LOCUS       NM_011347               3438 bp    mRNA    linear   ROD 11-OCT-2024
DEFINITION  Mus musculus selectin, platelet (Selp), mRNA.
ACCESSION   NM_011347 XM_912131
VERSION     NM_011347.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3438)
  AUTHORS   Ballard-Kordeliski,A., Lee,R.H., O'Shaughnessy,E.C., Kim,P.Y.,
            Jones,S.R., Pawlinski,R., Flick,M.J., Paul,D.S., Mackman,N.,
            Adalsteinsson,D.A. and Bergmeier,W.
  TITLE     4D intravital imaging studies identify platelets as the predominant
            cellular procoagulant surface in a mouse hemostasis model
  JOURNAL   Blood 144 (10), 1116-1126 (2024)
   PUBMED   38820498
REFERENCE   2  (bases 1 to 3438)
  AUTHORS   Sisak,S., Chae,R.C., Nelson,K.E., Schuster,R.M., Perez,E.C.,
            England,L.G., Caldwell,C.C., Lentsch,A.B., Goodman,M.D. and
            Pritts,T.A.
  TITLE     Microvesicles from stored red blood cells induce P-selectin and von
            Willebrand factor release from endothelial cells via a protein
            kinase C-dependent mechanism
  JOURNAL   Transfus Apher Sci 63 (2), 103890 (2024)
   PUBMED   38355315
  REMARK    GeneRIF: Microvesicles from stored red blood cells induce
            P-selectin and von Willebrand factor release from endothelial cells
            via a protein kinase C-dependent mechanism.
REFERENCE   3  (bases 1 to 3438)
  AUTHORS   Li,C.C., Munalisa,R., Lee,H.Y., Lien,T.S., Chan,H., Hung,S.C.,
            Sun,D.S., Cheng,C.F. and Chang,H.H.
  TITLE     Restraint Stress-Induced Immunosuppression Is Associated with
            Concurrent Macrophage Pyroptosis Cell Death in Mice
  JOURNAL   Int J Mol Sci 24 (16), 12877 (2023)
   PUBMED   37629059
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3438)
  AUTHORS   Hatchell,D., Alshareef,M., Vasas,T., Guglietta,S., Borucki,D.,
            Guo,C., Mallah,K., Eskandari,R. and Tomlinson,S.
  TITLE     A role for P-selectin and complement in the pathological sequelae
            of germinal matrix hemorrhage
  JOURNAL   J Neuroinflammation 20 (1), 143 (2023)
   PUBMED   37322469
  REMARK    GeneRIF: A role for P-selectin and complement in the pathological
            sequelae of germinal matrix hemorrhage.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3438)
  AUTHORS   Gullotta,G.S., De Feo,D., Friebel,E., Semerano,A., Scotti,G.M.,
            Bergamaschi,A., Butti,E., Brambilla,E., Genchi,A., Capotondo,A.,
            Gallizioli,M., Coviello,S., Piccoli,M., Vigo,T., Della Valle,P.,
            Ronchi,P., Comi,G., D'Angelo,A., Maugeri,N., Roveri,L., Uccelli,A.,
            Becher,B., Martino,G. and Bacigaluppi,M.
  TITLE     Age-induced alterations of granulopoiesis generate atypical
            neutrophils that aggravate stroke pathology
  JOURNAL   Nat Immunol 24 (6), 925-940 (2023)
   PUBMED   37188941
REFERENCE   6  (bases 1 to 3438)
  AUTHORS   Sammar,M., Aigner,S., Hubbe,M., Schirrmacher,V., Schachner,M.,
            Vestweber,D. and Altevogt,P.
  TITLE     Heat-stable antigen (CD24) as ligand for mouse P-selectin
  JOURNAL   Int Immunol 6 (7), 1027-1036 (1994)
   PUBMED   7524641
REFERENCE   7  (bases 1 to 3438)
  AUTHORS   Sanders,W.E., Wilson,R.W., Ballantyne,C.M. and Beaudet,A.L.
