LOCUS       NM_009154              10809 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus sema domain, seven thrombospondin repeats (type 1 and
            type 1-like), transmembrane domain (TM) and short cytoplasmic
            domain, (semaphorin) 5A (Sema5a), mRNA.
ACCESSION   NM_009154
VERSION     NM_009154.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 10809)
  AUTHORS   Bessa,P., Newman,A.G., Yan,K., Schaub,T., Dannenberg,R., Lajko,D.,
            Eilenberger,J., Brunet,T., Textoris-Taube,K., Kemmler,E., Deng,P.,
            Banerjee,P., Ravindran,E., Preissner,R., Rosario,M. and
            Tarabykin,V.
  TITLE     Semaphorin heterodimerization in cis regulates membrane targeting
            and neocortical wiring
  JOURNAL   Nat Commun 15 (1), 7059 (2024)
   PUBMED   39152101
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 10809)
  AUTHORS   Nagy,G.N., Zhao,X.F., Karlsson,R., Wang,K., Duman,R., Harlos,K., El
            Omari,K., Wagner,A., Clausen,H., Miller,R.L., Giger,R.J. and
            Jones,E.Y.
  TITLE     Structure and function of Semaphorin-5A glycosaminoglycan
            interactions
  JOURNAL   Nat Commun 15 (1), 2723 (2024)
   PUBMED   38548715
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 10809)
  AUTHORS   Lee,Y., Yeo,I.S., Kim,N., Lee,D.K., Kim,K.T., Yoon,J., Yi,J.,
            Hong,Y.B., Choi,B.O., Kosodo,Y., Kim,D., Park,J. and Song,M.R.
  TITLE     Transcriptional control of motor pool formation and motor circuit
            connectivity by the LIM-HD protein Isl2
  JOURNAL   Elife 12, e84596 (2023)
   PUBMED   37869988
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 10809)
  AUTHORS   Min,K.W., Kim,N., Lee,J.H., Sung,Y., Kim,M., Lee,E.J., Kim,J.M.,
            Kim,J.H., Lee,J., Cho,W., Yang,J.M., Kim,N., Kim,J., Lee,C.J.,
            Park,Y.G., Lee,S.H., Lee,H.W. and Kim,J.W.
  TITLE     Visuomotor anomalies in achiasmatic mice expressing a
            transfer-defective Vax1 mutant
  JOURNAL   Exp Mol Med 55 (2), 385-400 (2023)
   PUBMED   36737666
REFERENCE   5  (bases 1 to 10809)
  AUTHORS   Vieira,J.R., Shah,B., Dupraz,S., Paredes,I., Himmels,P.,
            Schermann,G., Adler,H., Motta,A., Gartner,L., Navarro-Aragall,A.,
            Ioannou,E., Dyukova,E., Bonnavion,R., Fischer,A., Bonanomi,D.,
            Bradke,F., Ruhrberg,C. and Ruiz de Almodovar,C.
  TITLE     Endothelial PlexinD1 signaling instructs spinal cord
            vascularization and motor neuron development
  JOURNAL   Neuron 110 (24), 4074-4089 (2022)
   PUBMED   36549270
REFERENCE   6  (bases 1 to 10809)
  AUTHORS   Simmons,A.D., Puschel,A.W., McPherson,J.D., Overhauser,J. and
            Lovett,M.
  TITLE     Molecular cloning and mapping of human semaphorin F from the
            Cri-du-chat candidate interval
  JOURNAL   Biochem Biophys Res Commun 242 (3), 685-691 (1998)
   PUBMED   9464278
REFERENCE   7  (bases 1 to 10809)
  AUTHORS   Wakana,S., Shiroishi,T., Puschel,A.W. and Imai,K.
  TITLE     The mouse semaphorin F (Semaf) maps to chromosome 15
  JOURNAL   Mamm Genome 8 (9), 698-699 (1997)
   PUBMED   9271677
REFERENCE   8  (bases 1 to 10809)
  AUTHORS   Adams,R.H., Betz,H. and Puschel,A.W.
