LOCUS       NM_011350               4060 bp    mRNA    linear   ROD 13-JUN-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), TM domain,
            and short cytoplasmic domain (Sema4f), transcript variant 1, mRNA.
ACCESSION   NM_011350
VERSION     NM_011350.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4060)
  AUTHORS   Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
            Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
            Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
  TITLE     Motor neurons use push-pull signals to direct vascular remodeling
            critical for their connectivity
  JOURNAL   Neuron 110 (24), 4090-4107 (2022)
   PUBMED   36240771
REFERENCE   2  (bases 1 to 4060)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4060)
  AUTHORS   Jones,M.R., Dilai,S., Lingampally,A., Chao,C.M., Danopoulos,S.,
            Carraro,G., Mukhametshina,R., Wilhelm,J., Baumgart-Vogt,E., Al
            Alam,D., Chen,C., Minoo,P., Zhang,J.S. and Bellusci,S.
  TITLE     A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b
            Signaling on Epithelial Tip Progenitor Cells During Early Mouse
            Lung Branching Morphogenesis
  JOURNAL   Front Genet 9, 746 (2019)
   PUBMED   30728831
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4060)
  AUTHORS   Memic,F., Knoflach,V., Morarach,K., Sadler,R., Laranjeira,C.,
            Hjerling-Leffler,J., Sundstrom,E., Pachnis,V. and Marklund,U.
  TITLE     Transcription and Signaling Regulators in Developing Neuronal
            Subtypes of Mouse and Human Enteric Nervous System
  JOURNAL   Gastroenterology 154 (3), 624-636 (2018)
   PUBMED   29031500
REFERENCE   5  (bases 1 to 4060)
  AUTHORS   Thompson,C.L., Ng,L., Menon,V., Martinez,S., Lee,C.K.,
            Glattfelder,K., Sunkin,S.M., Henry,A., Lau,C., Dang,C.,
            Garcia-Lopez,R., Martinez-Ferre,A., Pombero,A., Rubenstein,J.L.R.,
            Wakeman,W.B., Hohmann,J., Dee,N., Sodt,A.J., Young,R., Smith,K.,
            Nguyen,T.N., Kidney,J., Kuan,L., Jeromin,A., Kaykas,A., Miller,J.,
            Page,D., Orta,G., Bernard,A., Riley,Z., Smith,S., Wohnoutka,P.,
            Hawrylycz,M.J., Puelles,L. and Jones,A.R.
  TITLE     A high-resolution spatiotemporal atlas of gene expression of the
            developing mouse brain
  JOURNAL   Neuron 83 (2), 309-323 (2014)
   PUBMED   24952961
REFERENCE   6  (bases 1 to 4060)
  AUTHORS   Cohen,S., Funkelstein,L., Livet,J., Rougon,G., Henderson,C.E.,
            Castellani,V. and Mann,F.
  TITLE     A semaphorin code defines subpopulations of spinal motor neurons
            during mouse development
  JOURNAL   Eur J Neurosci 21 (7), 1767-1776 (2005)
   PUBMED   15869472
REFERENCE   7  (bases 1 to 4060)
  AUTHORS   Lillesaar,C. and Fried,K.
  TITLE     Neurites from trigeminal ganglion explants grown in vitro are
            repelled or attracted by tooth-related tissues depending on
            developmental stage
  JOURNAL   Neuroscience 125 (1), 149-161 (2004)
   PUBMED   15051154
REFERENCE   8  (bases 1 to 4060)
  AUTHORS   Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M.
  TITLE     Noggin is required for correct guidance of dorsal root ganglion
            axons
  JOURNAL   Dev Biol 251 (2), 283-293 (2002)
   PUBMED   12435358
REFERENCE   9  (bases 1 to 4060)
  AUTHORS   Schultze,W., Eulenburg,V., Lessmann,V., Herrmann,L., Dittmar,T.,
            Gundelfinger,E.D., Heumann,R. and Erdmann,K.S.
  TITLE     Semaphorin4F interacts with the synapse-associated protein
            SAP90/PSD-95
  JOURNAL   J Neurochem 78 (3), 482-489 (2001)
   PUBMED   11483650
REFERENCE   10 (bases 1 to 4060)
  AUTHORS   Encinas,J.A., Kikuchi,K., Chedotal,A., de Castro,F., Goodman,C.S.
            and Kimura,T.
