LOCUS       NM_199241               5758 bp    mRNA    linear   ROD 29-OCT-2024
DEFINITION  Mus musculus sema domain, transmembrane domain (TM), and
            cytoplasmic domain, (semaphorin) 6D (Sema6d), transcript variant 4,
            mRNA.
ACCESSION   NM_199241
VERSION     NM_199241.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5758)
  AUTHORS   Thowfeequ,S., Fiorentino,J., Hu,D., Solovey,M., Ruane,S.,
            Whitehead,M., Zhou,F., Godwin,J., Mateo-Otero,Y.,
            Vanhaesebroeck,B., Scialdone,A. and Srinivas,S.
  TITLE     An integrated approach identifies the molecular underpinnings of
            murine anterior visceral endoderm migration
  JOURNAL   Dev Cell 59 (17), 2347-2363 (2024)
   PUBMED   38843837
REFERENCE   2  (bases 1 to 5758)
  AUTHORS   Nakanishi,Y., Izumi,M., Matsushita,H., Koyama,Y., Diez,D.,
            Takamatsu,H., Koyama,S., Nishide,M., Naito,M., Mizuno,Y.,
            Yamaguchi,Y., Mae,T., Noda,Y., Nakaya,K., Nojima,S., Sugihara,F.,
            Okuzaki,D., Ikawa,M., Shimada,S., Kang,S. and Kumanogoh,A.
  TITLE     Semaphorin 6D tunes amygdalar circuits for emotional, metabolic,
            and inflammatory outputs
  JOURNAL   Neuron 112 (17), 2955-2972 (2024)
   PUBMED   39002542
  REMARK    GeneRIF: Semaphorin 6D tunes amygdalar circuits for emotional,
            metabolic, and inflammatory outputs.
REFERENCE   3  (bases 1 to 5758)
  AUTHORS   Hirai,T., Naito,Y., Koyama,S., Nakanishi,Y., Masuhiro,K., Izumi,M.,
            Kuge,T., Naito,M., Mizuno,Y., Yamaguchi,Y., Kang,S., Yaga,M.,
            Futami,Y., Nojima,S., Nishide,M., Morita,T., Kato,Y., Tsuda,T.,
            Takemoto,N., Kinugasa-Katayama,Y., Aoshi,T., Villa,J.K.,
            Yamashita,K., Enokida,T., Hoshi,Y., Matsuura,K., Tahara,M.,
            Takamatsu,H., Takeda,Y., Inohara,H. and Kumanogoh,A.
  TITLE     Sema6D forward signaling impairs T cell activation and
            proliferation in head and neck cancer
  JOURNAL   JCI Insight 9 (3), e166349 (2024)
   PUBMED   38329122
  REMARK    GeneRIF: Sema6D forward signaling impairs T cell activation and
            proliferation in head and neck cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5758)
  AUTHORS   Prieur,D.S., Francius,C., Gaspar,P., Mason,C.A. and Rebsam,A.
  TITLE     Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous Manner to
            Position and Target Retinal Ganglion Cell Axons
  JOURNAL   J Neurosci 43 (32), 5769-5778 (2023)
   PUBMED   37344233
  REMARK    GeneRIF: Semaphorin-6D and Plexin-A1 Act in a Non-Cell-Autonomous
            Manner to Position and Target Retinal Ganglion Cell Axons.
REFERENCE   5  (bases 1 to 5758)
  AUTHORS   Sun,T., Zeng,H., Fan,L., Fei,J. and Chen,G.
  TITLE     Semaphorin 6D regulate corralling, hematoma compaction and white
            matter injury in mice after intracerebral hemorrhage
  JOURNAL   J Stroke Cerebrovasc Dis 31 (11), 106803 (2022)
   PUBMED   36174325
  REMARK    GeneRIF: Semaphorin 6D regulate corralling, hematoma compaction and
            white matter injury in mice after intracerebral hemorrhage.
REFERENCE   6  (bases 1 to 5758)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   7  (bases 1 to 5758)
  AUTHORS   Toyofuku,T., Zhang,H., Kumanogoh,A., Takegahara,N., Yabuki,M.,
            Harada,K., Hori,M. and Kikutani,H.
  TITLE     Guidance of myocardial patterning in cardiac development by Sema6D
            reverse signalling
  JOURNAL   Nat Cell Biol 6 (12), 1204-1211 (2004)
   PUBMED   15543137
  REMARK    GeneRIF: Sema6D coordinates both compact-layer expansion and
            trabeculation, functioning as both a ligand and a receptor for
            Plexin-A1.