  TITLE     A novel class of murine semaphorins with homology to thrombospondin
            is differentially expressed during early embryogenesis
  JOURNAL   Mech Dev 57 (1), 33-45 (1996)
   PUBMED   8817451
REFERENCE   9  (bases 1 to 10809)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
REFERENCE   10 (bases 1 to 10809)
  AUTHORS   Inagaki,S., Furuyama,T. and Iwahashi,Y.
  TITLE     Identification of a member of mouse semaphorin family
  JOURNAL   FEBS Lett 370 (3), 269-272 (1995)
   PUBMED   7656991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB643469.1, AK141612.1 and AC110236.8.
            
            On Dec 9, 2006 this sequence version replaced NM_009154.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143026.1, AK141612.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-57                BB643469.1         1-57
            58-5009             AK141612.1         2-4953
            5010-10809          AC110236.8         180413-186212
FEATURES             Location/Qualifiers
     source          1..10809
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 13.02 cM"
     gene            1..10809
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /note="sema domain, seven thrombospondin repeats (type 1
                     and type 1-like), transmembrane domain (TM) and short
                     cytoplasmic domain, (semaphorin) 5A"
                     /db_xref="GeneID:20356"
                     /db_xref="MGI:MGI:107556"
     exon            1..487
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            488..584
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            585..782
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     CDS             659..3883
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /note="semaphorin F; semaphorin-5A; sema F; M-Sema D"
                     /codon_start=1
                     /product="semaphorin-5A precursor"
                     /protein_id="NP_033180.2"
                     /db_xref="CCDS:CCDS37055.1"
                     /db_xref="GeneID:20356"
                     /db_xref="MGI:MGI:107556"
                     /translation="MKGACILAWLFSSLGVWRLARPETQDPAKCQRAEHPVVSYKEIG
                     PWLREFRAENAVDFSRLTFDPGQKELVVGARNYLFRLELEDLSLIQAVEWECDEATKK
                     ACYSKGKSKEECQNYIRVLLVGGDRLFTCGTNAFTPVCTIRSLSNLTEIHDQISGMAR
                     CPYSPQHNSTALLTASGELYAATAMDFPGRDPAIYRSLGTLPPLRTAQYNSKWLNEPN
                     FVSSYDIGNFTYFFFRENAVEHDCGKTVFSRAARVCKNDIGGRFLLEDTWTTFMKARL
                     NCSRPGEVPFYYNELQGTFFLPELDLIYGIFTTNVNSIAASAVCVFNLSAISQAFNGP
                     FKYQENSRSAWLPYPNPNPNFQCGTMDQGLYVNLTERNLQDAQKFILMHEVVQPVTTV
                     PSFMEDNSRFSHLAVDVVQGRETLVHIIYLATDYGTIKKVRAPLSQSSGSCLLEEIEL
                     FPERRSEPIRSLQILHSQSVLFVGLQEHVAKIPLKRCHFHQTRSACIGAQDPYCGWDA
                     VMKKCTSLEESLSMTQWDQSIPTCPTRNLTVDGSFGPWSPWTPCTHTDGTAVGSCLCR
                     SRSCDSPAPQCGGWQCEGPRMEITNCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSN
                     PTPRHGGRVCVGQNREERYCNEHLLCPPHVFWTGWGPWERCTAQCGGGIQARRRTCEN
                     GPDCAGCNVEYQPCNTNACPELKKTTPWTPWTPVNISDNGGHYEQRFRYTCKARLPDP
                     NLLEVGRQRIEMRYCSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSR
                     DCSRGIRNRKRVCNNPEPKFGGMPCLGPSLEFQECNILPCPVDGVWSCWSSWSKCSAT
                     CGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQTCPESWSEWSDWSVCDASGTQ
                     VRARQCILLFPVGSQCSGNTTESRPCVFDSNFIPEVSVARSSSVEEKRCGEFNMFHMM
                     AVGLSSSILGCLLTLLVYTYCQRYQQQSHDATVIHPVSPAALNSSITNHINKLDKYDS
                     VEAIKAFNKNNLILEERNKYFNPHLTGKTYSNAYFTDLNNYDEY"
     exon            783..882
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            883..928
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            929..991
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            992..1090
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1304
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1590
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1726
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1931
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2139
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2257
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2258..2439
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2440..2583
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2584..2731
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2957
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            2958..3176
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3347
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3348..3503
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3504..3551
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3763
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     exon            3764..10809
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      10784..10789
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /note="hexamer: AATAAA"
     polyA_site      10809
                     /gene="Sema5a"
                     /gene_synonym="5930434A13; 9130201M22Rik; Semaf; semF"
                     /note="major polyA site"
ORIGIN      
        1 agcgctggtc tactcgctag gaaggcggcg tcagcagcgg ctgctcacgc tgtgcccact
       61 cccgcgcgcg ctgcgctccc gccgcgggtg ggctcctcag cccttggctg acggtggccc
      121 cagccttgtg gcgacctctg tatcccacct tcccactgcg ggggcgtccc ggcacgtgca
      181 atcctttttg ggggtgttct tggttcccac gcgcagctac taagcagagg gtacccaact
      241 ttgccacctc accggtcgcc ctctctcggc gcgagcctgt ccactcagct gcacaactgg
      301 agactccggc agactagctg gtccccagcc tggcgcgctg cgagaggagg atagctctgg
      361 agaagtggcg gggtgcagtg gtggcggctg cctcgacttc cctcgtagta cactgaagag
      421 gacccttgga gcagctccgg gccccggggc gctggatgac tagcaggagg aacgcgcccg
      481 gcatctgggc tggtgtgtga caactgggcc tgggtaccca tgaggctgtg cagttcagtg
      541 tgattcatga ccgaggctac acgtctttgc cctctctctc ctcggtactt ttcacacatg
      601 aggagaaggt gagcttcgca gaagacacgt tcccagagtc agagacccct tgcccaccat
      661 gaagggagcc tgcatccttg catggctgtt ctcaagcctg ggagtgtgga gacttgctag
      721 gcccgagacc caggaccctg ccaagtgcca gagagctgag caccctgtcg tctcttacaa
      781 agaaattggc ccctggttac gggagttcag agccgagaat gctgtggatt tctcgaggtt
