LOCUS       NM_001130456            3736 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus sema domain, transmembrane domain (TM), and
            cytoplasmic domain, (semaphorin) 6B (Sema6b), transcript variant 2,
            mRNA.
ACCESSION   NM_001130456
VERSION     NM_001130456.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3736)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3736)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   3  (bases 1 to 3736)
  AUTHORS   Yan,S., Thienthanasit,R., Chen,D., Engelen,E., Bruhl,J.,
            Crossman,D.K., Kesterson,R., Wang,Q., Bouazoune,K. and Jiao,K.
  TITLE     CHD7 regulates cardiovascular development through ATP-dependent and
            -independent activities
  JOURNAL   Proc Natl Acad Sci U S A 117 (46), 28847-28858 (2020)
   PUBMED   33127760
REFERENCE   4  (bases 1 to 3736)
  AUTHORS   Poltavski,D.M., Colombier,P., Hu,J., Duron,A., Black,B.L. and
            Makita,T.
  TITLE     Venous endothelin modulates responsiveness of cardiac sympathetic
            axons to arterial semaphorin
  JOURNAL   Elife 8, e42528 (2019)
   PUBMED   30735130
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3736)
  AUTHORS   Sar Shalom,H., Goldner,R., Golan-Vaishenker,Y. and Yaron,A.
  TITLE     Balance between BDNF and Semaphorins gates the innervation of the
            mammary gland
  JOURNAL   Elife 8, e41162 (2019)
   PUBMED   30628891
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3736)
  AUTHORS   Chen,B., Schaevitz,L.R. and McConnell,S.K.
  TITLE     Fezl regulates the differentiation and axon targeting of layer 5
            subcortical projection neurons in cerebral cortex
  JOURNAL   Proc Natl Acad Sci U S A 102 (47), 17184-17189 (2005)
   PUBMED   16284245
REFERENCE   7  (bases 1 to 3736)
  AUTHORS   Suto,F., Ito,K., Uemura,M., Shimizu,M., Shinkawa,Y., Sanbo,M.,
            Shinoda,T., Tsuboi,M., Takashima,S., Yagi,T. and Fujisawa,H.
  TITLE     Plexin-a4 mediates axon-repulsive activities of both secreted and
            transmembrane semaphorins and plays roles in nerve fiber guidance
  JOURNAL   J Neurosci 25 (14), 3628-3637 (2005)
   PUBMED   15814794
REFERENCE   8  (bases 1 to 3736)
  AUTHORS   Lillesaar,C. and Fried,K.
  TITLE     Neurites from trigeminal ganglion explants grown in vitro are
            repelled or attracted by tooth-related tissues depending on
            developmental stage
  JOURNAL   Neuroscience 125 (1), 149-161 (2004)
   PUBMED   15051154
REFERENCE   9  (bases 1 to 3736)
  AUTHORS   Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M.
  TITLE     Noggin is required for correct guidance of dorsal root ganglion
            axons
  JOURNAL   Dev Biol 251 (2), 283-293 (2002)
   PUBMED   12435358
REFERENCE   10 (bases 1 to 3736)
  AUTHORS   Eckhardt,F., Behar,O., Calautti,E., Yonezawa,K., Nishimoto,I. and
            Fishman,M.C.
  TITLE     A novel transmembrane semaphorin can bind c-src
  JOURNAL   Mol Cell Neurosci 9 (5-6), 409-419 (1997)
   PUBMED   9361278
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143229.1 and AK139358.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR,
            compared to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK139358.1, AK143229.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-81                AK143229.1         2-82
            82-3736             AK139358.1         2-3656
FEATURES             Location/Qualifiers
     source          1..3736
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="17"
                     /map="17 29.17 cM"
     gene            1..3736
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /note="sema domain, transmembrane domain (TM), and
                     cytoplasmic domain, (semaphorin) 6B"
                     /db_xref="GeneID:20359"
                     /db_xref="MGI:MGI:1202889"
     exon            1..130
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            131..283
