LOCUS       NM_013658               3224 bp    mRNA    linear   ROD 05-JUN-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), transmembrane
            domain (TM) and short cytoplasmic domain, (semaphorin) 4A (Sema4a),
            transcript variant 1, mRNA.
ACCESSION   NM_013658
VERSION     NM_013658.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3224)
  AUTHORS   Bhat,G.P., Maurizio,A., Motta,A., Podini,P., Diprima,S.,
            Malpighi,C., Brambilla,I., Martins,L., Badaloni,A., Boselli,D.,
            Bianchi,F., Pellegatta,M., Genua,M., Ostuni,R., Del Carro,U.,
            Taveggia,C., de Pretis,S., Quattrini,A. and Bonanomi,D.
  TITLE     Structured wound angiogenesis instructs mesenchymal barrier
            compartments in the regenerating nerve
  JOURNAL   Neuron 112 (2), 209-229 (2024)
   PUBMED   37972594
REFERENCE   2  (bases 1 to 3224)
  AUTHORS   Naito,Y., Koyama,S., Masuhiro,K., Hirai,T., Uenami,T., Inoue,T.,
            Osa,A., Machiyama,H., Watanabe,G., Sax,N., Villa,J.,
            Kinugasa-Katayama,Y., Nojima,S., Yaga,M., Hosono,Y., Okuzaki,D.,
            Satoh,S., Tsuda,T., Nakanishi,Y., Suga,Y., Morita,T., Fukushima,K.,
            Nishide,M., Shiroyama,T., Miyake,K., Iwahori,K., Hirata,H.,
            Nagatomo,I., Yano,Y., Tamiya,M., Kumagai,T., Takemoto,N.,
            Inohara,H., Yamasaki,S., Yamashita,K., Aoshi,T., Akbay,E.A.,
            Hosen,N., Shintani,Y., Takamatsu,H., Mori,M., Takeda,Y. and
            Kumanogoh,A.
  TITLE     Tumor-derived semaphorin 4A improves PD-1-blocking antibody
            efficacy by enhancing CD8+ T cell cytotoxicity and proliferation
  JOURNAL   Sci Adv 9 (20), eade0718 (2023)
   PUBMED   37205755
REFERENCE   3  (bases 1 to 3224)
  AUTHORS   Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
            Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
            Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
  TITLE     Motor neurons use push-pull signals to direct vascular remodeling
            critical for their connectivity
  JOURNAL   Neuron 110 (24), 4090-4107 (2022)
   PUBMED   36240771
REFERENCE   4  (bases 1 to 3224)
  AUTHORS   Xu,R., Hoss,C., Swiercz,J.M., Brandt,D.T., Lutz,V., Petersen,N.,
            Li,R., Zhao,D., Oleksy,A., Creigh-Pulatmen,T., Trokter,M.,
            Fedorova,M., Atzberger,A., Strandby,R.B., Olsen,A.A., Achiam,M.P.,
            Matthews,D., Huber,M., Grone,H.J., Offermanns,S. and Worzfeld,T.
  TITLE     A semaphorin-plexin-Rasal1 signaling pathway inhibits gastrin
            expression and protects against peptic ulcers
  JOURNAL   Sci Transl Med 14 (654), eabf1922 (2022)
   PUBMED   35857828
REFERENCE   5  (bases 1 to 3224)
  AUTHORS   Suga,Y., Nagatomo,I., Kinehara,Y., Koyama,S., Okuzaki,D., Osa,A.,
            Naito,Y., Takamatsu,H., Nishide,M., Nojima,S., Ito,D., Tsuda,T.,
            Nakatani,T., Nakanishi,Y., Futami,Y., Koba,T., Satoh,S., Hosono,Y.,
            Miyake,K., Fukushima,K., Shiroyama,T., Iwahori,K., Hirata,H.,
            Takeda,Y. and Kumanogoh,A.
  TITLE     IL-33 Induces Sema4A Expression in Dendritic Cells and Exerts
            Antitumor Immunity
  JOURNAL   J Immunol 207 (5), 1456-1467 (2021)
   PUBMED   34380650
REFERENCE   6  (bases 1 to 3224)
  AUTHORS   Oster,S.F., Bodeker,M.O., He,F. and Sretavan,D.W.
  TITLE     Invariant Sema5A inhibition serves an ensheathing function during
            optic nerve development
  JOURNAL   Development 130 (4), 775-784 (2003)
   PUBMED   12506007
REFERENCE   7  (bases 1 to 3224)
  AUTHORS   Dionne,M.S., Brunet,L.J., Eimon,P.M. and Harland,R.M.
  TITLE     Noggin is required for correct guidance of dorsal root ganglion
            axons
  JOURNAL   Dev Biol 251 (2), 283-293 (2002)
   PUBMED   12435358
REFERENCE   8  (bases 1 to 3224)
  AUTHORS   Kumanogoh,A., Marukawa,S., Suzuki,K., Takegahara,N., Watanabe,C.,
            Ch'ng,E., Ishida,I., Fujimura,H., Sakoda,S., Yoshida,K. and
            Kikutani,H.
