LOCUS       NM_009152               6850 bp    mRNA    linear   ROD 04-FEB-2025
DEFINITION  Mus musculus sema domain, immunoglobulin domain (Ig), short basic
            domain, secreted, (semaphorin) 3A (Sema3a), transcript variant 1,
            mRNA.
ACCESSION   NM_009152 XR_104921 XR_104922 XR_106695 XR_106696
VERSION     NM_009152.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6850)
  AUTHORS   Huang,S., Gao,D., Li,Z., He,H., Yu,X., You,X., Wu,D., Du,Z.,
            Zeng,J., Shi,X., Hu,Q., Nie,Y., Zhang,Z., Luo,Z., Wang,D., Zhao,Z.,
            Li,L., Wang,G., Wang,L., Zhou,Z., Chen,D. and Yang,F.
  TITLE     Neuronal guidance factor Sema3A inhibits neurite ingrowth and
            prevents chondrocyte hypertrophy in the degeneration of knee
            cartilage in mice, monkeys and humans
  JOURNAL   Bone Res 13 (1), 4 (2025)
   PUBMED   39746903
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6850)
  AUTHORS   Erickson,A.G., Motta,A., Kastriti,M.E., Edwards,S., Coulpier,F.,
            Theoulle,E., Murtazina,A., Poverennaya,I., Wies,D., Ganofsky,J.,
            Canu,G., Lallemend,F., Topilko,P., Hadjab,S., Fried,K.,
            Ruhrberg,C., Schwarz,Q., Castellani,V., Bonanomi,D. and Adameyko,I.
  TITLE     Motor innervation directs the correct development of the mouse
            sympathetic nervous system
  JOURNAL   Nat Commun 15 (1), 7065 (2024)
   PUBMED   39152112
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6850)
  AUTHORS   Huang,P., Jiang,R.X., Wang,F., Qiao,W.W., Ji,Y.T., Meng,L.Y. and
            Bian,Z.
  TITLE     PIEZO1 Promotes Odontoblast-Mediated Reactionary Dentinogenesis via
            SEMA3A
  JOURNAL   J Dent Res 103 (9), 889-898 (2024)
   PUBMED   38910430
  REMARK    GeneRIF: PIEZO1 Promotes Odontoblast-Mediated Reactionary
            Dentinogenesis via SEMA3A.
REFERENCE   4  (bases 1 to 6850)
  AUTHORS   Lupo,F., Pezzini,F., Pasini,D., Fiorini,E., Adamo,A., Veghini,L.,
            Bevere,M., Frusteri,C., Delfino,P., D'agosto,S., Andreani,S.,
            Piro,G., Malinova,A., Wang,T., De Sanctis,F., Lawlor,R.T.,
            Hwang,C.I., Carbone,C., Amelio,I., Bailey,P., Bronte,V.,
            Tuveson,D., Scarpa,A., Ugel,S. and Corbo,V.
  TITLE     Axon guidance cue SEMA3A promotes the aggressive phenotype of
            basal-like PDAC
  JOURNAL   Gut 73 (8), 1321-1335 (2024)
   PUBMED   38670629
  REMARK    GeneRIF: Axon guidance cue SEMA3A promotes the aggressive phenotype
            of basal-like PDAC.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6850)
  AUTHORS   Tsuboi,E., Asakawa,Y., Hirose,N., Yanoshita,M., Sumi,C., Takano,M.,
            Onishi,A., Nishiyama,S., Kubo,N., Kita,D. and Tanimoto,K.
  TITLE     The role of semaphorin 3A on chondrogenic differentiation
  JOURNAL   In Vitro Cell Dev Biol Anim 60 (6), 609-615 (2024)
   PUBMED   38727898
  REMARK    GeneRIF: The role of semaphorin 3A on chondrogenic differentiation.
REFERENCE   6  (bases 1 to 6850)
  AUTHORS   Adams,R.H., Betz,H. and Puschel,A.W.
  TITLE     A novel class of murine semaphorins with homology to thrombospondin
            is differentially expressed during early embryogenesis
  JOURNAL   Mech Dev 57 (1), 33-45 (1996)
   PUBMED   8817451
REFERENCE   7  (bases 1 to 6850)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     The sensory innervation of the mouse spinal cord may be patterned
            by differential expression of and differential responsiveness to
            semaphorins
  JOURNAL   Mol Cell Neurosci 7 (5), 419-431 (1996)
   PUBMED   8812066
REFERENCE   8  (bases 1 to 6850)
  AUTHORS   Inagaki,S., Furuyama,T. and Iwahashi,Y.
