LOCUS       NM_001360135            3603 bp    mRNA    linear   ROD 09-JUL-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), transmembrane
            domain (TM) and short cytoplasmic domain, (semaphorin) 4B (Sema4b),
            transcript variant 2, mRNA.
ACCESSION   NM_001360135 XM_011250830
VERSION     NM_001360135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3603)
  AUTHORS   Casden,N., Belzer,V., El Khayari,A., El Fatimy,R. and Behar,O.
  TITLE     Astrocyte-to-microglia communication via Sema4B-Plexin-B2 modulates
            injury-induced reactivity of microglia
  JOURNAL   Proc Natl Acad Sci U S A 121 (22), e2400648121 (2024)
   PUBMED   38781210
  REMARK    GeneRIF: Astrocyte-to-microglia communication via Sema4B-Plexin-B2
            modulates injury-induced reactivity of microglia.
REFERENCE   2  (bases 1 to 3603)
  AUTHORS   Amin,A., Badenes,M., Tushaus,J., de Carvalho,E., Burbridge,E.,
            Faisca,P., Travnickova,K., Barros,A., Carobbio,S., Domingos,P.M.,
            Vidal-Puig,A., Moita,L.F., Maguire,S., Strisovsky,K., Ortega,F.J.,
            Fernandez-Real,J.M., Lichtenthaler,S.F. and Adrain,C.
  TITLE     Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits
            adipocyte differentiation and thermogenesis
  JOURNAL   Mol Metab 73, 101731 (2023)
   PUBMED   37121509
  REMARK    GeneRIF: Semaphorin 4B is an ADAM17-cleaved adipokine that inhibits
            adipocyte differentiation and thermogenesis.
REFERENCE   3  (bases 1 to 3603)
  AUTHORS   Sweetat,S., Casden,N. and Behar,O.
  TITLE     Improved neuron protection following cortical injury in the absence
            of Semaphorin4B
  JOURNAL   Front Cell Neurosci 16, 1076281 (2022)
   PUBMED   36531136
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3603)
  AUTHORS   Xu,R., Hoss,C., Swiercz,J.M., Brandt,D.T., Lutz,V., Petersen,N.,
            Li,R., Zhao,D., Oleksy,A., Creigh-Pulatmen,T., Trokter,M.,
            Fedorova,M., Atzberger,A., Strandby,R.B., Olsen,A.A., Achiam,M.P.,
            Matthews,D., Huber,M., Grone,H.J., Offermanns,S. and Worzfeld,T.
  TITLE     A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin
            expression and protects against peptic ulcers
  JOURNAL   Sci Transl Med 14 (654), eabf1922 (2022)
   PUBMED   35857828
REFERENCE   5  (bases 1 to 3603)
  AUTHORS   Sar Shalom,H., Goldner,R., Golan-Vaishenker,Y. and Yaron,A.
  TITLE     Balance between BDNF and Semaphorins gates the innervation of the
            mammary gland
  JOURNAL   Elife 8, e41162 (2019)
   PUBMED   30628891
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3603)
  AUTHORS   He,Z. and Tessier-Lavigne,M.
  TITLE     Neuropilin is a receptor for the axonal chemorepellent Semaphorin
            III
  JOURNAL   Cell 90 (4), 739-751 (1997)
   PUBMED   9288753
REFERENCE   7  (bases 1 to 3603)
  AUTHORS   Furuyama,T., Inagaki,S., Kosugi,A., Noda,S., Saitoh,S., Ogata,M.,
            Iwahashi,Y., Miyazaki,N., Hamaoka,T. and Tohyama,M.
  TITLE     Identification of a novel transmembrane semaphorin expressed on
            lymphocytes
  JOURNAL   J Biol Chem 271 (52), 33376-33381 (1996)
   PUBMED   8969198
REFERENCE   8  (bases 1 to 3603)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
REFERENCE   9  (bases 1 to 3603)
  AUTHORS   Messersmith,E.K., Leonardo,E.D., Shatz,C.J., Tessier-Lavigne,M.,
            Goodman,C.S. and Kolodkin,A.L.
  TITLE     Semaphorin III can function as a selective chemorepellent to
            pattern sensory projections in the spinal cord
  JOURNAL   Neuron 14 (5), 949-959 (1995)
   PUBMED   7748562
REFERENCE   10 (bases 1 to 3603)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC109232.17.