      841 aacatttgac ccaggacaga aagaacttgt cgtaggagcg agaaactatc tcttcagatt
      901 agagcttgag gatctgtctc tcatccaggc tgtggagtgg gagtgtgacg aagccaccaa
      961 gaaggcctgt tacagcaagg gcaaatcgaa ggaggaatgt cagaactaca tacgagtgct
     1021 cttagttggt ggggaccggc tattcacctg tgggaccaat gccttcacac ctgtctgtac
     1081 catccgctcg ttaagtaacc tgactgagat ccatgatcag atcagtggca tggcccgctg
     1141 tccctacagt ccccagcaca attctaccgc cctactcact gccagtggtg agctctatgc
     1201 tgcaacagcc atggatttcc cagggcgaga tccagccatt taccgaagtc tgggcacttt
     1261 gcctcctctt cgaactgcac agtacaactc caaatggctc aatgaaccaa actttgtgtc
     1321 ttcctacgac atcggaaatt tcacctactt cttcttccga gaaaacgccg tggaacatga
     1381 ctgtgggaag acggtgttct ccagggctgc ccgggtctgt aaaaatgaca ttggagggcg
     1441 atttcttctg gaggacacct ggactacctt catgaaggct cgcctcaact gctcccggcc
     1501 tggtgaggtg cccttctact acaatgagct gcagggtact ttcttcctgc cggagctgga
     1561 tctgatctat ggtatcttca ccaccaatgt aaacagcatc gctgcctctg ctgtctgtgt
     1621 cttcaacctg agcgccatct cacaggcctt caatggaccc ttcaagtacc aagaaaactc
     1681 tcgctcagcc tggctgcctt atcccaaccc caaccccaat tttcagtgcg gcaccatgga
     1741 ccagggcctg tacgtaaacc tgacggaaag aaacctacag gatgctcaga agttcattct
     1801 gatgcatgaa gtggtgcagc cagtgaccac agtgccctct ttcatggagg acaacagccg
     1861 cttctcccac ttagctgttg atgttgtgca aggcagggag actctggtcc acatcattta
     1921 tctggccaca gattatggca ccattaagaa agtacgagct cccctgagtc agagctcagg
     1981 cagctgtttg ctggaagaga ttgagctttt cccagagagg aggagtgagc ccatcaggag
     2041 cctgcagatc ctccacagcc agagtgtcct atttgtggga ctacaggagc atgtggccaa
     2101 gatccccctg aagaggtgcc acttccatca aacacgcagt gcctgcattg gcgctcagga
     2161 cccttactgt ggctgggatg cggtgatgaa gaaatgcacc agcctggagg agagtctgag
     2221 catgacccag tgggatcaga gcatccccac ctgtccgacc agaaatctca ctgtagatgg
     2281 gagctttggc ccatggtcac cgtggacacc ctgtacacac actgatggca ctgctgtggg
     2341 ctcctgcctc tgccggtccc gctcctgtga cagcccagct cctcagtgtg gtggttggca
     2401 gtgtgagggc cctagaatgg agatcaccaa ctgttccagg aatggaggct ggactccctg
     2461 gacctcctgg tctccgtgca gcacgacctg tggcattggc ttccaagtgc ggcagcgatc
     2521 ctgcagcaac cccacgccca ggcatggcgg gcgcgtgtgc gtgggccaga acagggagga
     2581 aagatactgc aatgaacatt tgctctgccc accacacgtg ttctggacag gctggggacc
     2641 ttgggaacgg tgcacagccc agtgcggggg tggcattcaa gcccgccgga ggacctgtga
     2701 aaatgggcct gactgtgcag gatgcaatgt ggaataccag ccttgtaaca ccaatgcatg
     2761 cccggagctg aagaagacca caccctggac accctggacc cctgtcaaca tctctgacaa
     2821 tggaggtcac tatgagcagc gtttccgcta tacctgtaaa gctcgcctgc cagatccaaa
     2881 tttgctggaa gtaggaagac agaggataga aatgcggtac tgttccagcg atggaaccag
     2941 tggctgctcc acagacggac tttctggaga ctttctaaga gctgggagat actctgctca
     3001 tacagtcaat ggggcatggt cagcctggac ttcctggtca cagtgcagca gagactgcag
     3061 caggggcatt cggaaccgga agcgtgtttg caacaaccca gaacccaagt ttgggggcat
     3121 gccatgcctt ggcccatcgc tggagttcca ggaatgcaac attttacctt gtccagtgga
     3181 tggtgtgtgg tcttgctggt catcctggtc taaatgttca gcaacctgtg gaggtggcca
     3241 ctacatgaga acccgttctt gttcgaatcc agccccagca tatggagggg acatctgcct