  TITLE     Identification of a member of mouse semaphorin family
  JOURNAL   FEBS Lett 370 (3), 269-272 (1995)
   PUBMED   7656991
REFERENCE   9  (bases 1 to 6850)
  AUTHORS   Messersmith,E.K., Leonardo,E.D., Shatz,C.J., Tessier-Lavigne,M.,
            Goodman,C.S. and Kolodkin,A.L.
  TITLE     Semaphorin III can function as a selective chemorepellent to
            pattern sensory projections in the spinal cord
  JOURNAL   Neuron 14 (5), 949-959 (1995)
   PUBMED   7748562
REFERENCE   10 (bases 1 to 6850)
  AUTHORS   Puschel,A.W., Adams,R.H. and Betz,H.
  TITLE     Murine semaphorin D/collapsin is a member of a diverse gene family
            and creates domains inhibitory for axonal extension
  JOURNAL   Neuron 14 (5), 941-948 (1995)
   PUBMED   7748561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC121125.9, BC057588.1 and AC022368.2.
            
            On Jul 19, 2011 this sequence version replaced NM_009152.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 2 and 3 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: D85028.2, BC057588.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849387
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-353               AC121125.9         173123-173475       c
            354-3405            BC057588.1         1-3052
            3406-6850           AC022368.2         73458-76902         c
FEATURES             Location/Qualifiers
     source          1..6850
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 4.31 cM"
     gene            1..6850
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="sema domain, immunoglobulin domain (Ig), short
                     basic domain, secreted, (semaphorin) 3A"
                     /db_xref="GeneID:20346"
                     /db_xref="MGI:MGI:107558"
     exon            1..761
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     CDS             650..2968
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="semaphorin-3A; sema D; semaphorin-D; sema III;
                     collapsin-1; semaphorin III"
                     /codon_start=1
                     /product="semaphorin-3A precursor"
                     /protein_id="NP_033178.2"
                     /db_xref="CCDS:CCDS19092.1"
                     /db_xref="GeneID:20346"
                     /db_xref="MGI:MGI:107558"
                     /translation="MGWFTGIACLFWGVLLTARANYANGKNNVPRLKLSYKEMLESNN
                     VITFNGLANSSSYHTFLLDEERSRLYVGAKDHIFSFNLVNIKDFQKIVWPVSYTRRDE
                     CKWAGKDILKECANFIKVLEAYNQTHLYACGTGAFHPICTYIEVGHHPEDNIFKLQDS
                     HFENGRGKSPYDPKLLTASLLIDGELYSGTAADFMGRDFAIFRTLGHHHPIRTEQHDS
                     RWLNDPRFISAHLIPESDNPEDDKVYFFFRENAIDGEHSGKATHARIGQICKNDFGGH
                     RSLVNKWTTFLKARLICSVPGPNGIDTHFDELQDVFLMNSKDPKNPIVYGVFTTSSNI
                     FKGSAVCMYSMSDVRRVFLGPYAHRDGPNYQWVPYQGRVPYPRPGTCPSKTFGGFDST
                     KDLPDDVITFARSHPAMYNPVFPINNRPIMIKTDVNYQFTQIVVDRVDAEDGQYDVMF
                     IGTDVGTVLKVVSVPKETWHDLEEVLLEEMTVFREPTTISAMELSTKQQQLYIGSTAG
                     VAQLPLHRCDIYGKACAECCLARDPYCAWDGSSCSRYFPTAKRRTRRQDIRNGDPLTH
                     CSDLQHHDNHHGPSLEERIIYGVENSSTFLECSPKSQRALVYWQFQRRNEDRKEEIRM
                     GDHIIRTEQGLLLRSLQKKDSGNYLCHAVEHGFMQTLLKVTLEVIDTEHLEELLHKDD
                     DGDGSKIKEMSSSMTPSQKVWYRDFMQLINHPNLNTMDEFCEQVWKRDRKQRRQRPGH
                     SQGSSNKWKHMQESKKGRNRRTHEFERAPRSV"
     exon            762..919
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            920..982
