LOCUS       NM_001126047            3808 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), transmembrane
            domain (TM) and short cytoplasmic domain, (semaphorin) 4C (Sema4c),
            transcript variant 2, mRNA.
ACCESSION   NM_001126047 XM_898566 XM_985534
VERSION     NM_001126047.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3808)
  AUTHORS   Salamon,I., Park,Y., Miskic,T., Kopic,J., Matteson,P., Page,N.F.,
            Roque,A., McAuliffe,G.W., Favate,J., Garcia-Forn,M., Shah,P.,
            Judas,M., Millonig,J.H., Kostovic,I., De Rubeis,S., Hart,R.P.,
            Krsnik,Z. and Rasin,M.R.
  TITLE     Celf4 controls mRNA translation underlying synaptic development in
            the prenatal mammalian neocortex
  JOURNAL   Nat Commun 14 (1), 6025 (2023)
   PUBMED   37758766
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3808)
  AUTHORS   Chen,D., Wu,C., Wei,S., Guo,Y., Wu,M., Zhou,S., Fu,F., Tang,W.,
            Xue,L., Zhang,J., Li,Y., Dai,J., Li,Y., Ye,S. and Wang,S.
  TITLE     Semaphorin 4C regulates ovarian steroidogenesis through
            RHOA/ROCK1-mediated actin cytoskeleton rearrangement
  JOURNAL   Mol Hum Reprod 29 (5) (2023)
   PUBMED   36892447
  REMARK    GeneRIF: Semaphorin 4C regulates ovarian steroidogenesis through
            RHOA/ROCK1-mediated actin cytoskeleton rearrangement.
REFERENCE   3  (bases 1 to 3808)
  AUTHORS   Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
            Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
            Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
  TITLE     Motor neurons use push-pull signals to direct vascular remodeling
            critical for their connectivity
  JOURNAL   Neuron 110 (24), 4090-4107 (2022)
   PUBMED   36240771
REFERENCE   4  (bases 1 to 3808)
  AUTHORS   Niu,F., Che,P., Yang,Z., Zhang,J., Yang,L., Zhuang,M., Ou,X. and
            Ji,S.J.
  TITLE     m6A regulation of cortical and retinal neurogenesis is mediated by
            the redundant m6A readers YTHDFs
  JOURNAL   iScience 25 (9), 104908 (2022)
   PUBMED   36039295
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3808)
  AUTHORS   Xiao,Z., Liu,S., Li,Z., Cui,J., Wang,H., Wang,Z., Ren,Q., Xia,L.,
            Wang,Z. and Li,Y.
  TITLE     The Maternal Microbiome Programs the m6A Epitranscriptome of the
            Mouse Fetal Brain and Intestine
  JOURNAL   Front Cell Dev Biol 10, 882994 (2022)
   PUBMED   35874829
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3808)
  AUTHORS   Inagaki,S., Ohoka,Y., Sugimoto,H., Fujioka,S., Amazaki,M.,
            Kurinami,H., Miyazaki,N., Tohyama,M. and Furuyama,T.
  TITLE     Sema4c, a transmembrane semaphorin, interacts with a post-synaptic
            density protein, PSD-95
  JOURNAL   J Biol Chem 276 (12), 9174-9181 (2001)
   PUBMED   11134026
REFERENCE   7  (bases 1 to 3808)
  AUTHORS   Ohoka,Y., Hirotani,M., Sugimoto,H., Fujioka,S., Furuyama,T. and
            Inagaki,S.
  TITLE     Semaphorin 4C, a transmembrane semaphorin, [corrected] associates
            with a neurite-outgrowth-related protein, SFAP75
  JOURNAL   Biochem Biophys Res Commun 280 (1), 237-243 (2001)
   PUBMED   11162505
  REMARK    Erratum:[Biochem Biophys Res Commun 2001 Feb 16;281(1):266]
REFERENCE   8  (bases 1 to 3808)
  AUTHORS   .
  TITLE     Unified nomenclature for the semaphorins/collapsins. Semaphorin
            Nomenclature Committee
  JOURNAL   Cell 97 (5), 551-552 (1999)
   PUBMED   10367884
REFERENCE   9  (bases 1 to 3808)
  AUTHORS   Wang,L.H., Kalb,R.G. and Strittmatter,S.M.
