LOCUS       NM_013661               5104 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus sema domain, seven thrombospondin repeats (type 1 and
            type 1-like), transmembrane domain (TM) and short cytoplasmic
            domain, (semaphorin) 5B (Sema5b), mRNA.
ACCESSION   NM_013661 XM_993330
VERSION     NM_013661.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5104)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 5104)
  AUTHORS   Sampath Kumar,A., Tian,L., Bolondi,A., Hernandez,A.A., Stickels,R.,
            Kretzmer,H., Murray,E., Wittler,L., Walther,M., Barakat,G.,
            Haut,L., Elkabetz,Y., Macosko,E.Z., Guignard,L., Chen,F. and
            Meissner,A.
  TITLE     Spatiotemporal transcriptomic maps of whole mouse embryos at the
            onset of organogenesis
  JOURNAL   Nat Genet 55 (7), 1176-1185 (2023)
   PUBMED   37414952
REFERENCE   3  (bases 1 to 5104)
  AUTHORS   Yan,K., Bormuth,I., Bormuth,O., Tutukova,S., Renner,A., Bessa,P.,
            Schaub,T., Rosario,M. and Tarabykin,V.
  TITLE     TrkB-dependent EphrinA reverse signaling regulates callosal axon
            fasciculate growth downstream of Neurod2/6
  JOURNAL   Cereb Cortex 33 (5), 1752-1767 (2023)
   PUBMED   35462405
REFERENCE   4  (bases 1 to 5104)
  AUTHORS   Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
            Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
            Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
  TITLE     Motor neurons use push-pull signals to direct vascular remodeling
            critical for their connectivity
  JOURNAL   Neuron 110 (24), 4090-4107 (2022)
   PUBMED   36240771
REFERENCE   5  (bases 1 to 5104)
  AUTHORS   Rossaint,J., Meersch,M., Thomas,K., Mersmann,S., Lehmann,M.,
            Skupski,J., Tekath,T., Rosenberger,P., Kellum,J.A., Pavenstadt,H.
            and Zarbock,A.
  TITLE     Remote ischemic preconditioning causes transient cell cycle arrest
            and renal protection by a NF-kappaB-dependent Sema5B pathway
  JOURNAL   JCI Insight 7 (14), e158523 (2022)
   PUBMED   35727636
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5104)
  AUTHORS   Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M.
  TITLE     Noggin is required for correct guidance of dorsal root ganglion
            axons
  JOURNAL   Dev Biol 251 (2), 283-293 (2002)
   PUBMED   12435358
REFERENCE   7  (bases 1 to 5104)
  AUTHORS   Furuyama,T., Inagaki,S., Kosugi,A., Noda,S., Saitoh,S., Ogata,M.,
            Iwahashi,Y., Miyazaki,N., Hamaoka,T. and Tohyama,M.
  TITLE     Identification of a novel transmembrane semaphorin expressed on
            lymphocytes
  JOURNAL   J Biol Chem 271 (52), 33376-33381 (1996)
   PUBMED   8969198
REFERENCE   8  (bases 1 to 5104)
  AUTHORS   Adams,R.H., Betz,H. and Puschel,A.W.
  TITLE     A novel class of murine semaphorins with homology to thrombospondin
            is differentially expressed during early embryogenesis
  JOURNAL   Mech Dev 57 (1), 33-45 (1996)
   PUBMED   8817451
REFERENCE   9  (bases 1 to 5104)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
REFERENCE   10 (bases 1 to 5104)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CT010576.9 and AC154653.2.
