tcataagcgc atccaccaca ttcctgtgca
     4141 cacacagtaa gttcttatag aagatggaaa atgcaaaagt acagaatgtt aagctatggt
     4201 ggcactgctt tacctgagtg tctgaatcca agctaaggta ccagaagccc cagctctctg
     4261 tcacctgtgt gcgcacgggt aacagaactg ttacattgag cttatgagaa gaatacagat
     4321 aagtgagaaa cagcacttgg tgtaactagt gagtcggcaa aattaaagcc ggtaatgttt
     4381 ttgtgaaatt tcaattttgg aacctgaaag aaatgttgca ttgttctgtt tagcccatag
     4441 tctctaaaaa tgagtaaaag tttaagaaat acacactgct ggtgacatct ctttctgca
//