  TITLE     A PDZ protein regulates the distribution of the transmembrane
            semaphorin, M-SemF
  JOURNAL   J Biol Chem 274 (20), 14137-14146 (1999)
   PUBMED   10318831
REFERENCE   10 (bases 1 to 3808)
  AUTHORS   Inagaki,S., Furuyama,T. and Iwahashi,Y.
  TITLE     Identification of a member of mouse semaphorin family
  JOURNAL   FEBS Lett 370 (3), 269-272 (1995)
   PUBMED   7656991
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY166322.1, AK148298.1 and
            AC084391.1.
            
            [WARNING] On Aug 1, 2024 this sequence was replaced by
            NM_001126047.4.
            
            On Jan 17, 2015 this sequence version replaced NM_001126047.2.
            
            Summary: This gene encodes a member of the semaphorin family of
            proteins that have diverse functions in neuronal development, heart
            morphogenesis, vascular growth, tumor progression and immune cell
            regulation. Lack of the encoded protein in some mice causes
            exencephaly resulting in neonatal lethality. Mice that bypass
            exencephaly show no obvious behavioral defects but display distinct
            pigmentation defects. Alternative splicing of this gene results in
            multiple transcript variants. [provided by RefSeq, Jan 2015].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK148298.1, SRR7345562.3588593.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-158               BY166322.1         2-159
            159-1297            AK148298.1         1-1139
            1298-1298           AC084391.1         44720-44720
            1299-2581           AK148298.1         1141-2423
            2582-3808           AC084391.1         47641-48867
FEATURES             Location/Qualifiers
     source          1..3808
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 15.32 cM"
     gene            1..3808
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /note="sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 4C"
                     /db_xref="GeneID:20353"
                     /db_xref="MGI:MGI:109252"
     exon            1..366
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            367..512
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     CDS             404..2908
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /note="semaphorin-4C; semaphorin I; semaphorin-C-like 1"
                     /codon_start=1
                     /product="semaphorin-4C precursor"
                     /protein_id="NP_001119519.1"
                     /db_xref="CCDS:CCDS48240.1"
                     /db_xref="GeneID:20353"
                     /db_xref="MGI:MGI:109252"
                     /translation="MAPHWAVWLLAAGLWGLGIGAEMWWNLVPRKTVSSGELVTVVRR
                     FSQTGIQDFLTLTLTEHSGLLYVGAREALFAFSVEALELQGAISWEAPAEKKIECTQK
                     GKSNQTECFNFIRFLQPYNSSHLYVCGTYAFQPKCTYINMLTFTLDRAEFEDGKGKCP
                     YDPAKGHTGLLVDGELYSATLNNFLGTEPVILRYMGTHHSIKTEYLAFWLNEPHFVGS
                     AFVPESVGSFTGDDDKIYFFFSERAVEYDCYSEQVVARVARVCKGDMGGARTLQKKWT
                     TFLKARLVCSAPDWKVYFNQLKAVHTLRGASWHNTTFFGVFQARWGDMDLSAVCEYQL
                     EQIQQVFEGPYKEYSEQAQKWARYTDPVPSPRPGSCINNWHRDNGYTSSLELPDNTLN
                     FIKKHPLMEDQVKPRLGRPLLVKKNTNFTHVVADRVPGLDGATYTVLFIGTGDGWLLK