REFERENCE   8  (bases 1 to 5758)
  AUTHORS   Toyofuku,T., Zhang,H., Kumanogoh,A., Takegahara,N., Suto,F.,
            Kamei,J., Aoki,K., Yabuki,M., Hori,M., Fujisawa,H. and Kikutani,H.
  TITLE     Dual roles of Sema6D in cardiac morphogenesis through
            region-specific association of its receptor, Plexin-A1, with
            off-track and vascular endothelial growth factor receptor type 2
  JOURNAL   Genes Dev 18 (4), 435-447 (2004)
   PUBMED   14977921
  REMARK    GeneRIF: Plexin-S1, with Sema6D, exerts distinct biological
            activities at adjacent regions, crucial for complex cardiac
            morphogenesis.
REFERENCE   9  (bases 1 to 5758)
  AUTHORS   Taniguchi,M. and Shimizu,T.
  TITLE     Characterization of a novel member of murine semaphorin family
  JOURNAL   Biochem Biophys Res Commun 314 (1), 242-248 (2004)
   PUBMED   14715272
REFERENCE   10 (bases 1 to 5758)
  AUTHORS   Qu,X., Wei,H., Zhai,Y., Que,H., Chen,Q., Tang,F., Wu,Y., Xing,G.,
            Zhu,Y., Liu,S., Fan,M. and He,F.
  TITLE     Identification, characterization, and functional study of the two
            novel human members of the semaphorin gene family
  JOURNAL   J Biol Chem 277 (38), 35574-35585 (2002)
   PUBMED   12110693
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL935323.6.
            
            On May 27, 2022 this sequence version replaced NM_199241.3.
            
            Transcript Variant: This variant (4) uses an alternate in-frame
            splice site and contains two additional in-frame exons in the
            central coding region, compared to variant 1. The encoded isoform
            (Sema6D-4) is longer than isoform Sema6D-1. The 5' UTR is
            incomplete because the evidence for this variant is for the CDS
            only, and multiple possible 5' UTR exon combinations exist.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB091536.1, SRR10223970.4399.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-163               AL935323.6         40229-40391
            164-275             AL935323.6         40795-40906
            276-336             AL935323.6         41444-41504
            337-399             AL935323.6         41626-41688
            400-501             AL935323.6         41801-41902
            502-592             AL935323.6         42134-42224
            593-712             AL935323.6         42658-42777
            713-801             AL935323.6         43478-43566
            802-1019            AL935323.6         44292-44509
            1020-1151           AL935323.6         44619-44750
            1152-1307           AL935323.6         45058-45213
            1308-1481           AL935323.6         45294-45467
            1482-1622           AL935323.6         46216-46356
            1623-1700           AL935323.6         46455-46532
            1701-1762           AL935323.6         46931-46992
            1763-1819           AL935323.6         47353-47409
            1820-1987           AL935323.6         48852-49019
            1988-5758           AL935323.6         50669-54439
FEATURES             Location/Qualifiers
     source          1..5758
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 60.69 cM"
     gene            1..5758
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /note="sema domain, transmembrane domain (TM), and
                     cytoplasmic domain, (semaphorin) 6D"
                     /db_xref="GeneID:214968"
                     /db_xref="MGI:MGI:2387661"
     exon            1..163
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     CDS             55..3276
