LOCUS       NM_018744               6901 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus sema domain, transmembrane domain (TM), and
            cytoplasmic domain, (semaphorin) 6A (Sema6a), transcript variant 1,
            mRNA.
ACCESSION   NM_018744
VERSION     NM_018744.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6901)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6901)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 6901)
  AUTHORS   Lettieri,A., Oleari,R., van den Munkhof,M.H., van Battum,E.Y.,
            Verhagen,M.G., Tacconi,C., Spreafico,M., Paganoni,A.J.J.,
            Azzarelli,R., Andre',V., Amoruso,F., Palazzolo,L., Eberini,I.,
            Dunkel,L., Howard,S.R., Fantin,A., Pasterkamp,R.J. and Cariboni,A.
  TITLE     SEMA6A drives GnRH neuron-dependent puberty onset by tuning median
            eminence vascular permeability
  JOURNAL   Nat Commun 14 (1), 8097 (2023)
   PUBMED   38062045
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6901)
  AUTHORS   James,R.E., Hamilton,N.R., Huffman,L.N., Pasterkamp,J., Goff,L.A.
            and Kolodkin,A.L.
  TITLE     Semaphorin 6A in Retinal Ganglion Cells Regulates Functional
            Specialization of the Inner Retina
  JOURNAL   bioRxiv (2023)
   PUBMED   38014224
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6901)
  AUTHORS   Shao,A., Gearhart,M.D., Chan,S.C., Miao,Z., Susztak,K. and
            Igarashi,P.
  TITLE     Multiomics analysis reveals that hepatocyte nuclear factor 1beta
            regulates axon guidance genes in the developing mouse kidney
  JOURNAL   Sci Rep 12 (1), 17586 (2022)
   PUBMED   36266461
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 6901)
  AUTHORS   Mitchell,K.J., Pinson,K.I., Kelly,O.G., Brennan,J., Zupicich,J.,
            Scherz,P., Leighton,P.A., Goodrich,L.V., Lu,X., Avery,B.J.,
            Tate,P., Dill,K., Pangilinan,E., Wakenight,P., Tessier-Lavigne,M.
            and Skarnes,W.C.
  TITLE     Functional analysis of secreted and transmembrane proteins critical
            to mouse development
  JOURNAL   Nat Genet 28 (3), 241-249 (2001)
   PUBMED   11431694
REFERENCE   7  (bases 1 to 6901)
  AUTHORS   Leighton,P.A., Mitchell,K.J., Goodrich,L.V., Lu,X., Pinson,K.,
            Scherz,P., Skarnes,W.C. and Tessier-Lavigne,M.
  TITLE     Defining brain wiring patterns and mechanisms through gene trapping
            in mice
  JOURNAL   Nature 410 (6825), 174-179 (2001)
   PUBMED   11242070
REFERENCE   8  (bases 1 to 6901)
  AUTHORS   Klostermann,A., Lutz,B., Gertler,F. and Behl,C.
  TITLE     The orthologous human and murine semaphorin 6A-1 proteins
            (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated
            phosphoprotein-like protein (EVL) via a novel carboxyl-terminal
            zyxin-like domain
  JOURNAL   J Biol Chem 275 (50), 39647-39653 (2000)
   PUBMED   10993894
REFERENCE   9  (bases 1 to 6901)
  AUTHORS   Zhou,L., White,F.A., Lentz,S.I., Wright,D.E., Fisher,D.A. and
            Snider,W.D.
  TITLE     Cloning and expression of a novel murine semaphorin with structural
            similarity to insect semaphorin I
  JOURNAL   Mol Cell Neurosci 9 (1), 26-41 (1997)
   PUBMED   9204478
REFERENCE   10 (bases 1 to 6901)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK042751.1, BC059238.1, AC124466.3 and AI606937.1.
