LOCUS       NM_001025379            3686 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), short basic
            domain, secreted, (semaphorin) 3G (Sema3g), mRNA.
ACCESSION   NM_001025379 XM_138955 XM_909484
VERSION     NM_001025379.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3686)
  AUTHORS   Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
            Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
            Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
  TITLE     Motor neurons use push-pull signals to direct vascular remodeling
            critical for their connectivity
  JOURNAL   Neuron 110 (24), 4090-4107 (2022)
   PUBMED   36240771
REFERENCE   2  (bases 1 to 3686)
  AUTHORS   Lu,P., Wang,P., Wu,B., Wang,Y., Liu,Y., Cheng,W., Feng,X., Yuan,X.,
            Atteya,M.M., Ferro,H., Sugi,Y., Rydquist,G., Esmaily,M.,
            Butcher,J.T., Chang,C.P., Lenz,J., Zheng,D. and Zhou,B.
  TITLE     A SOX17-PDGFB signaling axis regulates aortic root development
  JOURNAL   Nat Commun 13 (1), 4065 (2022)
   PUBMED   35831318
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3686)
  AUTHORS   Hyun,J., Lee,M., Rehman,J., Pajcini,K.V. and Malik,A.B.
  TITLE     Notch1 promotes ordered revascularization through Semaphorin 3g
            modulation of downstream vascular patterning signalling factors
  JOURNAL   J Physiol 600 (3), 509-530 (2022)
   PUBMED   34921404
  REMARK    GeneRIF: Notch1 promotes ordered revascularization through
            Semaphorin 3g modulation of downstream vascular patterning
            signalling factors.
REFERENCE   4  (bases 1 to 3686)
  AUTHORS   Chen,D.Y., Sun,N.H., Chen,X., Gong,J.J., Yuan,S.T., Hu,Z.Z.,
            Lu,N.N., Korbelin,J., Fukunaga,K., Liu,Q.H., Lu,Y.M. and Han,F.
  TITLE     Endothelium-derived semaphorin 3G attenuates ischemic retinopathy
            by coordinating beta-catenin-dependent vascular remodeling
  JOURNAL   J Clin Invest 131 (4) (2021)
   PUBMED   33586674
  REMARK    GeneRIF: Endothelium-derived semaphorin 3G attenuates ischemic
            retinopathy by coordinating beta-catenin-dependent vascular
            remodeling.
REFERENCE   5  (bases 1 to 3686)
  AUTHORS   Naganuma,H., Miike,K., Ohmori,T., Tanigawa,S., Ichikawa,T.,
            Yamane,M., Eto,M., Niwa,H., Kobayashi,A. and Nishinakamura,R.
  TITLE     Molecular detection of maturation stages in the developing kidney
  JOURNAL   Dev Biol 470, 62-73 (2021)
   PUBMED   33197428
REFERENCE   6  (bases 1 to 3686)
  AUTHORS   Matsuda,I., Fukaya,M., Nakao,H., Nakao,K., Matsumoto,H., Mori,K.,
            Watanabe,M. and Aiba,A.
  TITLE     Development of the somatosensory cortex, the cerebellum, and the
            main olfactory system in Semaphorin 3F knockout mice
  JOURNAL   Neurosci Res 66 (3), 321-329 (2010)
   PUBMED   20006658
REFERENCE   7  (bases 1 to 3686)
  AUTHORS   Kolk,S.M., Gunput,R.A., Tran,T.S., van den Heuvel,D.M.,
            Prasad,A.A., Hellemons,A.J., Adolfs,Y., Ginty,D.D., Kolodkin,A.L.,
            Burbach,J.P., Smidt,M.P. and Pasterkamp,R.J.
  TITLE     Semaphorin 3F is a bifunctional guidance cue for dopaminergic axons
            and controls their fasciculation, channeling, rostral growth, and
            intracortical targeting
  JOURNAL   J Neurosci 29 (40), 12542-12557 (2009)
   PUBMED   19812329
REFERENCE   8  (bases 1 to 3686)
  AUTHORS   Yoshida,Y., Han,B., Mendelsohn,M. and Jessell,T.M.
