LOCUS       NM_017390               1570 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus semenogelin 1 (Semg1), mRNA.
ACCESSION   NM_017390
VERSION     NM_017390.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1570)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1570)
  AUTHORS   Sakaguchi,D., Miyado,K., Iwamoto,T., Okada,H., Yoshida,K., Kang,W.,
            Suzuki,M., Yoshida,M. and Kawano,N.
  TITLE     Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female
            Reproductive Tract
  JOURNAL   Int J Mol Sci 21 (11), 3961 (2020)
   PUBMED   32486486
  REMARK    GeneRIF: Human Semenogelin 1 Promotes Sperm Survival in the Mouse
            Female Reproductive Tract.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1570)
  AUTHORS   Mariani,N.A.P., Camara,A.C., Silva,A.A.S., Raimundo,T.R.F.,
            Andrade,J.J., Andrade,A.D., Rossini,B.C., Marino,C.L., Kushima,H.,
            Santos,L.D. and Silva,E.J.R.
  TITLE     Epididymal protease inhibitor (EPPIN) is a protein hub for seminal
            vesicle-secreted protein SVS2 binding in mouse spermatozoa
  JOURNAL   Mol Cell Endocrinol 506, 110754 (2020)
   PUBMED   32044375
  REMARK    GeneRIF: Epididymal protease inhibitor (EPPIN) is a protein hub for
            seminal vesicle-secreted protein SVS2 binding in mouse spermatozoa.
REFERENCE   4  (bases 1 to 1570)
  AUTHORS   Shindo,M., Inui,M., Kang,W., Tamano,M., Tingwei,C., Takada,S.,
            Hibino,T., Yoshida,M., Yoshida,K., Okada,H., Iwamoto,T., Miyado,K.
            and Kawano,N.
  TITLE     Deletion of a Seminal Gene Cluster Reinforces a Crucial Role of
            SVS2 in Male Fertility
  JOURNAL   Int J Mol Sci 20 (18), 4557 (2019)
   PUBMED   31540031
  REMARK    GeneRIF: SVS3, SVS4, SVS5, and SVS6 do not function in the
            protection of sperm against a uterine immune attack in the absence
            of SVS2. Thus, Svs2 is the critical gene in the seminal vesicle
            proteins gene cluster.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1570)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   6  (bases 1 to 1570)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1570)
  AUTHORS   Kawano,N., Yoshida,K., Iwamoto,T. and Yoshida,M.
  TITLE     Ganglioside GM1 mediates decapacitation effects of SVS2 on murine
            spermatozoa
  JOURNAL   Biol Reprod 79 (6), 1153-1159 (2008)
   PUBMED   18753612
REFERENCE   8  (bases 1 to 1570)
  AUTHORS   Kawano,N. and Yoshida,M.
  TITLE     Semen-coagulating protein, SVS2, in mouse seminal plasma controls
            sperm fertility
  JOURNAL   Biol Reprod 76 (3), 353-361 (2007)
   PUBMED   17123940
  REMARK    GeneRIF: the fertility of ejaculated sperm is associated with SVS2
            distribution in the female reproductive tract, SVS2 functions as a
            decapacitation factor for mouse sperm.
REFERENCE   9  (bases 1 to 1570)
  AUTHORS   Nelson,P.S., Pritchard,C., Abbott,D. and Clegg,N.
  TITLE     The human (PEDB) and mouse (mPEDB) Prostate Expression Databases
  JOURNAL   Nucleic Acids Res 30 (1), 218-220 (2002)
   PUBMED   11752298
REFERENCE   10 (bases 1 to 1570)
  AUTHORS   Lundwall,A.
  TITLE     The cloning of a rapidly evolving seminal-vesicle-transcribed gene
            encoding the major clot-forming protein of mouse semen
  JOURNAL   Eur J Biochem 235 (1-2), 424-430 (1996)
   PUBMED   8631362
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DV056729.1, BB871464.1, AK144285.1 and AK035204.1.