  TITLE     Class IV semaphorin Sema4A enhances T-cell activation and interacts
            with Tim-2
  JOURNAL   Nature 419 (6907), 629-633 (2002)
   PUBMED   12374982
REFERENCE   9  (bases 1 to 3224)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
REFERENCE   10 (bases 1 to 3224)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY201883.1, AK153164.1 and AK077976.1.
            
            On Jul 22, 2009 this sequence version replaced NM_013658.2.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. All four variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK154392.1, AK077976.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 BY201883.1         2-10
            10-1808             AK153164.1         2-1800
            1809-2096           AK077976.1         1790-2077
            2097-2976           AK153164.1         2089-2968
            2977-3224           AK077976.1         2958-3205
FEATURES             Location/Qualifiers
     source          1..3224
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 38.83 cM"
     gene            1..3224
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /note="sema domain, immunoglobulin domain (Ig),
                     transmembrane domain (TM) and short cytoplasmic domain,
                     (semaphorin) 4A"
                     /db_xref="GeneID:20351"
                     /db_xref="MGI:MGI:107560"
     exon            1..214
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            215..382
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     CDS             244..2526
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /note="semaphorin-4A; sema B; semaphorin-B"
                     /codon_start=1
                     /product="semaphorin-4A precursor"
                     /protein_id="NP_038686.3"
                     /db_xref="CCDS:CCDS17475.1"
                     /db_xref="GeneID:20351"
                     /db_xref="MGI:MGI:107560"
                     /translation="MALPSLGQDSWSLLRVFFFQLFLLPSLPPASGTGGQGPMPRVKY
                     HAGDGHRALSFFQQKGLRDFDTLLLSDDGNTLYVGAREAVLALNIQNPGIPRLKNMIP
                     WPASERKKTECAFKKKSNETQCFNFIRVLVSYNATHLYACGTFAFSPACTFIELQDSL
                     LLPILIDKVMDGKGQSPFDPVHKHTAVLVDGMLYSGTMNNFLGSEPILMRTLGSQPVL
                     KTDIFLRWLHADASFVAAIPSTQVVYFFFEETASEFDFFEELYISRVAQVCKNDVGGE
                     KLLQKKWTTFLKAQLLCAQPGQLPFNIIRHAVLLPADSPSVSRIYAVFTSQWQVGGTR
                     SSAVCAFSLTDIERVFKGKYKELNKETSRWTTYRGSEVSPRPGSCSMGPSSDKALTFM
                     KDHFLMDEHVVGTPLLVKSGVEYTRLAVESARGLDGSSHVVMYLGTSTGSLHKAVVPQ
                     DSSAYLVEEIQLSPDSEPVRNLQLAPAQGAVFAGFSGGIWRVPRANCSVYESCVDCVL
                     ARDPHCAWDPESRLCSLLSGSTKPWKQDMERGNPEWVCTRGPMARSPRRQSPPQLIKE
                     VLTVPNSILELPCPHLSALASYHWSHGRAKISEASATVYNGSLLLLPQDGVGGLYQCV
                     ATENGYSYPVVSYWVDSQDQPLALDPELAGVPRERVQVPLTRVGGGASMAAQRSYWPH
                     FLIVTVLLAIVLLGVLTLLLASPLGALRARGKVQGCGMLPPREKAPLSRDQHLQPSKD
                     HRTSASDVDADNNHLGAEVA"
     exon            383..543
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            544..606
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            607..705
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            706..811
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            812..928
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1053
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1226
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            1227..1377
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            1378..1558
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            1559..1677
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            1678..1835
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            1836..1933
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
     exon            1934..3224
                     /gene="Sema4a"
                     /gene_synonym="Semab; SemB"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aagccagcca ggatctgtca caactcgagg tagaaattct ggtttccctg gcctgaaacc
