LOCUS       NM_144851               6415 bp    mRNA    linear   ROD 09-OCT-2024
DEFINITION  Mus musculus SUMO1/sentrin specific peptidase 1 (Senp1), transcript
            variant 2, mRNA.
ACCESSION   NM_144851
VERSION     NM_144851.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6415)
  AUTHORS   Liu,Z., Bian,X., Li,L., Liu,L., Feng,C., Wang,Y., Ni,J., Li,S.,
            Lu,D., Li,Y., Ma,C., Yu,T., Xiao,X., Xue,N., Wang,Y., Zhang,C.,
            Ma,X., Gao,X., Fan,X., Liu,X. and Fan,G.
  TITLE     SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes Prevents
            Myocardial Fibrosis by Paracrine Signaling
  JOURNAL   Adv Sci (Weinh) 11 (34), e2400741 (2024)
   PUBMED   38992961
  REMARK    GeneRIF: SENP1-Mediated HSP90ab1 DeSUMOylation in Cardiomyocytes
            Prevents Myocardial Fibrosis by Paracrine Signaling.
REFERENCE   2  (bases 1 to 6415)
  AUTHORS   Ou,X., Wang,H., Shen,Y., Zhang,W., Sun,J. and Liu,S.
  TITLE     SENP1 regulates intermittent hypoxia-induced microglia mediated
            inflammation and cognitive dysfunction via wnt/beta-catenin pathway
  JOURNAL   Eur J Pharmacol 975, 176659 (2024)
   PUBMED   38762158
  REMARK    GeneRIF: SENP1 regulates intermittent hypoxia-induced microglia
            mediated inflammation and cognitive dysfunction via
            wnt/beta-catenin pathway.
REFERENCE   3  (bases 1 to 6415)
  AUTHORS   Qing,Z., Luo,Q., Duan,J., Lin,J., Huang,H., Yang,S. and Zeng,Z.
  TITLE     SENP1 attenuates hypoxia-reoxygenation injury in liver sinusoid
            endothelial cells by relying on the HIF-1alpha signaling pathway
  JOURNAL   Mol Med Rep 29 (4) (2024)
   PUBMED   38426545
  REMARK    GeneRIF: SENP1 attenuates hypoxia-reoxygenation injury in liver
            sinusoid endothelial cells by relying on the HIF-1alpha signaling
            pathway.
REFERENCE   4  (bases 1 to 6415)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 6415)
  AUTHORS   Chen,W., Xu,Z., Jiang,J., Chen,L., Chen,Y., Yu,T., Chen,H. and
            Shi,R.
  TITLE     LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by binding
            to SENP1 to promote intestinal fibrosis in Crohn's disease
  JOURNAL   Int J Biol Macromol 262 (Pt 1), 129921 (2024)
   PUBMED   38309408
  REMARK    GeneRIF: LncRNA MSC-AS1 regulates SNIP1 SUMOylation-mediated EMT by
            binding to SENP1 to promote intestinal fibrosis in Crohn's disease.
REFERENCE   6  (bases 1 to 6415)
  AUTHORS   Yamaguchi,T., Sharma,P., Athanasiou,M., Kumar,A., Yamada,S. and
            Kuehn,M.R.
  TITLE     Mutation of SENP1/SuPr-2 reveals an essential role for
            desumoylation in mouse development
  JOURNAL   Mol Cell Biol 25 (12), 5171-5182 (2005)
   PUBMED   15923632
  REMARK    GeneRIF: Data describe a mutation in SENP1 that causes increased
            steady-state levels of the sumoylated forms of a number of proteins
            and results in placental abnormalities incompatible with embryonic
            development.
REFERENCE   7  (bases 1 to 6415)
  AUTHORS   Gomez-del Arco,P., Koipally,J. and Georgopoulos,K.
  TITLE     Ikaros SUMOylation: switching out of repression
  JOURNAL   Mol Cell Biol 25 (7), 2688-2697 (2005)
   PUBMED   15767674
REFERENCE   8  (bases 1 to 6415)
  AUTHORS   Yamada,S., Nakajima,H. and Kuehn,M.R.
  TITLE     Novel testis- and embryo-specific isoforms of the
            phosphofructokinase-1 muscle type gene
  JOURNAL   Biochem Biophys Res Commun 316 (2), 580-587 (2004)
   PUBMED   15020257
REFERENCE   9  (bases 1 to 6415)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 6415)
  AUTHORS   Nishiguchi,S., Joh,T., Horie,K., Zou,Z., Yasunaga,T. and Shimada,K.
