LOCUS       NM_013657               4956 bp    mRNA    linear   ROD 19-NOV-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), short basic
            domain, secreted, (semaphorin) 3C (Sema3c), mRNA.
ACCESSION   NM_013657
VERSION     NM_013657.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4956)
  AUTHORS   Pineiro-Sabaris,R., MacGrogan,D. and de la Pompa,J.L.
  TITLE     Deficient GATA6-CXCR7 signaling leads to bicuspid aortic valve
  JOURNAL   Dis Model Mech 17 (9) (2024)
   PUBMED   39253784
REFERENCE   2  (bases 1 to 4956)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4956)
  AUTHORS   Kibalnyk,Y., Afanasiev,E., Noble,R.M.N., Watson,A.E.S.,
            Poverennaya,I., Dittmann,N.L., Alexiou,M., Goodkey,K.,
            Greenwell,A.A., Ussher,J.R., Adameyko,I., Massey,J., Graf,D.,
            Bourque,S.L., Stratton,J.A. and Voronova,A.
  TITLE     The chromatin regulator Ankrd11 controls cardiac neural crest
            cell-mediated outflow tract remodeling and heart function
  JOURNAL   Nat Commun 15 (1), 4632 (2024)
   PUBMED   38951500
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4956)
  AUTHORS   Kim,N., Li,Y., Yu,R., Kwon,H.S., Song,A., Jun,M.H., Jeong,J.Y.,
            Lee,J.H., Lim,H.H., Kim,M.J., Kim,J.W. and Oh,W.J.
  TITLE     Repulsive Sema3E-Plexin-D1 signaling coordinates both axonal
            extension and steering via activating an autoregulatory factor,
            Mtss1
  JOURNAL   Elife 13, e96891 (2024)
   PUBMED   38526535
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4956)
  AUTHORS   Bhat,G.P., Maurizio,A., Motta,A., Podini,P., Diprima,S.,
            Malpighi,C., Brambilla,I., Martins,L., Badaloni,A., Boselli,D.,
            Bianchi,F., Pellegatta,M., Genua,M., Ostuni,R., Del Carro,U.,
            Taveggia,C., de Pretis,S., Quattrini,A. and Bonanomi,D.
  TITLE     Structured wound angiogenesis instructs mesenchymal barrier
            compartments in the regenerating nerve
  JOURNAL   Neuron 112 (2), 209-229 (2024)
   PUBMED   37972594
REFERENCE   6  (bases 1 to 4956)
  AUTHORS   Chedotal,A., Del Rio,J.A., Ruiz,M., He,Z., Borrell,V., de
            Castro,F., Ezan,F., Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and
            Soriano,E.
  TITLE     Semaphorins III and IV repel hippocampal axons via two distinct
            receptors
  JOURNAL   Development 125 (21), 4313-4323 (1998)
   PUBMED   9753685
REFERENCE   7  (bases 1 to 4956)
  AUTHORS   Chen,H., Chedotal,A., He,Z., Goodman,C.S. and Tessier-Lavigne,M.
  TITLE     Neuropilin-2, a novel member of the neuropilin family, is a high
            affinity receptor for the semaphorins Sema E and Sema IV but not
            Sema III
  JOURNAL   Neuron 19 (3), 547-559 (1997)
   PUBMED   9331348
  REMARK    Erratum:[Neuron 1997 Sep;19(3):559]
REFERENCE   8  (bases 1 to 4956)
  AUTHORS   Adams,R.H., Betz,H. and Puschel,A.W.
  TITLE     A novel class of murine semaphorins with homology to thrombospondin
            is differentially expressed during early embryogenesis
  JOURNAL   Mech Dev 57 (1), 33-45 (1996)
   PUBMED   8817451
REFERENCE   9  (bases 1 to 4956)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
REFERENCE   10 (bases 1 to 4956)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC161507.2 and
            AC122936.3.