     3301 gggactgcac acagaagagg cactctgcaa cacacagacc tgcccagaaa gctggtcaga
     3361 gtggtcagac tggtctgtgt gcgatgcatc tggtacccag gtccgtgctc ggcagtgcat
     3421 ccttctgttt ccagtgggca gccaatgttc tggaaatact acagagagcc ggccttgtgt
     3481 atttgactct aatttcatcc cagaagtatc tgtggcaaga tccagcagcg tagaagaaaa
     3541 aaggtgtgga gagttcaaca tgttccacat gatggccgtg gggcttagca gttccattct
     3601 tggctgcctc ctcacactgc ttgtctacac ctactgccag aggtaccagc agcagtccca
     3661 tgatgcaact gtcatccacc ctgtctctcc tgccgccctc aacagcagca taactaacca
     3721 catcaacaaa ctggacaaat atgattctgt ggaggccatc aaggcattta acaaaaacaa
     3781 cttgatccta gaggagagaa acaaatactt caacccacat ctcactggga agacctattc
     3841 caacgcctac tttacagatc tcaacaatta tgatgaatac tagcagctct tatactttgg
     3901 gctcgttgta aactcgctgc tcctcaaaac cgtgctccat ggctgcccat atttctgagg
     3961 cttcagagat gacgtgtgga accatttcaa gtgcatttca aaccaggact ttcccatcgc
     4021 taccaaaaaa gtgcacaccc ttaaatgcct aaatgtggtg ttgtgaaaat ctggtctata
     4081 gaaaacattt ggttgttgcg aagtgagcca tggtatgaca ttttgtattg tgctcatcct
     4141 aaactctaac tggtctactg tttttcagga gttttatttc ataaatgtgc caaccatatt
     4201 gaaaagtgtc tttggaaaca tagcatcgtc atgcttttga gtgtagagga tcaggatgtt
     4261 ttaacttgga aacaaacaaa caaataacca ggcactttaa tctgagagat gcctcccccc
     4321 ctgccccccc cccacacaca cacagagtcc agagtaattc acagaatgaa ggtgtggcta
     4381 atgccaactc ccccaacctg gtgactctag gttcttagaa acagcttgtt tgcacttgga
     4441 gtgattctgc ctagggattc cacctgccct ggagcaccaa gtcgtggtct actgagaccc
     4501 gctgctttgg tctggggcag tgactgtcat cactgtttgg tgaacacatg aagcagagag
     4561 cagcgagtga gacacacaac agtgttctac agcttgcagt gaaactaacc ttactctgac
     4621 ttttggattc catgtcatcc caggaagctc cttgccacgc tgtgagcctg aagaccaact
     4681 tcccagacag tgagcttcct ggctgaagag ccactctgag catttgggta gactccacac
     4741 cctttcctcc ctccctccat gaggagaaaa ttcttcaaca tttatgatgg aaaataatga
     4801 aagtaccaaa ctgtaattga aagcgacttt aaaaaaaatt gtgtgttatg cagtgtttaa
     4861 ttaactgatg taattgaaag ctacttttca ttttttattt ttttgtgtta tgcagtgctg
     4921 ttaatggctt tcttttgtac tcagcatctc tgatgtggct aatgtgcagc aaggccccta
     4981 tcaagagcat taaaggtgtg taaagctgtt cctccttgca gtcacactgg agtggcactc
     5041 cagtaccatg ctctcctcat ttgtcccctg ctgccccaag accagaggag ggaaaggctc
     5101 tggtgtgctt tacctcagtt gctgccttcc ttgtcctccg gcttactgag tcccacttct
     5161 gctctaagac agtagctgtc agaatgtatc atgagaggta atggagaaga ttagggtttc
     5221 agtgaccctc ctctctcatc ctaatggttg aatgttctaa ggctactctt gaggtcctca
     5281 gaggagtaaa gagtggttag catctgatct aatgctttct aaggtgagga caaaaggttt
     5341 gtctacacca atggtcacta tgataaaggc ctgggtaggc actcatgtgt tcttatgaat
     5401 atataaactt tcatgcctat gcagatatag agcacaggga gtgaagatta cagttttttt
     5461 tttaatgagt atatgttttc ccccatggaa tataaagaag caatctcaga acacattcca
     5521 aaaaatctta tgattaatca caaattattc tcctataaac acatttttca gacataactc
     5581 tgtgttaaaa ttgaaattaa aacagcagat gggctctggg agatgtgtca gattgtgaag
     5641 aaatggcata tgggaatatt ggagtgggac attatgtggc atttcacaca ctttttctac
     5701 agtgtatgag gcctccattg cacacacatt tttaaaatcc tcactcacca gacagaatgt
     5761 gtcagatgat ttattcattg tctctagggt ggatttttag tggctgcttc aactcatctc