            
            On Jun 16, 2005 this sequence version replaced NM_018744.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059238.1, AF030430.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2398              AK042751.1         2-2399
            2399-4317           BC059238.1         2361-4279
            4318-6869           AC124466.3         23576-26127
            6870-6901           AI606937.1         1-32                c
FEATURES             Location/Qualifiers
     source          1..6901
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="18"
                     /map="18 25.08 cM"
     gene            1..6901
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /note="sema domain, transmembrane domain (TM), and
                     cytoplasmic domain, (semaphorin) 6A"
                     /db_xref="GeneID:20358"
                     /db_xref="MGI:MGI:1203727"
     exon            1..631
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            632..769
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     CDS             670..3765
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; semaphorin-6A; sema Q; sema VIA; semaphorin Q;
                     semaphorin VIA; semaphorin-6A-1; Mutant line 997"
                     /codon_start=1
                     /product="semaphorin-6A isoform 1 precursor"
                     /protein_id="NP_061214.2"
                     /db_xref="CCDS:CCDS37813.1"
                     /db_xref="GeneID:20358"
                     /db_xref="MGI:MGI:1203727"
                     /translation="MRPAALLLCLTLLHCAGAGFPEDSEPISISHGNYTKQYPVFVGH
                     KPGRNTTQRHRLDIQMIMIMNRTLYVAARDHIYTVDIDTSHTEEIYCSKKLTWKSRQA
                     DVDTCRMKGKHKDECHNFIKVLLKKNDDTLFVCGTNAFNPSCRNYRVDTLETFGDEFS
                     GMARCPYDAKHANIALFADGKLYSATVTDFLAIDAVIYRSLGDSPTLRTVKHDSKWLK
                     EPYFVQAVDYGDYIYFFFREIAVEYNTMGKVVFPRVAQVCKNDMGGSQRVLEKQWTSF
                     LKARLNCSVPGDSHFYFNILQAVTDVIRINGRDVVLATFSTPYNSIPGSAVCAYDMLD
                     IANVFTGRFKEQKSPDSTWTPVPDERVPKPRPGCCAGSSSLEKYATSNEFPDDTLNFI
                     KTHPLMDEAVPSIINRPWFLRTMVRYRLTKIAVDNAAGPYQNHTVVFLGSEKGIILKF
                     LARIGSSGFLNGSLFLEEMNVYNPEKCSYDGVEDKRIMGMQLDRASGSLYVAFSTCVI
                     KVPLGRCERHGKCKKTCIASRDPYCGWVRESGSCAHLSPLSRLTFEQDIERGNTDGLG
                     DCHNSFVALNGHASSLYPSTTTSDSASRDGYESRGGMLDWNDLLEAPGSTDPLGAVSS
                     HNHQDKKGVIRESYLKSNDQLVPVTLLAIAVILAFVMGAVFSGIIVYCVCDHRRKDVA
                     VVQRKEKELTHSRRGSMSSVTKLSGLFGDTQSKDPKPEAILTPLMHNGKLATPSNTAK
                     MLIKADQHHLDLTALPTPESTPTLQQKRKPNRGSREWERNQNIINACTKDMPPMGSPV
                     IPTDLPLRASPSHIPSVVVLPITQQGYQHEYVDQPKMSEVVAQMALEDQAATLEYKTI
                     KEHLSSKSPNHGVNLVENLDSLPPKVPQREASLGPPGTSLSQTGLSKRLEMQHSSSYG
                     LEYKRSYPTNSLTRSHQTTTLKRNNTNSSNSSHLSRNQSFGRGDNPPPAPQRVDSIQV
                     HSSQPSGQAVTVSRQPSLNAYNSLTRSGLKRTPSLKPDVPPKPSFAPLSTSMKPNDAC
                     T"
     exon            770..887
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            888..948
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            949..1011
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1012..1113
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1204