  TITLE     PlexinA1 signaling directs the segregation of proprioceptive
            sensory axons in the developing spinal cord
  JOURNAL   Neuron 52 (5), 775-788 (2006)
   PUBMED   17145500
REFERENCE   9  (bases 1 to 3686)
  AUTHORS   Takemoto,M., He,L., Norlin,J., Patrakka,J., Xiao,Z., Petrova,T.,
            Bondjers,C., Asp,J., Wallgard,E., Sun,Y., Samuelsson,T., Mostad,P.,
            Lundin,S., Miura,N., Sado,Y., Alitalo,K., Quaggin,S.E.,
            Tryggvason,K. and Betsholtz,C.
  TITLE     Large-scale identification of genes implicated in kidney glomerulus
            development and function
  JOURNAL   EMBO J 25 (5), 1160-1174 (2006)
   PUBMED   16498405
REFERENCE   10 (bases 1 to 3686)
  AUTHORS   Taniguchi,M., Masuda,T., Fukaya,M., Kataoka,H., Mishina,M.,
            Yaginuma,H., Watanabe,M. and Shimizu,T.
  TITLE     Identification and characterization of a novel member of murine
            semaphorin family
  JOURNAL   Genes Cells 10 (8), 785-792 (2005)
   PUBMED   16098142
  REMARK    GeneRIF: In adulthood, Sema3G is mainly expressed in the lung and
            kidney, and a little in the brain. We also found that Sema3G binds
            Neuropilin-2, but not Neuropilin-1, and induces the repulsion of
            sympathetic axons.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AB127607.1.
            
            On or before Jan 13, 2006 this sequence version replaced
            XM_909484.1, XM_138955.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB127607.1, AK129018.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 19.09 cM"
     gene            1..3686
                     /gene="Sema3g"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, (semaphorin) 3G"
                     /db_xref="GeneID:218877"
                     /db_xref="MGI:MGI:3041242"
     exon            1..153
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..2381
                     /gene="Sema3g"
                     /note="semaphorin-3G; Semaphorin 3G"
                     /codon_start=1
                     /product="semaphorin-3G precursor"
                     /protein_id="NP_001020550.1"
                     /db_xref="CCDS:CCDS26908.1"
                     /db_xref="GeneID:218877"
                     /db_xref="MGI:MGI:3041242"
                     /translation="MDPSAWAICCLLGSLLFHVGIPSPGPSPSVPRLRLSYRDLLSTN
                     RSAIFLGPRGSLDLQVMYLDEYRDRLFLGSRDALYSLRLDQAWPDPREVLWLPQPGQK
                     VECVRKGKDPLTECANFVRVLQPHNRTHLLACGTGAFQPICTFITVGHRGEHVLRLDA
                     SSVENGRGRCPHEPSRPFASTFVGGELYTGLTADFLGREAMIFRSGGPRPALRSDSDQ
                     SLLHEPRFVMAARIPDNSDRDDDKVYFFFSETVPSPDGGPGHVTISRVGRVCVNDAGG
                     QRVLVNKWSTFLKARLVCSVPGPGGAETHFDQLEDVFLLWPKAGKSLEVYALFSTVSA
                     VFQGFAVCVYHMVDIWEVFNGPFAHRDGPQHQWGPYGGKVPFPRPGVCPSKMTAQPGR
                     PFGSTKDYPDEVLQFVRDHPLMFQPVRPRRGRPVLVKTHLAQRLRQIVVDRVEAEDGT
                     YDVIFLGTDSGSVLKVIALQGGGLTEPEEVVLEELQVFKVPTPITEMEISVKRQTLYV
                     GSPLGVARLQLHQCETYGSACAECCLARDPYCAWDGTACARYRPSSGKRRFRRQDIRH
