LOCUS       NM_009151               2604 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus selectin, platelet (p-selectin) ligand (Selplg), mRNA.
ACCESSION   NM_009151
VERSION     NM_009151.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2604)
  AUTHORS   Jiang,C., Mei,M., Liu,Y., Hou,M., Jiao,J., Tan,Y. and Tan,X.
  TITLE     PSGL-1 is an evolutionarily conserved antiviral restriction factor
  JOURNAL   mBio 14 (5), e0038723 (2023)
   PUBMED   37787515
  REMARK    GeneRIF: PSGL-1 is an evolutionarily conserved antiviral
            restriction factor.
REFERENCE   2  (bases 1 to 2604)
  AUTHORS   Xu,Q., Shi,M., Ding,L., Xia,Y., Luo,L., Lu,X., Zhang,X. and
            Deng,D.Y.B.
  TITLE     High expression of P-selectin induces neutrophil extracellular
            traps via the PSGL-1/Syk/Ca2+/PAD4 pathway to exacerbate acute
            pancreatitis
  JOURNAL   Front Immunol 14, 1265344 (2023)
   PUBMED   37841279
  REMARK    GeneRIF: High expression of P-selectin induces neutrophil
            extracellular traps via the PSGL-1/Syk/Ca[2+]/PAD4 pathway to
            exacerbate acute pancreatitis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2604)
  AUTHORS   Goth,C.K., Mehta,A.Y., McQuillan,A.M., Baker,K.J., Hanes,M.S.,
            Park,S.S., Stavenhagen,K., Hjorto,G.M., Heimburg-Molinaro,J.,
            Chaikof,E.L., Rosenkilde,M.M. and Cummings,R.D.
  TITLE     Chemokine binding to PSGL-1 is controlled by O-glycosylation and
            tyrosine sulfation
  JOURNAL   Cell Chem Biol 30 (8), 893-905 (2023)
   PUBMED   37463583
  REMARK    GeneRIF: Chemokine binding to PSGL-1 is controlled by
            O-glycosylation and tyrosine sulfation.
REFERENCE   4  (bases 1 to 2604)
  AUTHORS   Hope,J.L., Otero,D.C., Bae,E.A., Stairiker,C.J., Palete,A.B.,
            Faso,H.A., Lin,M., Henriquez,M.L., Roy,S., Seo,H., Lei,X.,
            Wang,E.S., Chow,S., Tinoco,R., Daniels,G.A., Yip,K., Campos,A.R.,
            Yin,J., Adams,P.D., Rao,A. and Bradley,L.M.
  TITLE     PSGL-1 attenuates early TCR signaling to suppress CD8+ T cell
            progenitor differentiation and elicit terminal CD8+ T cell
            exhaustion
  JOURNAL   Cell Rep 42 (5), 112436 (2023)
   PUBMED   37115668
REFERENCE   5  (bases 1 to 2604)
  AUTHORS   Harbour,J.C., Abdelbary,M., Schell,J.B., Fancher,S.P., McLean,J.J.,
            Nappi,T.J., Liu,S., Nice,T.J., Xia,Z., Fruh,K. and Nolz,J.C.
  TITLE     T helper 1 effector memory CD4+ T cells protect the skin from
            poxvirus infection
  JOURNAL   Cell Rep 42 (5), 112407 (2023)
   PUBMED   37083328
REFERENCE   6  (bases 1 to 2604)
  AUTHORS   van den Berg,T.K., Nath,D., Ziltener,H.J., Vestweber,D., Fukuda,M.,
            van Die,I. and Crocker,P.R.
  TITLE     Cutting edge: CD43 functions as a T cell counterreceptor for the
            macrophage adhesion receptor sialoadhesin (Siglec-1)
  JOURNAL   J Immunol 166 (6), 3637-3640 (2001)
   PUBMED   11238599
REFERENCE   7  (bases 1 to 2604)
  AUTHORS   Hirata,T., Merrill-Skoloff,G., Aab,M., Yang,J., Furie,B.C. and
            Furie,B.
  TITLE     P-Selectin glycoprotein ligand 1 (PSGL-1) is a physiological ligand
            for E-selectin in mediating T helper 1 lymphocyte migration
  JOURNAL   J Exp Med 192 (11), 1669-1676 (2000)
   PUBMED   11104809
REFERENCE   8  (bases 1 to 2604)
  AUTHORS   Norman,K.E., Katopodis,A.G., Thoma,G., Kolbinger,F., Hicks,A.E.,
            Cotter,M.J., Pockley,A.G. and Hellewell,P.G.