  TITLE     Molecular cloning and analysis of in vivo expression of murine
            P-selectin
  JOURNAL   Blood 80 (3), 795-800 (1992)
   PUBMED   1379089
REFERENCE   8  (bases 1 to 3438)
  AUTHORS   Weller,A., Isenmann,S. and Vestweber,D.
  TITLE     Cloning of the mouse endothelial selectins. Expression of both E-
            and P-selectin is inducible by tumor necrosis factor alpha
  JOURNAL   J Biol Chem 267 (21), 15176-15183 (1992)
   PUBMED   1378846
REFERENCE   9  (bases 1 to 3438)
  AUTHORS   Bevilacqua,M., Butcher,E., Furie,B., Furie,B., Gallatin,M.,
            Gimbrone,M., Harlan,J., Kishimoto,K., Lasky,L., McEver,R. et al.
  TITLE     Selectins: a family of adhesion receptors
  JOURNAL   Cell 67 (2), 233 (1991)
   PUBMED   1717161
REFERENCE   10 (bases 1 to 3438)
  AUTHORS   Watson,M.L., Kingsmore,S.F., Johnston,G.I., Siegelman,M.H., Le
            Beau,M.M., Lemons,R.S., Bora,N.S., Howard,T.A., Weissman,I.L.,
            McEver,R.P. et al.
  TITLE     Genomic organization of the selectin family of leukocyte adhesion
            molecules on human and mouse chromosome 1
  JOURNAL   J Exp Med 172 (1), 263-272 (1990)
   PUBMED   1694218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110499.19 and BC109159.1.
            
            On Apr 2, 2011 this sequence version replaced NM_011347.1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M72332.1, M87861.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-114               AC110499.19        50365-50478         c
            115-2480            BC109159.1         1-2366
            2481-3438           AC110499.19        15716-16673         c
FEATURES             Location/Qualifiers
     source          1..3438
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.42 cM"
     gene            1..3438
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /note="selectin, platelet"
                     /db_xref="GeneID:20344"
                     /db_xref="MGI:MGI:98280"
     exon            1..126
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     CDS             124..2430
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /note="P-selectin; granule membrane protein 140; CD62
                     antigen-like family member P; leukocyte-endothelial cell
                     adhesion molecule 3; platelet activation dependent
                     granule-external membrane protein"
                     /codon_start=1
                     /product="P-selectin precursor"
                     /protein_id="NP_035477.1"
                     /db_xref="CCDS:CCDS48422.1"
                     /db_xref="GeneID:20344"
                     /db_xref="MGI:MGI:98280"
                     /translation="MAGCPKGSWTPRLRSVILGGAQLIWFSALISELVNQKEVAAWTY
                     NYSTKAYSWNNSRVFCRRHFTDLVAIQNKNEIAHLNDVIPFFNSYYWIGIRKINNKWT
                     WVGTNKTLTEEAENWADNEPNNKKNNQDCVEIYIKSNSAPGKWNDEPCFKRKRALCYT
                     ASCQDMSCSNQGECIETIGSYTCSCYPGFYGPECEYVKECGKVNIPQHVLMNCSHPLG
                     EFSFNSQCTFSCAEGYELDGPGELQCLASGIWTNNPPKCDAVQCQSLEAPPHGTMACM
                     HPIAAFAYDSSCKFECQPGYRARGSNTLHCTGSGQWSEPLPTCEAIACEPPEIPIHGS