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     CDS             160..2820
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /note="semaphorin-6B; sema N; sema VIB; semaphorin-N;
                     semaphorin VIB"
                     /codon_start=1
                     /product="semaphorin-6B precursor"
                     /protein_id="NP_001123928.1"
                     /db_xref="CCDS:CCDS28896.1"
                     /db_xref="GeneID:20359"
                     /db_xref="MGI:MGI:1202889"
                     /translation="MWTPRVPPPRPALSFFLLLLLGVTYGLFPEEPPPLSVAPRDYLS
                     HYPVFVGSGPGRLTAAEGAEDLNIQRVLRVNRTLFIGDRDNLYQVELEPSTSTELRYQ
                     RKLTWRSNPSDIDVCRMKGKQEGECRNFVKVLLLRDESTLFVCGSNAFNPICANYSMD
                     TLQLLGDSISGMARCPYDPKHANVALFSDGMLFTATVTDFLAIDAVIYRSLGDRPTLR
                     TVKHDSKWFKEPYFVHAVEWGSHVYFFFREIAMEFNYLEKVVVSRVARVCKNDVGGSP
                     RVLEKQWTSFLKARLNCSVPGDSHFYFNVLQAVTGVVSLGGRPVILAVFSTPSNSIPG
                     SAVCAFDMNQVAAVFEGRFREQKSPESIWTPVPEDQVPRPRPGCCAAPGMQYNASSAL
                     PDEILNFVKTHPLMDEAVPSLGHSPWIVRTLMRHQLTRVAVDVGAGPWGNQTIVFLGS
                     EAGTVLKFLVKPNASVSGTTGPSIFLEEFETYRPDRCGRPSSAGEWGQRLLSLELDAA
                     SGGLLAAFPRCVVRVPVARCQLYSGCMKNCIGSQDPYCGWAPDGSCIFLRPGTSATFE
                     QDVSGASTSGLGDCTGLLRASLSDDRAGLVSVNLLVTSSVAAFVVGAVVSGFSVGWFV
                     GLRERRELARRKDKEAILAHGGSEAVLSVSRLGERRGTGPGGRGGAGGGPGGPPEALL
                     APLMQNGWTKAALLHGGPHDLDTGLLPTPEQTPLPQKRLPTPHPHAHALGSRAWDHSH
                     ALLSASASTSLLLLAPARASEQPQVPAEPGPESRLCAPRSCRASHPGDFPLTPHASPD
                     RRRVVSAPTGPLDPSVGDGLPGPWSPPATSSLRRPGPHGPPTAALRRTHTFNSGEARP
                     GGHRPRRHPPADSTHLLPCGTGERTAPPVP"
     exon            284..407
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            408..468
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            469..531
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            532..633
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            634..724
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            725..844
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            845..933
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            934..1151
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1152..1283
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1284..1433
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1616
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1766
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1767..1844
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..1903
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     exon            1904..3736
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3710..3715
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /note="hexamer: AATAAA"
     polyA_site      3736
                     /gene="Sema6b"
                     /gene_synonym="Sema; Seman; semaZ; VIb"
                     /note="major polyA site"
ORIGIN      
        1 agagatgcgg ccccggccgg gacaccgcgc tgcgcccccg cgggagccgc ccgcgcgtgg
       61 gagcccgggc tgagacgctg cggggccggg gccggggccg agccgagcag gtgctcggcc
      121 tgcgctggag gtgtcatctg tggtcatccg gtcctcacca tgtggacccc gcgagtgccc
      181 cctccacgcc cggccctgtc gtttttcctg ctgttgctcc tgggggtcac ctatggcctt
      241 ttcccagaag aaccacctcc actcagcgtg gctcccaggg actacttgag ccactatccc
      301 gtgttcgtgg gcagcgggcc tggtcgtctg accgctgcgg agggtgctga ggacctcaac
      361 atccagagag tgctacgtgt taacaggaca ctgttcattg gggacagaga taacctgtac
      421 caagtagaac tggagccatc cacttccacg gagctgcgat atcagaggaa gctgacctgg
      481 cgctccaacc ccagtgacat cgatgtgtgt cgaatgaagg gcaagcaaga gggtgagtgt
      541 cggaactttg tcaaggtgct cctgcttcgc gatgagtcca cgctgttcgt gtgcggctcc
      601 aatgcgttca atcccatctg cgccaattac agtatggaca cactgcagct tcttggtgac