  TITLE     P-selectin glycoprotein ligand-1 supports rolling on E- and
            P-selectin in vivo
  JOURNAL   Blood 96 (10), 3585-3591 (2000)
   PUBMED   11071658
REFERENCE   9  (bases 1 to 2604)
  AUTHORS   Yang,J., Hirata,T., Croce,K., Merrill-Skoloff,G., Tchernychev,B.,
            Williams,E., Flaumenhaft,R., Furie,B.C. and Furie,B.
  TITLE     Targeted gene disruption demonstrates that P-selectin glycoprotein
            ligand 1 (PSGL-1) is required for P-selectin-mediated but not
            E-selectin-mediated neutrophil rolling and migration
  JOURNAL   J Exp Med 190 (12), 1769-1782 (1999)
   PUBMED   10601352
REFERENCE   10 (bases 1 to 2604)
  AUTHORS   Yang,J., Galipeau,J., Kozak,C.A., Furie,B.C. and Furie,B.
  TITLE     Mouse P-selectin glycoprotein ligand-1: molecular cloning,
            chromosomal localization, and expression of a functional P-selectin
            receptor
  JOURNAL   Blood 87 (10), 4176-4186 (1996)
   PUBMED   8639776
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CJ134610.1, BE859840.1, BG083864.2, BG070861.2, BY553294.1 and
            AC159240.3.
            
            On Nov 2, 2007 this sequence version replaced NM_009151.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156933.1, AK155762.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-639               CJ134610.1         2-640
            640-1042            BE859840.1         140-542
            1043-1414           BG083864.2         214-585
            1415-1852           BG070861.2         1-438               c
            1853-1867           BY553294.1         433-447
            1868-2604           AC159240.3         112694-113430
FEATURES             Location/Qualifiers
     source          1..2604
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 55.59 cM"
     gene            1..2604
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
                     /note="selectin, platelet (p-selectin) ligand"
                     /db_xref="GeneID:20345"
                     /db_xref="MGI:MGI:106689"
     exon            1..153
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
                     /inference="alignment:Splign:2.1.0"
     exon            154..2604
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
                     /inference="alignment:Splign:2.1.0"
     CDS             159..1412
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
                     /note="P-selectin glycoprotein ligand 1; selectin P
                     ligand"
                     /codon_start=1
                     /product="P-selectin glycoprotein ligand 1 precursor"
                     /protein_id="NP_033177.3"
                     /db_xref="CCDS:CCDS51621.1"
                     /db_xref="GeneID:20345"
                     /db_xref="MGI:MGI:106689"
                     /translation="MSPSFLVLLTILGPGNSLQLQDPWGHETKEAPGPVHLRERRQVV
                     GDDDFEDPDYTYNTDPPELLKNVTNTVAAHPELPTTVVMLERDSTSAGTSERATEKIA
                     TTDPTAPGTGGTAVGMLSTDSATQWSLTSVETVQPASTEVETSQPAPMEAETSQPAPM
                     EAETSQPAPMEAETSQPAPMEADTSQPAPMEADTSKPAPTEAETSKPAPTEAETSQPA
                     PNEAETSKPAPTEAETSKPAPTEAETTQLPRIQAVKTLFTTSAATEVPSTEPTTMETA
                     STESNESTIFLGPSVTHLPDSGLKKGLIVTPGNSPAPTLPGSSDLIPVKQCLLIILIL
                     ASLATIFLVCTVVLAVRLSRKTHMYPVRNYSPTEMICISSLLPEGGDGAPVTANGGLP
                     KVQDLKTEPSGDRDGDDLTLHSFLP"
     regulatory      1831..1836
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
                     /note="hexamer: AATAAA"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