            
            On Nov 17, 2006 this sequence version replaced NM_013657.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC066852.1, AK140348.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AC161507.2         85458-85607         c
            151-291             AC161507.2         83453-83593         c
            292-452             AC161507.2         6555-6715           c
            453-515             AC161507.2         5358-5420           c
            516-635             AC122936.3         125229-125348
            636-726             AC122936.3         132759-132849
            727-846             AC122936.3         134738-134857
            847-989             AC122936.3         137351-137493
            990-1104            AC122936.3         138620-138734
            1105-1174           AC122936.3         140621-140690
            1175-1319           AC122936.3         144248-144392
            1320-1542           AC122936.3         156952-157174
            1543-1631           AC122936.3         173695-173783
            1632-1673           AC122936.3         176720-176761
            1674-1831           AC122936.3         179220-179377
            1832-1899           AC122936.3         184163-184230
            1900-2030           AC122936.3         186390-186520
            2031-4956           AC122936.3         189652-192577
FEATURES             Location/Qualifiers
     source          1..4956
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 7.99 cM"
     gene            1..4956
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, (semaphorin) 3C"
                     /db_xref="GeneID:20348"
                     /db_xref="MGI:MGI:107557"
     exon            1..150
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            151..291
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     CDS             189..2444
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /note="semaphorin-3C; semaphorin E; sema E"
                     /codon_start=1
                     /product="semaphorin-3C precursor"
                     /protein_id="NP_038685.3"
                     /db_xref="CCDS:CCDS19099.1"
                     /db_xref="GeneID:20348"
                     /db_xref="MGI:MGI:107557"
                     /translation="MAFRAICVLVGVFICSICVRGSSQPQARVYLTFDELRETKTSEY
                     FSLSHQQLDYRILLMDEDQDRIYVGSKDHILSLNINNISQEPLSVFWPASTIKVEECK
                     MAGKDPTHGCGNFVRVIQTFNRTHLYVCGSGAFSPVCTYLNRGRRSEDQVFMIDSKCE
                     SGKGRCSFNPNVNTVSVMINEELFSGMYIDFMGTDAAIFRSLTKRNAVRTDQHNSKWL
                     SEPMFVDAHVIPDGTDPNDAKVYFFFKERLTDNNRSTKQIHSMIARICPNDTGGQRSL
                     VNKWTTFLKARLVCSVTDEDGPETHFDELEDVFLLETDNPRTTLVYGIFTTSSSVFKG
                     SAVCVYHLSDIQTVFNGPFAHKEGPNHQLISYQGRIPYPRPGTCPGGAFTPNMRTTKD
                     FPDDVVTFIRNHPLMYNSIYPIHRRPLIVRIGTDYKYTKIAVDRVNAADGRYHVLFLG
                     TDRGTVQKVVVLPTNSSASGELILEELEVFKNHVPITTMKISSKKQQLYVSSNEGVSQ
                     VSLHRCHIYGTACADCCLARDPYCAWDGHSCSRFYPTGKRRSRRQDVRHGNPLTQCRG
                     FNLKAYRNAAEIVQYGVRNNSTFLECAPKSPQASIKWLLQKDKDRRKEVKLNERIIAT
                     SQGLLIRSVQDSDQGLYHCIATENSFKQTIAKINFKVLDSEMVAVVTDKWSPWTWAGS
                     VRALPFHPKDILGAFSHSEMQLINQYCKDTRQQQQLGEEPQKMRGDYGKLKALINSRK
                     SRNRRNQLPES"
     exon            292..452
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            453..515
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            516..635
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            636..726
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            727..846