                     MDCVPSTGTFGYNSSCTFLCAEGFVLKGNDAIQCADSGQWTAPAPFCEALQCPEFPVP
                     SKAQVNCSDPFGTLTYQSVCSFSCDEGSLLVGASVIRCLATGHWNGAPPECQAVSCAP
                     MLSPENGSMTCVQPLGNSTYKSTCQFMCDEGFYLSGPERLDCSPSGHWTGTPPTCEAI
                     KCPGIFAPEQGNLDCSHVHGEFGVGSICHFSCNEDFELLGSENVECTVSGRWSAPPPT
                     CKGITSLPAPAVRCPALTTPGQGTMSCQHHLGSFGPNTTCYFGCKTGFTLRGANSLRC
                     RASGQWTAVTPMCRAVKCSELHMDTAVAMNCSNPWGNFSYGSTCTFQCPEGQSLNGSV
                     RATCREDGHWSDAMPTCQAGTLTIQEALTYLGGAVASTTGLAVGGTLLALLRKRLRKK
                     DDGKCPLNPHSHLGTYGVFTNAAYDPTP"
     exon            127..217
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            218..604
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            605..712
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            713..898
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            899..1084
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1085..1270
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1271..1456
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1457..1642
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1643..1828
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            1829..2038
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            2039..2224
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            2225..2344
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            2345..2375
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            2376..2431
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     exon            2432..3438
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3413..3418
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /note="hexamer: AATAAA"
     polyA_site      3435
                     /gene="Selp"
                     /gene_synonym="CD62P; GMP-140; Grmp; LECAM3; PADGEM"
                     /note="major polyA site"
ORIGIN      
        1 acatttctgg aaagcgaata ggaagttgtt ttgttaggca gcctgacatc aacgggaggc
       61 agcaaaagta taagaagtgt ggttttggct agagggaaga aagccagacg gatcagagag
      121 gacatggctg gctgcccaaa aggttcctgg acgccaagac tccggagtgt gatcctggga
      181 ggggctcaac tcatctggtt cagtgctttg atctctgagc ttgtaaatca gaaggaagtg
      241 gctgcgtgga cctataacta cagcacaaag gcatactcat ggaataactc acgggtgttc
      301 tgtaggaggc acttcacaga cttagtggcc atccagaata agaatgaaat cgctcacctc
      361 aatgacgtca tcccattctt caactcttac tactggattg gtatccgaaa gatcaacaat
      421 aagtggacct gggtgggaac aaataagaca ctcacggagg aggctgagaa ctgggccgac
      481 aacgagccca acaacaagaa gaacaatcag gactgtgtgg agatctacat caagagtaac
      541 tcggcccctg gcaagtggaa tgatgaaccc tgttttaaac gaaagcgggc cctgtgctac
      601 acagcctcct gccaggacat gtcctgcagc aaccaagggg agtgcatcga gaccattggg
      661 agctatacct gctcctgcta cccaggcttc tatgggccag agtgtgaata cgtcaaggag
      721 tgtggaaaag tcaacatccc tcaacatgtt ctcatgaact gcagccatcc cctgggggag
      781 ttctccttca actcacagtg caccttcagc tgtgctgagg gctacgagct ggacggaccc
      841 ggcgagctgc aatgtttggc ttctgggatc tggacaaata accccccgaa gtgtgacgct
      901 gtgcaatgtc agagcctgga agcccctccc catggaacca tggcctgtat gcacccaatt