                     /note="hexamer: AATAAA"
     polyA_site      1853
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
                     /note="major polyA site"
     polyA_site      1868
                     /gene="Selplg"
                     /gene_synonym="CD162; Psgl-1; Psgl1; Selp1; Selpl"
ORIGIN      
        1 attctcgctt ccttcttcca caccctgccg ttgggggttg gcgggcagat tgggaccaca
       61 agtgtctggc agtgtggact ggggccctgt cactgaggca gagtcgtttg cttctgggcc
      121 ctgaggcagc tgccccatgc tctgttgggc acggtaccat gtccccaagc ttccttgtgc
      181 tgctgaccat cttgggccct ggcaacagcc ttcagctgca ggacccctgg gggcatgaaa
      241 ccaaggaagc cccgggtcct gtgcatctcc gggaacggag gcaggtggtt ggggatgacg
      301 attttgagga ccctgactat acgtataaca cagacccccc agaattgctg aaaaatgtca
      361 ccaacaccgt ggctgctcac cctgagctgc caaccaccgt ggtcatgcta gagagagatt
      421 ccacgagcgc tggaacctcc gagagagcca ctgagaagat tgccaccact gaccctactg
      481 ccccaggtac aggagggaca gctgttggga tgctgagcac agactctgcc acacagtgga
      541 gtctaacctc agtagagacc gtccaaccag catccacaga ggtagagacc tcgcagccag
      601 cacccatgga ggcagagacc tcgcagccag cacccatgga ggcagagacc tcgcagccag
      661 cacccatgga ggcagagacc tcgcagccag cacccatgga ggcagacacc tcgcagccag
      721 cacccatgga ggcagacacc tcaaagccag cacccacgga ggcagagacc tcaaagccag
      781 cacccacgga ggcagagacc tctcagccag cacccaacga ggcagagacc tcaaaaccag
      841 cacccacgga ggcagagacc tcaaaaccag cacccacgga ggcagagacc acccagcttc
      901 ccaggattca ggctgtaaaa actctgttta caacgtctgc agccaccgaa gtcccttcca
      961 cagaacctac caccatggag acggcgtcca cagagtctaa cgagtctacc atcttccttg
     1021 ggccatccgt gactcactta cctgacagcg gcctgaagaa agggctgatt gtgacccctg
     1081 ggaattcacc tgccccaacc ctgccaggga gttcagatct catcccggtg aagcaatgtc
     1141 tgctgattat cctcatcttg gcttctctgg ccaccatctt cctcgtgtgc acagtggtgc
     1201 tggcggtccg tctgtcccgt aagacccaca tgtacccagt gcggaactac tcccccacgg
     1261 agatgatctg catctcgtcc ctgctacctg aggggggaga cggggcccct gtcacagcca
     1321 atgggggcct gcccaaggtc caggacctga agacagagcc cagtggggac cgggatgggg
     1381 acgacctcac cctgcacagc ttcctccctt agactcccct gcctgcccac ctaagcgaga
     1441 cctttgctag ctccactctc acccgctggt cacagaggtc atagatctgg gcttcctggg
     1501 tgaaatgtat tcacgggagt ctttagagcg cccaccgctg tgtgtctccc tgcaggtcac
     1561 tggatacctg tccttgcgtt ctccagaaag actcagctcc cttattccac tcccaaaagc
     1621 tactctgttg gttgccatgg taacccggta agagaggagc tttgtgggag gccgccatgt
     1681 ctgcttctct gattccagtg gcaggtagcc tggctttccc aggtccctgg cttggaggga
     1741 tggtccttcc tttgggcccg tgtgaaccaa cgagtttccg tacagtgaca gaatgacctc
     1801 gcgctgcggc ctggcccagc acaggcatcc aataaacata ttataataaa cgatagctga
     1861 gtccttcatg tgcctaggct gccatctcca gccctcccgg agggcgctta gaccattgtc
     1921 cacaccgctc ttagacatct aatacatgct tgggcaactg caaggggcac tggagggttt
     1981 aagcgacacg tggtaggtag catatgccca tcacccaagc agtacaggag ttcaaggtca
     2041 tccttggctc gttaactgcc tgggctacat gagaccctgt ctccgagaaa actaaagctg
     2101 ggtctggctg gctggctcag ccggtgaagg tgcttgctgc tacgcctcat ggcctaagct
     2161 ccaggggggc cctcatggtg gaaggagaag gctgactctc caaaactgtt ctctggcatc
     2221 catactcaca ggtaaatatg aacacaacta cacaagctag agaactttat tgaatctacc
     2281 ctttccaagg tgggtcaaag gaggaaggtc cctttggtgt tggccaattt ctttttaaag
     2341 atttatttat gtttatgagt atgctgtcac tgtcttcaga cacagcagaa gagggcatcg
     2401 gatcccatta cagacttgag ccaccccgtg ggtactggga attgaactca ggaactctgg
     2461 aagagcagtc agtgctctta acagctgagc catcccttca gcagccctgt cagatttttt
     2521 tttttaatca ccaaagagat tttattcaag tttctaacac aaatgagtta ttttggtttt
     2581 gaattacaga actaagtcca aact
//
