LOCUS       NM_001405023            3776 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), short basic
            domain, secreted, (semaphorin) 3F (Sema3f), transcript variant 4,
            mRNA.
ACCESSION   NM_001405023 XM_017313226
VERSION     NM_001405023.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3776)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3776)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 3776)
  AUTHORS   Puelles,L. and Hidalgo-Sanchez,M.
  TITLE     The Midbrain Preisthmus: A Poorly Known Effect of the Isthmic
            Organizer
  JOURNAL   Int J Mol Sci 24 (11), 9769 (2023)
   PUBMED   37298722
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3776)
  AUTHORS   Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
            Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
            Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
  TITLE     Motor neurons use push-pull signals to direct vascular remodeling
            critical for their connectivity
  JOURNAL   Neuron 110 (24), 4090-4107 (2022)
   PUBMED   36240771
REFERENCE   5  (bases 1 to 3776)
  AUTHORS   Gerstmann,K., Kindbeiter,K., Telley,L., Bozon,M., Reynaud,F.,
            Theoulle,E., Charoy,C., Jabaudon,D., Moret,F. and Castellani,V.
  TITLE     A balance of noncanonical Semaphorin signaling from the
            cerebrospinal fluid regulates apical cell dynamics during
            corticogenesis
  JOURNAL   Sci Adv 8 (46), eabo4552 (2022)
   PUBMED   36399562
REFERENCE   6  (bases 1 to 3776)
  AUTHORS   Jimenez,D., Garcia,C., de Castro,F., Chedotal,A., Sotelo,C., de
            Carlos,J.A., Valverde,F. and Lopez-Mascaraque,L.
  TITLE     Evidence for intrinsic development of olfactory structures in Pax-6
            mutant mice
  JOURNAL   J Comp Neurol 428 (3), 511-526 (2000)
   PUBMED   11074448
REFERENCE   7  (bases 1 to 3776)
  AUTHORS   Giger,R.J., Cloutier,J.F., Sahay,A., Prinjha,R.K., Levengood,D.V.,
            Moore,S.E., Pickering,S., Simmons,D., Rastan,S., Walsh,F.S.,
            Kolodkin,A.L., Ginty,D.D. and Geppert,M.
  TITLE     Neuropilin-2 is required in vivo for selective axon guidance
            responses to secreted semaphorins
  JOURNAL   Neuron 25 (1), 29-41 (2000)
   PUBMED   10707970
REFERENCE   8  (bases 1 to 3776)
  AUTHORS   Eckhardt,F. and Meyerhans,A.
  TITLE     Cloning and expression pattern of a murine semaphorin homologous to
            H-sema IV
  JOURNAL   Neuroreport 9 (17), 3975-3979 (1998)
   PUBMED   9875739
REFERENCE   9  (bases 1 to 3776)
  AUTHORS   Chedotal,A., Del Rio,J.A., Ruiz,M., He,Z., Borrell,V., de
            Castro,F., Ezan,F., Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and
            Soriano,E.
  TITLE     Semaphorins III and IV repel hippocampal axons via two distinct
            receptors
  JOURNAL   Development 125 (21), 4313-4323 (1998)
   PUBMED   9753685
REFERENCE   10 (bases 1 to 3776)
  AUTHORS   Tajbakhsh,S., Borello,U., Vivarelli,E., Kelly,R., Papkoff,J.,
            Duprez,D., Buckingham,M. and Cossu,G.
  TITLE     Differential activation of Myf5 and MyoD by different Wnts in
            explants of mouse paraxial mesoderm and the later activation of
            myogenesis in the absence of Myf5
  JOURNAL   Development 125 (21), 4155-4162 (1998)
   PUBMED   9753670
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC152718.6 and AC162905.4.