                     AVSLGPWIHMVEELQVFDQEPVESLVLSQSKKVLFAGSRSQLVQLSLADCTKYRFCVD
                     CVLARDPYCAWNVNTSRCVATTSGRSGSFLVQHVANLDTSKMCNQYGIKKVRSIPKNI
                     TVVSGTDLVLPCHLSSNLAHAHWTFGSQDLPAEQPGSFLYDTGLQALVVMAAQSRHSG
                     PYRCYSEEQGTRLAAESYLVAVVAGSSVTLEARAPLENLGLVWLAVVALGAVCLVLLL
                     LVLSLRRRLREELEKGAKASERTLVYPLELPKEPASPPFRPGPETDEKLWDPVGYYYS
                     DGSLKIVPGHARCQPGGGPPSPPPGIPGQPLPSPTRLHLGGGRNSNANGYVRLQLGGE
                     DRGGSGHPLPELADELRRKLQQRQPLPDSNPEESSV"
     exon            513..661
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            662..724
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            725..823
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            824..920
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            921..1037
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            1038..1189
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1365
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            1366..1510
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            1511..1733
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            1734..1846
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            1847..2007
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            2008..2078
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..3808
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3769..3774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /note="hexamer: AATAAA"
     polyA_site      3794
                     /gene="Sema4c"
                     /gene_synonym="M-Sema F; sema I; Semacl1; Semaf; Semai"
                     /note="major polyA site"
ORIGIN      
        1 gtaaagggtc cccaagcctc agtgccgggt aagcaaggca gcgggtcgca gccccctcct
       61 gggcgggcct tcgcgtcccg cccccggcca ccactcgaca ccctctgcct gacgtcaagg
      121 ggttgggggc ggagagcggc ggtggcggcg gctgcagcgg agaaagaacc ggcgcccggc
      181 gcggtggagc gccgaatccg agctcagggg cgccgagagc cgtgctgaga ccgaggggcg
      241 gtggcacggg acagccttag cgtgctggcg ggcgggcgca gtctggagcg gcgcgggggc
      301 aggggaggac ggtggccgga gtcaaacgcg agggcagcgc ccagggattg gagctgcacg
      361 aaagagggct gctggactga agtttagacc ctgggtgtct gccatggccc cacactgggc
      421 tgtctggctg ctggcagcag ggctgtgggg cctgggcatc ggggctgaga tgtggtggaa
      481 ccttgtgccc cggaagacag tatcttctgg ggagctggtc acagtagtga ggcggttctc
      541 ccagacaggc atccaggact tcctgacact gaccctgaca gaacattctg gccttttata
      601 tgtgggggcc cgagaggcgc tgtttgcctt cagtgtagag gctctggagc tgcaaggagc
      661 gatctcttgg gaggctccag ctgagaagaa aattgaatgt acccagaaag ggaagagcaa
      721 ccagaccgaa tgcttcaact tcatccgctt ccttcagcca tacaattcct cccatctgta
      781 tgtctgcggc acctatgcct tccagcccaa gtgcacctac atcaacatgc tcacgttcac
      841 cttggaccgt gcagaatttg aggatgggaa gggtaaatgc ccatatgacc cagctaaggg
      901 tcacaccgga ctccttgtgg acggtgagct gtactcagcc acactcaata acttcctggg
      961 cacagagccg gttatccttc gatacatggg gacccaccac tccatcaaga cagagtacct
     1021 ggctttttgg ctgaatgaac cccactttgt aggctctgcc tttgtccctg agagtgtggg
     1081 aagcttcacg ggagacgatg acaagatcta cttcttcttc agtgagcggg cagtggagta
     1141 tgactgctat tccgagcagg tggtggctcg tgtggcgaga gtctgtaagg gtgacatggg
