LOCUS       NM_011352               3298 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), and GPI
            membrane anchor, (semaphorin) 7A (Sema7a), mRNA.
ACCESSION   NM_011352
VERSION     NM_011352.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3298)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3298)
  AUTHORS   Liu,L., Jiang,Y. and Steinle,J.J.
  TITLE     Semaphorin 7a regulates inflammatory mediators and permeability in
            retinal endothelial cells
  JOURNAL   Microvasc Res 150, 104587 (2023)
   PUBMED   37453650
  REMARK    GeneRIF: Semaphorin 7a regulates inflammatory mediators and
            permeability in retinal endothelial cells.
REFERENCE   3  (bases 1 to 3298)
  AUTHORS   Cai,C., Luo,Q., Jia,L., Xia,Y., Lan,X., Wei,X., Shi,S., Liu,Y.,
            Wang,Y., Xiong,Z., Shi,R., Huang,C. and Chen,Z.
  TITLE     TRIM67 Implicates in Regulating the Homeostasis and Synaptic
            Development of Mitral Cells in the Olfactory Bulb
  JOURNAL   Int J Mol Sci 24 (17), 13439 (2023)
   PUBMED   37686246
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3298)
  AUTHORS   Lu,Q., Liu,Z., Zhao,L., Xu,L., Liu,C., Li,L., Cao,Y., Li,F., Wu,L.,
            Wang,L., Chen,T., You,T., Ren,L., Wang,G., Tang,C. and Zhu,L.
  TITLE     Sema7A protects against high-fat diet-induced obesity and hepatic
            steatosis by regulating adipo/lipogenesis
  JOURNAL   Mol Metab 70, 101698 (2023)
   PUBMED   36842496
  REMARK    GeneRIF: Sema7A protects against high-fat diet-induced obesity and
            hepatic steatosis by regulating adipo/lipogenesis.
            Erratum:[Mol Metab. 2023 Dec;78:101827. doi:
            10.1016/j.molmet.2023.101827.. PMID: 37871636]
REFERENCE   5  (bases 1 to 3298)
  AUTHORS   Li,X., Xie,W., Pan,Q., Zhang,X., Zhang,L., Zhao,N., Xie,Q., Ding,J.
            and Chai,J.
  TITLE     Semaphorin 7A interacts with nuclear factor NF-kappa-B p105 via
            integrin beta1 and mediates inflammation
  JOURNAL   Cell Commun Signal 21 (1), 24 (2023)
   PUBMED   36717921
  REMARK    GeneRIF: Semaphorin 7A interacts with nuclear factor NF-kappa-B
            p105 via integrin beta1 and mediates inflammation.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3298)
  AUTHORS   Mine,T., Harada,K., Matsumoto,T., Yamana,H., Shirouzu,K., Itoh,K.
            and Yamada,A.
  TITLE     CDw108 expression during T-cell development
  JOURNAL   Tissue Antigens 55 (5), 429-436 (2000)
   PUBMED   10885563
REFERENCE   7  (bases 1 to 3298)
  AUTHORS   .
  TITLE     Unified nomenclature for the semaphorins/collapsins. Semaphorin
            Nomenclature Committee
  JOURNAL   Cell 97 (5), 551-552 (1999)
   PUBMED   10367884
REFERENCE   8  (bases 1 to 3298)
  AUTHORS   Sato,Y. and Takahashi,H.
  TITLE     Molecular cloning and expression of murine homologue of semaphorin
            K1 gene
  JOURNAL   Biochim Biophys Acta 1443 (3), 419-422 (1998)
   PUBMED   9878861
REFERENCE   9  (bases 1 to 3298)
  AUTHORS   Xu,X., Ng,S., Wu,Z.L., Nguyen,D., Homburger,S., Seidel-Dugan,C.,
            Ebens,A. and Luo,Y.
  TITLE     Human semaphorin K1 is glycosylphosphatidylinositol-linked and
            defines a new subfamily of viral-related semaphorins
  JOURNAL   J Biol Chem 273 (35), 22428-22434 (1998)
   PUBMED   9712866
REFERENCE   10 (bases 1 to 3298)
  AUTHORS   Lange,C., Liehr,T., Goen,M., Gebhart,E., Fleckenstein,B. and
            Ensser,A.
  TITLE     New eukaryotic semaphorins with close homology to semaphorins of
            DNA viruses
  JOURNAL   Genomics 51 (3), 340-350 (1998)
   PUBMED   9721204
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC165246.2.