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /note="isoform Sema6D-4 precursor is encoded by transcript
                     variant 4; semaphorin-6D"
                     /codon_start=1
                     /product="semaphorin-6D isoform Sema6D-4 precursor"
                     /protein_id="NP_954711.1"
                     /db_xref="CCDS:CCDS16673.1"
                     /db_xref="GeneID:214968"
                     /db_xref="MGI:MGI:2387661"
                     /translation="MGFLLLWFCVLFLLVSRLRAVSFPEDDEPLNTVDYHYSRQYPVF
                     RGRPSGNESQHRLDFQLMLKIRDTLYIAGRDQVYTVNLNEIPQTEVIPSKKLTWRSRQ
                     QDRENCAMKGKHKDECHNFIKVFVPRNDEMVFVCGTNAFNPMCRYYRLRTLEYDGEEI
                     SGLARCPFDARQTNVALFADGKLYSATVADFLASDAVIYRSMGDGSALRTIKYDSKWI
                     KEPHFLHAIEYGNYVYFFFREIAVEHNNLGKAVYSRVARICKNDMGGSQRVLEKHWTS
                     FLKARLNCSVPGDSFFYFDVLQSITDIIQINGIPTVVGVFTTQLNSIPGSAVCAFSMD
                     DIEKVFKGRFKEQKTPDSVWTAVPEDKVPKPRPGCCAKHGLAEAYKTSIDFPDDTLAF
                     IKSHPLMDSAVPPIADEPWFTKTRVRYRLTAIEVDRSAGPYQNYTVIFVGSEAGVVLK
                     VLAKTSPFSLNDSVLLEEIEAYNPAKCSAESEEDRKVVSLQLDKDHHALYVAFSSCVV
                     RIPLSRCERYGSCKKSCIASRDPYCGWLSQGVCERVTLGMLPGGYEQDTEYGNTAHLG
                     DCHESLPPSTTPDYKIFGGPTSDMEVSSSSVTTVASSPEITSKVIDTWRPKLTSSRKF
                     VVQDDPNTSDFTDTISGIPKGVRWEVQSGESNQMVHMNVLITCVFAAFVLGAFIAGVA
                     VYCYRDMFVRKNRKIHKDAESAQSCTDSSGSFAKLNGLFDSPVKEYQQNIDSPKLYSN
                     LLTSRKELPPNTDTKSMAVDHRGQPPELAALPTPESTPVLHQKTLQAMKSHSEKAHSH
                     GASRKEHPQFFPSSPPPHSPLSHGHIPSAIVLPNATHDYNTSFSNSNAHKAEKKLQSM
                     DHPLTKSSSKREHRRSVDSRNTLNDLLKHLNDPNSNPKAILGEIHMAHQTLMLDPVGP
                     MAEVPPKVPNREASLYSPPSTLPRNSPTKRVDVPTTPGVPMTSLERQRGYHKNSSQRH
                     SISAVPKNLNSPNGVLLSRQPSMNRGGYMPTPTGAKVDYIQGTPVSVHLQPSLSRQSS
                     YTSNGTLPRTGLKRTPSLKPDVPPKPSFVPQTTSVRPLNKYTY"
     exon            164..275
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            276..336
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            337..399
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            400..501
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            502..592
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            593..712
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            713..801
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            802..1019
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1151
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1307
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1308..1481
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1482..1622
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1623..1700
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1701..1762
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1819
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1820..1987
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..5758
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5717..5722
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /note="hexamer: AATAAA"
     regulatory      5734..5739
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /note="hexamer: ATTACA"
     polyA_site      5737
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
                     /note="major polyA site"
     polyA_site      5758
                     /gene="Sema6d"
                     /gene_synonym="1110067B02Rik; D330011G23; mKIAA1479"
ORIGIN      