  TITLE     A survey of genes expressed in undifferentiated mouse embryonal
            carcinoma F9 cells: characterization of low-abundance mRNAs
  JOURNAL   J Biochem 116 (1), 128-139 (1994)
   PUBMED   7798170
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK054521.1, AK028565.1, BF453574.1, CX203962.1, AK009838.1 and
            AW490919.1.
            
            On Jul 8, 2011 this sequence version replaced NM_144851.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK028565.1, AK088597.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-259               AK054521.1         2-260
            260-2932            AK028565.1         2-2674
            2933-3728           AK028565.1         2676-3471
            3729-3915           BF453574.1         110-296
            3916-3953           CX203962.1         57-94
            3954-5887           AK009838.1         1-1934
            5888-6415           AW490919.1         1-528               c
FEATURES             Location/Qualifiers
     source          1..6415
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 54.04 cM"
     gene            1..6415
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /note="SUMO1/sentrin specific peptidase 1"
                     /db_xref="GeneID:223870"
                     /db_xref="MGI:MGI:2445054"
     exon            1..287
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            288..335
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            336..466
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            467..551
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            552..711
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            712..883
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            884..987
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            988..1259
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1314
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1353
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1438
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1439..1594
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1595..1726
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1930
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            1931..2010
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2011..2095
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2096..2191
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..6400
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3895..3900
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /note="hexamer: AATAAA"
     polyA_site      3915
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /note="major polyA site"
     regulatory      6360..6365
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
                     /note="hexamer: AATAAA"
     polyA_site      6400
                     /gene="Senp1"
                     /gene_synonym="2310046A20Rik; D15Ertd528e; E330036L07Rik;
                     suPr-2"
ORIGIN      
        1 agtactccaa gtgcgacgaa gagaaaaagc cccagtctga cagggtgaca gggagatgga
       61 gacgcgagtc aaacgctccc tccacgtctc gggcctcgcc acctcgcgca ggcgtcccgc
      121 gagcctgtag ctcgctcttt gacctcttgt cccaccccct tccctcctcc gcgcccgcca
      181 aacggtcttc cggtagagta aagaaggttc cggttcccgg aggttcccgg gctttgcggt
      241 ccgcgcccgg ccggaaaccc ctttgcctag cagccggttc cggttcggat tctgtgtctt
      301 tactaaagcc agtgatgtga agagacctga aatggatgac acagctgatg gggtgaagat
      361 ggacgctggg gaggtgacct tagtgaacca cggctccact ttcagaaccc accgcccgcc
      421 acagtcaggc tttccagagg agcagcttct gctttctgac cagcagagct tgcctttcag
      481 gcagggtact ttagatggat ctttcacgtg ttctacaaga agcccagcct atcgtccaga