                     GNPAVQCLGQGQSQNKAASGLMTRVFGTEHNSTFLECLPKSPQAAVRWFLQRPGDKGT
                     DQVKTDERVVQTAQGLLFRRLSRHDAGNYTCTTLEHGFSQTVVRFALEVIAAVQLDSL
                     FLRESRLEEPSAWGSLASASPKTWYKDILQLTGFANLPRVDEYCERVWCRGVGERSGS
                     FRGKGKQAKGKSWAGLELGKKMKSRVLAEHNRTPREVEAT"
     exon            154..314
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            315..377
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            378..497
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            498..588
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            589..705
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            706..851
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            852..966
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            967..1036
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1037..1181
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1182..1413
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..1505
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1506..1547
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1548..1782
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1783..1916
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
     exon            1917..3686
                     /gene="Sema3g"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagcaggatc agagggcagc tcattttttt ttcccagcat ggacccatct gcgtgggcca
       61 tctgctgcct cctggggagc cttctgttcc atgtgggcat ccccagccct ggtcccagcc
      121 ccagtgtgcc tcgtctgcgg ctctcctaca gagatctcct gtctaccaac cgctctgcca
      181 tctttctggg cccacggggt tccctagacc tccaagtcat gtacctggat gagtatcgag
      241 atcgcctctt tctgggaagc cgagatgccc tttactctct gagactggat caggcatggc
      301 cagacccccg ggaggtcttg tggctgccac agccaggaca gaaggtggaa tgtgtccgca
      361 agggaaaaga ccctttgacg gagtgtgcca acttcgtgcg ggtcttacaa ccccataacc
      421 ggacccatct gctggcctgt ggcacaggag ccttccaacc catctgcacc ttcatcacag
      481 tggggcatcg aggggagcat gtgctccgct tggatgctag cagcgtcgag aatggaaggg
      541 ggcgttgccc acatgagccc agccgaccct tcgccagcac ctttgtaggt ggggagctat
      601 acacaggtct cactgccgat ttcctgggac gtgaggccat gattttccgg agtgggggtc
      661 cccgaccagc cctgcgttct gactctgacc agagcctcct acatgaaccc cggtttgtga
      721 tggctgctcg gatcccagat aactctgacc gggacgacga caaggtgtac ttcttcttct
      781 ccgagactgt cccgtcacca gatggtggcc caggtcatgt caccatcagc cgagtgggcc
      841 gcgtctgtgt gaatgatgct ggtggccagc gggtgctggt gaacaaatgg agcactttcc
      901 tcaaggcccg gctggtgtgc tctgtgcctg gcccgggtgg ggctgagact cactttgacc
      961 agctagagga tgtgttcctg ctgtggccca aggccgggaa gagcctcgag gtgtatgcgc
     1021 tgttcagcac tgtcagtgct gtgttccagg gctttgctgt ctgtgtgtac cacatggtag
     1081 acatctggga ggtcttcaat gggccctttg cccaccgaga tggccctcag catcagtggg
     1141 gaccctatgg gggcaaggtg cccttccctc gccccggtgt gtgtcctagc aagatgaccg
     1201 cacagccagg ccgacccttt ggcagcacca aggactaccc agacgaggtg ttgcagtttg
