LOCUS       NM_011346               2341 bp    mRNA    linear   ROD 28-JAN-2025
DEFINITION  Mus musculus selectin, lymphocyte (Sell), transcript variant 1,
            mRNA.
ACCESSION   NM_011346
VERSION     NM_011346.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2341)
  AUTHORS   Canesso,M.C.C., Castro,T.B.R., Nakandakari-Higa,S., Lockhart,A.,
            Luehr,J., Bortolatto,J., Parsa,R., Esterhazy,D., Lyu,M., Liu,T.T.,
            Murphy,K.M., Sonnenberg,G.F., Reis,B.S., Victora,G.D. and Mucida,D.
  TITLE     Identification of antigen-presenting cell-T cell interactions
            driving immune responses to food
  JOURNAL   Science, eado5088 (2024) In press
   PUBMED   39700315
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   2  (bases 1 to 2341)
  AUTHORS   Li,Y., Gunderson,R.C., Xu,Z., Ai,W., Shen,F., Ye,J., Xu,B. and
            Michie,S.A.
  TITLE     Mucosal Addressin Cell Adhesion Molecule-1 Mediates T Cell
            Migration into Pancreas-Draining Lymph Nodes for Initiation of the
            Autoimmune Response in Type 1 Diabetes
  JOURNAL   Int J Mol Sci 25 (21), 11350 (2024)
   PUBMED   39518902
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2341)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 2341)
  AUTHORS   Hanson,C.H., Henry,B., Andhare,P., Lin,F.J., Pak,H., Turner,J.S.,
            Adams,L.J., Liu,T., Fremont,D.H., Ellebedy,A.H. and Laidlaw,B.J.
  TITLE     CD62L expression marks a functionally distinct subset of memory B
            cells
  JOURNAL   Cell Rep 42 (12), 113542 (2023)
   PUBMED   38060451
  REMARK    GeneRIF: CD62L expression marks a functionally distinct subset of
            memory B cells.
REFERENCE   5  (bases 1 to 2341)
  AUTHORS   Merkenschlager,J., Berz,R.M., Ramos,V., Uhlig,M., MacLean,A.J.,
            Nowosad,C.R., Oliveira,T.Y. and Nussenzweig,M.C.
  TITLE     Continually recruited naive T cells contribute to the follicular
            helper and regulatory T cell pools in germinal centers
  JOURNAL   Nat Commun 14 (1), 6944 (2023)
   PUBMED   37907454
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2341)
  AUTHORS   Morse,H.C. 3rd.
  TITLE     Genetic nomenclature for loci controlling surface antigens of mouse
            hemopoietic cells
  JOURNAL   J Immunol 149 (10), 3129-3134 (1992)
   PUBMED   1431091
  REMARK    Review article
            Erratum:[J Immunol 1993 Mar 15;150(6):2563]
REFERENCE   7  (bases 1 to 2341)
  AUTHORS   Oakey,R.J., Watson,M.L. and Seldin,M.F.
  TITLE     Construction of a physical map on mouse and human chromosome 1:
            comparison of 13 Mb of mouse and 11 Mb of human DNA
  JOURNAL   Hum Mol Genet 1 (8), 613-620 (1992)
   PUBMED   1301170
REFERENCE   8  (bases 1 to 2341)
  AUTHORS   Capeless,C.G., Whitney,G. and Azen,E.A.
  TITLE     Chromosome mapping of Soa, a gene influencing gustatory sensitivity
            to sucrose octaacetate in mice
  JOURNAL   Behav Genet 22 (6), 655-663 (1992)
   PUBMED   1290451
REFERENCE   9  (bases 1 to 2341)
  AUTHORS   Birkenmeier,E.H., Schneider,U. and Thurston,S.J.
  TITLE     Fingerprinting genomes by use of PCR with primers that encode
            protein motifs or contain sequences that regulate gene expression
  JOURNAL   Mamm Genome 3 (10), 537-545 (1992)
   PUBMED   1421760
  REMARK    Erratum:[Mamm Genome 1993;4(2):133]
REFERENCE   10 (bases 1 to 2341)
  AUTHORS   Douville,P.J. and Carbonetto,S.
  TITLE     Genetic linkage analysis in recombinant inbred mice of P40, a
            putative clone for the high-affinity laminin receptor
  JOURNAL   Mamm Genome 3 (8), 438-446 (1992)
   PUBMED   1353694
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY210690.1, AK137509.1 and AA182222.1.