            
            On Apr 19, 2022 this sequence version replaced XM_017313226.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMN00849374, SAMN00849375
                              [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-545               AC152718.6         118443-118987
            546-706             AC152718.6         122814-122974
            707-867             AC162905.4         2609-2769
            868-930             AC162905.4         2874-2936
            931-1050            AC162905.4         3038-3157
            1051-1143           AC162905.4         3877-3969
            1144-1237           AC162905.4         5546-5639
            1238-1357           AC162905.4         6976-7095
            1358-1497           AC162905.4         7237-7376
            1498-1612           AC162905.4         7481-7595
            1613-1682           AC162905.4         7766-7835
            1683-1827           AC162905.4         7991-8135
            1828-2050           AC162905.4         9778-10000
            2051-2139           AC162905.4         10549-10637
            2140-2181           AC162905.4         10734-10775
            2182-2339           AC162905.4         10946-11103
            2340-2407           AC162905.4         11285-11352
            2408-3776           AC162905.4         11632-13000
FEATURES             Location/Qualifiers
     source          1..3776
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.91 cM"
     gene            1..3776
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, (semaphorin) 3F"
                     /db_xref="GeneID:20350"
                     /db_xref="MGI:MGI:1096347"
     exon            1..545
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            546..706
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     CDS             595..3057
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /note="isoform 4 precursor is encoded by transcript
                     variant 4; semaphorin-3F; semaphorin IV"
                     /codon_start=1
                     /product="semaphorin-3F isoform 4 precursor"
                     /protein_id="NP_001391952.1"
                     /db_xref="GeneID:20350"
                     /db_xref="MGI:MGI:1096347"
                     /translation="MLVTAFILWASLLTGAWPATPIQDQLPATPRVRLSFKELKATGT
                     AHFFNFLLNTTDYRILLKDEDHDRMYVGSKDYVLSLDLHDINREPLIIHWAASPQRIE
                     ECILSGKDGNGECGNFVRLIQPWNRTHLYVCGTGAYNPMCTYVNRGRRAQALPWTQMQ
                     VVRGRGSRATDGADRPTPTAPRQDYIFYLEPEKLESGKGKCPYDPKLDTASALINEEL
                     YAGVYIDFMGTDAAIFRTLGKQTAMRTDQYNSRWLNDPSFIHAELIPDSAERNDDKLY
                     FFFRERSAEAPQNPAVYARIGRICLNDDGGHCCLVNKWSTFLKARLVCSVPGEDGIET
                     HFDELQDVFVQQTQDVRNPVIYAVFTSSGSVFRGSAVCVYSMADIRMVFNGPFAHKEG
                     PNYQWMPFSGKMPYPRPGTCPGGTFTPSMKSTKDYPDEVINFMRTHPLMYQAVYPLQR
                     RPLVVRTGAPYRLTTVAVDQVDAADGRYEVLFLGTDRGTVQKVIVLPKDDQEVEELML
                     EEVEVFKEPAPVKTMTISSKRQQLYVASAVGVTHLSLHRCQAYGAACADCCLARDPYC
                     AWDGQACSRYTASSKRRSRRQDVRHGNPIRQCRGFNSNANKNAVESVQYGVAGSAAFL
                     ECQPRSPQATVKWLFQRDPSDRRREVSSCVLSPPPTPTPRGYAAPWIWEFFYSGESLR
                     EKCTSVASLGQPSTGEAKAGGSLEFKASLVYRASSRSTPPGLPRETQKNKKFRICTLS
                     GLYLLVWNITWVSSSIWKFCGYFLGKPSPCSSSRGNAMRVSQLGILIKWKFCVRSKIF
                     SFIVQKPRPPPPQPQPPGHHPS"
     exon            707..867
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            868..930
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1050
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1051..1143
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1237
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1238..1357
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1358..1497
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1498..1612
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1613..1682
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1683..1827
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..2050
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            2051..2139
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            2140..2181
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            2182..2339
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            2340..2407
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..3776
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3745..3750
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /note="hexamer: TATAAA"
     polyA_site      3776
                     /gene="Sema3f"
                     /gene_synonym="Sema4; Semak"
                     /note="major polyA site"
ORIGIN      