            
            On Dec 5, 2019 this sequence version replaced NM_001360135.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154969.1, AK134973.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-183               AC109232.17        100812-100994
            184-347             AC109232.17        115020-115183
            348-410             AC109232.17        115487-115549
            411-509             AC109232.17        117848-117946
            510-621             AC109232.17        118553-118664
            622-735             AC109232.17        118954-119067
            736-887             AC109232.17        119172-119323
            888-1069            AC109232.17        121107-121288
            1070-1220           AC109232.17        121410-121560
            1221-1431           AC109232.17        122345-122555
            1432-1547           AC109232.17        122666-122781
            1548-1714           AC109232.17        123012-123178
            1715-1797           AC109232.17        126158-126240
            1798-3603           AC109232.17        126820-128625
FEATURES             Location/Qualifiers
     source          1..3603
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 45.51 cM"
     gene            1..3603
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /note="sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 4B"
                     /db_xref="GeneID:20352"
                     /db_xref="MGI:MGI:107559"
     exon            1..183
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     CDS             66..2537
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /note="semaphorin-4B; semaphorin-C"
                     /codon_start=1
                     /product="semaphorin-4B precursor"
                     /protein_id="NP_001347064.1"
                     /db_xref="CCDS:CCDS21391.1"
                     /db_xref="GeneID:20352"
                     /db_xref="MGI:MGI:107559"
                     /translation="MGRASRSAVLRRALLLLLLLLLLRTTTTRALGPRISVPLGSEER
                     LIRKFEAENISNYTALLLSQDGKTLYVGAREALFALNSNLSFLPGGEYQELLWSADAD
                     RKQQCSFKGKDPKRDCQNYIKILLPLNSSHLLTCGTAAFSPLCAYIHIASFTLAQDEA
                     GNVILEDGKGRCPFDPNFKSTALVVDGELYTGTVSSFQGNDPAISRSQSSRPTKTESS
                     LNWLQDPAFVASAYVPESLGSPIGDDDKIYFFFSETGQEFEFFENTIVSRVARVCKGD
                     EGGERVLQQRWTSFLKAQLLCSRPDDGFPFNVLQDVFTLNPNPQDWRKTLFYGVFTSQ
                     WHRGTTEGSAICVFTMNDVQKAFDGLYKKVNRETQQWYTETHQVPTPRPGACITNSAR
                     ERKINSSLQLPDRVLNFLKDHFLMDGQVRSRLLLLQPRARYQRVAVHRVPGLHSTYDV
                     LFLGTGDGRLHKAVTLSSRVHIIEELQIFPQGQPVQNLLLDSHGGLLYASSHSGVVQV
                     PVANCSLYPTCGDCLLARDPYCAWTGSACRLASLYQPDLASRPWTQDIEGASVKELCK
                     NSSYKARFLVPGKPCKQVQIQPNTVNTLACPLLSNLATRLWVHNGAPVNASASCRVLP
                     TGDLLLVGSQQGLGVFQCWSIEEGFQQLVASYCPEVMEEGVMDQKNQRDGTPVIINTS
                     RVSAPAGGRASWGADKSYWNEFLVMCTLFVFAMVLLFLFFLYRHRDGMKLFLKQGECA
                     SVHPKTRPIVLPPETRPLNGVGPPSTPLDHRGYQALSDSSPGPRVFTESEKRPLSIQD
                     SFVEVSPVCPRPRVRLGSEIRDSVV"
     exon            184..347
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            348..410
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            411..509
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            510..621
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            622..735
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            736..887
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            888..1069
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1070..1220
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1221..1431
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1547
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1714
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1715..1797
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     exon            1798..3603
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3579..3584
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /note="hexamer: AATAAA"
     polyA_site      3603
                     /gene="Sema4b"
                     /gene_synonym="mKIAA1745; sema C; Semac; SemC"
                     /note="major polyA site"
ORIGIN      
        1 acttgagcaa cctgagccgg aggaggacgc cgctgcctgc tgcggtccga gctccacgcg
       61 ccgcgatggg ccgggcgagc cgctccgctg tcctgcggcg cgcgctgctg ctgctgctgc
