LOCUS       NM_009169                491 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SEM1, 26S proteasome complex subunit (Sem1), mRNA.
ACCESSION   NM_009169
VERSION     NM_009169.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 491)
  AUTHORS   Mishra,A.P., Hartford,S.A., Sahu,S., Klarmann,K., Chittela,R.K.,
            Biswas,K., Jeon,A.B., Martin,B.K., Burkett,S., Southon,E., Reid,S.,
            Albaugh,M.E., Karim,B., Tessarollo,L., Keller,J.R. and Sharan,S.K.
  TITLE     BRCA2-DSS1 interaction is dispensable for RAD51 recruitment at
            replication-induced and meiotic DNA double strand breaks
  JOURNAL   Nat Commun 13 (1), 1751 (2022)
   PUBMED   35365640
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 491)
  AUTHORS   Hupe,M., Li,M.X., Gertow Gillner,K., Adams,R.H. and Stenman,J.M.
  TITLE     Evaluation of TRAP-sequencing technology with a versatile
            conditional mouse model
  JOURNAL   Nucleic Acids Res 42 (2), e14 (2014)
   PUBMED   24165879
REFERENCE   3  (bases 1 to 491)
  AUTHORS   Birnbaum,R.Y., Everman,D.B., Murphy,K.K., Gurrieri,F.,
            Schwartz,C.E. and Ahituv,N.
  TITLE     Functional characterization of tissue-specific enhancers in the
            DLX5/6 locus
  JOURNAL   Hum Mol Genet 21 (22), 4930-4938 (2012)
   PUBMED   22914741
REFERENCE   4  (bases 1 to 491)
  AUTHORS   Wei,S.J., Williams,J.G., Dang,H., Darden,T.A., Betz,B.L.,
            Humble,M.M., Chang,F.M., Trempus,C.S., Johnson,K., Cannon,R.E. and
            Tennant,R.W.
  TITLE     Identification of a specific motif of the DSS1 protein required for
            proteasome interaction and p53 protein degradation
  JOURNAL   J Mol Biol 383 (3), 693-712 (2008)
   PUBMED   18775730
REFERENCE   5  (bases 1 to 491)
  AUTHORS   Krizhanovsky,V., Soreq,L., Kliminski,V. and Ben-Arie,N.
  TITLE     Math1 target genes are enriched with evolutionarily conserved
            clustered E-box binding sites
  JOURNAL   J Mol Neurosci 28 (2), 211-229 (2006)
   PUBMED   16679559
REFERENCE   6  (bases 1 to 491)
  AUTHORS   Merlo,G.R., Paleari,L., Mantero,S., Genova,F., Beverdam,A.,
            Palmisano,G.L., Barbieri,O. and Levi,G.
  TITLE     Mouse model of split hand/foot malformation type I
  JOURNAL   Genesis 33 (2), 97-101 (2002)
   PUBMED   12112878
REFERENCE   7  (bases 1 to 491)
  AUTHORS   Tontsch,S., Zach,O. and Bauer,H.C.
  TITLE     Identification and localization of M-CoREST (1A13), a mouse
            homologue of the human transcriptional co-repressor CoREST, in the
            developing mouse CNS
  JOURNAL   Mech Dev 108 (1-2), 165-169 (2001)
   PUBMED   11578870
REFERENCE   8  (bases 1 to 491)
  AUTHORS   Crackower,M.A., Heng,H.H., Shi,X., Scherer,S.W. and Tsui,L.C.
  TITLE     Fluorescent in situ mapping of the murine deleted in split
            hand/split foot 1 (dss1) gene to chromosome 6
  JOURNAL   Mamm Genome 8 (9), 704 (1997)
   PUBMED   9271682
REFERENCE   9  (bases 1 to 491)
  AUTHORS   Crackower,M.A., Scherer,S.W., Heng,H.H. and Tsui,L.C.