     5821 attactttct tttaagaaaa gaataaatcc tcctggcata gcactatttt actgttttaa
     5881 aaataatctc cccttcttga atatttctct agtttaaaag gtcactctct ttcccctcgg
     5941 aaaaagagta caaatatttc aagaacgtat ggctacactt gataggaaat gctttctaaa
     6001 tgacctgtaa tctggccttc atcaatttga tatagtaacc ccaccccaga gtttgaaaca
     6061 agacagtttt ctgatactag tattgctttt ttgaagtctc atttttgact gcctccttct
     6121 ctgttcaaat ccccacctcc aaccaccacg ggtccctttc tcttattttg ctgaacaatt
     6181 ggagcaattc cttaggaatg ccttgagcta tattctgctt ttcactacct gctgtgtggc
     6241 ttattttctg taggtgtaca gctgcggccc ctggtgcagt gtatgccaca ctccagacct
     6301 ttcactggca caacacaaac acatgcatac catacacgca tacacacaca cacacacaca
     6361 cacacacaca cacacacaca cacaaacatt tttatttccc tccctacttc ctccccataa
     6421 cccttcttct tttcttttct gccttcttta ttccctctct ttcttctttc cttttgcctt
     6481 ttgatgaaag aaacacacgg aggaattaat attctaagct acatctggct gaacctgttg
     6541 ctaaatgaca ttaatcaact tattttctag agttagggtt caattttggc gtcctctctc
     6601 tgattagact gtcatcaatc attctatgtg ctgacattct gcagaaaaaa aaaagaagag
     6661 aatttttgca cattgtatag ccagaagtat ttccaaatac cctggggact ttcttggaac
     6721 tgggggtttg tcacctttga ctgaagctat ctcagtgagt cctaagaaac tctgggacat
     6781 tgggtgaagc tctgcttcac agaaaaacct ctgtcaacat agtcctagac tttttcttca
     6841 aaaccatcca gtgcaagcta ggcaccttta tgcctctgcc ccttaagact tactcatagc
     6901 accttagtac ctttgtcctg ttggatgcat caaaatgcat attaaagtag attctacctg
     6961 acattaacat gtatgttgat ggaagagaag agggtttctt gagtgcatga tggaatgaca
     7021 gagacactaa aggaattgaa gagaagccat aaactgaatg gctgtgatag catctgctat
     7081 ggaaatgtct ctgtccctag gaaggaccaa tccatgtgtt tgatctggac cctgttgact
     7141 aacaggtaat actgaaaaga aaaaaaaaaa gatgtggaat gtgatatgaa aaagcaagag
     7201 tcatgttact ctctgctaat tatgctgctg cgtgccctct ggtaaggatc tggcccacaa
     7261 ccaagtactg aggttctggc atttggacgt atccataatc aagtgtcctg ggtgcatggg
     7321 tcttagtcaa gggcatcgtt atctccttat ttatctacaa aggaatgaaa actgccagtg
     7381 ttgactgacc cccatgtcag caaatgttcc accttaatca ttgatagaat caggtcttgc
     7441 cttcaatact gtaggcaatt tctcatcaaa gggaattcca cctatggact atattattac
     7501 gtagctgaat agctcaagag atgtcatcct aaatatgcat cagacttgta ctctgtcagt
     7561 ttgcctaagc acagcctact ggtaattgaa tttggctata tccacatgtt tcttttctga
     7621 ctattttccc tttttgaata accacaaata tttccccaac aaatcaagcc aaattcttca
     7681 tcagtttttc cccagagtca tcaacttttt aaacttttcc tagactcttt agtgggccgt
     7741 tcaagtttta aatcacactt tggagtacac taacttcagt gctactgtgt caaaacacag
     7801 ttggggagct ccaactggaa gtagcagaca ctatgtacca atgggtggta cagtagactg
     7861 tgtcagcatt agatcatctg gtggcaggtt atgtccaagt ctcctggatc aaaaatatca
     7921 gtttccatgg agatatcaaa acagtgcact tagactcctt ttcaagttct ctggtgtctt
     7981 tctagagtct aaagattcgc atgcccagtt catccattca ttcttactac ttcatgaagc
     8041 atctagagac ttatgttaat acactattgt caagattcca aagcctgtta gtaccatggg
     8101 tatgtcatac tgtcttctag cagttactgc agagcattgt gagtactctg cttctttggg
     8161 aaatgcatat gaaatgggaa aacttaactt aatattcttg ttaacctaag agatgtacca
     8221 cagggaatga tgtatgagag attacagtcc agggcctagg gattgtttaa tctctgcagc
     8281 ttatctttcc agttgttatc attaattaaa gtgatgtaag gagattttcc aagatctata