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            847..989
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1104
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1174
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1175..1319
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1542
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1543..1631
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1632..1673
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1674..1831
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1832..1899
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            1900..2030
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..4956
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4932..4937
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /note="hexamer: AATAAA"
     polyA_site      4956
                     /gene="Sema3c"
                     /gene_synonym="1110036B02Rik; Semae; SemE"
                     /note="major polyA site"
ORIGIN      
        1 ctgctacaaa gaaactcagc accggccggc aggaatccca ccctccggac tcactaagtc
       61 tttaaaggtc ttctggggaa aggacctagg ggactggaaa tccaagcccg gagcaagtgg
      121 ctgacttctc ctggatcttt tcccacctcg gtattttccc ttggatatta attcccaaat
      181 cagaagaaat ggcattccgg gcgatttgtg tgttggttgg agtatttatt tgttccattt
      241 gtgtacgagg atcttcccag ccccaagcaa gagtttattt aacatttgat gagcttcgag
      301 aaaccaaaac ctctgagtac tttagtctgt cccaccagca gttagactac agaatattgc
      361 tgatggatga agatcaagac cggatatatg tggggagcaa agaccacatc ctgtctttga
      421 atatcaacaa tatcagtcaa gaacctttga gtgttttctg gccagcatca acaatcaaag
      481 ttgaagagtg caaaatggct ggcaaagatc ctacacatgg ctgtggaaat ttcgtccggg
      541 tgattcagac attcaaccgt actcacctgt atgtctgtgg gagtggagcg ttcagcccag
      601 tgtgcaccta cctgaaccgg ggaaggaggt cagaggacca ggtattcatg atcgactcta
      661 agtgtgaatc tggcaaagga cgatgctctt tcaacccgaa tgtgaacact gtgtctgtta
      721 tgatcaatga ggaactcttc tcaggaatgt atatagactt catgggaaca gatgctgcta
      781 ttttccgaag tttaactaag aggaatgcag ttcgaactga tcaacataat tcaaaatggc
      841 tgagtgaacc catgtttgtg gacgcacatg tgatcccaga tggcactgat ccaaatgatg
      901 ctaaggtcta tttcttcttc aaagaaagac tgactgacaa caataggagc acaaaacaga
      961 ttcattccat gattgcaaga atatgcccta atgacactgg tggacaacgt agtcttgtca
     1021 acaagtggac cacattctta aaggcaagac ttgtatgctc agtcacagat gaagatggcc
     1081 cagagacaca ttttgatgaa ctagaggatg tctttctgct ggaaactgac aatccaagga
     1141 caacactcgt gtatggcatc ttcaccacat caagctctgt ttttaaggga tcggcagtgt
     1201 gtgtgtatca tttatctgat atacagactg tattcaatgg gccctttgcc cacaaggaag
     1261 ggcccaatca ccagctgatc tcctatcaag gtagaatccc atatcctcgc ccaggaactt
     1321 gcccaggagg ggcctttaca cccaatatga gaaccaccaa ggacttccca gatgacgttg
     1381 tcacttttat tcggaaccac cctctcatgt acaattccat ctaccccatc cacagaaggc
     1441 ctctgatagt ccgcataggc actgactaca agtacacaaa gattgctgtg gaccgtgtca
     1501 acgctgctga tgggagatac cacgttctgt ttctgggcac agatcggggc accgtgcaga
     1561 aggtcgtagt ccttcctacc aatagctctg ccagtgggga actcatcctg gaggagctgg
     1621 aagtcttcaa gaatcatgtt cccataacaa caatgaaaat ctcatccaaa aagcaacagt
     1681 tgtacgtgag ctccaatgag ggggtttccc aagtctctct gcatcgctgc catatctacg
     1741 gcacagcctg tgcggactgc tgcttggcga gggatccata ctgtgcctgg gatggccact
     1801 cttgctctag gttctacccc actgggaagc ggaggagccg aagacaagat gtgagacatg
     1861 gaaacccact gacacaatgc cgagggttca atctgaaagc atacagaaat gcagctgaaa
     1921 ttgttcagta tggagtaaga aataacagca ctttccttga gtgtgctccc aagtctccac
     1981 aggcatctat caagtggttg ctgcagaaag acaaagacag gaggaaggag gttaaactga
     2041 acgagcgcat tatagctact tcccaaggac tactgattcg ctctgttcaa gattctgacc