  TITLE     Cloning, expression, and genetic mapping of Sema W, a member of the
            semaphorin family
  JOURNAL   Proc Natl Acad Sci U S A 96 (5), 2491-2496 (1999)
   PUBMED   10051670
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC158652.5.
            
            On Aug 3, 2022 this sequence version replaced NM_011350.4.
            
            Summary: This gene encodes a member of semaphorin family of
            membrane-bound and secreted proteins that are involved in guiding
            axonal growth. The encoded protein is a transmembrane protein
            localized to the glutamatergic synapses via its association with a
            synapse-associated scaffolding protein. In oligodendrocyte
            precursor cells, the encoded protein contributes to the outward
            migration and differentiation. Alternative splicing results in
            multiple transcript variants encoding different isoforms. [provided
            by RefSeq, May 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC094567.1, AK143196.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               AC158652.5         123502-123784       c
            284-435             AC158652.5         121102-121253       c
            436-495             AC158652.5         119936-119995       c
            496-594             AC158652.5         119628-119726       c
            595-688             AC158652.5         114939-115032       c
            689-808             AC158652.5         103604-103723       c
            809-960             AC158652.5         103358-103509       c
            961-1139            AC158652.5         102573-102751       c
            1140-1287           AC158652.5         102225-102372       c
            1288-1510           AC158652.5         101864-102086       c
            1511-1620           AC158652.5         101630-101739       c
            1621-1781           AC158652.5         101363-101523       c
            1782-1840           AC158652.5         98408-98466         c
            1841-4060           AC158652.5         95926-98145         c
FEATURES             Location/Qualifiers
     source          1..4060
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 35.94 cM"
     gene            1..4060
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /note="sema domain, immunoglobulin domain (Ig), TM domain,
                     and short cytoplasmic domain"
                     /db_xref="GeneID:20355"
                     /db_xref="MGI:MGI:1340055"
     exon            1..283
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     CDS             121..2454
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /note="isoform a precursor is encoded by transcript
                     variant 1; semaphorin-4F; semaphorin-W"
                     /codon_start=1
                     /product="semaphorin-4F isoform a precursor"
                     /protein_id="NP_035480.3"
                     /db_xref="CCDS:CCDS20264.1"
                     /db_xref="GeneID:20355"
                     /db_xref="MGI:MGI:1340055"
                     /translation="MLARAERPRPGPRPPPVSLFPPPSSLLLLLLAMLSAPVCGRVPR
                     SVPRTSLPISEADSYLTRFAAPHTYNYSALLVDPASHTLYVGARDSIFALTLPFSGEK
                     PRRIDWMVPETHRQNCRKKGKKEDECHNFIQILAIANASHLLTCGTFAFDPKCGVIDV
                     SSFQQVERLESGRGKCPFEPAQRSAAVMAGGVLYTATVKNFLGTEPIISRAVGRAEDW
                     IRTETLSSWLNAPAFVAAMVLSPAEWGDEDGDDEIFFFFTETSRVLDSYERIKVPRVA