     8341 catactaatc tatggccttg aggtagtctc tctagataat cttataaaat gaaggaaatg
     8401 tgttgctttc cagtttgcta cttctccttt taggtaacaa aaatcctgtg gattattaat
     8461 gtacacattg aactattgat agaagttgca aaagtttctc ttccttgtag acttcatatc
     8521 ataatgttgt attaacagaa atttgataca cgttgctgaa gcaacatgga aacctgtctc
     8581 ttaaaatagc tcagactgca aagactgtat gcagtctcct ggataccaaa ttcagagcct
     8641 ggtgcaaata gtatatttca ttaaaaaaaa actcagccct gaaacatgat ctctttgaaa
     8701 gacgatgtcc tgccatttat gcttattatc catgaccaga gcctttatca actctgttcc
     8761 caagcagaaa tgctttactg ggaacatact gtacatgtaa ctaaactgat caaggatact
     8821 ctttgatcag aaagacaaaa gcagcaatag ggaatcacta aaatacaaat aaggcaggaa
     8881 aatctccacc ccttcataat ccatcaagga cctaaaacca ggagattagc cataattctc
     8941 atctttatct gcttcttggg aatttaatac cgacaggttc caatgttaga caaatacaag
     9001 taaaacaaaa agcctaggct ctgttaaaca aaactgttct tccatctaga caataaagga
     9061 ggcctgttat ctgcagaagg tgatactgac cttcctgtac aaagttgcta gtgcctttta
     9121 taagctatgt gctgttgctc ttcctggtta ttgattgttc caattagaag ccatgcattg
     9181 gttgtctaca ctttgaggaa atctattctg tgtgtcgtct ctttgaactc aggaacagga
     9241 aatgagagaa atgtctcatg ttcaagtgtg gttttgctct caaaacagat caagagtgtg
     9301 ttgtgtccag atgaagtggc cctgttccag cctgtaagaa actgatgttg ctttaatttt
     9361 ttacatcttc atggaacttt attagagact gtcctgtggt atgagagtca gctctgtttc
     9421 tgtagaagtc aatgggtgtt tctgttgctc ttcatgcacg gacataggta tgagggaaac
     9481 agatgcaggc tacttacagt gacacatatt gtgaagtgag aaccaactag aacatcattt
     9541 gggctgtttt gtcatatttt gcaaatccag tatcagaact gctcaaaagt tcacaaaatt
     9601 attacttttc gcctgggttt aagaaattag tagtgtgttc tatgctgaag ttgaccactg
     9661 atctcttaca ctgttactgt ggactcaaat cagctgatag atctgcttcg aaagcatgca
     9721 cagtgggatt ctccaaccac tgaatcacca tgatgctcac ctcatctgcc aataagatgc
     9781 accagctttt cccagtgtaa gattctgcag aacctgtgac cacttggttt tgacttgaca
     9841 cctgctacgc ttccttgcct gttttgtgat agaaaataaa attgtctagg attgctcact
     9901 cattgaaatt tcttctaggc caacttcagc ccttggtaaa cttgcagact gttaccgatc
     9961 ttaagattaa aacttcaaag gcaatatata ttagttacca cagagccatt tcaagagtga
    10021 gatagctctg tatttccctg acagttttct gaaagaacag ccacttggtt ctgtgtggga
    10081 ctgctgctgg ctagtgagta ttctctccct gctacaatag gcaagccaca ctattaagcc
    10141 cctgtgtttg gctgtcagta tttgccctga agtctcaata gccatgtgca ttggtatttt
    10201 ctgaagctat catttttctg tttcactcat taacccactg gattgatatt cttcctgaga
    10261 gctggccagg cccttacctc aaattttact taatgacacc tggcagatat cttgttttca
    10321 gaaatgagtt taagacccta attatgtcaa cccaggcagg gaactaattc tgtctttcat
    10381 ggaaccaatt atggaagttc caaaaggggt gggcaggggc acttcccaac caatcaacca
    10441 aaccaaactc acacctgtct aaccaaacat taatacgaat gaaccattat tacagcagtg
    10501 gaaatgtctc tttgtatctg ccctagacac attccaggat caatgtctcc accttcctca
    10561 ttacttttaa caatgaagtc ataaaatggt cctgcatttt gccaagagca cagcattgct
    10621 ccccacctag acctccttct ccatcccgct catcgtctct ctgccaacgt tttgtgaaaa
    10681 ctaaaagaat cctaattatg tacagataaa aattgtatta tattttttgt acttaatgtt
    10741 ttgtgtaaat agtttgcctt gttcagttgt atgtgagtat tgaaataaac cctgccattt
    10801 aagaaacaa
//