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1205..1324
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1325..1413
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1631
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1763
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1764..1919
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2096
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2097..2237
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2238..2318
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2319..2377
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2378..2398
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2399..2563
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     exon            2564..6894
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6870..6875
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /note="hexamer: AATAAA"
     polyA_site      6894
                     /gene="Sema6a"
                     /gene_synonym="A730020P05Rik; Sema6A-1; Semaq; VIa"
                     /note="major polyA site"
ORIGIN      
        1 actcggctgc ctaggcgctc gggacgcagc acaggcgctt ttccgcggtg ccgattgccc
       61 gagatgcccg cctaggagcg tgcggccgcg gccagcgtcg ccacacccgg gacactgcac
      121 tcggggttgc agagccggcc agagccctgc acctctgcct caacccccca caccgccccc
      181 cgccctgaaa tgactagtta atgggcgctg gcaccgccga ggggactcag aagtgaatcc
      241 aagtggaatt tggatttgga aaaagagttt cttgagcatt taccctggtc ctcgctggtt
      301 ttcttctttt ttctgttttt tccctttttt ctttttcttt tttcagttat tttattttac
      361 tttttatttt tattttttat ttttggtctt cctctcacct cctcttctgt cattggagat
      421 gaacacagct cgcttgcatc ccagaaagta atcgccgtga ctgttgcccc caaagagaca
      481 agcacacatg taggaatgac aaaggcttgc gaaggaaaga gcgcagctca aggcccagag
      541 agatcttctc gataatggat tactaaatgg gatactcgcc gtgtcagtcc gctccgagcc
      601 gcggccgcct gcccgtcgat gcaccgaaaa gggtgaagta gagaagcaag tccccccgct
      661 gaacctacta tgcggccagc agccttactg ctgtgtctca cactgctaca ctgcgctggg
      721 gctggtttcc cagaagattc cgagccaatc agtatttcgc atggcaacta tacaaaacag
      781 tatccggtgt ttgtgggcca caagccagga cggaacacca cgcagaggca caggctggac
      841 atccagatga tcatgatcat gaacagaacc ctctacgttg ctgctcgaga ccatatttat
      901 actgttgata tagacacatc ccacacagaa gaaatttact gtagcaaaaa actgacatgg
      961 aaatctagac aggctgacgt agacacatgc aggatgaagg ggaaacataa ggatgaatgt
     1021 cacaacttca ttaaagttct tctcaagaag aatgatgata cgctgtttgt ctgtggaacc
     1081 aatgccttca acccttcctg cagaaactac agggtcgata ccttggaaac ttttggggat
     1141 gaatttagcg gaatggccag atgcccttat gatgccaaac atgccaacat cgctctgttt
     1201 gcagatggaa aactctactc ggctacagtg actgactttc tggccattga tgcagtcatt
     1261 tacaggagcc tcggagacag ccctaccctc aggactgtca agcatgattc aaagtggttg
     1321 aaagagccgt actttgtcca agccgtggat tatggggact atatctactt cttcttcaga
     1381 gaaattgcag tagaatacaa cactatgggg aaggttgttt tccctagggt ggctcaggtc
     1441 tgtaagaatg acatgggagg gtctcagaga gtcctggaga agcagtggac atctttcctg
     1501 aaggctcgcc tgaactgctc ggtgcctgga gactctcatt tttatttcaa tatactccag
     1561 gcagttacag atgtgattcg cattaatggc cgtgatgttg tcttggcaac cttttccaca
     1621 ccttataaca gcatcccagg ttctgcagtc tgtgcctatg acatgcttga cattgctaat
     1681 gttttcactg ggaggttcaa ggaacagaaa tcacctgact ctacctggac acccgttcca