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            983..1102
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1103..1196
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1316
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1317..1459
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1460..1574
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1575..1644
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1645..1789
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            1790..2009
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..2101
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            2102..2143
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2301
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            2302..2369
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            2370..2512
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     exon            2513..6850
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4335..4340
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="hexamer: AATATA"
     polyA_site      4353
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="major polyA site"
     regulatory      4422..4427
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="hexamer: AATAAA"
     polyA_site      4444
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="major polyA site"
     regulatory      5910..5915
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="hexamer: AATACA"
     polyA_site      5930
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
     regulatory      6312..6317
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="hexamer: TATAAA"
     polyA_site      6333
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
     regulatory      6769..6774
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
                     /note="hexamer: AATAAA"
     polyA_site      6789
                     /gene="Sema3a"
                     /gene_synonym="coll-1; Hsema-I; SEMA1; Semad; SemD"
ORIGIN      
        1 gtgacaagag ggaaggggag tgggttgagc tcgctcctct cccattgtca gcgcgtctag
       61 tgagtgttgg gaaaacctgt ccgcgggatc ctgtgtcatc tctccctgct tgtgcacagg
      121 aaaagtccgc gctgctctgc tcacggctgc tcgcaccccc tctctctcct ctctctcttt
      181 ctctgtttcc ctttcattct gcttcctcgg agccgaatga agcagggaga gggagcagga
      241 ttagagtcag ccaccggcta tcagcggagc ggagataaaa ggaactgctt cttaagcgcc
      301 actgccgcag cccttgttaa tttttttctt cttcttcttc ttctttccac acaacagttg
      361 tgcctcatta tccggtgcct ggctcgattt ttttctttct tttttctttt tttcttttct
      421 ttcttccttt tttttttttt tctttttttg agggtttgaa gtttctgtga ttccgtgact
      481 gttacagaag agacgttagt gttgccatga ggtcttgatt gtctgcattt atgaatgaaa
      541 ctgacctaaa tcacctgtta cctccagttt ccagattgtt tgaacttctc tggccgcaca
      601 atacaggaag gaaggctgcc gcagctcagg gacctccagc gtctgcagca tgggctggtt
      661 cactgggatt gcctgtcttt tctggggtgt attacttaca gccagagcaa actatgcaaa
      721 cggaaagaac aatgtgccaa gactgaaatt atcgtacaaa gaaatgttgg aatccaacaa
      781 tgtgatcact tttaatggct tggccaacag ctccagttac cacaccttcc ttctggatga
      841 agaacggagt agactatatg ttggagcaaa agatcatata ttttcattca acttggtgaa
      901 cattaaagat tttcaaaaga ttgtgtggcc agtatcttac acaaggagag atgaatgcaa
      961 atgggctgga aaagatatcc tgaaagaatg tgccaatttc atcaaggtcc tggaggctta
     1021 taatcagact cacttgtatg cctgtggaac tggggctttc catccaatct gcacctatat
     1081 tgaagttgga catcatcctg aggacaacat ttttaagctg caggactcac attttgaaaa
     1141 cggtcgtggg aagagccctt atgatcccaa actactgact gcctctcttc taatagacgg