            
            On Sep 3, 2009 this sequence version replaced NM_017390.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK035204.1, AK144285.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849381 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 DV056729.1         36-44
            10-76               BB871464.1         2-68
            77-1443             AK144285.1         2-1368
            1444-1570           AK035204.1         1369-1495
FEATURES             Location/Qualifiers
     source          1..1570
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 84.82 cM"
     gene            1..1570
                     /gene="Semg1"
                     /gene_synonym="Svs2; SvsII"
                     /note="semenogelin 1"
                     /db_xref="GeneID:53878"
                     /db_xref="MGI:MGI:1858275"
     exon            1..171
                     /gene="Semg1"
                     /gene_synonym="Svs2; SvsII"
                     /inference="alignment:Splign:2.1.0"
     CDS             99..1226
                     /gene="Semg1"
                     /gene_synonym="Svs2; SvsII"
                     /note="seminal vesicle secretory protein 2; seminal
                     vesicle protein, secretion 2; semenoclotin; semenogelin I"
                     /codon_start=1
                     /product="semenogelin I precursor"
                     /protein_id="NP_059086.3"
                     /db_xref="CCDS:CCDS17027.1"
                     /db_xref="GeneID:53878"
                     /db_xref="MGI:MGI:1858275"
                     /translation="MKSSVFVLSLLLILERQSAVVGQYGATKGHFQSSSSEGFMLGQK
                     GRLSFGIKGGSDEAAEESLFMQSQRRVYGQGGGDMTQTRVSQEHTSVKGAALCRNGQV
                     SQLKSQESQIKSYGQVKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGQLKSGGPAF
                     GQVKSQESQIKSYGQLKSSGQLKSGGSAFGQVKSSVSQIKSYGQLKSGGSQVKSYGQT
                     KSYGEEGQLNSFSQLKSQGAQLKSYGQQKSQQQSSFSQVKSQSSQLKSYGQQKSLKGF
                     SQQTQHKGFAMDEGMSQVRKQFSDDDLSVQQKSTQQMKTEEDLSQFGQQRQYGQERSQ
                     SYKGYLEQYRKKVQEQQRKNFNPGNYFTKGGADLYQAQLKG"
     exon            172..1266
                     /gene="Semg1"
                     /gene_synonym="Svs2; SvsII"
                     /inference="alignment:Splign:2.1.0"
     exon            1267..1570
                     /gene="Semg1"
                     /gene_synonym="Svs2; SvsII"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1415..1420
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Semg1"
                     /gene_synonym="Svs2; SvsII"
                     /note="hexamer: AATAAA"
     polyA_site      1436
                     /gene="Semg1"
                     /gene_synonym="Svs2; SvsII"
                     /note="major polyA site"
ORIGIN      
        1 gccttttgta gcttcagcca tatccatgct acatccagct agagaagata taaacgtgcc
       61 agtcagctca gctctcagtg aaggtccttc ttgacaagat gaagtcctct gtcttcgtcc
      121 tttctctgct cctcattctg gaaagacagt cagctgtggt tggacaatat ggggctacaa
      181 aaggccactt ccagagcagc tcctcagagg gatttatgct tggtcagaaa ggccgtctca
      241 gtttcgggat caaaggagga agtgacgaag cagctgaaga aagccttttc atgcaatcac
      301 aacgccgggt gtatggccag ggtggtggtg acatgaccca gacacgtgtt tcacaagagc
      361 atacaagtgt caaaggggcc gcactttgtc gtaatggaca agtatcccaa ctgaaatccc
      421 aagaatccca aataaaatcc tatggccaag tgaaatccag tggacagctg aaatctggag
      481 gatcagcctt tggacaagtg aagtccagtg tgtcccaaat aaaatcctat ggacagctga
      541 aatccggtgg tcagttgaaa tctggaggac cagcctttgg acaagtgaaa tcccaagaat
      601 cccaaataaa atcttatgga caattgaaat ccagtggaca actgaaatct ggaggatcgg
      661 cctttggaca agtgaagtcc agtgtgtccc aaataaaatc ctatggacag ctgaaatccg
      721 gtggatccca agtaaaatcc tatggtcaaa caaaatccta tggtgaagaa ggtcaactga
      781 actctttcag ccaactaaaa tcccaaggtg cccaactaaa atcctatggt caacaaaaat
      841 ctcaacaaca gtcctccttt agccaagtaa aatctcaaag ttcccaacta aagtcctatg
      901 gccaacaaaa atccctcaaa ggtttttctc aacaaactca gcataaagga tttgccatgg
      961 atgaaggtat gtcacaagtg cggaaacaat ttagtgacga tgacctctca gtacaacaga
     1021 agtctaccca acagatgaaa acagaggaag acttatccca attcggacaa cagcggcaat
     1081 atggacaaga gcgctcacaa tcctataaag gatatcttga gcaatacaga aagaaagtac
     1141 aagaacaaca acgaaaaaat tttaatcccg gtaactattt tacaaaggga ggagcagacc
     1201 tctatcaagc tcagcttaag ggataacata ttcactgacc aactaaagac caagatcaat
     1261 atcaaggact cgcctcacca gagtcaagtc tatgatacct tcaagatgca gactgcaatg
     1321 tcacccagat cgttggttca tggacaaccc tctactcaca tttgcttttc tgtaggactt
     1381 ctggccctgg agcttcctca aacacttgct ttccaataaa aagataactt tccgcatcac
     1441 ttgtacttgt tgactgagaa ctggttcctg agaactgtgt ctggatttgg gaatattccc
     1501 aatgggcagt tccaaaagga agagacagtt gtatggcatt gggaaaaaca gcaataaaat
     1561 ccatatttat
//
