LOCUS       NM_001042779            3746 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), short basic
            domain, secreted, (semaphorin) 3B (Sema3b), transcript variant 1,
            mRNA.
ACCESSION   NM_001042779
VERSION     NM_001042779.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3746)
  AUTHORS   Yombo,D.J.K., Ghandikota,S., Vemulapalli,C.P., Singh,P.,
            Jegga,A.G., Hardie,W.D. and Madala,S.K.
  TITLE     SEMA3B inhibits TGFbeta-induced extracellular matrix protein
            production and its reduced levels are associated with a decline in
            lung function in IPF
  JOURNAL   Am J Physiol Cell Physiol 326 (6), C1659-C1668 (2024)
   PUBMED   38646784
  REMARK    GeneRIF: SEMA3B inhibits TGFbeta-induced extracellular matrix
            protein production and its reduced levels are associated with a
            decline in lung function in IPF.
REFERENCE   2  (bases 1 to 3746)
  AUTHORS   Lozano-Vidal,N., Stanicek,L., Bink,D.I., Juni,R.P., Hooglugt,A.,
            Kremer,V., Phelp,P., van Bergen,A., MacInnes,A.W., Dimmeler,S. and
            Boon,R.A.
  TITLE     Aging-regulated PNUTS maintains endothelial barrier function via
            SEMA3B suppression
  JOURNAL   Commun Biol 7 (1), 541 (2024)
   PUBMED   38714838
  REMARK    GeneRIF: Aging-regulated PNUTS maintains endothelial barrier
            function via SEMA3B suppression.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3746)
  AUTHORS   Martins,L.F., Brambilla,I., Motta,A., de Pretis,S., Bhat,G.P.,
            Badaloni,A., Malpighi,C., Amin,N.D., Imai,F., Almeida,R.D.,
            Yoshida,Y., Pfaff,S.L. and Bonanomi,D.
  TITLE     Motor neurons use push-pull signals to direct vascular remodeling
            critical for their connectivity
  JOURNAL   Neuron 110 (24), 4090-4107 (2022)
   PUBMED   36240771
REFERENCE   4  (bases 1 to 3746)
  AUTHORS   Gerstmann,K., Kindbeiter,K., Telley,L., Bozon,M., Reynaud,F.,
            Theoulle,E., Charoy,C., Jabaudon,D., Moret,F. and Castellani,V.
  TITLE     A balance of noncanonical Semaphorin signaling from the
            cerebrospinal fluid regulates apical cell dynamics during
            corticogenesis
  JOURNAL   Sci Adv 8 (46), eabo4552 (2022)
   PUBMED   36399562
REFERENCE   5  (bases 1 to 3746)
  AUTHORS   Tomizawa,Y., Sekido,Y., Kondo,M., Gao,B., Yokota,J., Roche,J.,
            Drabkin,H., Lerman,M.I., Gazdar,A.F. and Minna,J.D.
  TITLE     Inhibition of lung cancer cell growth and induction of apoptosis
            after reexpression of 3p21.3 candidate tumor suppressor gene SEMA3B
  JOURNAL   Proc Natl Acad Sci U S A 98 (24), 13954-13959 (2001)
   PUBMED   11717452
  REMARK    GeneRIF: The human ortholog of this gene functions as a tumor
            suppressor gene.
REFERENCE   6  (bases 1 to 3746)
  AUTHORS   Chedotal,A., Del Rio,J.A., Ruiz,M., He,Z., Borrell,V., de
            Castro,F., Ezan,F., Goodman,C.S., Tessier-Lavigne,M., Sotelo,C. and
            Soriano,E.
  TITLE     Semaphorins III and IV repel hippocampal axons via two distinct
            receptors
  JOURNAL   Development 125 (21), 4313-4323 (1998)
   PUBMED   9753685
REFERENCE   7  (bases 1 to 3746)
  AUTHORS   Adams,R.H., Betz,H. and Puschel,A.W.