        1 gagcgtcccg tcccgccagc ggcctcgaga cctgagcagc tagggaacaa accgcagcgg
       61 tccagggagc cccgagcgca gcgtagagcc agggtacgct tcgaggaccc gcgcagcccc
      121 gctcggtctc cgggccctag tcagacagcc aggcaagcgc agcgccaccc ggccgagccc
      181 agcgcagcgc tctgtagcct agcgcgcgcc accgcccgcg ccccgcaccg gggaatgcgc
      241 cctcggcgcg caggccaggg ggcgcccgca gcccgccccg ggggaggcgg ccccgagcgc
      301 ccctgagcct ttccatggcc cgggctaggg cccggggcct cggctgctga cgtgcacgaa
      361 gccaggggac ccagtgaagc cgagtccgcg gtgcggatcc cggctcaggc taagagacaa
      421 gagggcgcgg acagggccgt ggcccggggg gggggcagct aaagcggacc ggccggacgc
      481 gaacctctcc gctgctgcgg cggccaccgc tgcccgggcg cccaggcccc gccgccgtgg
      541 acgaggtgtc cacagaactg gagcctgctt cctgggcccc aggcccctcc cacgatgctt
      601 gtcactgcct tcatcctctg ggcttccctg ctgaccgggg cctggcctgc tacccctatc
      661 caggaccagc ttccagccac acctagagtc cgactgtcat tcaaagaact taaggccacc
      721 ggtaccgccc acttcttcaa ctttctgctc aacactacag actacagaat cctgctcaag
      781 gatgaggacc atgaccgcat gtatgtgggc agcaaggact acgtgctgtc cctggacctg
      841 catgacatca accgagagcc ccttattatc cattgggcag cctccccgca gcgcattgag
      901 gagtgcatac tgtcaggcaa ggatggcaat ggagagtgtg gtaacttcgt ccggctcatc
      961 cagccttgga accgaacaca cctgtatgtg tgtgggaccg gtgcctacaa ccccatgtgc
     1021 acctatgtga accgtggccg tcgcgcacag gccctaccgt ggacccagat gcaggtggtc
     1081 agaggccgag gcagcagggc caccgatggt gccgaccgcc cgacgcccac agccccacgc
     1141 caggattaca tcttctacct ggagcctgag aaactggagt caggaaaagg caaatgtccc
     1201 tatgacccca agctggacac agcctcagcc ctcatcaatg aggaactcta tgcaggagtg
     1261 tacatcgatt ttatgggtac cgatgcagcc attttccgca cgctggggaa gcagacagcc
     1321 atgcgcacag atcagtacaa ctcccggtgg ctcaatgatc cttccttcat acatgctgag
     1381 ctcatccctg acagtgcaga gcgcaatgac gataaactct acttcttctt ccgagagcgc
     1441 tcggcagagg cgccacagaa ccctgctgtg tatgcccgca tcgggcgcat ctgcctcaac
     1501 gatgacggtg gccattgctg cctggtcaac aagtggagca cattcctgaa ggctcggctc
     1561 gtctgctccg tgccaggcga ggatggtatt gagacccact tcgacgaact ccaggatgtg
     1621 tttgtccagc agacccagga cgtcaggaac ccagtcattt atgctgtctt tacctcttca
     1681 ggctctgtgt tccgagggtc tgcagtgtgt gtctactcca tggctgatat ccgcatggtc
     1741 ttcaatgggc cttttgctca caaggagggc cccaactatc aatggatgcc cttctcagga
     1801 aagatgccct atcctcggcc tggcacatgc cctggtggaa ccttcacgcc ctcgatgaag
     1861 tccactaagg actaccctga tgaagtgatc aacttcatgc gcactcatcc gctcatgtac
     1921 caggccgtct acccgctcca gcggcgaccc ctggtggtcc gtacaggcgc tccctaccgc
     1981 ctcaccactg tcgctgtgga ccaggtggat gcagctgatg gacgctatga ggtgcttttc
     2041 ctgggcacag accgcgggac agtgcagaag gtcatcgtgc tgcccaagga cgaccaggag
     2101 gtggaagagc tgatgctaga ggaagtggag gtcttcaagg aaccagcacc tgttaagacc
     2161 atgaccatct cttccaagag gcaacaactg tatgtggcct cagccgtggg tgtcacacac
     2221 ctgagcctgc accgctgcca ggcctatgga gctgcctgtg ccgactgctg ccttgcccgc
     2281 gatccctact gtgcctggga tggccaggcc tgctctcgct acacagcatc ctccaagagg
     2341 cggagtcgcc ggcaagatgt ccgccacggg aaccctatca gacagtgccg tggtttcaat
     2401 tccaatgcaa acaagaatgc cgtagagtct gtgcagtacg gagtggccgg cagcgcagct
     2461 ttccttgagt gtcagccccg ctcacctcaa gccactgtca agtggctgtt ccagcgagat
     2521 cccagtgatc ggcgccgtga ggtgagttcc tgtgtccttt ccccaccccc cacccccacc
     2581 cccaggggct atgctgcacc gtggatatgg gagttctttt acagcggtga gtccttgaga
     2641 gagaaatgta ctagtgtggc cagcctgggg cagcccagca ctggggaggc aaaggcaggc
     2701 ggatctcttg agttcaaggc cagtctggtc tacagagcaa gttccaggag caccccacca
     2761 gggctaccca gagaaaccca aaagaacaaa aaattccgta tctgtactct gtcggggtta
     2821 taccttcttg tttggaacat cacgtgggtg agctccagta tatggaaatt ctgtggatat
     2881 tttctgggaa agccctcccc gtgttcctct tcccgtggaa atgctatgcg ggtgtcgcaa
     2941 ttgggtattc tcattaaatg gaaattctgt gtgcgctcca aaattttctc attcattgtt
     3001 cagaaaccac gcccaccgcc cccccaaccc caacccccgg gtcatcatcc ttcctgaaag
     3061 tgggaatatt tgtggatacc ttattcatat ccctctcacg tacaaacagt acctggggct
     3121 atttttctct tcttggaata tgaaaatgcc acgtgggtgt ctctacttgg aatggtcaca
     3181 aacgtggtgg tctcacctgg aagctggcta gggccttgga gtggtgaccc aacccctgag
     3241 ccccaccccc tgcccctgca gattcgcgca gaggaccgct tcctgcgtac agagcagggg
     3301 ctgttgcttc gcgccctgca gcttggtgac cgcggcctct actcctgcac ggccactgag
     3361 aacaacttca agcacatcgt cacgcgggtg cagctgcatg tactgggccg ggatgccgtc
     3421 catgctgccc tcttcccccc actggctgtg agcgtccctc cacctcctgg cacaggccct
     3481 ccaacgcctc cttaccagga gctggcccag ctcctagccc agccggaagt gggcctcatc
     3541 catcagtact gccagggtta ctggcgccac gtgcccccca gacccaggga ggcgccagga
     3601 gcacttaggc ctcctgaact ccaggaccag aaaaagccga ggaaccgccg ccaccaccct
     3661 ccggacacat gaggccagct gctggaggcc tgcataggac cagcctagcc cctcatccct
     3721 tttaatataa aagatatata tatatataaa aatatctata ttctatacat acccta
//