      121 tactgctgct gctgcggacg acgactacgc gggcgctcgg cccccggatc agtgtgccgc
      181 tgggctctga agaaaggctg attagaaaat ttgaagctga aaacatctcc aactacacgg
      241 cccttctgct gagccaggat ggcaagacgc tgtatgtggg ggcccgagag gccctctttg
      301 cacttaacag caacctcagc ttcttgccag gcggggagta ccaagagctg ctgtggagtg
      361 cagatgctga caggaagcag cagtgcagct tcaagggcaa ggacccaaag cgtgactgtc
      421 aaaactacat caagatcctc ctgccactca acagcagcca cctgctcacc tgtggcacgg
      481 ccgccttcag ccccctgtgt gcttacattc acatagcgag ctttacttta gcccaagatg
      541 aggccggcaa tgtcattctg gaggatggca agggtcgttg tccctttgac cccaacttca
      601 agtccacggc tctggtggtt gatggtgagc tgtacactgg aacagtcagt agcttccagg
      661 gaaacgaccc agccatttcc cggagccaga gttcccgccc caccaagact gagagctccc
      721 tcaactggct acaagaccct gcctttgtgg cctcggccta cgtccccgag agcctgggca
      781 gccccatagg tgatgatgat aagatctact tcttcttcag cgagacgggc caggagtttg
      841 agttctttga gaacaccatc gtgtcccgag ttgcccgagt ctgtaagggc gatgagggtg
      901 gagagcgggt gttgcagcaa cgctggacct cctttctcaa ggctcagctc ctgtgctccc
      961 ggcctgatga tggctttccc tttaacgtgc tacaagatgt cttcaccctg aaccccaacc
     1021 ctcaggattg gcgcaagacc cttttctatg gggtctttac ctcccagtgg cacagaggga
     1081 ccacagaagg ctctgccatc tgcgtcttca ccatgaatga tgtgcagaag gcctttgacg
     1141 gcctgtacaa gaaagtaaac agagagacac agcagtggta taccgagacc caccaggtgc
     1201 ccacaccgcg gccgggagcg tgcattacca acagtgcccg ggaacggaag atcaactcgt
     1261 ccctgcagct cccagaccga gtgctgaact tcctcaagga tcacttcttg atggatgggc
     1321 aggtccgcag tcgcctgctg ctgctgcagc ccagagcccg ctaccagcgt gtggctgtgc
     1381 accgtgtgcc tggcctgcac agcacttatg atgtcctatt tctgggcact ggtgatggcc
     1441 gcctgcacaa agcagtgacc ctgagctcca gagtccacat cattgaggag ctgcagatct
     1501 tccctcaagg acagcctgtg cagaacctgc tcttggacag ccatggggga ctgttgtatg
     1561 cctcctccca ttccggggtg gtgcaagtgc ccgtagccaa ctgcagcctg tacccaacct
     1621 gtggagactg cctcctggct cgagacccct actgcgcctg gactggctct gcctgcaggc
     1681 tcgctagcct ctaccagcct gatctggcct ccaggccatg gacccaggac attgagggtg
     1741 ccagtgtcaa ggaactctgc aagaattcct catacaaggc ccggtttctt gtgccaggta
     1801 agccatgtaa acaagtccag atccaaccaa acacagtgaa caccctggcc tgcccactcc
     1861 tctcaaacct ggccactcgg ctctgggtgc acaatggagc cccagtcaat gcctctgcct
     1921 cctgccgcgt gttacccacc ggggacctgc tgctggtggg cagccagcag ggtttggggg
     1981 tgttccagtg ttggtcgata gaagaaggat tccagcagct tgtggccagc tactgcccag
     2041 aggtgatgga ggagggggta atggaccaaa agaaccagcg tgatggtacc ccagtcatta
     2101 tcaacacatc acgagtgagt gcaccggctg gtggcagggc cagctggggt gcggacaagt
     2161 cctactggaa tgaattcctg gtgatgtgta ctctgtttgt gtttgctatg gtgcttttgt
     2221 ttctgttctt tctctaccga catcgggatg gcatgaaact cttcctaaag cagggcgaat
     2281 gtgccagtgt gcaccccaag actcgcccta tagtgctacc acctgagacc cgaccgctga
     2341 atggtgtcgg ccctcctagc accccacttg accaccgagg ctaccaggct ctgtcggata
     2401 gctccccagg gcccagagtc ttcactgaat cagagaagag gccactgagc atccaggaca
     2461 gctttgtaga ggtgtctccc gtgtgtcccc ggccccgagt tcgactgggc tctgagatcc
     2521 gagactctgt ggtatgagag ctgactttag atgtggtcac cctgacctca ggggttgtga
     2581 gtgttcagtg gaggtcagct acctctgctt ctcacagaac acagccacgg taccctgact
     2641 ggagggcagc tggtaccaca ggcccaacag cccagccagc tgcttccagt gtctggccga
     2701 gaactgggct gcctccaggg gccagagggt ccttgtctgg gtggcagaac tctgctactt
     2761 aactgagccc tttgtttaaa actgcaaatg tgaagccaga gaggaaggag aaacagacaa
     2821 ggaagactac aacatagcca ctccagttca gcctgctggg ctcttgggga cttctccaaa
     2881 gtggctttgt gagcaagccg aagttgagaa tccctccccg actggactat tctaccttcc
     2941 gccttactct gctgctgagg ctaccctttc tcactgcaga atcagggccc tgctccagct
     3001 tcagccaacc gaggacatat ctgtgaccgc tgacacccta ccacctcagg gaccagaggg
     3061 ctaggctgat tctgcagccc tcctcaccag accctgggct cagtcccagt tcccggactt
     3121 ctccagcctg tatcaggctg tggcctcaaa agcaagggag tgacccccaa ggggggttgt
     3181 gacagaagac ttgcctactg tccttttccc agtcagagaa ctatgtccct acccatcgac
     3241 gtcttttttt tttttttttt tttttttttt tggtttttcg agacaggctt tctctgtgta
     3301 gccctggctg tcctggaact cactttgtag accaggctgg tctcgaactt agaaatccgc
     3361 ctgactgcct cccaagtgct gggattaaag gcgtgtgcca ccactgcccg gccccaccca
     3421 tcttctaatt cctacacaga ctcctggatc ctcgttcctt gtcctagctc accgtgcccg
     3481 tcactctaag ggatgctgac actgcccatc acaaggaccc tgaatttaca tgggttttat
     3541 attttttttt aataagatgc actttacttt cttttttaaa taaaatccga caaattatag
     3601 tta
//