  TITLE     A novel class of murine semaphorins with homology to thrombospondin
            is differentially expressed during early embryogenesis
  JOURNAL   Mech Dev 57 (1), 33-45 (1996)
   PUBMED   8817451
REFERENCE   8  (bases 1 to 3746)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
REFERENCE   9  (bases 1 to 3746)
  AUTHORS   Sekido,Y., Bader,S., Latif,F., Chen,J.Y., Duh,F.M., Wei,M.H.,
            Albanesi,J.P., Lee,C.C., Lerman,M.I. and Minna,J.D.
  TITLE     Human semaphorins A(V) and IV reside in the 3p21.3 small cell lung
            cancer deletion region and demonstrate distinct expression patterns
  JOURNAL   Proc Natl Acad Sci U S A 93 (9), 4120-4125 (1996)
   PUBMED   8633026
REFERENCE   10 (bases 1 to 3746)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY138852.1, AK037034.1,
            AL672219.7 and AK014333.1.
            
            [WARNING] On Oct 10, 2024 this sequence was replaced by
            NM_001042779.3.
            
            On Apr 22, 2014 this sequence version replaced NM_001042779.1.
            
            Summary: This gene encodes a secreted protein that belongs to the
            class 3 semaphorin/collapsin family. Members of this family play a
            role in growth cone guidance during neurogenesis. The encoded
            protein inhibits axonal extension. This protein is thought to be an
            osteoblast protein that regulates bone mass and affects skeletal
            homeostasis. A similar gene in humans functions as a tumor
            suppressor gene. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Apr 2014].
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 3. Variants 1 through 5 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK037034.1, AK148232.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                BY138852.1         1-12
            13-2910             AK037034.1         2-2899
            2911-2911           AL672219.7         171658-171658       c
            2912-3303           AK037034.1         2901-3292
            3304-3746           AK014333.1         2993-3435
FEATURES             Location/Qualifiers
     source          1..3746
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 58.31 cM"
     gene            1..3746
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, (semaphorin) 3B"
                     /db_xref="GeneID:20347"
                     /db_xref="MGI:MGI:107561"
     exon            1..121
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            122..180
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            181..321
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            322..508
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     CDS             400..2649
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /note="semaphorin-3B; sema A; semaphorin-A"
                     /codon_start=1
                     /product="semaphorin-3B precursor"
                     /protein_id="NP_001036244.1"
                     /db_xref="CCDS:CCDS23501.1"
                     /db_xref="GeneID:20347"
                     /db_xref="MGI:MGI:107561"
                     /translation="MGRAEAAAMIPGLALLWVAGLGDTAPNLPRLRLSFQELQARHGV
                     RTFRLERTCCYEALLVDEERGRLFVGAENHVASLSLDNISKRAKKLAWPAPVEWREEC
                     NWAGKDIGTECMNFVKLLHTYNHTHLLACGTGAFHPTCAFVEVGHRLEEPMLQLDRRK
                     LEDGKGKTPYDPRHRAASVLVGEELYSGVTADLMGRDFTIFRSLGQNPSLRTEPHDSR
                     WLNEPKFVKVFWIPESENPDDDKIYFFFRESAVEAAPAMGRMSVSRVGQICRNDLGGQ