            
            On Dec 22, 2022 this sequence version replaced NM_013661.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X97818.1, SRR7652917.698312.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-314               CT010576.9         108124-108437
            315-518             CT010576.9         189412-189615
            519-618             CT010576.9         194845-194944
            619-664             CT010576.9         199650-199695
            665-727             AC154653.2         48503-48565
            728-826             AC154653.2         48832-48930
            827-1040            AC154653.2         49312-49525
            1041-1326           AC154653.2         50164-50449
            1327-1462           AC154653.2         52852-52987
            1463-1670           AC154653.2         54257-54464
            1671-1878           AC154653.2         54600-54807
            1879-1996           AC154653.2         61317-61434
            1997-2178           AC154653.2         61560-61741
            2179-2322           AC154653.2         62770-62913
            2323-2470           AC154653.2         63043-63190
            2471-2696           AC154653.2         63278-63503
            2697-2915           AC154653.2         63600-63818
            2916-3086           AC154653.2         64412-64582
            3087-3236           AC154653.2         64686-64835
            3237-3281           AC154653.2         65410-65454
            3282-3487           AC154653.2         65813-66018
            3488-5104           AC154653.2         66237-67853
FEATURES             Location/Qualifiers
     source          1..5104
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 25.37 cM"
     gene            1..5104
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /note="sema domain, seven thrombospondin repeats (type 1
                     and type 1-like), transmembrane domain (TM) and short
                     cytoplasmic domain, (semaphorin) 5B"
                     /db_xref="GeneID:20357"
                     /db_xref="MGI:MGI:107555"
     exon            1..314
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            315..518
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     CDS             365..3646
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /note="semaphorin-5B; sema G; semaphorin-G"
                     /codon_start=1
                     /product="semaphorin-5B precursor"
                     /protein_id="NP_038689.2"
                     /db_xref="CCDS:CCDS28140.1"
                     /db_xref="GeneID:20357"
                     /db_xref="MGI:MGI:107555"
                     /translation="MVVPGPLALSLLLSSLTLLVSHLSSSQDIASESSSEQQMCTRRE
                     HPIVAFEDLKPWVFNFTYPGVRDFSQLALDPSRNQLIVGARNYLFRLSLANVSLLQAT
                     EWASSEDTRRSCQSKGKTEEECQNYVRVLIVSGRKVFMCGTNAFSPVCSSRQVGNLSR
                     TIEKINGVARCPYDPRHNSTAVISSQGELYAATVIDFSGRDPAIYRSLGSGPPLRTAQ
                     YNSKWLNEPNFVAAFDIGLFAYFFLRENAVEHDCGRTVYSRVARVCKNDVGGRFLLED
                     TWTTFMKARLNCSRPGEVPFYYNELQSAFHLPEQDLIYGVFTTNVNSIAASAVCAFNL
                     SAISKAFNGPFRYQENPRAAWLPIANPIPNFQCGTLPETGPNENLTERSLQDAQRLFL
                     MSEAVQPVTPEPCVTQDSVRFSHLVVDLVQAKDTLYHVLYIGTESGTILKALSTASRS
                     LRGCYLEELHVLPPGRLEPLRSLRILHSARALFVGLSDRVLRVPLERCSAYHSQGACL
                     GARDPYCGWDGKRQLCSTLEDSSNMSLWIQNITTCPVRNVTRDGGFGPWSPWKPCEHL
                     DGDNSGSCLCRARSCDSPRPRCGGLECLGPSIHIANCSRNGAWTAWSSWAQCSTSCGI
                     GFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPIFWASWGSWSKCSNNCGG
                     GVQSRRRSCENGNSCPGCGVEFKTCNPEACPEVRRNTPWTPWLPVNVTQGGARQEQRF
                     RFTCRAPLPDPHGLQFGKRRTETRTCPADGTGACDTDALVEDLLRSGSTSPHTLNGGW
                     ATWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRGAWS
                     CWTAWSQCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCSTQACPEGWSLWS
                     EWGVCTEDGAQSRSRSCEELLPGPGACVGNSSQSRPCPYSEIPVILPASSVEETTSCG
                     GFNLIHLIVTGVSCFLVSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYKGGGTP
                     KNEKYTPMEFKTLNKNNLIPDDRANFYPLQQTNVYTTTYYPSPLNKPSFRPEASPGQR
                     CFPNS"
     exon            519..618
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            619..664
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            665..727
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            728..826
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            827..1040
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1041..1326
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1327..1462
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1463..1670
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1671..1878
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1879..1996
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            1997..2178
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2179..2322
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2323..2470
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2696
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2697..2915
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            2916..3086
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3087..3236
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3237..3281
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3282..3487
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     exon            3488..5104
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4602..4607
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /note="hexamer: ATTAAA"
     polyA_site      4627
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /note="major polyA site"
     regulatory      5081..5086
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
                     /note="hexamer: AATAAA"
     polyA_site      5104
                     /gene="Sema5b"
                     /gene_synonym="mKIAA1445; Semag; SemG"
ORIGIN      
        1 actctcctcc tcccggctcg ctccggcgcg cggggtctgg agctagttgg agcgcggggg
       61 ttggtgctgg agcccagctc cgccgagccc cgccggtcgg ccgcgcatcc agcggctgtt
      121 ggagcagccg gagcgcagcc gggcccgaca ggagtcggag actgcggcgg agcgctgaac
      181 ccgtagtccg gagccttgct gttcggccgc cccattccca gaccggccac cagccctcgg
      241 gttcgtcgct gtggtccgca ccgccctgag cccagggccg cggggagccc ggcacctgcg
      301 cgtgctgccg ggaggtcttc cccgtggcct gcctccagga gccgggactg cagaggggcc
      361 caccatggta gtcccaggac ccctggctct ctcgctgttg ctgtccagcc tcaccctgct
      421 ggtgtcccac ctctccagct cccaggacat tgccagtgag tccagcagtg agcaacagat
      481 gtgcacgcgg agggagcacc ccatcgtggc ctttgaagat ctgaagccgt gggtctttaa
      541 cttcacctac cctggagtcc gggatttctc ccagcttgct cttgatccct cgaggaatca
      601 gctcatcgtg ggagccagga actacctctt cagactcagc ctcgccaatg tctccctcct
      661 tcaggctaca gagtgggcct ccagtgagga cacgcgccgc tcctgccaga gcaaagggaa
      721 aacggaggag gagtgtcaga actatgtacg agtcctgatt gtttccggcc ggaaggtgtt
      781 catgtgcggt accaatgcct tttccccagt gtgctccagc agacaggtag ggaacctcag
      841 ccggactatt gagaagatca acggtgtggc ccggtgcccc tatgacccac gccacaactc
      901 tacagccgtc atctcctctc agggggagct ctatgcagcc acagtcattg acttctccgg
      961 tcgggaccca gccatctacc gcagcctggg cagtgggcca ccgcttcgca ctgcccagta
     1021 taactccaaa tggctcaatg agccaaattt tgtggcagcc tttgacatcg ggctgtttgc
     1081 gtatttcttc cttcgggaga atgccgtgga gcatgattgt gggcgcactg tgtactctcg
     1141 ggtggcccgg gtgtgcaaga atgatgtagg tggccgtttc ctgctggagg acacgtggac
     1201 cacattcatg aaggcccggc tcaactgctc ccgcccggga gaggtcccct tctactataa
     1261 tgagctgcag agtgccttcc atctgcccga gcaggacctc atctatggcg tcttcaccac
     1321 taacgtaaac agcattgcgg cttctgctgt ctgcgccttc aacctcagtg ccatctccaa
     1381 ggctttcaat ggcccatttc gttaccagga aaaccccagg gctgcctggc tcccaatcgc
     1441 caatcccatc cccaatttcc agtgtggcac tctgccggag actggcccca acgagaacct
     1501 cacggagcgc agcctgcagg acgcacagcg gctcttcctg atgagcgaag ctgtgcagcc
     1561 agtgacacca gagccctgtg tcacccagga cagcgtccgc ttctcacatc tcgtggtaga
     1621 ccttgtgcaa gctaaggaca cgctctatca cgtactctac ataggcacgg agtcgggtac
     1681 catcctgaaa gcgctgtcca cggccagccg cagcctccgt ggctgctacc tggaggagct
     1741 acatgtgctg cctcctgggc gccttgaacc tctgcggagc ctgcgcatcc tgcacagcgc