     1741 gacgaacgag tccctaagcc caggccaggc tgttgtgctg gatcatcctc tttagaaaaa
     1801 tatgcaacct ccaatgagtt tcccgatgat accctgaact tcattaagac gcatccactc
     1861 atggacgagg cagtgccttc catcatcaac agaccttggt tcctgagaac aatggtcaga
     1921 taccgcctga ccaaaattgc agtagacaac gctgccgggc catatcagaa tcacactgtg
     1981 gttttcctgg gatcagaaaa gggaatcatc ctgaagttct tggccaggat aggaagcagt
     2041 ggtttcctaa atggcagcct tttcctggag gagatgaatg tttacaaccc agaaaagtgc
     2101 agctatgatg gtgtagaaga caaaaggatc atgggcatgc agctcgacag agcgagtggc
     2161 tcactctatg ttgcattctc tacttgtgtg atcaaggtgc ctcttggccg ctgtgagcga
     2221 catgggaagt gtaaaaaaac ctgcatcgcc tccagagacc cgtattgtgg gtgggtaagg
     2281 gaaagtggtt cctgtgccca tctgtcaccc cttagcagac tgacatttga gcaggacatt
     2341 gagcgtggca atacggacgg cctaggagac tgtcacaatt ccttcgtggc actgaatggg
     2401 cacgccagtt ccctctatcc cagcaccact acgtcagatt cggcatcccg agacgggtat
     2461 gagtctaggg gaggcatgct ggactggaac gacctgctcg aggcacctgg cagcacagac
     2521 cctttggggg cagtgtcctc tcataaccac caggacaaga agggagtgat tcgggaaagt
     2581 tacctcaaaa gcaacgacca gcttgttcct gtcaccctcc tggccattgc agtcattctg
     2641 gcttttgtca tgggggccgt cttctcgggc atcatcgtgt attgtgtgtg cgatcaccgg
     2701 cgcaaagacg tggcagtagt gcagcgcaag gagaaagagc tcactcactc gcgtcgggga
     2761 tctatgagca gtgtcaccaa gctcagtggc ctctttgggg acacccagtc caaggaccca
     2821 aagcctgagg ccatcctcac accactcatg cacaacggca agctggccac gcctagcaac
     2881 accgccaaga tgctcatcaa ggctgaccag catcacctag acctcaccgc cctgcccacc
     2941 ccagagtcca ccccgacact gcagcagaaa cggaaaccca accgcggcag tcgcgagtgg
     3001 gagaggaacc agaacatcat caatgcctgc accaaggaca tgcctcccat gggttcccct
     3061 gtgattccca cggacctgcc cctccgggcc tccccaagcc acatccccag cgtggtggtc
     3121 ctgcccatca cgcagcaggg ctaccagcac gagtacgtag atcagcccaa aatgagcgag
     3181 gtggtggctc agatggcact ggaggaccag gctgccaccc tggagtataa gaccatcaaa
     3241 gagcacctga gtagcaagag tcccaaccat ggggtgaacc ttgtggagaa cctggacagc
     3301 ctgcccccta aagttccaca gcgcgaggcc tccctaggtc ccccgggaac ctcactgtca
     3361 cagaccggcc tgagcaagag gctggagatg caacactcct cctcctatgg gctcgaatat
     3421 aagaggagct accccacgaa ctcgctcaca agaagccacc agaccaccac tctcaaaaga
     3481 aacaatacta actcctccaa ttcctcccac ctctccagga accagagctt tggccgggga
     3541 gacaacccac cccccgcccc gcagcgggtg gactctatcc aggtgcacag ctcccagccc
     3601 tctggccagg ccgtgactgt ttcgaggcag cccagcctca atgcctacaa ctcactgacg
     3661 aggtcggggc tgaagcgcac cccctcgcta aagccagatg taccccccaa accttccttt
     3721 gctccccttt ccacatccat gaagcccaat gatgcatgta cataatccca ggggttgggg
     3781 ggccaggagt tgaagcatcc gatgaggcga ggcacccacc cagctgagca aggtctccat
     3841 tgcctcgagt atccacccga ccaagatggc cctggaggag ctgaggacgc tgggtcctcc
     3901 tccctgggac atagggatac tcttcaaaat tgggccgtgt ggtctggtga aggtttagca
     3961 atccacctct gcgttctctt ccttcacatc cacgtcatac agcaggtcgg actcacgaaa
     4021 gacttcagta tcatcacaaa catgagccaa aagcacatct ccaccccatc ctcacatgaa
     4081 cacaggccac agtcacattc gtgcactaca tacacataca cacacacaca cacacacaca
     4141 cacaccatac cacaccacac cacaccacac cacaccacac cacaccacat cacaccacac
     4201 cacacacgca atggtaaacg acaaccacat tttgtccctg actatacagg acgttaccaa
     4261 acttggctaa gcatcagaaa ctttaaaaca cacacacaca cacaaccatt ttttttttaa