                     RSLVNKWTTFLKARLVCSVPGVEGDTHFDQLQDVFLLSSRDRQTPLLYAVFSTSSGVF
                     QGSAVCVYSMNDVRRAFLGPFAHKEGPTHQWVSYQGRVPYPRPGMCPSKTFGTFSSTK
                     DFPDDVIQFARNHPLMYNPVLPMGGRPLFLQVGAGYTFTQIAADRVAAADGHYDVLFI
                     GTDVGTVLKVISVPKGSRPNSEGLLLEELQVFEDSAAITSMQISSKRQQLYIASRSAV
                     AQIALHRCTALGRACAECCLARDPYCAWDGSACTRFQPTAKRRFRRQDIRNGDPSTLC
                     SGDSSHSVLLEKKVLGVESGSAFLECEPRSLQAHVQWTFQGAGEAAHTQVLAEERVER
                     TARGLLLRGLRRQDSGVYLCVAVEQGFSQPLRRLVLHVLSAAQAERLARAEEAAAPAP
                     PGPKLWYRDFLQLVEPGGGGGANSLRMCRPQPGHHSVAADSRRKGRNRRMHVSELRAE
                     RGPRSAAHW"
     exon            509..666
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            667..729
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            730..849
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            850..943
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1063
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1064..1209
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1210..1321
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1322..1391
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1392..1536
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1537..1756
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1848
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1849..1890
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            1891..2048
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            2049..2104
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            2105..2244
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     exon            2245..3746
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3047..3052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /note="hexamer: AATAAA"
     polyA_site      3067
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /note="major polyA site"
     regulatory      3184..3189
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /note="hexamer: ATTAAA"
     polyA_site      3204
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /note="major polyA site"
     regulatory      3278..3283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
                     /note="hexamer: AGTAAA"
     polyA_site      3307
                     /gene="Sema3b"
                     /gene_synonym="SemA; sema5; Semaa; semaV"
ORIGIN      
        1 agtgaaaggc ccaaggctcc tggtggtggc ccctcctgcc acccctccac ctcagctctg
       61 acatggccca ctgaagggaa gggcaagagg caaggagggg aggaactgat ctttccaaaa
      121 gctcctggga cctgagcttg ctgtggagtg tacagtcatc ccttagctgt ggagggacag
      181 caactgcttt gctctttgca cttggtgccc tctggaatga ccacaggatc tgactctcat
      241 ctgtcggctc ttcgcccttt actgcctggg gaccttgtcc gcatcatcag tatccttgtc
      301 tctgccccag gctggcatga aatcctgggg cagagtccag gactgctgaa ggctcctcca
      361 cacacgcctg ctgaaccctg agcgccctga gctgccggca tggggcgggc tgaggccgcc
      421 gccatgatcc caggcctggc ccttctctgg gtagcagggc taggggatac tgcccctaac
      481 cttccccgcc ttcggctctc ctttcaagaa ttacaggccc ggcatggtgt ccgaaccttc
      541 aggctggagc ggacctgctg ttatgaagcc ttgctggtgg atgaggagcg tggacgcctg
      601 tttgtgggtg ctgagaacca cgtggcttcc ctcagcctgg acaacatcag caagcgagcc
      661 aagaagctgg cctggcccgc ccccgtggaa tggcgtgaag aatgcaactg ggcagggaag
      721 gacattggta ccgagtgcat gaacttcgtg aagctgctgc acacctacaa ccacacccac
      781 ttgctggcct gtggcacagg ggctttccac ccaacctgtg cctttgtgga ggtgggccac
      841 cggctggagg aacccatgct tcaactggac cggaggaaac ttgaggacgg caaggggaag