     1201 tgagttgtac tctggaactg ctgcggactt catgggacgg gacttcgcta tcttcagaac
     1261 actggggcac catcacccca tcaggacgga gcagcatgac tcccggtggc tcaatgatcc
     1321 tagattcatc agtgcccatc tcatcccaga gagtgacaac cctgaagatg acaaagtata
     1381 ttttttcttc cgagaaaatg caatagacgg agaacactct ggaaaagcca ctcatgctag
     1441 aataggtcag atatgcaaga atgactttgg tggacacaga agtcttgtga ataaatggac
     1501 aacattccta aaagcacgcc tgatttgctc tgtgcccggt cccaatggca ttgacaccca
     1561 ttttgatgaa ttgcaggatg tattcctaat gaactctaaa gatcctaaaa atccgatcgt
     1621 ctatggagtg ttcacaacat caagcaacat ctttaaggga tctgctgtgt gcatgtacag
     1681 catgagtgat gtaagaaggg tgttccttgg tccatatgct cacagagatg gtcccaacta
     1741 tcagtgggtg ccttaccaag gaagagtccc ttatccacgg ccaggaactt gtcccagtaa
     1801 aacatttggc ggatttgact ccacaaagga ccttcctgat gatgtcataa cttttgcaag
     1861 aagtcatcca gccatgtaca acccagtgtt tcctataaat aatcgcccga tcatgatcaa
     1921 aacagatgta aattatcagt tcacacaaat tgttgtagac cgagtggatg cagaagatgg
     1981 ccagtatgat gttatgttca tcggaacaga tgttggaacc gttcttaaag tggtttcagt
     2041 ccccaaggag acttggcatg acctagaaga agttcttctg gaagaaatga ccgtcttccg
     2101 ggaaccaaca actatttcgg caatggagct ttctactaaa cagcaacagc tgtacattgg
     2161 ctcaactgcg ggagtggcac agcttcctct acaccgctgt gacatctatg gcaaagcctg
     2221 tgcagaatgc tgcctcgctc gggaccctta ctgtgcctgg gatgggtcct catgctcacg
     2281 ctattttcct actgcaaaga ggcgcacaag acgacaagat ataaggaatg gagacccact
     2341 gactcactgc tctgacttgc agcaccatga taatcatcat gggcccagcc ttgaagagag
     2401 aatcatctat ggagtggaaa acagtagtac attcttggaa tgcagtccga agtcacagag
     2461 agccttggta tattggcaat ttcagaggag aaatgaagat cgaaaagagg agatcagaat
     2521 gggtgatcat atcatcagga cagaacaagg gctcctgctc cgtagcctgc agaagaagga
     2581 ttcaggcaat tacctgtgtc acgctgtgga acacggattc atgcaaactc ttcttaaggt
     2641 aaccctggaa gtcattgaca cagaacattt ggaagaactt cttcataaag atgacgatgg
     2701 agatggctct aagataaaag aaatgtcgag cagcatgacg cccagccaga aagtctggta
     2761 ccgagacttc atgcagctca ttaaccaccc caacctgaac acgatggatg agttctgtga
     2821 acaagtgtgg aaaagggacc gaaagcaacg ccgacaaagg ccggggcact ctcaagggag
     2881 cagcaacaag tggaagcaca tgcaagagag caagaaaggt agaaacagga ggacccacga
     2941 gtttgagcgg gcacccagaa gtgtctgagc tgcgccacct cccaaaacct caaacaagta
     3001 caaacttgct tagataataa ctggaaaaaa tgcaatacac atgaacattt catggcatta
     3061 tgtggatgtt tacaatgatg ggaagttcaa ccgggttcca ccaatttaag tccgtgagga
     3121 actttcccag caggctttct tcagtatacc aacgcttgac agagatcaca ggtgagcata
     3181 gatgttcacg tccgctgact tagtgtttcc tctgaaagtt cattttgctt ccttctttgc
     3241 ctgagaaata aaaatgtcat ttgccatcga aaggagaaaa actgcatcag caaagccatt
     3301 ttattgaagc aagagttgaa aataaactgc atggatttag taagcagatg aatattccaa
     3361 aacgtgattg gattcaagga tgttttgtct accagcactc gtgtttgtat gtactggaga
     3421 agtaaaataa ggagaatgac actgagtgaa atagtctatg gagatataaa aacacaaacc
     3481 acccatcatc cagagtaatg gagtacattg atctactact gatgtcttct ttcagctttg
     3541 atctaaagat gtattttatt aaagttataa tttaaatgta ccatggcaaa tatgcagtaa
     3601 agattagctg tttcctaagc tagagtaggt cttgtcttgc agttaccatg ctatatcgtt
     3661 tgtttaaaaa ttccaactgt gtgctgcttt tttacattgt gttttcagtt ctgtaagagg
     3721 cagtatatca ctttaggtcc ctactcactg tactattact tactgacacc aagaattatg
     3781 gtcttcccct ttgaagaaac caaacagata gaaggttatc accctgactt gcaaaggtat
     3841 tatctaagtt aactctcaca tacataatgt tttcagtcaa ccaaaaatta agacagcaca
     3901 aagagaagaa aacagtcatt agaggcatcc tgaaggatca agagcaaaat taaattcatg
     3961 tgtctcatga aaagaacatt gtcttaacag agtgttgata aaatgtcttt ccctcttggc