      661 agcatcagcg gtatggcccg ctgcccctat gaccccaaac atgccaatgt cgccctcttc
      721 tcagatggga tgctcttcac agccacggtg actgacttcc tagccatcga cgctgttatc
      781 taccgcagcc ttggggaccg gcccacactg cgcacagtaa agcacgactc caagtggttt
      841 aaagagccgt actttgtgca tgcagtggag tggggaagcc acgtctattt cttcttccgg
      901 gagatcgcca tggagtttaa ctacctggaa aaggtggtgg tgtctcgagt ggcccgtgtg
      961 tgcaagaatg acgtgggcgg ctcgccacga gtgctggaga agcagtggac ttccttcctg
     1021 aaggcccggc tcaactgctc agtgccaggg gattcacact tctacttcaa cgtcctgcag
     1081 gctgtgacgg gcgtggtgag cctgggtggt cgtccggtga tcctcgctgt cttctcaact
     1141 cctagcaaca gcatccccgg ctcagccgtc tgcgcctttg acatgaacca agtggctgct
     1201 gtgtttgaag gccgcttccg ggaacagaag tcgcctgagt cgatctggac accagtgcct
     1261 gaagaccaag tgccacggcc caggcctggg tgctgcgcgg cacctggcat gcagtacaac
     1321 gcgtccagtg ccctccctga cgagatcctc aactttgtaa agacccaccc actgatggat
     1381 gaggcagtac cttccctggg tcactcgccg tggattgtga gaactctgat gcggcaccag
     1441 ctgacccgag tggctgtgga tgtgggtgcg ggtccatggg gcaatcagac aatagtcttc
     1501 cttggctccg aggctggcac agtcctcaaa tttcttgtga agcccaacgc cagtgtctca
     1561 gggaccacag ggcccagcat ctttttggag gagtttgaga cctaccggcc agacaggtgt
     1621 ggacgaccca gcagtgctgg tgagtggggg cagcgacttc tcagcctgga gctggatgca
     1681 gcctcagggg gcctgctggc agccttcccc cgctgtgtgg ttcgtgttcc tgttgcccgt
     1741 tgccagctgt actcggggtg catgaagaac tgtattggca gccaggatcc atactgcggg
     1801 tgggcccctg atggctcctg catcttcctc agaccaggaa ctagtgccac gtttgagcaa
     1861 gatgtgtccg gggccagcac ctctggctta ggtgactgca ctggactctt gcgcgccagc
     1921 ctctcagatg accgcgcagg gctggtgtcg gtgaacctgc tagtgacgtc ctcggtggca
     1981 gcgttcgtgg tgggtgccgt ggtgtccggc ttcagtgtag gctggttcgt gggtctccgc
     2041 gagcggcggg agctggcccg gcgcaaggac aaggaggcca ttctggcgca cggcggcagc
     2101 gaggcagttc tgagcgtgag ccgactaggc gagcgcaggg ggaccgggcc cgggggtcgt
     2161 ggaggagccg gcggcggtcc cggaggtccc ccggaggccc tgctggcccc gcttatgcag
     2221 aatggctgga caaaggcagc gctgctgcat ggtggccctc acgacctgga cacggggctg
     2281 ctgcccaccc cagagcagac gcctctaccc cagaaacgcc tgcccacgcc acacccacac
     2341 gcccacgccc tggggtctcg agcctgggac cacagccacg cgctgctgtc ggcctcagcc
     2401 tccacctcct tgctcctact ggcgcccgcc cgcgcctctg agcagcccca ggtgccagcc
     2461 gagccgggcc cggaatctcg cctctgcgcc cccagatcct gccgggcctc tcacccaggc
     2521 gacttcccgc tcacgcccca cgccagcccg gaccgccggc gggtggtgtc cgcacccacg
     2581 ggccccttgg acccttcggt gggcgacggc ctgcccgggc catggagccc acctgcaacc
     2641 agcagcctgc ggaggccggg tccccacggg ccccccacag ccgccctacg gcgcacacac
     2701 acattcaaca gcggcgaggc tcggcccggg ggtcatcgtc ctcgccgcca cccacccgcg
     2761 gactctacac acttgctgcc ctgcgggacg ggcgagcgga ctgcaccccc ggtaccctag
     2821 gccaggcgga tgcctcgacg gtgccaacca cagcgacccg ggcgccagcc caggtcaccg
     2881 agccctactg gcgccgagtg gggcgcgttt gttcctcacc cacgcgcgtg gggatcccct
     2941 cgccacaggg aagcacaaga accccctcca tcccggagga tgcaggacac gaagccccgg
     3001 ggtgggcggg aggaggctga ccttttacct gcgcatagac tttgattttt gtttattttg
     3061 agtttttttt tttttctaag aaattgcaca gccccattct tacttggggt ggcggccggg
     3121 gtgggggttg aggacgtggg gtgaggggag gcagctgcag acatgagcct tcccgcctca
     3181 acacatcctc cgtagaaggg accccctccc tgctcctggg tccctgcgtg tgtgggtgtg
     3241 tgtccgtgtg catggcctgt ttgtgtgcaa gggcccagga cagaagtatg tgtgcgtgtg
     3301 tgtgtgcgta tgcgtgtgag acagggccgc cgtgggtgtg cgtgtgtgcg actcagaatg
     3361 tgggtggtgg cgccctcaga gaccctggca ttggctgagc caatgttggg ccttctgaaa
     3421 agaagcccag gggatggggc cttcaaggtg ccggtttgga gttcaaatcc tgctcctgca
     3481 gaggggacct gggggtccag gctgggagat gggggaacct gcttctaaag ggcttgtggg
     3541 ggttttggga gggtggaggt gggcagacgc ccctgtaaat acagccctgg ggtggtcaga
     3601 gaggcccatg ccacccgtcc ccacttgtga catccccttc gaccaccagc tgaccatgca
     3661 tgccacgtgg ccagctgagt ccaggaccct ctccagccct atccccatca ataaaactct
     3721 gtttacatcc accggc
//