      901 actccttatg acccaaggca tcgggctgcc tcggtgctgg tgggggaaga actgtattct
      961 ggggtgacag cagaccttat gggccgggac tttaccatct ttcgaagcct tggtcagaat
     1021 ccgagtctcc gaacagagcc ccatgattcc cgctggctca atgaacccaa gtttgtcaag
     1081 gtcttttgga tcccagagag tgagaaccct gatgacgata aaatctattt cttcttccgc
     1141 gagtccgctg tggaagcagc accagcaatg gggcgcatgt ctgtgtctcg tgttggccag
     1201 atctgcagga atgacctggg tggccagcgg agcttggtca acaaatggac cacatttctg
     1261 aaggcgcggc ttgtgtgctc agtacctgga gttgagggtg acacccactt tgaccaactt
     1321 caggatgttt tccttctgtc ctcccgagac cgccagacac ctcttctcta tgctgtcttc
     1381 tccacctcca gtggtgtctt ccagggctct gctgtgtgcg tgtacagcat gaacgatgtg
     1441 cgccgagcct tcttgggacc ttttgctcac aaagaggggc ctacacacca gtgggtgtcc
     1501 taccagggtc gtgtccccta cccaagacct ggcatgtgcc ccagcaagac ctttggcacc
     1561 ttcagctcca ccaaggactt cccagatgac gttatccagt ttgctcggaa ccaccctctc
     1621 atgtacaacc cagtcctgcc catggggggg cgccctctct tcctacaagt gggagctggg
     1681 tacaccttca cccaaatcgc cgcagaccga gtagcagctg ccgatggaca ctacgatgtt
     1741 ctcttcattg gtacagatgt gggcacagtg ctgaaagtga tctcagtccc caaaggcagc
     1801 cgacctaatt ctgaaggact tctcctggaa gagctgcagg tgttcgagga ctctgccgct
     1861 atcaccagca tgcaaatctc ctctaaaagg caacaactct acatagcatc gcgcagcgca
     1921 gtggcccaga ttgctttgca tcgctgcact gccctaggcc gcgcctgcgc agaatgctgc
     1981 ttggcccgtg atccttactg cgcctgggat ggatcagctt gcacacgctt ccagcctacg
     2041 gccaagagac ggttccggag gcaagacata aggaatggcg accccagcac cctatgctct
     2101 ggagactctt ctcactctgt gctgctggag aagaaggtgt tgggtgtgga gagcggcagc
     2161 gcgtttctgg agtgtgagcc ccgctcgctc caggcgcatg tgcagtggac cttccaaggt
     2221 gcaggggagg cagctcacac ccaggtgctg gctgaggaga gagtagagcg cactgcgcgg
     2281 gggctgctgt tgcgggggct gcggcgccag gactctggcg tgtatctttg cgtcgcggtt
     2341 gaacaaggct tttcacaacc actgcgtcgc ctggtgctgc atgtgttgag tgcggcgcag
     2401 gctgaacgac tggcacgggc agaggaagca gccgctcctg cacctcctgg ccctaaactc
     2461 tggtaccggg actttctgca gttggtggag ccaggcggtg gcggaggtgc aaactccctg
     2521 cgaatgtgcc gcccgcagcc cgggcaccac tctgtggcag cagattcacg tcgtaagggt
     2581 cgcaacagac ggatgcatgt ctctgagctc cgtgctgagc gtggaccacg tagtgcagct
     2641 cactggtgac tcggctgtcc ccacaatggg acgaggctga atatgacact ccaaagaggg
     2701 gcagacagat gccaggaaga caaatgagtt atggctgggc cacactgagg tccttgggcc
     2761 aacagagaca cctaaccctt acataggccc tggccaaagg gtagcttatt tattaacaag
     2821 ataacccgtg gatgtagcct caaagagtgg cctaagctca attcaggatc taaccaggag
     2881 ggaggggaca gagacgtggg gttccagagt ggaccaggac cagagagttg tcttgggtgg
     2941 cagccctggg gaaagaattc tctttcttgg gcagcaagca gcaagctgtg aacagattag
     3001 accgttgggt atggggtgag gcaggccaac tgtactaaag taacgcaata aacacattat
     3061 cagctgacat tggaatggcc ccagcagaca acaggtagtc ctagaccttg ctgggggctc
     3121 ttgggtatcg ccctaggggt ctcaagacct gcattttcct catccaagaa tgctaaagtg
     3181 aagattaaac gtgttagtag acgactacgc tggttccagt gagcctctgg ggtactggca
     3241 atacacagtg cattagtggc aggaccaagc tctctgaagt aaaaccaata ctggctgttg
     3301 tgggcaagga tgtattaatt cactgaacgg gtggtgtttg agctgaataa gaaggagcca
     3361 atcaccaatg tctggtgaca gaacattccg ggatagaaga accagggcaa caacgtcgtg
     3421 gagcagggga cagaccctcc aagtctgcgg aacaaccagg aggctgatat ggtgttatgg
     3481 cactatggac tcctgatggt ttggaaggta gatcccacca gccctgcttt tcaccgttga
     3541 gaaacagaac agagtccacc cagactaagg cctgcaagct ggaccagcac ccttcaagag
     3601 agccacgtgc ctctctctcc gtggcctgtc aagcccttgt gaagaggaga gggaggaccc
     3661 aaaacctctt aagtgcttta gccatgcttc ttcattttta ttctcagtac agttggccag
     3721 gaacctttgt tcctgtttta cagatg
//