      541 ttatcactca gataaccctt cctcagacag tttccttggc tcaggtgacg taagaacctt
      601 tggtcaaagt gcaaatggac aatggagaaa ttccactcca gcgtcaggct cagcgccaca
      661 aaaaccaaga aatagccgaa gtctttgcct cgaaacccgg aagacctcaa gtggattatc
      721 aaacaccttt gtgggcaagt ccaatcacca ctgccacatg tctgcgtatg aaaagtcatt
      781 tcccattaag cctgccccaa gtccatcctg gagtgggtca tgtcgtcgga gtcttttaag
      841 ccctaagaaa actcagaggc gacatttcag cacagcagaa gagacagttc aagaagaaga
      901 gaaggagatc tacagacagc tgctgcagat ggtcacaggg aagcagttct gtgtagcgaa
      961 acccaccaca cattttccgt tacgcctgtc tcggtgtctt agttccaata agaactcttt
     1021 gaaagactcg ctgttgagaa acggaaactc ttgtgcatct catgtcattg gttctgatac
     1081 gtcatcctct ggatctgcca gcattttaac tgcacaggag cagttgtccc acagtgcaca
     1141 ttccctgtca tctggtaccc cagatgttgc ctttggatcc aaagactctg atcctcacca
     1201 tcacctcgct gcacctcatc agccaaatag cttaccagca tcaaatacac agtccgaagg
     1261 gtcagactct gtgattttac ttaaagtgaa agaatctcag actccagctt ccagccctac
     1321 gttcttccag gcagagctat ggatcaaaga attaactagc gtttatgact ctcgagctcg
     1381 ggaaagattg cgccggattg aagagcagaa agcattggca ctacagcttc aaaaccagcg
     1441 actgcaggag caggaacatg cagtacttga ctccgtagag cttcaccttc gtgtgcctct
     1501 tgaaaaggag attcctgtca cagctgccca agaaaccagg aaaaaaagcc accagctgac
     1561 tgacagtgaa gacgaatttc ctgaaattac agaggaaatg gaaaaagaaa taaagaatgt
     1621 atttcgtaac ggtaaccagg atgaagtcct cagtgaggca ttccgcttga ccattacacg
     1681 caaagacatt cagactctaa accatctaaa ctggctcaat gatgagatca tcaatttcta
     1741 catgaacatg ctaatggaac gcagtaaaga gaaggggttt ccaagtgtac atgcgtttaa
     1801 taccttcttc ttcactaagc taaaaacagc tggttatcag gcagtgaaac gctggacaaa
     1861 gaaggtggat gtattctccg ttgatattct tctggtgccc attcacttgg gtgtgcactg
     1921 gtgtctagct gttgtagact ttagaaggaa gagtatcacc tactatgatt ctatgggtgg
     1981 aataaacaac gaggcctgca ggatcctctt gcaataccta aaacaagaaa gtgttgacaa
     2041 gaaaaggaaa gagtttgaca ccaacggctg gcagctcttc agcaagaaga gccaggaaat
     2101 cccacagcag atgaatggga gtgactgtgg aatgtttgct tgcaaatatg ctgactgcat
     2161 taccaaagac agaccaatca acttcacaca gcaacacatg ccatatttcc gaaagcgaat
     2221 ggtctgggag atcctccacc ggaagctctt gtgaagattc tcagtgagca gacactgagc
     2281 gtgtggggga ccaacctttg ccatcgacag ccggagacct tggaaagagc tgctcctccc
     2341 tcccctgttc ttgtacagcc cttgaccctg gaccaggccc ggcgagatgc attcacaagc
     2401 acatctgcct tcccttttgt agctcagatc ctatttttgc aaagaaactt tggtgctgtg
     2461 aaggggtgag ggaacatccc tcctgaagag actgcttttc acttcagctc tgccgtcttc
     2521 ttttccaagg gctcccgctc actgagtccc tcactaggag cccaagagag cctcgggaag
     2581 aatctcggtt tcctgtaaac ccttgttgct cggccttacc gagaagcagg aaagagcatg
     2641 ggcagcaggt aggggtaaaa ccaccagcat gtaggacaca catccccaag acgcagagtc
     2701 ggcaatggag ctgcttaagt ccctcctcca ggaccttcct atttatgtgc cctccatgac
     2761 cgactgcttc tcctccaagc tgtttcttca ctggtagcgt catcccatcc taagcacact
     2821 acacaagccc tggcagaccc taaagtctcg agcagtccgt tccttacaag cagggctgca
     2881 tgtgcgagca cgcacgtgct gtgggagggc ccccagaagt actgagcgca gcagccgggc
     2941 cccagcttca gtgctgcctg cttctgacca agaagaagga ccttggcggt tagcatcaca
     3001 cgccagagta ggatgaatac aggtctaggt ggtctgtggc tagttagttt aaatatgctt
     3061 ctagcctcag agagttttat atacatatat gcctatatgt gtgtatacat acatatatac
     3121 acacacacac acaatgtgaa atatatattt cacagggata tgtttttaaa agttaaaaaa
     3181 aaaaaaaaga ctgaatgtgt ttaccattta gtctgtaggt ttattttcat ctttcaaatt
     3241 ccagcacaca gtgatcccag caagccctgt gtatcgggcc tttgtagatt tcctaagagt
     3301 gttttgagac ctggatgaat ctggtttagg agtaaaggtt atcaaggtaa atgatgctgt
     3361 cagctgaaga tggggtgaat tagacaggta aacttgaggt ttttaaactg ctctttgttg
     3421 ttgtttgtag cacctctccc cctgcccatc tcagagctcc tgaggtgaga tggtgagggg