            
            On Jun 19, 2018 this sequence version replaced NM_011352.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC057875.1, AK156123.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-217               AC165246.2         69123-69339         c
            218-360             AC165246.2         55773-55915         c
            361-402             AC165246.2         55240-55281         c
            403-495             AC165246.2         54834-54926         c
            496-583             AC165246.2         54540-54627         c
            584-694             AC165246.2         54281-54391         c
            695-834             AC165246.2         53609-53748         c
            835-1019            AC165246.2         52926-53110         c
            1020-1128           AC165246.2         52034-52142         c
            1129-1327           AC165246.2         51746-51944         c
            1328-1455           AC165246.2         49069-49196         c
            1456-1610           AC165246.2         48738-48892         c
            1611-1672           AC165246.2         48533-48594         c
            1673-3298           AC165246.2         46586-48211         c
FEATURES             Location/Qualifiers
     source          1..3298
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 31.63 cM"
     gene            1..3298
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /note="sema domain, immunoglobulin domain (Ig), and GPI
                     membrane anchor, (semaphorin) 7A"
                     /db_xref="GeneID:20361"
                     /db_xref="MGI:MGI:1306826"
     exon            1..217
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..2034
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /note="semaphorin-7A; semaphorin-L; semaphorin-K1"
                     /codon_start=1
                     /product="semaphorin-7A precursor"
                     /protein_id="NP_035482.1"
                     /db_xref="CCDS:CCDS23235.1"
                     /db_xref="GeneID:20361"
                     /db_xref="MGI:MGI:1306826"
                     /translation="MTPPPPGRAAPSAPRARVLSLPARFGLPLRLRLLLVFWVAAASA
                     QGHSRSGPRISAVWKGQDHVDFSQPEPHTVLFHEPGSFSVWVGGRGKVYHFNFPEGKN
                     ASVRTVNIGSTKGSCQDKQDCGNYITLLERRGNGLLVCGTNARKPSCWNLVNDSVVMS
                     LGEMKGYAPFSPDENSLVLFEGDEVYSTIRKQEYNGKIPRFRRIRGESELYTSDTVMQ
                     NPQFIKATIVHQDQAYDDKIYYFFREDNPDKNPEAPLNVSRVAQLCRGDQGGESSLSV
                     SKWNTFLKAMLVCSDAATNRNFNRLQDVFLLPDPSGQWRDTRVYGVFSNPWNYSAVCV
                     YSLGDIDRVFRTSSLKGYHMGLPNPRPGMCLPKKQPIPTETFQVADSHPEVAQRVEPM
                     GPLKTPLFHSKYHYQKVVVHRMQASNGETFHVLYLTTDRGTIHKVVESGDQDHSFVFN
                     IMEIQPFHRAAAIQAISLDADRRKLYVTSQWEVSQVPLDMCEVYSGGCHGCLMSRDPY
                     CGWDQDRCVSIYSSQRSVLQSINPAEPHRECPNPKPDEAPLQKVSLARNSRYYLTCPM
                     ESRHATYLWRHEENVEQSCEPGHQSPSCILFIENLTARQYGHYRCEAQEGSYLREAQH
                     WELLPEDRALAEQLMGHARALAASFWLGVLPTLILGLLVH"
     exon            218..360
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            361..402
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            403..495
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            496..583
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            584..694
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            695..834
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1019
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1128
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            1129..1327
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            1328..1455
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            1456..1610
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            1611..1672
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..3298
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3278..3283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /note="hexamer: AATAAA"
     polyA_site      3298
                     /gene="Sema7a"
                     /gene_synonym="2900057C09Rik; CDw108; H-Sema K1; H-Sema-L;
                     M-Sema-L; sema K1; sema L; Semal"