                     RVCAGDLGGRKTLQQRWTTFLKADLLCPGPEHGRASGVLQDMTELRPQPGAGTPLFYG
                     IFSSQWEGAAISAVCAFRPQDIRAVLNGPFRELKHDCNRGLPVMDNEVPQPRPGECIT
                     NNMKFQQFGSSLSLPDRVLTFIRDHPLMDRPVFPADGRPLLVTTDTAYLRVVAHRVTS
                     LSGKEYDVLYLGTEDGHLHRAVRIGAQLSVLEDLALFPETQPVESMKLYHDWLLVGSH
                     TEVTQVNTSNCGRLQSCSECILAQDPVCAWSFRLDACVAHAGEHRGMVQDIESADVSS
                     LCPKEPGEHPVVFEVPVATVGHVVLPCSPSSAWASCVWHQPSGVTSLTPRRDGLEVVV
                     TPGAMGAYACECQEGGAARVVAAYSLVWGSQRGPANRAHTVVGAGLVGFFLGVLAASL
                     TLLLIGRRQQRRRQRELLARDKVGLDLGAPPSGTTSYSQDPPSPSPEDERLPLALGKR
                     GSGFGGFPPPFLLDSCPSPAHIRLTGAPLATCDETSI"
     exon            284..435
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            436..495
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            496..594
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            595..688
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            689..808
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            809..960
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            961..1139
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            1140..1287
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            1288..1510
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1620
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            1621..1781
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            1782..1840
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     exon            1841..4060
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4043..4048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /note="hexamer: AATAAA"
     polyA_site      4060
                     /gene="Sema4f"
                     /gene_synonym="Sema W"
                     /note="major polyA site"
ORIGIN      
        1 atctcaccgc tgcaggccga gctcggccga gggtacccga gaggggccga ggcccgcgca
       61 gtagcggtac tgagtagagg ctgcccgacg cgccccaccc ggcaccaggc ggagccagag
      121 atgctggcca gggccgagcg gccccgcccg ggcccccggc cgcctccggt ctctctcttc
      181 ccgccgccgt cgtcgctgct gctgctgctg ctggcgatgc tgagcgcccc ggtgtgcggc
      241 cgcgtccccc gctcggtgcc cagaacctcg ctgcccatct ccgaggctga ctcctatctc
      301 acccggtttg cggcccctca tacgtacaat tactctgctc tcctggtgga tcctgcttct
      361 cacacacttt acgtcggtgc acgggacagc atcttcgctt taaccctgcc cttctctggg
      421 gaaaagcctc gaaggatcga ctggatggtg cccgagactc acagacagaa ctgtaggaag
      481 aaaggcaaga aagaggacga atgtcacaat tttatccaga ttctcgccat tgccaatgcc
      541 tctcacctcc tcacgtgtgg caccttcgct tttgatccga agtgcggggt tattgatgtg
      601 tccagtttcc agcaggttga aagacttgag agtggccggg ggaaatgtcc ttttgagcca
      661 gctcaacggt cagcagctgt aatggctggg ggcgtcctct acaccgccac tgtgaaaaac
      721 ttcctgggga cagagccgat tatctcccga gctgtgggtc gagctgagga ctggattcga
      781 acagagacct tgtcatcctg gcttaatgcc ccagcctttg tcgcagctat ggtcctgagc
      841 ccggctgagt ggggggatga agatggagac gatgaaatct tctttttctt cacggagacc
      901 tcccgagtct tggactcata tgagcgcatc aaggtcccac gagtggcccg tgtgtgtgcg
      961 ggggaccttg ggggccggaa gacccttcag cagagatgga cgacgtttct aaaggctgac
     1021 ctgctgtgtc cagggcccga gcatggaagg gcctcggggg ttctgcagga tatgacagag
     1081 cttcgacctc agcctggcgc ggggaccccc ctcttttatg gcatcttttc ctcccagtgg
     1141 gaaggagccg ccatttctgc tgtgtgtgcc ttccgacccc aagacatccg ggcagtgctg
     1201 aatggtccct ttagagagct aaaacatgac tgcaacaggg gactacctgt catggacaac