     3481 acacagtgcc agtgtcgttt tgtacttaag ttccacaaca gggacgtttt tctactttgt
     3541 gtatggtggc cggtagtttt ctatgcagtc ttctccccga ttccctgcgc ccagccctgc
     3601 cagcactgtg ctctctctcc ttgggcttat ttggaaattt tactctgttt tataccaatc
     3661 ttgtttagta catttttcta tgttttacca caagtcacaa tttgaaaaca acaactattt
     3721 tttttactac tccattgtta aatgaatgtt accgtctcca ctccagcagc ctgtgcccct
     3781 cttgcctccc cctgcatgtt ggggatgagg gccactgtcc atgtgtgtct ccttctctcg
     3841 ctgcctctcc ttccccctct cctccctttc tttttctctt ggtttcccat aggaaataaa
     3901 tagctttcta tatgagttgc gggccctttc acagtctctt ttagaaaact ggcgtgcaga
     3961 ctcagcacag gactcaagga tgttgtctgc ttctcagtcc ttaatgtatt taggtgacag
     4021 cttacacggt ggcagtgtga ctacttagtc taaaggcgtc cctctcaggc ttttctcact
     4081 gttgtctgag gctcatcaca ggatacgttt ctgtgtttat tgtttgttcc tttagacaat
     4141 atctgctata tcttcctcag agactttttg tatggaccaa agcaacaaat atttattgcc
     4201 atgaatacaa gaatatgaga catgcaacag aagcactttg taaaataggt agaattgttg
     4261 agccagtctg gagttggctc ccttctccaa tgcagtttaa acgtcccagg taaaagctag
     4321 tgatcctaag accactgtcc accccggagc aagaggataa gtcagactgg gacggggtgg
     4381 cctcatggga accaagtaca gacttgtaga ctgtccttag agtcagccaa caggagcagg
     4441 acaagtgtcg gaaacttcaa gagggaactc tgatgaccaa gactgaagct gtttttgtat
     4501 ttcatggcca agggtatgct acagactatg cctgttgttt tccatctgtc tctttttccc
     4561 ctgacaacat ctccctgatg ctgataatca tctccctccc ctgtaaaagg aatatgtgaa
     4621 ggatgatagc ttagcagtta cagacttttc aacaaaaccc ccagtcctcc agcagtcatc
     4681 cctggagtgt acccagagaa aatgacactg cttctgccct tttgagaaca tgtgctatga
     4741 tgtatggaag ctggctacat ccatttgatc acttgagacc cactgtgacc cccaggagtc
     4801 ctgtgtaggg ttcagtgtga gtacttgaac atagatagcc tagagactcg ctgtcagttc
     4861 actcttctgt gtgtgaggag tacgtcctcc tattctttag actgccctca gcactgcttt
     4921 agcatttagt ggttcaaggg gacagcagat caccaccacc tggtttatac acccatggta
     4981 tgaacaatca ttactggatg gaaagagaga gagagagaga gagagagagt tcgttaaaga
     5041 gctgcttttt gtttaaatct taacctctga tctttctgtg tcatcctcca agctctgaaa
     5101 gaaggtcaga gtaaaaacgg cggacattgt gtttcgttct gtcttccctt gctctactct
     5161 cgtgcccaat gccaggtgga gtgaggtgct ctgcgttact gtcgaaggtc agtgtcagca
     5221 ccgccttggt tgtagcatca aggctgcacg agccttgcta aatgcagcat gcctagatgt
     5281 gccctggcct tgtgtctggg ctggggaatg gctgatgatg atgtggtgac gctagagact
     5341 gccttcccct cgacagagcc agctgctagg aagggctaat gtgggagaat ggtccccaag
     5401 agcacaggct ccattctgct caggcattca gtctaatcct tgtccaagta cccactcagt
     5461 gtgtgtgcac ccagggctga ttaaagctct ccctggtcac actaccttaa aatctcttgt
     5521 ctggacttct gtagtcctga tgatagaatg gcctaacttc tccctgtttg tcttgtctgc
     5581 cttctcatag ggggcacagc atggagatgc caaggccagg aggctgggtt ggtgctgttt
     5641 ttctagccaa gagtgcaagc gtctatattc tcatctgaaa agaacaaggc agggctcgtt
     5701 ctatgaaaca tttcttaaga agaatagtgt tgtgagggtg tgaggagaat tggttatttg
     5761 tcataacttc caaacactgt aggctcagag cagccattcc gacctcaaac agggctcttt
     5821 aacagaagca ccgtcctcat cagtaggtca tgttgccatt tggggctctc gggctacacc
     5881 ccaagaggct tatcagaaca tctttttaac cccttaggta gttcctcctc cgtccttttt
     5941 attgacaggg atatcccttg cacattcaga tgatggcttc ctttctcttt gtcttgtcct
     6001 gtaaaggcac tgccttacct gtaactcacg gggaatcctc tgtctgaaga cttgataagt
     6061 gtgagaggtc aagccctgga cttgggagcc ctggagggtg agaaaggtgg gttaacaaag
     6121 gaagtaaaag ccacctgtcc tcagggtctt acagtctgta agtttatagt ttgcctgatt
     6181 tggaaggcta agcaaacaca gatacacctt gtcaagaaag aatgcgggct cattagcaca
     6241 cagttcagaa tgaagctgga gtggaggaaa ggactgaggt ggagatgtgt cagggatgat
     6301 ctcgccttta tctgtatatg tgactcccta ggtttttttt ttttaattga tttatttaaa
     6361 ataaattctg tggattttgc ttctgtgctt tgactgggaa aaaaaaaaaa aaaaa
//