     1261 tccgagacca cccactcatg ttccagcctg tgaggcctcg gcgtggccgc cctgtcctgg
     1321 tcaaaactca cttggctcag cgactgcgcc agattgtggt ggatcgagtg gaggctgagg
     1381 atgggaccta tgatgtcatc ttcctaggga ctgattcggg ttctgtgctc aaagtcattg
     1441 ccctccaggg tggtggcttg actgaacctg aagaggtggt tttggaggag ctccaggtgt
     1501 ttaaggtgcc aacgcccatc actgagatgg agatctctgt caaaaggcaa acgctgtatg
     1561 tgggctctcc actgggtgtg gcccggctgc agctgcacca gtgtgagact tacggcagtg
     1621 cctgtgctga gtgctgcctg gcccgggacc catactgtgc ttgggatggc actgcctgtg
     1681 cccgctaccg ccccagctct ggcaagcgca ggttccgtcg gcaggacata cgccatggca
     1741 accctgctgt gcagtgtctg ggccagggcc agagccaaaa caaagcagct tcggggctca
     1801 tgaccagagt ctttggcaca gagcacaaca gcaccttcct tgagtgcctg cccaagtctc
     1861 ctcaggctgc agtgcgctgg ttcttacaaa ggccagggga taaggggact gaccaggtga
     1921 agacagatga gagagttgtg cagacggccc aagggctgct gttccgaagg ctcagccgcc
     1981 atgacgcagg aaactacact tgcaccactc tggaacatgg cttctcccag accgtggtcc
     2041 gttttgccct ggaggtgatt gcagctgtgc aactggacag cctgttcctt cgggagtcaa
     2101 ggctagagga gccctcagcc tggggaagcc tggcctctgc ctcccccaag acttggtata
     2161 aggacatcct tcagctcacg ggcttcgcca acctgccccg tgtggatgag tactgtgaac
     2221 gtgtatggtg caggggtgtc ggggagcgct caggctcctt ccgcggaaag ggaaagcaag
     2281 cgaagggcaa gagctgggca gggctggaac tgggcaagaa gatgaagagc agggtgctgg
     2341 ctgagcacaa tcggacaccc cgggaggtag aagccacata gaagatgact gaggagcagg
     2401 tggtcgggct gggctggggg actcaacggt atctctctcc cacccagcta ggaaagagga
     2461 gtccagaact cctgattgat tacctcttag aggaaatctc caccacctac aggaaagact
     2521 aggggttggt gggaggagcc ttgcacctca gcctacccct gcctttctcc gagttctcag
     2581 tcccgggctg gaactggcac ctccagacca cttgtagtcc caaggggcct gctatttgtt
     2641 ctcagagatg gtgtggcttc cggagcacat ttccggttgt gcccagaggc aaggcgggtg
     2701 gttctttccc agcttgctga acaatggcca ttctgagtga ccctctgagt gggtgtatgg
     2761 gtggctctaa gggagtatat attgtcagtc caccagagga ggggaaagta gattcctaag
     2821 gtagaacctg ataagaaaca cttgccccac agaggtgtga gagaaggtgg aggcgctgag
     2881 gaggtggggt tgtgctgttt atctgtctcc atgctttgga atctagatga ttccctgcct
     2941 cagctccctc ccatctccta ctcacagagg caggaactgc tgggacctgg aggttgcctg
     3001 ggcctggccc ttgccccctt tttaaacttg gaagagttgt ctcacaatat gatacccttt
     3061 cccaggtccc acattgtcag gccaggcttg ctggggtgct cacacctcac catcagagtg
     3121 tcttcctggg accaggggaa ggttctgtgg accagaaaga ggaagtgggg agctggaggg
     3181 taggagtgcc tcgaaggatg ggctaccttt ccgagggtga ggcgggcatg ctcaggccgg
     3241 tgaggttagc aacggacact ctgaaaacca gcagccagtg gtgaggatcg gcctcctggg
     3301 ctttgtctag ggccacgagg aactagagag aggtgagacc atgggtccat gggtccatga
     3361 gcaggtgtcc tcaagagcca aggtgacatt agttggttca ggagcccctg ggcaggccag
     3421 atacttccaa tgctagagtc tctactgagg gtggtcatga cagttcgttt acaagactcc
     3481 catggttttt tgtggtactt gggattgaat ctagggtctc atgcatgctg gataaatgct
     3541 ctaccactga gtgaaagccc agctctctct ctatgggaga acagaaagct ggtatggtaa
     3601 atcctgctgt tctgggggtg ggggtggggc tgagtgacaa gggctgggga gaagcttggc
     3661 catcagcagt ttctgcagct ggggag
//