     1261 gaggtgcccc agcccagacc tggagagtgc atcaccaaca acatgaagtt ccagcagttt
     1321 ggatcctcac tctccctgcc agaccgtgtg ctcaccttta tcagagacca cccgctcatg
     1381 gacaggcccg tgtttccagc tgatggccgc cccctgctgg tcactacgga tacagcctat
     1441 ctcagagttg tggctcaccg ggtgaccagc ctctcaggga aagaatatga tgtgctctac
     1501 ctggggacag aggatgggca cctccatcgg gctgtgcgca tcggagctca gctcagtgtc
     1561 ctggaggatc tggccttgtt cccggaaaca cagccggttg aaagcatgaa attgtaccat
     1621 gattggcttc tggtgggctc ccatactgag gtgacacaag tgaacaccag caactgtggc
     1681 cgtctccaga gctgctcaga atgtatcctg gcccaggatc ccgtgtgtgc ctggagcttc
     1741 cggctcgatg cttgtgtggc ccatgcaggc gagcaccgtg ggatggttca agacatagag
     1801 tcagcagatg tctcttcttt gtgtccaaaa gaacctggag aacatccggt agtgtttgaa
     1861 gttccagtgg ctacggtggg ccacgtggtc ctgccgtgct cccccagttc tgcctgggca
     1921 tcctgtgtgt ggcaccagcc cagtggagtg acttcgctca ccccacgaag ggatgggcta
     1981 gaggtggtgg tgaccccagg ggccatgggg gcttatgctt gcgagtgtca ggagggtgga
     2041 gccgcccgtg tggtggctgc ttatagcttg gtgtggggca gccagagggg gcccgcaaac
     2101 cgggcccaca ccgttgtggg ggctgggctg gttggctttt tcctgggtgt tctagcagca
     2161 tctctcactc tcctcctgat tggtcgccgt cagcagcggc ggcgacagag ggagcttcta
     2221 gctagagaca aggtgggctt agatctgggg gctccacctt ctgggaccac aagctatagc
     2281 caagaccctc cctctccttc acctgaagat gaacggctgc ccctggccct gggtaagcgg
     2341 ggcagtggtt ttggtggctt ccctccaccc ttcctgctgg attcttgccc gagcccagcc
     2401 cacatccggc tcactggggc tcctctggcc acgtgcgatg agacgtctat ctaaagccag
     2461 gaaaatgact gccagccatg agcaatctct ggaactagcg gctacgaaga ccagggtcac
     2521 tgaacctggg agacgatcat ggctgctcca ttctcttgga gtctgtgtga tcacacgtca
     2581 gtgtctgtcc tctggacctg gatgagctga gggccagacc tttgcctgat tcctgattct
     2641 catgagagat caaccctgta gccctctgct atggcctctt gtcttgggcc catcatcagc
     2701 ttgtggggtg gagcaaggac acaggctctg atttgcttat ggtgggcccc cggaaagagg
     2761 gagcactgcg gggtggttgg agcgcgtgtg ccctgcatcc gtgtggtgcc tgtatgatga
     2821 ttttccagtt tgctgactct ggggagcgca tgatccccgg actgccttga gatctctccc
     2881 aactcagttt ccctttgtcc cttgaagagt gtgtgtctat acactggtgt gcctcgaaga
     2941 cctgtccagg tgtgtgtgga tgacagggcc ggtgcctagg tgcttttggg gggtcggaga
     3001 ggaaggttgg aacgggggac aactttaccc tcggtagcca gtgagggaaa ccacacgacc
     3061 ccatcacccc acagcgcttc ttcaactttg agcaaagttc ccaaagtgac cttctggtgg
     3121 gaagggcagc aggacacgtg gccccgtcct tctcctcatc tttctcctct ggctgccacc
     3181 actgccgtgc caccgctgct ttttccctgg ctggagtgga ggctgagccc tctttccttg
     3241 gcttccattt aaaatgaact tcacaacatt ctagctattg agggatgaca aaaggaaccc
     3301 agaaaagtgt gtaggaaatt acaagcaggt tcaagaagat ttgcctcagt gactttcacc
     3361 cttgccctaa agcaggagtc ccctagcagg actccctgaa attgtatgca aagaaatgtc
     3421 tgtccatgtg tggcatgtgt gcgtgcgtgc gtgtgtgtgt gtgtgtgtgt gtgtgtgtgt
     3481 gtgtgtgtgt gatggctttc atcagattct caaggcctta atgaggttaa aggaccatgg
     3541 tccatagtca ccacacttgg gccacataaa tggaggaggt gttgctgtga ggcagttcct
     3601 ccctggcctg ctgcctgagg ccagtccctg gacacactgc tgctggagat cccacctctc
     3661 tccagtcctc ctcggaagct agtgaagcta ggctctgcac gtgcttgaag acaccatcgc
     3721 ctcctttctt gcttcgttat tcctgtgtgc gctgcatctg ctccgtcctg ctcttggcct
     3781 gtgaatgtgc ctcgtccatc cctggtgagg gacctcgaac cccggtgagg atgcagccct
     3841 ttccagttga agtttctgtt ctactttcct tgacagcagc ctgtgaatta ctcaagagtc
     3901 cccttgggtt tggagttacc agtggctttg agtaggatct ttggcacgta gtctaaccta
     3961 gggacattgg ttattcatct gtaaagtggg gatataccta cctcagggtt gctgcaagga
     4021 tcaaacgagg aaacgtatga acaataaagc attacccaga
//