     1801 gcgtgcgctc ttcgtgggat tgagcgacag ggtgctgcgg gtcccactgg agaggtgttc
     1861 ggcctatcat agccaggggg catgcctggg agcacgggac ccatactgcg gctgggatgg
     1921 gaagcggcaa ctttgcagca cgcttgaaga cagttccaac atgagcctgt ggatccagaa
     1981 catcacaacc tgtcctgtac gaaatgtgac acgggatggg ggcttcggcc catggtcacc
     2041 atggaaaccg tgtgagcact tagatggaga caactcgggt tcttgcctgt gccgggccag
     2101 atcctgtgac tccccaaggc ctcgctgtgg gggcctcgag tgcctggggc catccatcca
     2161 tattgccaat tgctccagga atggggcgtg gaccgcatgg tcatcgtggg ctcagtgcag
     2221 cacgtcctgt gggatcggct tccaggtccg tcagcgaagt tgcagcaacc cggcgccccg
     2281 ccatgggggc cgcatttgcg tgggcaagag ccgggaggag cggttctgta atgaaaatac
     2341 accttgccca gtgcccatct tctgggcttc ctggggttcc tggagcaagt gcagcaacaa
     2401 ctgtggaggc ggcgtgcagt cgcgacgccg ttcttgcgag aatggcaact cgtgcccggg
     2461 ttgcggcgtg gagttcaaga cctgcaaccc cgaggcttgc ccggaagtgc gacgcaacac
     2521 accctggacg ccctggctgc ccgtgaacgt gacccagggt ggagcgcgcc aggagcagcg
     2581 attccgcttc acctgccgcg cgccgctgcc ggacccgcac ggtctgcagt tcggcaagag
     2641 gaggacagag accaggactt gcccggcaga cggcaccgga gcctgcgaca ccgacgccct
     2701 ggtggaggat ctcctgcgca gcgggagcac gtcaccacac actctgaacg gaggctgggc
     2761 cacctggggc ccgtggtcat cctgctcccg ggactgcgag ctgggcttcc gcgtccgcaa
     2821 gagaacttgt accaacccgg agcctcgcaa cgggggcttg ccctgcgtgg gagacgctgc
     2881 ggagtaccaa gactgcaacc cacaggcttg cccagtgcgg ggtgcttggt cctgctggac
     2941 cgcatggtcc cagtgctcag catcctgcgg tggtggccac tatcaacgca cccgttcctg
     3001 caccagcccc gccccatccc caggtgagga catctgcctc ggcctgcaca cggaggaggc
     3061 cctatgttca acacaggcct gcccagaagg ctggtcactg tggtctgagt ggggtgtctg
     3121 cactgaggat ggggcccaga gccggagccg gagctgtgag gagcttctcc caggaccagg
     3181 tgcctgtgtt ggcaacagca gccagagccg gccctgcccc tacagtgaga ttcctgtcat
     3241 cctacctgct tccagtgtgg aggagaccac cagctgtgga gggttcaatc tcatccacct
     3301 gatagtcact ggtgtgtcct gcttcctggt ttctgggctc ttgaccttgg cagtgtacct
     3361 gtcttgccag cactgccagc gccagtctca ggagtccacg cttgtccatc ctgccacacc
     3421 taaccacttg cactacaagg gtgggggcac ccccaagaat gagaagtaca cccctatgga
     3481 attcaagaca ctgaacaaga acaacttaat ccctgatgac agagccaact tctacccact
     3541 gcagcagacc aatgtgtata caaccacgta ctaccccagc ccactgaaca agcccagctt
     3601 ccggcctgag gcctcacctg gacagcgctg tttccccaac agctgatccc accctcctgg
     3661 gacttgggct ccttgccttc ccgaggcaga gaagagtgga atgggaccgt agaaccactt
     3721 tggtttaccc tctgcactgg gccaagaact tgctgcctag ccagtaaggg tcccatctgg
     3781 cttcagaaag ctctggctgt cattgaccat gggagagagg gctggcttca ggctggcaca
     3841 tggctgcaga tccagctcag cccaggtctc atggtctcct ctgacccacc atcactttcc
     3901 cctgccatgt ctgagctgtg gacctattgg gtatgtgagg aacttggaga gtagagatgg
     3961 cagagaatgg gttcttaggt ttgagctgga aatgacttcc aatggccacc accagctaag
     4021 tctgcccctt cttactggtc cccccaaagt ccggggctgc gtccagcttg tcagtgaaaa
     4081 gaattcatca aatgtcccat caaatgttcc agaagtttca aatctcagcc cagggctggc
     4141 gcactccaat gctgttctct aagtgtcaca ggggaccact cactgctggc ttaggttgac
     4201 acctctgtca gacagtctgt atcttgacca gaggcatccc tctggtaaga ggcagtgagg
     4261 actgagaacc ggagcctgga ctgtactgag aggcccttca caggactctt ggcacaggtc
     4321 ttagtcttgc cttcaggatg cactcaaggt ggcccagaag gaagactcaa gaccatagga
     4381 ggcagagtct ggcctccatg cctgtggaga ctgttgctgc tcaagattcg ttggctgaga
     4441 actgcttgag agtctctgct ggcccctcat gtattcagga acgcgcgcac gcgcgcatac
     4501 acacacacac acacacacac acacacacac acacacacac agacagacat acacaccatc
     4561 tgctacagca acaaaaagga tgttaagctg tggcattatt aattaaagat gatatccagt
     4621 ctccaaatgg aactgtcttt gtgcatatgt gtgtggaccc tcttggcatg gtgtagtcca
     4681 tcagtgcagt gctctgaggt aacagatggt ttctcaagac ggaggaaaca acccagtgga
     4741 gtttgacttt aatagaggcc atctttctct gtgggtttat gtgcatgcac acacccgtgt
     4801 gtgtgcgcgc gcgcatacac acacacacac acctttctct ttcagaaaag aagctggggt
     4861 agggggtaaa tggaattcac cagtgaggcc acaaggccca gcaaaggcaa catcagatgt
     4921 gggcctaccc tgagcagctc ctgtgtggag ttggggaatc cagcaggagg gcattgatga
     4981 ggaggattca tgagatatgt tggaagctga gtttaacaaa acccaattga gaaatgatgc
     5041 ctgtgggcag gcgaagccta atggagtttg tgctggatta aataaaaatc acctcagagc
     5101 ctca
//