     1201 gggagcacgg acgctgcaga agaaatggac gacgttcctg aaggctcggt tggtgtgctc
     1261 agcccctgac tggaaggtct acttcaacca gctgaaggcg gtgcacaccc tgcggggcgc
     1321 ctcttggcac aacaccacct tcttcggggt ttttcaagcg cgatggggcg atatggacct
     1381 gtctgcagtt tgtgagtacc agttggaaca gatccagcaa gtgtttgagg gtccctacaa
     1441 ggagtacagt gagcaagccc agaagtgggc ccgctatact gacccggtac ccagccctcg
     1501 gcctggttcg tgtatcaaca actggcaccg agacaatggc tacaccagtt ccctggaact
     1561 gccggacaac accctcaact tcatcaagaa gcaccccctg atggaggacc aggtgaagcc
     1621 tcggttgggc cgccccctac ttgtgaagaa gaacactaac ttcacacacg tggtggccga
     1681 cagggtccca gggcttgatg gtgccaccta tacagtgttg ttcattggta caggagatgg
     1741 ctggctgctg aaggctgtga gcctggggcc ctggatccac atggtggagg aactgcaggt
     1801 gtttgaccag gagccagtgg aaagtctggt gctgtctcag agcaagaagg tgctctttgc
     1861 tggctcccgc tctcagctgg ttcagctgtc tctggccgac tgcacaaagt accgtttctg
     1921 tgtagactgt gtcctggcca gggaccctta ctgtgcctgg aatgtcaaca ccagccgctg
     1981 tgtggccacc accagtggtc gctcggggtc ctttctggtc caacatgtgg cgaacttgga
     2041 cacttcaaag atgtgtaacc agtatggcat taaaaaagtc agatctattc ccaagaacat
     2101 caccgttgtg tcaggcacag acctggtcct accctgccac ctctcgtcca atttggccca
     2161 tgcccactgg accttcggaa gccaggacct gcctgcagaa caacctggct cctttcttta
     2221 tgacacggga ctccaggcgc tggtggtgat ggccgcacag tcccgtcact ctggacccta
     2281 tcgttgctat tcagaggagc aggggacaag actggctgca gaaagctacc ttgttgctgt
     2341 cgtggccggc tcgtcggtga cactggaggc acgggctccc ttggaaaacc tggggctcgt
     2401 gtggctcgct gtggtggccc tgggggctgt gtgcctggtg ctgctgctgc tggtcctatc
     2461 gctccgccgg cgacttcgag aagagctaga aaagggtgcc aaggcatctg agaggacact
     2521 ggtgtacccc ttggaactgc ccaaggagcc tgccagtccc cccttccgtc ctggccccga
     2581 aactgatgag aaactttggg atcctgtcgg gtactactat tcggatggct ctctcaagat
     2641 tgtgcctggt cacgcccggt gccagcctgg gggtgggccc ccttccccac ctcctggcat
     2701 acctggccag cctctgcctt ctccaactcg gctccaccta ggaggtggtc ggaactcaaa
     2761 tgccaatggt tatgtgcgtt tacagttggg cggagaggac cgaggaggat ctgggcaccc
     2821 actgcctgag ctcgcggatg aattacgacg gaaactacaa cagcgccagc cgctgcctga
     2881 ctccaaccca gaggagtctt cagtatgagg ggaccccccc acctcattgg cggggggggg
     2941 tctcatggga ggtgcactct taacttttgc acaggcacca gctacctcag ggacatggca
     3001 ggggcacttg ctctgcctgg gacagacact gcccagcatt tgcccggccg tgaggacctg
     3061 ctcagcatgg gcactgccac ttggtgtggc tcaccaggac ttcagcctca caggagacac
     3121 accctcctct gtgaatttga gacatgtggg accccagcag ccaaaacttt gcaaggaaga
     3181 ggtttcaaga tgtgggcgtg tttgtgcata tatgtgttgg tatgcatgtg gaagaatgtg
     3241 tgtgtgtgtg tgtgtgtgtt gtaactttcc tgtctctatc acgtcttccc ttggcctggg
     3301 gtcctcctgg ttgagtcttt ggagctatga aggggaaggg ggtcatagca ctttgcttct
     3361 cctaccccca gctgtcccaa gctttggggc agtgatgtac atacggggaa gggaaggaca
     3421 gggtgttgta ccccttttgg gggagtgcgg gactcggggg tgggcctagc cctgctccta
     3481 gggctgtgaa tgttttcagg gcgggggttg ggggtggaga tggaacctcc tgcttcaggg
     3541 ggaggggtgg gcagggcctc ccacttgccc tccgggttcg gtggtatttt atatttgcgc
     3601 tcttctgaca gggctgggaa gggttgttgg gggagggaag ggaggaggtg ggcatgctat
     3661 ggatactggc ctatcctctc cctgctctgg gaaaagggct aacagtgtaa cttattgtgt
     3721 ccccacatat ttatttgttg taaatatttg agtattttta tattgacaaa taaaatggag
     3781 aaaatgaaat ttaaccctgc cacacaga
//