        1 gtagctaagt gggacttctg aggaggggga gctcagattt cttcttggcc aaccatgggg
       61 ttccttctgc tttggttctg cgtgctgttc cttctggtct ccaggttacg ggcggtcagc
      121 ttcccagaag acgatgagcc cctcaacacg gttgactatc actattcaag gcaatatccg
      181 gtttttagag gacgcccttc aggcaacgaa tcgcagcaca ggctggactt tcagctgatg
      241 ttgaaaattc gagacacact ttatattgct ggcagggatc aagtctatac agtgaactta
      301 aatgaaatcc cccaaacaga ggtgatacca agcaagaagc tgacgtggag gtccagacag
      361 caggatcgag aaaattgtgc tatgaaaggc aagcataaag atgaatgcca caacttcatc
      421 aaagtctttg tcccaagaaa tgatgagatg gtttttgtct gtggtaccaa tgctttcaac
      481 ccgatgtgca gatactatag gttgagaacg ttagagtatg atggggaaga aattagtggc
      541 ctggcacgat gcccgtttga tgcccgacaa accaatgtcg ccctctttgc tgatggaaaa
      601 ctctattctg ccacagtggc tgatttcctg gccagtgatg ctgtcattta cagaagcatg
      661 ggagatggat ctgcccttcg cacaataaaa tacgattcca agtggatcaa agaaccacac
      721 ttccttcatg ccatagaata tggaaactat gtctatttct tcttcagaga aatcgccgtg
      781 gaacataata acttaggcaa ggctgtgtat tcccgcgtgg ctcgcatttg taaaaacgac
      841 atgggtggct cacagcgggt cctggagaaa cactggactt ccttccttaa ggctcggctg
      901 aactgctccg ttcctggaga ttcctttttc tacttcgacg tcctgcagtc tataacagac
      961 ataatccaaa tcaatggcat ccccactgtg gttggggtct tcaccacaca gctcaacagc
     1021 attcctggtt ctgcagtctg tgcctttagc atggacgaca ttgagaaagt gttcaaaggg
     1081 cggttcaaag agcagaaaac cccagactct gtttggacag cagttcccga agacaaagta
     1141 ccaaaaccaa ggcctggctg ttgtgccaaa cacggcctcg cagaagctta caagacctcc
     1201 atcgactttc cagatgacac cctggctttc atcaagtccc acccgctgat ggactctgcc
     1261 gtcccaccca ttgccgatga gccctggttc acaaagacac gggtcaggta caggttgaca
     1321 gccatcgaag tggaccgttc agcagggcca taccaaaact acacagtcat ctttgttggc
     1381 tctgaagctg gcgtggtact taaagttttg gcaaagacca gtcctttctc tctgaatgac
     1441 agtgtattac tcgaagagat tgaagcttat aacccagcca agtgcagcgc cgagagtgag
     1501 gaggacagaa aggtggtctc attacagctg gacaaggatc accatgcttt atacgtggcc
     1561 ttctctagct gcgtggtccg catccccctc agccgctgtg agcgctacgg atcgtgtaaa
     1621 aagtcttgca ttgcatcacg tgacccgtac tgtggttggt taagccaggg agtttgtgag
     1681 agagtgaccc tagggatgct ccctggagga tatgagcagg acacggagta cggcaacaca
     1741 gcccacctag gggactgcca cgaaagtttg cctccttcaa ctacaccaga ttacaaaata
     1801 tttggcggtc caacatctga catggaggta tcctcatctt ctgttaccac tgtggcaagt
     1861 agcccagaaa ttacatctaa agtgattgat acctggagac ctaaactgac gagctcccgg
     1921 aaatttgtag ttcaagatga cccaaatact tctgatttta ctgatactat atcaggtatc
     1981 ccaaagggtg tacggtggga agtccagtct ggagaatcca atcagatggt ccacatgaat
     2041 gtcctcatca cctgcgtgtt tgccgctttt gtcttgggcg cgttcatcgc aggagtggcc
     2101 gtgtactgct accgtgacat gttcgttcgg aagaacagaa agatccataa agacgcagaa
     2161 tccgcccagt cgtgcacaga ctccagcgga agcttcgcca agctgaacgg cctctttgac
     2221 agccccgtca aggaatacca gcagaacatt gattctccca aactctacag caacctgctg
     2281 accagtcgga aggaactgcc accaaacacg gatacaaagt ccatggccgt ggaccacaga
     2341 ggccagcctc ccgagctggc tgctctcccc acgccggaat ccacacctgt cctccaccag
     2401 aagaccctgc aggccatgaa gagccactct gagaaggccc acagccacgg tgcttcaagg
     2461 aaagaacacc cccagttttt tccttctagt cctccacccc attccccatt gagtcacggg
     2521 catatcccca gtgccatcgt tcttccaaac gccactcacg actacaatac atccttctcc
     2581 aactcgaatg cccacaaagc cgaaaagaag cttcagagca tggatcaccc tcttacgaag
     2641 tcatccagta agcgggagca ccggcggtct gtggattcca ggaatactct caatgatctc
     2701 ctgaagcatc taaatgaccc aaacagtaac cccaaagcca tcctgggaga gatccatatg
     2761 gctcatcaaa ccctcatgct ggacccggtg ggaccaatgg ctgaggtccc acccaaggtc
     2821 cctaaccggg aggcatctct atactcccct ccctccacac tccccagaaa tagtccaacc