     4021 ttgaatattt gcatgatgtg tgaggcatag gactcgctca tgattccaca tcccaccaaa
     4081 gattctattt tcagtcactt aatgatttcc aaagcagaga gaaagagcgg gggtgggggg
     4141 aatcagtgac attcaggaca tgttctaaca acaaaatgac acatttctca actatttctt
     4201 tgtgaatcaa ctaaatttta cccaccctgt atgatacaat tatttgtctg aacaacttat
     4261 aagtgtttta tctcaatgag agtgaaacta tacacttcac ctagaaagtg caaaattctt
     4321 tgttttatga ataaaatata agataacaca aaatgtttca gaatgtatag cctttgttgg
     4381 ttggagatga tttcctaaga atcattgagt tcaaaatgct taataaattc aacattatag
     4441 accagttcat tggtgctaca ggcctcactt caggaatttt tttcttcgat ccttcagcat
     4501 gcacaaaaat gcaaagtaaa tatcttcttg ctaagaaatg aagtggcgtt gatattttaa
     4561 ctccagttgt ctcctaattc taattaactc agtattaact tctcacctca actacaccaa
     4621 attgtcattc cctcgccact gaaatagttc acagatggaa gcttctgttt cagttttaat
     4681 gattatttaa ataaaaaaac aatttgttga catgtctttc atataaaagc ctaaaatcat
     4741 cctacatctg attttaggct cattgactaa tggtgttgct tttggaaata tgtcttcaaa
     4801 ggcaagctga atggatgaat tatttgagat cacactctga acagaaaata ttgtcaggaa
     4861 cattaagtga gagaaagagg gatgctccaa ataagccatt ctctcattta atagggtctt
     4921 aactgtccaa acatttaatg ttatatttca ttctaaattt gcatctgata caagtatatt
     4981 ggcaattaca taactctccc atttctttct agctcttaac aataaaggat ctaatggaag
     5041 gaaggttgtt taataacttt atggatgcct ttcaaaatcg gaatgcattt tgtttagcac
     5101 taagaaatag caatagaaaa ctgcttaggt ttcaattaaa agtgttaaaa acaagcaaat
     5161 atattaacat gtctcaatca atcaccatgt ctaagtttca aagaaagtta ttgattaact
     5221 agggaataaa taaataaata cacacataca tacataaatc ttatgacagt tataacctcc
     5281 cattgtgtat tgagagagga cagtttgcac gaagaagaat gtcccattta ctaagtaatt
     5341 tagatggact ttggcatatg catgtatcat cacaggtaag acctgcctaa gagatgcatg
     5401 tgaccttaag caaattacca cagcagtctc acaatagtct caagttgaaa aagatacatc
     5461 acagtggaga gagcaggccc cgctgatagc aactgtaaag tgtaaatgca tgcaaatgca
     5521 cacttattgc ttcttttatg tataatttag tgatttataa tggtatgtgt ttaatatttt
     5581 tgctacctac acattagaca aaggtgtaaa taattttgaa aagagtagaa agagcactgt
     5641 aaattacaag tttctataga tgctccattc cagtttgttc accatcatcc tcaagtgcaa
     5701 gatttcccat acaagtgatg cggtggctta tgtactactt aagggcagag agggtgtgcc
     5761 cctcgaagag catgcttttt gccaggtcgt aaattgttcc gtatctgtat ttatcattgc
     5821 atttcagatg ggaactagaa aactggagag aaaaatgtaa cgatattgct gctgtaaatt
     5881 attccttttt agcatgtatt cagttgctaa atacacattt cttcaaaata tttgaattca
     5941 gatgtcttta ctgttccata taacatatgg tattgaggaa gataagcttc gaagccttcg
     6001 agaaccagag tcaggaatca gcataattag ctaacagatt tcttcattgt agtattctgt
     6061 aaactgtgtt ctatatttat agtgatgatg tgaatttttt gccctttaaa ctaaatgctg
     6121 ttctctttat gtcatacctg gaaagaacac atggatgaaa gtctttaatc agtggattat
     6181 gatgtgaagc atcataattc aagatcaata ccgattccag atgattggca tctagaggcc
     6241 tgtcctgcag ctcatgggca agcactgcat taatatggat ttatttctgt aatgtgttca
     6301 agtccttctc ttataaatac tattttaaac acatatttaa ttcactgaaa gtctgtcaga
     6361 gtttatttgc ttcaaagaca catttgacaa acaggtctta gcactattat atactaacat
     6421 gatggttaca aactggcctg gtgccaaaga atccaaagct tttaatttta acttggtaat
     6481 aattatttaa gtcaatgtta atatttacag tatatctttc cttaaagaag caaacattat
     6541 tttcaaaagt atggaaattc tattagcttt attttaaaaa ctttcctata ctagctaatt
     6601 caaaaatcac acatttgtat attaatagat aaagacaaac ccaaagtgaa agttgcccca
     6661 gaaatgggtt ttcttataac tggtcaactt tcttgattaa cctaaccaaa gaaaaatctt
     6721 atttcttcat ttccaacacc caagtgcaca aacacagtct atggtagaaa taaaaccaaa
     6781 ttaataaaag aggaatgatt ttaagttatg atattaggac ccagacgtga cagcatcaac
     6841 ctacaattcc
//