  TITLE     Cloning of a DSS1 pseudogene (DSS1P1) and mapping to human
            chromosome band 5q14
  JOURNAL   Mamm Genome 8 (2), 159-160 (1997)
   PUBMED   9060422
REFERENCE   10 (bases 1 to 491)
  AUTHORS   Crackower,M.A., Scherer,S.W., Rommens,J.M., Hui,C.C., Poorkaj,P.,
            Soder,S., Cobben,J.M., Hudgins,L., Evans,J.P. and Tsui,L.C.
  TITLE     Characterization of the split hand/split foot malformation locus
            SHFM1 at 7q21.3-q22.1 and analysis of a candidate gene for its
            expression during limb development
  JOURNAL   Hum Mol Genet 5 (5), 571-579 (1996)
   PUBMED   8733122
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC124582.4 and AK160432.1.
            
            On May 2, 2007 this sequence version replaced NM_009169.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AV452471.1, AV501474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-9                 AC124582.4         167364-167372       c
            10-476              AK160432.1         3-469
            477-491             AC124582.4         146989-147003       c
FEATURES             Location/Qualifiers
     source          1..491
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 2.59 cM"
     gene            1..491
                     /gene="Sem1"
                     /gene_synonym="DSS1; Shfdg1; Shfg; Shfm1"
                     /note="SEM1, 26S proteasome complex subunit"
                     /db_xref="GeneID:20422"
                     /db_xref="MGI:MGI:109238"
     exon            1..180
                     /gene="Sem1"
                     /gene_synonym="DSS1; Shfdg1; Shfg; Shfm1"
                     /inference="alignment:Splign:2.1.0"
     CDS             105..317
                     /gene="Sem1"
                     /gene_synonym="DSS1; Shfdg1; Shfg; Shfm1"
                     /note="26S proteasome complex subunit DSS1; split
                     hand/foot deleted protein 1 homolog; deleted in split
                     hand/split foot protein 1 homolog; split hand/foot
                     malformation type 1 protein homolog; split hand/foot
                     deleted gene 1; split hand/foot malformation
                     (ectrodactyly) type 1"
                     /codon_start=1
                     /product="26S proteasome complex subunit SEM1"
                     /protein_id="NP_033195.1"
                     /db_xref="CCDS:CCDS39422.1"
                     /db_xref="GeneID:20422"
                     /db_xref="MGI:MGI:109238"
                     /translation="MSEKKQPVDLGLLEEDDEFEEFPAEDWAGLDEDEDAHVWEDNWD
                     DDNVEDDFSNQLRAELEKHGYKMETS"
     exon            181..274
                     /gene="Sem1"
                     /gene_synonym="DSS1; Shfdg1; Shfg; Shfm1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..491
                     /gene="Sem1"
                     /gene_synonym="DSS1; Shfdg1; Shfg; Shfm1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      460..465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sem1"
                     /gene_synonym="DSS1; Shfdg1; Shfg; Shfm1"
                     /note="hexamer: AATAAA"
     polyA_site      478
                     /gene="Sem1"
                     /gene_synonym="DSS1; Shfdg1; Shfg; Shfm1"
                     /note="major polyA site"
ORIGIN      
        1 tcgtctctat ggttgcgccg gcgttgtcag gatcggcgcc tccggagtac tgaggcttcc
       61 gactttgcgg ccggtccgag cagcttgggt cttggcgcgg cgcgatgtcc gaaaagaagc
      121 agccggtcga cttgggtctc ttggaagagg acgacgagtt cgaggagttt cccgcggaag
      181 actgggctgg cttagatgaa gatgaagatg cacatgtctg ggaggataat tgggatgatg
      241 acaatgtaga agatgacttc tctaaccagt tacgtgctga gctggagaag cacggctaca
      301 agatggagac atcatagcat ctgggaatgt cccaggaacc tcaatcatgg actctaccac
      361 agtctaggac agagaaagca ggacgggata ctttaaagaa catgtttatt tcattatctg
      421 cttcaattta tttttgtttt ataacaaaaa aaataagtaa ataaatgttt tgatttaatc
      481 tttttggttc a
//