      961 gctgcctttg cctacgactc cagctgtaaa tttgagtgcc agcctggata tagagcgagg
     1021 ggctccaaca cactccactg cactggctct ggtcagtgga gtgaaccact gccaacctgt
     1081 gaagctattg cgtgtgaacc tccggagatc cccatccatg ggagcatgga ctgcgtccca
     1141 tctacaggaa cctttgggta caacagcagc tgcacttttc tctgtgcaga ggggttcgtg
     1201 ctgaagggaa atgatgccat tcagtgtgct gactccgggc agtggacagc cccagcccca
     1261 ttctgtgaag cgttgcaatg tccagagttt ccggttccca gtaaagccca ggtgaactgc
     1321 tcggatccct tcggtacctt gacgtaccag tcagtctgca gcttttcctg tgatgaaggc
     1381 tcgctcttgg tgggagcaag tgtgataaga tgcctggcta ctggacactg gaatggggct
     1441 cctcccgaat gtcaagctgt gtcctgtgcc cctatgctca gtcctgagaa tggatccatg
     1501 acctgcgttc agcctcttgg gaattccacc tacaaatcca catgccagtt catgtgcgat
     1561 gaaggatttt atctatctgg accggaaaga ctggattgtt ctccatctgg acactggaca
     1621 ggcacccctc ccacgtgtga agccatcaag tgtccaggaa tcttcgcccc agagcaaggc
     1681 aacctggatt gttctcatgt ccacggagag tttggtgttg gctctatctg tcacttctcc
     1741 tgcaatgagg actttgagct actgggatct gaaaatgtgg aatgcacagt gtctggaaga
     1801 tggtcagcac ctccgccaac ctgcaaaggc ataacatcac ttcctgcccc agcagtccga
     1861 tgccctgccc tcacgactcc tggacagggc acaatgtcct gccaacacca cctgggaagc
     1921 tttggtccga acaccacttg ttactttggg tgcaaaaccg gatttacact caggggagcc
     1981 aactcgctcc gctgcagggc ttcaggacaa tggacagcag tgacccccat gtgcagagcg
     2041 gtcaaatgct ccgaattgca catggacaca gcagtagcaa tgaactgttc caatccctgg
     2101 ggaaacttta gctatggatc aacctgcacc ttccagtgcc cagaggggca gtcactgaac
     2161 ggctctgtga gagcaacctg ccgagaggac ggtcactggt cagatgccat gccaacctgc
     2221 caagcaggga cactgacaat ccaggaagct ctgacgtact tgggtggtgc agtggcttct
     2281 acaacaggcc tggcagtggg cgggacactc ctggctctgc taagaaagcg tctcagaaag
     2341 aaagatgatg gaaaatgccc cttgaaccct cacagccacc taggaacata cggagtcttc
     2401 actaacgctg catatgaccc aaccccttaa gaaacccggt ctgccaatgt ctcattcgat
     2461 ttctcaggat tccacatgca agtgtcaagt ttcctgtcac acttgactgt aactccatgg
     2521 catttgggca tttgctgagg ttctctgtag tttaaaacaa aaaacaaaac aaaacaaaaa
     2581 aaaggacagg aacctagaaa aagaactatg cactttccca cctctccacc caccccttcc
     2641 tgctccgccc ctcaccttcc tccagctccg ccccttcctg ctccgcccct caccttcctc
     2701 cagctccgcc ccttcctgct ccgcccctca ccttcctcca gctcagccac agacccagga
     2761 gcaaatgttt ctgctctggt ctgtggcttg ttgttacttt gctgttgctg aaaacgggag
     2821 agtccaaggc cctggagcat cttcctcacc aggtgaccag gctctggaaa accgaaggtc
     2881 tttctcttgg gattgcagag tagcaatgtt ggtgggcagg cagacctcta gtttaagggg
     2941 atgcctgctt taagatctcc tgggtcttcc atgtttcata tcaatgaggt tgtttacacc
     3001 tctgctgctg agactttcac agaaacctcc agatggtact aggggacaca gaagatctgg
     3061 aacagagcca agacgtcaca tctgactgca gactttccct ccaccaaagc acccaaagat
     3121 cattgtttgg atgtataaat aactcaactt ccccaaatgt caagctcttt gtgttttgtt
     3181 caataagttc tgtgtatagc actttgtcta ccaccaatgt ggtcacagtt acaaccctct
     3241 aaatgacagc tggaccttcc agtgaaagca caaatgtatg tcgtatatcc cctgaccaca
     3301 gaggaaaaaa acaaaaacaa aagtcagagg agcagaaaaa ggtcctcttt gcaattactg
     3361 ttctgcagga aagaacagat attgttttat atgtaattta atgcacatat ttaataaata
     3421 agtcactgaa aattacat
//