     2881 aagagagtag atgtccccac cactcctggg gtgccaatga cttctctgga aagacaaagg
     2941 ggttatcaca aaaattcctc ccagaggcac tctatatctg ccgtgcctaa aaacttaaac
     3001 tcaccaaatg gtgttttgtt atctagacag ccgagtatga accgtggagg ctatatgccc
     3061 accccaacag gggcgaaggt ggactatatt caggggacac cggtgagtgt tcatctgcag
     3121 ccctccctct ccagacagag cagctatacc agtaatggca ccctccccag gacgggacta
     3181 aagaggacac catccttaaa acctgatgtg ccaccaaagc cttcctttgt tccgcaaacc
     3241 acatctgtca gaccactgaa caagtacacg tactaggcct caagtatgct attcccgtgt
     3301 ggctttatcc tgtccctgct gttgcgagga agctgtgagg gtaccttcag atgagatacc
     3361 tgcttgtatt ttaagagaaa caagtagcca aagaaactct gtcactttgg taacaccaga
     3421 acttgccaca tgtagctact acagcaaggc ttctgtgtac ttgccggaaa cgaagggagg
     3481 tcctgctcac tccatttctt tcgtttgaag cagaagggat gtgtagccag ggaaggctcc
     3541 cttcaccagt gtaaagagct gatacagtac tcagaagact gaacaaatac ttgaaaatgg
     3601 gttcaatgta gactgccatt ctgtgtggtc ttcccattaa atgtgaacat tttaatatgt
     3661 atgcattcac cttgcctctt gcacaaatgt caaaatggaa agatgggaat gtctcaaaac
     3721 aaaatgagct tggagattac caagcagttt gctgaaaatt caatctttga cccaaactgt
     3781 agcaattttt attttctgag tgtggcactg ttttgtttta tttttttgtt ttgttttgtt
     3841 tttcaatgcc accaacaaac tatgttaaga gaggggcgag tgtgtgtgtg tgtgtgtgtg
     3901 tgtgtgtgtg tgtgtgtgtg agagagagag agagagagag agagagagag agagagagag
     3961 atctacccat tagaattgat ttaggtgccc attgcatctt ttgtactatg gagttgttta
     4021 cagtaagcat gactgaacaa gcactaacat cctcctacac cggtccatcg tgttcggctc
     4081 tgatcaggaa tagacaaggc ttctttgact gtcaagtgat taacatatgg tacccggtgt
     4141 cagaacattt aagcgttcta aataattttg tgctgctatc catcagaacg tctattccag
     4201 ccttgccagc ttaagaactt agagaaatta agaggtatct ttgatgtatc taccagtatt
     4261 caatagtaac atttacctgt ccactgtgaa tcaaagcctg gggcacgcta ctcaacctta
     4321 gacacactta caggctttta ttttgattgt gttattttat tttccataca gtaaaaaatg
     4381 tcctctctta actcctctca cccccaactc ccaaggcaaa agagaaacca aaagtaggac
     4441 aaaagaaaga gacagacaga cagacagaca gaacaggaat tacagttggc ttagcaggga
     4501 ggatctgtag agctctcgat gatccttcct ccatgtgtgt cctgtgagga ttttgctcat
     4561 gagtcatgca ggcagtgaca gtgaactgta aataccacat gtgagtttac ctggatctgt
     4621 gcattttgtg ccttattcac tcgagtggta gaagttccgc ggtatgttga gtgtttccac
     4681 tacagagcat catttcccat gtgccacttg taaatgtttt gcagccagca cctgaggact
     4741 tcttatacag tcataaagcc acctagagcg atttgttgtt gagcaacgcc gccccttccc
     4801 tccaggatca gaagcagcac ccacccttgc catgataaac attccatccc ctgctgttct
     4861 gataatgtga agtcagatga gggttcccag gttatgtggc acctgcggaa accatgtcta
     4921 gagtcgtttc tatgtagctt ggcagagccc actgatggct gcaggtgtgt agcctactga
     4981 cagctttggt taacccactg cacatcaccc agtcatttac ccaacttact ctagaaatgt
     5041 ccacagctaa ggaaggctcc tgagccagtc aggcggagtt caagtgatat cttgggacag
     5101 tgaccatggt ctgcattact tgggggagga tggggtacaa gacaccagat catttttata
     5161 caggatgtag agtactgatg cggttgatct tttccttcaa gaacattctt ttctatagaa
     5221 aaatgattcc ctgtgatctt ctggaagctc caaagctgaa acccttcagc tttgcaacta
     5281 aaaatattac agtttaataa tcaattaaac caaccaacaa taagcactac acatctgcca
     5341 ccaacaatgt tgtttgcatt taccttacca atattaatcc cagcgtggta actctgtgtg
     5401 accccgataa cattttgtaa cattgtgctg ccttagagtt tgtactgtga gttctatcag
     5461 tatttatgtt gaaatttcta acatggattc tagtctctat tctgttaatt taattttaaa
     5521 tgctttatcc atttgtgcaa aggtaaacac agattgtatc ttttttaatg gtacggcata
     5581 aaaaaataac cctaaagtga agtggctcta tactgtttta tagagtactt taacgtgtat
     5641 agatatcttg taaacttgta ttgtggatgt gtaaataata tgtactttgg gtttttaaca
     5701 ccgcatgtaa agtcaaaata aaatatccaa gtcattacat cctgcctttt gatgttaa
//