                     /note="major polyA site"
ORIGIN      
        1 agtctcggct gcttgccgct gtcgctccgg ggctgcggga tgacgcctcc tcctcccgga
       61 cgtgccgccc ccagcgcacc gcgcgcccgc gtcctcagcc tgccggctcg gttcgggctc
      121 ccgctgcggc tgcggcttct gctggtgttc tgggtggccg ccgcctccgc ccaaggccac
      181 tcgaggagcg gaccccgcat ctccgccgtc tggaaagggc aggaccatgt ggactttagc
      241 cagcctgagc cacacaccgt gcttttccat gagccgggca gcttctctgt ctgggtgggt
      301 ggacgtggca aggtctacca cttcaacttc cccgagggca agaatgcctc tgtgcgcacg
      361 gtgaacatcg gctccacaaa ggggtcctgt caggacaaac aggactgtgg gaattacatc
      421 actcttctag aaaggcgggg taatgggctg ctggtctgtg gcaccaatgc ccggaagccc
      481 agctgctgga acttggtgaa tgacagtgtg gtgatgtcac ttggtgagat gaaaggctat
      541 gcccccttca gcccggatga gaactccctg gttctgtttg aaggagatga agtgtactct
      601 accatccgga agcaggaata caacgggaag atccctcggt ttcgacgcat tcggggcgag
      661 agtgaactgt acacaagtga tacagtcatg cagaacccac agttcatcaa ggccaccatt
      721 gtgcaccaag accaagccta tgatgataag atctactact tcttccgaga agacaaccct
      781 gacaagaacc ccgaggctcc tctcaatgtg tcccgagtag cccagttgtg caggggggac
      841 cagggtggtg agagttcgtt gtctgtctcc aagtggaaca ccttcctgaa agccatgttg
      901 gtctgcagcg atgcagccac caacaggaac ttcaatcggc tgcaagatgt cttcctgctc
      961 cctgacccca gtggccagtg gagagatacc agggtctatg gcgttttctc caacccctgg
     1021 aactactcag ctgtctgcgt gtattcgctt ggtgacattg acagagtctt ccgtacctca
     1081 tcgctcaaag gctaccacat gggccttccc aaccctcgac ctggcatgtg cctcccaaaa
     1141 aagcagccca tacccacaga aaccttccag gtagctgata gtcacccaga ggtggctcag
     1201 agggtggaac ctatggggcc actgaagaca ccattgttcc attctaagta ccattaccag
     1261 aaagtggtcg ttcaccgcat gcaagccagc aatggagaga ccttccatgt gctttatcta
     1321 accacagaca ggggcaccat tcacaaggtg gtggaatcag gggaccagga ccatagcttt
     1381 gtcttcaata tcatggagat ccagcccttt caccgtgcag cggccatcca ggctatatca
     1441 ttggatgctg accggcggaa gctctatgtg acctcccagt gggaagtgag ccaggtaccc
     1501 ctggacatgt gtgaggtcta cagcgggggc tgccatggct gcctcatgtc ccgagacccc
     1561 tactgtggct gggaccagga ccgctgcgtg tctatctaca gctcccaacg atcagtgctg
     1621 cagtccatta atccagcgga gccacacaga gagtgtccca accctaaacc agacgaggct
     1681 ccattgcaga aggtttccct ggctcggaac tctcgatact acctgacctg ccccatggag
     1741 tcccgccacg ccacttactt atggcgccat gaggagaatg tggaacagag ctgtgagcca
     1801 ggccaccaaa gccctagctg catcctgttc attgagaacc tcacggcccg tcagtatggc
     1861 cactaccgct gcgaggccca agagggctcc tacctccgtg aggctcaaca ctgggagctg
     1921 ctgccagagg acagagcact ggccgaacaa ctaatgggcc atgcccgggc cctggccgcc
     1981 tccttctggc tgggggtcct gcccacactc atacttggtc tgctggttca ctagggcttc
     2041 taggagctgg gggcgcccca ggcttctgta gcccaggagt actagaataa tgtcacactc
     2101 agccggccgg cccggaagct ccctgtccac tgattcttcc aggggtactg aataatccag
     2161 tgggggacaa agggcctgga gacgtctagc cgcaggcggc tgctggggcc caggtggggt
     2221 agggacagtg agggactata gaaggaaggc gccgactgtg aagctgggcc atcagcaact
     2281 caagacttta tcttctcgag aatatttttt cgaaatctca cacttgactt catgcagtga
     2341 tgcacctggc ctgagagccc atcagcctgg cagtgggctt tgggaagggg agctgggacc
     2401 ccccatctct ggaccttggg gctgagtcct ttgcgtcctt ccctgttcca ctgctgggtg
     2461 gccagtgtcc ctgcagaccc gggctgctcc tctgtacctc cctcacagcc tgggtcccac
     2521 cggacagcgc cttgcatgtt tattgaagga tgtttgcttt ccggacggaa gggcgggaaa
     2581 agctctattt ttatgttagg cttatttcat gtatagctac ttctgactgc atctgtatga
     2641 aaataccaaa actacatgct ggggttgggg gggcgggtag agggagggtc tgggaagggg
     2701 ggggctgatc ccaggctggg gctccctggg ataggatcag agtccaggga caggcatggg
     2761 tttgacgaga gtggcatgag ctggctctgc cctgggagcc cagtctgagg gcatgagcct
     2821 ccagtgtggg gggtggttac gggaggggtg ggtgagggag acaggggaga gcgaagaaga
     2881 aaactgagcc ctaggttgat ttgccgtggt cattttgaag gaggagccgg gtccacaggg
     2941 ggaggttcca ggactctgcc cttggcattg tgggttgggg ggcaggggga gtctcctccc
     3001 ttcccctcag cccccttccc caggggctgt gcttccatgc tcctaacctc ccaccttcag
     3061 ctcaggacat gtcctaactt aggctaaact gtgaaaattc ccgtggagat ggcccaggcc
     3121 gagcttccca agtgggcctc ccagcccaca gtccatagat ttcagcagag agctgaccct
     3181 tctccagctg tgtctggggc agggcctggg gccgggggcc ttccagcttc cgtcccttat
     3241 ctcttctcaa tgcactttaa taatgtaaca tattactaat aaacaagcta tttattta
//