       61 cacactggct ctggcaggat gggtgcctgg agggccgcgc gcccgttcca gccaggctga
      121 gcctgcttgc cttgcctgga cccccttctt tgcctcggat ggcaccctga ttcagggttt
      181 gaacacagga cttctcagtg tggctggctc aaggaaccat ctggtgacca tctcaggctg
      241 accatggccc taccatccct gggccaggac tcatggagtc tcctgcgtgt ttttttcttc
      301 caactcttcc tgctgccatc actgccacct gcttctggga ctggtggtca ggggcccatg
      361 cccagagtca aataccatgc tggagacggg cacagggccc tcagcttctt ccaacaaaaa
      421 ggcctccgag actttgacac gctgctcctg agtgacgatg gcaacactct ctatgtgggg
      481 gctcgagagg ccgtcctggc cttgaatatc cagaacccag gaatcccaag gctaaagaac
      541 atgataccct ggccagccag tgagagaaaa aagaccgaat gtgcctttaa gaagaagagc
      601 aatgagacac agtgtttcaa cttcattcga gtcctggtct cttacaatgc tactcacctc
      661 tatgcctgtg ggacctttgc cttcagccct gcctgtacct tcattgaact ccaagattcc
      721 ctcctgttgc ccatcttgat agacaaggtc atggacggga agggccaaag cccctttgac
      781 cctgttcaca agcacacagc tgtcttggtc gatgggatgc tttattccgg caccatgaac
      841 aacttcctgg gcagcgagcc catcctgatg cggacactgg gatcccagcc tgttctcaag
      901 actgacatct tcttacgctg gctgcacgcg gatgcctcct tcgtggcagc cattccatcc
      961 acccaggtcg tctatttctt ctttgaggag acagccagcg agtttgactt ctttgaagag
     1021 ctgtatatat ccagggtggc tcaagtctgc aagaacgacg tgggcggtga aaagctgctg
     1081 cagaagaagt ggaccacctt cctcaaagcc cagttgctct gcgctcagcc agggcagctg
     1141 ccattcaaca tcatccgcca cgcggtcctg ctgcccgccg attctccctc tgtttcccgc
     1201 atctacgcag tctttacctc ccagtggcag gttggcggga ccaggagctc agcagtctgt
     1261 gccttctctc tcacggacat tgagcgagtc tttaaaggga agtacaagga gctgaacaag
     1321 gagacctccc gctggaccac ttaccggggc tcagaggtca gcccgaggcc aggcagttgc
     1381 tccatgggcc cctcctctga caaagccttg accttcatga aggaccattt tctgatggat
     1441 gagcacgtgg taggaacacc cctgctggtg aagtctggtg tggagtacac acggcttgct
     1501 gtggagtcag ctcggggcct tgatgggagc agccatgtgg tcatgtatct gggtacctcc
     1561 acggggtccc tgcacaaggc tgtggtgcct caggacagca gtgcttatct cgtggaggag
     1621 attcagctga gccctgactc tgagcctgtt cgaaacctgc agctggcccc cgcccagggt
     1681 gcagtgtttg caggcttctc tggaggcatc tggagagttc ccagggccaa ttgcagtgtc
     1741 tacgagagct gtgtggactg tgtgcttgcc agggaccctc actgtgcctg ggaccctgaa
     1801 tcaagactct gcagccttct gtctggctct accaagcctt ggaagcagga catggaacgc
     1861 ggcaacccgg agtgggtatg cacccgtggc cccatggcca ggagcccccg gcgtcagagc
     1921 ccccctcaac taattaaaga agtcctgaca gtccccaact ccatcctgga gctgccctgc
     1981 ccccacctgt cagcactggc ctcttaccac tggagtcatg gccgagccaa aatctcagaa
     2041 gcctctgcta ccgtctacaa tggctccctc ttgctgctgc cgcaggatgg tgtcgggggc
     2101 ctctaccagt gtgtggcgac tgagaacggc tactcatacc ctgtggtctc ctattgggta
     2161 gacagccagg accagcccct ggcgctggac cctgagctgg cgggcgttcc ccgtgagcgt
     2221 gtgcaggtcc cgctgaccag ggtcggaggc ggagcttcca tggctgccca gcggtcctac
     2281 tggccccatt ttctcatcgt taccgtcctc ctggccatcg tgctcctggg agtgctcact
     2341 ctcctcctcg cttccccact gggggcgctg cgggctcggg gtaaggttca gggctgtggg
     2401 atgctgcccc ccagggaaaa ggctccactg agcagggacc agcacctcca gccctccaag
     2461 gaccacagga cctctgccag tgacgtagat gccgacaaca accatctggg cgccgaagtg
     2521 gcttaaacag ggacacagat ccgcagctga gcagagcaag ccactggcct tgttggctat
     2581 gccaggcaca gtgccactct gaccagggta ggaggctctc ctgctaacgt gtgtcaccta
     2641 cagcacccag taggtcctcc cctgtgggac tctcttctgc aagcacattg ggctgtctcc
     2701 atacctgtac ttgtgctgtg acaggaagag ccagacaggt ttctttgatt ttgattgacc
     2761 caagagccct cctgtaacaa acgtgctcca ggagaccatg aaaggtgtgg ctgtctggga
     2821 ttctgtggtg acaaacctaa gcatccgagc aagctggggc tattcctgca aactccatcc
     2881 tgaacgctgt cactctagaa gcagctgctg ctttgaacac cagcccaccc tccttcccaa
     2941 gagtctctat ggagttggcc ccttgtgttt cctttaccag tcatgccata ctgtttggga
     3001 agtcatctct gaagtctaac caccttcctt cttgcttcag tttggacaga ttgttattat
     3061 tgtctctgcc ctggctagaa tggggggcat aatctgagcc ttgttccctt gtccagtgtg
     3121 gctgaccctt gacctcttcc ttcctcctcc ctttgttttg ggattcagaa aactgcttgt
     3181 cacagacaat ttatttttta ttaaaaaaga tataagcttt aaag
//