     2101 aaggactcta ccactgcatt gccactgaga acagcttcaa acagaccata gccaagatca
     2161 acttcaaagt tttagattca gaaatggtgg ccgttgtgac agacaagtgg tccccgtgga
     2221 catgggctgg ctctgtgagg gctctaccct tccatccaaa ggacatcctg ggggcattca
     2281 gccactcgga aatgcagctc atcaatcagt actgcaaaga cacccggcag cagcagcagc
     2341 tgggggaaga accacagaag atgagagggg actatggcaa gctgaaggct ctcatcaaca
     2401 gcaggaaaag cagaaacagg aggaatcagc ttccagagtc ataaaacatt catccatgaa
     2461 gttttgcttc caggaacaaa tgctctgtct tcactagtca actattaaat aaaatcttgt
     2521 gctttaccca tgagaaattt ctgacaaaag ctggagactc actctaaagt gtgttctctg
     2581 tgaactgaaa agagcatgca ttttcttgta tgatacagac tagcactaga catgtcatgg
     2641 tccttgtggt gcataaaaaa tatttaactt atcccagatt ttatttatat ctttatgtgt
     2701 cttttcttca aaatcaatgc gacaacagaa gcagaactgt tacagcctcg gttgagcgag
     2761 ggccataaat ttccctgtgc tcttccttcc gtgctctagg ggtttagctt tctaattgtc
     2821 actggctttt atacatgaaa aagaattcca gttcacaatt ttcacatagt aaatgtcata
     2881 taaatgtgtg tgacatccag tgtcatgtag gttacacaaa tgacagggaa gagagcatcc
     2941 agatgttacg taaagtcaag agtgactcat aaagagcaag tgatgagttc atatgcttcc
     3001 agtgatttat cttcttgctt gttcctttgt ttaagattgt aagatgtgtc ggctgctgat
     3061 agctgccatc aatgtttgtt ctcttgtttt agaaaaacaa aagaaatggc ctgtaccatc
     3121 caaggccttt gatgggagat ctatcagtga gccattgacg tttctactgt tatgttatca
     3181 tcttccaaac aaaagtgctt tgtttttttg gaagttattt aagttattat agacttacat
     3241 aaactattgc attatttaat tgatttactg ttttggtttt aatcccctag tctacctgga
     3301 aaattaaaga caacaaggat gcagtattat taaagcattc aacttttcca tgcagagtga
     3361 agctatccaa agggaaaagg aagattaaaa aaaaagcata caatttgtca tgtaaaggaa
     3421 ttagtaacat gtagtttgtt ttctacctta gtaatcaaat tctaggagta atttgtacat
     3481 ccaaggaacc agtttcacaa agcataatga tttttcaggc aaggtttcat gatttgtaaa
     3541 catatctgtg atgggaaagt tattattaca tcaagaaaga aaatctcaac acattttaaa
     3601 caaaacagac ttcttttaaa gactatctat tttcacccag atattttttc cacttgataa
     3661 tacttcttta ggaatgttga tacacatgtt taactattgg aaaattttag cactatcttc
     3721 taattatata cttggattgt ttaatgagaa aagtataata ctaaaattag tttctccaat
     3781 ttaaatgaat aaaatatagg agattttctt atatgtcttt taattataca actttcattt
     3841 tatttaattt tattttaata tgtttatatt ttcagataaa aagagaagtt ttactaaaac
     3901 accattgaaa catacttctt attaacagtt catctagaat gtaactacag gggatctaca
     3961 tcattttata atgctgtgga aaaacctgca ggaagtaaaa ctatggatag gagtgtaagt
     4021 tggtagtaga ctacgtgttt agcatgcaca aagacctggg ctcaaacaga aagaaaggaa
     4081 gaaagacacc aaggaaggag ggcaagcagg aaaaagaaca gactgactgg agagaagaag
     4141 ggcaggaaag tggtaaagaa ggcaaagaaa gatggaggga atacattcat tatcagaaga
     4201 ttaaaaaatg gtagttaaat gatggtcaat tctggtgttc ttaagagtgc acctcagtgt
     4261 tgtagaaaac accagttaaa atagcataaa tgtacccaaa tgtgtacagt gctacaataa
     4321 tctatggggt tagcatatgg ttaaaatgtt tggttagcat gtttaaaatg ttcacacttt
     4381 gggttttctt atacatataa aaatagccat gcgttcacgt gtgatgctaa caccatcctc
     4441 tttctgtgtt tgtaattaat ctattgtatg gaaacagcta cttccccttg ctccacttac
     4501 cttcaaactg ccagccactt ggctattatt tgttctattt agtacctcct gggttggttt
     4561 ttaaccataa ttacatttca aatcttcatt tctttttctt taaagatata gaaattgctg
     4621 tgcagcatag cccggccaaa actaaaacat atatctctca aaagcataac taatacatat
     4681 tgagtatggg tgattactcg gttttatttt gtttacttgg gaaaattaat aattaaacat
     4741 gtttttcttt tgtattgtac ataaaattac ctagaaatgc acttttcctc caaaatgtag
     4801 gttcgtgaat agacttagca tgatgaagct gtctttacag tgaatgctta ccctgtgtag
     4861 agaaagcaaa ctagatgtag ttaccacatg agaatttaat tagatgttga aaaaaataat
     4921 ttgtctggaa aaataaagca ttcaattccc ctgaaa
//