     4321 aaaaaatcat gaaaattaaa aaaaaataat aaaggattca ttgataattc taactcagac
     4381 tttaacaatg gcagaagttt actatgcgca gatactgtga aatgcccacc agtgttacag
     4441 ctttgttata gcaggtaaat gccatgttgg gcaacgatgt catagatttc tgctcctctt
     4501 cgcttttaat gaataacgtg accgttaacg caagtaactc ttatttattg tccacccctt
     4561 ttctttttcc tcaaggaaaa gactcttcca aatgccacca catgaacagc tctgcggaag
     4621 cccgtggaaa gttaaactat ttaacgtgaa atccattaac tggaataatt gagtttcttt
     4681 atttttacaa taaattcact gagtaaataa tttggagctg gaattctgag ctttgtgttt
     4741 ggactatcgg atcagtagct aaaggacagt gctaggaagg aatatttatt taaatctagt
     4801 taatttgtca gttgggtttc tcgccaagag gaaaaaaaaa tgtttaaaaa tccttccaga
     4861 gtctaacttc cagccaggac agaaatgttt agaatggtgc ctaagcccca ttgccgtaaa
     4921 catggctttg tctgaggacc ccaccatcag gaaggcatta gcttgtgaaa cctgccccta
     4981 ccccctaccc ccgatccccg acccccacca tctcatttca ccttgcatgt gagacagcaa
     5041 aacaaagatc cacaaactgt gtgaactaat taatatgctg gctgctacct tgcataaatt
     5101 aatgatttga tcacacgggt gtttcatgag gttacatctg tgaatagcct gttttccaca
     5161 tgtaaatttg tgccttacac tctgagttgt atacacttgt aaactgtcgt tatgatcaac
     5221 tttcttttcc tacttgaaat aaaggcagat atttatttaa accctgccct ccattcagcc
     5281 ctctggaaga ctggagacaa gcaaatggaa cagacacggt agcgatggtt gtaatgctga
     5341 aggctgggtg atacccttca gttctccctg ccttcccttg tgccaacgcc agccaccctt
     5401 tggccatgct gcagagcatg gacctccagt gttgtgggtg gaaaaaaccc ctttccctta
     5461 tattcccaga tcatttcaat ttggtgacat cttcctgagc cagccgagaa aggactgtgt
     5521 tcactgactg gagaatcttg ctgcggtggt tagggaggca actgggaggc gtctccgagc
     5581 tgtgccttca gcacacccag gcgatacaca gagaatcaac cagaaaatag accaggcagg
     5641 ctggtccctg ctgtgattaa tgggtacccc aaagtacaaa ctaacgacaa tggatgctga
     5701 aaaatccatt tctggggcaa aagtattttt ttgtttattt gtttctgttt tttttttttt
     5761 aattctttta tctgtttgtt gtttgtagag ggttgggagg ggtagtgtgt ggttttgttt
     5821 tttgcttttt ttgtttttcc cctcccttgg ttttcatttg ctaaagcaca cagaaggcac
     5881 ctttgtttac tctatcatga acaaaagaat tgtctgcaca ctgtaatccg tgagcactgt
     5941 ttccatataa acagtttatt tggtggtctc ttggtctctt ttctttttcc agtttgatct
     6001 aggttttgtt ttgtctttaa aataaaacaa caataataat aataataaaa ctttcagaaa
     6061 aaaaaagatt ggcaagaaca aattcgaatt ggttatttaa aatttctatg ttgcacccgc
     6121 cgtccgagca gtcctgcaga gcccacggtg tacagccgag aacaggtgta tagccctttg
     6181 ttccaagact tgcctcggac cagctagact gttgtttgag atacataaga tatcactggt
     6241 tttgttttgc tctttagagg agtcattgtt catggtctgt aaccattgca ccctgaagcc
     6301 agaaaggctt ttctagaaac agatggtgtc ttctctattt ccttttcttc acaaatacaa
     6361 aaatgaaaag gaaggtgcct gtcagccacc ccataccctc tcctcccttt tgactcccaa
     6421 gagtattacc ccaacctcat gcccatgtta atgggcatca ttgcctcagt tgtgttacgg
     6481 agacccatgt caaaacccac attcctacac cccacacccc gctcctttcg gtgtcccaca
     6541 tgtattgagc tggtcttctg cttttccctg tccctctccc tttctgccct gaccttgcat
     6601 tcgggggtag ggaggagatt gcccatgaac ctgagcgtgc cttcgctttc caccctggct
     6661 agacagtgtc gatgcaacaa acgcagactt acattggttg taaagttgta aaaatattgt
     6721 gatgtcacca attttccttc cgtctccaca catcctaaca tctgattcac agtttaatgt
     6781 atgtagttta aaagaaaagg agagagagga tgaaaaagaa agggggaaga gcggaaaaat
     6841 caagggatat ggctctatta cttaagagta ataaaatcag actgttctac gttaaaaaaa
     6901 a
//