            
            On Aug 11, 2009 this sequence version replaced NM_011346.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK157273.1, AK137509.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                BY210690.1         2-89
            89-2318             AK137509.1         1-2230
            2319-2341           AA182222.1         416-438
FEATURES             Location/Qualifiers
     source          1..2341
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.37 cM"
     gene            1..2341
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /note="selectin, lymphocyte"
                     /db_xref="GeneID:20343"
                     /db_xref="MGI:MGI:98279"
     exon            1..116
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     CDS             114..1232
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; lymphocyte antigen 22; lymph node homing
                     receptor; leukocyte adhesion molecule 1; CD62 antigen-like
                     family member L; lymphocyte surface MEL-14 antigen;
                     leukocyte-endothelial cell adhesion molecule 1"
                     /codon_start=1
                     /product="L-selectin isoform 1 precursor"
                     /protein_id="NP_035476.1"
                     /db_xref="CCDS:CCDS35753.1"
                     /db_xref="GeneID:20343"
                     /db_xref="MGI:MGI:98279"
                     /translation="MVFPWRCEGTYWGSRNILKLWVWTLLCCDFLIHHGTHCWTYHYS
                     EKPMNWENARKFCKQNYTDLVAIQNKREIEYLENTLPKSPYYYWIGIRKIGKMWTWVG
                     TNKTLTKEAENWGAGEPNNKKSKEDCVEIYIKRERDSGKWNDDACHKRKAALCYTASC
                     QPGSCNGRGECVETINNHTCICDAGYYGPQCQYVVQCEPLEAPELGTMDCIHPLGNFS
                     FQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQVVQCEPLEAPELGTMDCIHPL
                     GNFSFQSKCAFNCSEGRELLGTAETQCGASGNWSSPEPICQETNRSFSKIKEGDYNPL
                     FIPVAVMVTAFSGLAFLIWLARRLKKGKKSQERMDDPY"
     exon            117..198
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     exon            199..585
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     exon            586..693
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     exon            694..879
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     exon            880..1065
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1066..1194
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1195..1213
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     exon            1214..2321
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1510..1515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /note="hexamer: TATAAA"
     polyA_site      1540
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /note="major polyA site"
     regulatory      2203..2208
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /note="hexamer: AATACA"
     polyA_site      2208
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /note="major polyA site"
     polyA_site      2257
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
     polyA_site      2260
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
     regulatory      2281..2286
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
                     /note="hexamer: GATAAA"
     polyA_site      2321
                     /gene="Sell"
                     /gene_synonym="CD62L; L-selectin; LAM-1; LECAM-1; LECAM1;
                     Lnhr; Ly-22; Ly-m22; Lyam-1; Lyam1"
ORIGIN      
        1 gacattggca cattcttcct gagcgcagca cgccctcctt gtgcaagaac tctgagcccc
       61 aggtgcagga ggctgaggcc tgcagagaga cttgcagaga gacccagcaa gccatggtgt
      121 ttccatggag atgtgagggt acttactggg gctcgaggaa catcctgaag ctgtgggtct
      181 ggacactgct ctgttgtgac ttcctgatac accatggaac tcactgttgg acttaccatt
      241 attctgaaaa gcccatgaac tgggaaaatg ctagaaagtt ctgcaagcaa aattacacag
      301 atttagtcgc catacaaaac aagagagaaa ttgagtattt agagaataca ttgcccaaaa
      361 gcccttatta ctactggata ggaatcagga aaattgggaa aatgtggaca tgggtgggaa
      421 ccaacaaaac tctcactaaa gaagcagaga actggggtgc tggggagccc aacaacaaga
      481 agtccaagga ggactgtgtg gagatctata tcaagaggga acgagactct gggaaatgga
      541 acgatgacgc ctgtcacaaa cgaaaggcag ctctctgcta cacagcctct tgccagccag
      601 ggtcttgcaa tggccgtgga gaatgtgtgg aaactatcaa caatcacacg tgcatctgtg
      661 atgcagggta ttacgggccc cagtgtcagt atgtggtcca gtgtgagcct ttggaggccc
      721 ctgagttggg taccatggac tgcatccacc ccttgggaaa cttcagcttc cagtccaagt
      781 gtgctttcaa ctgttctgag ggaagagagc tacttgggac tgcagaaaca cagtgtggag
      841 catctggaaa ctggtcatct ccagagccaa tctgccaagt ggtccagtgt gagcctttgg
      901 aggcccctga gttgggtacc atggactgca tccacccctt gggaaacttc agcttccagt
      961 ccaagtgtgc tttcaactgt tctgagggaa gagagctact tgggactgca gaaacacagt
     1021 gtggagcatc tggaaactgg tcatctccag agccaatctg ccaagagaca aacagaagtt
     1081 tctcaaagat caaagaaggt gactacaacc ccctcttcat tcctgtagcc gtcatggtca
     1141 ccgcattctc ggggctggca tttctcattt ggctggcaag gcggttaaaa aaaggcaaga
     1201 aatctcaaga aaggatggat gatccatact gattcatcct ttgtgaaagg aaagccatga
     1261 agtgctaaag acaaaacatt ggaaaataac gtcaagtcct cccgtgaaga ttttacacgc
     1321 aggcatctcc cacattagag atgcagtgtt tgctcaacga atctggaagg atttcttcat
     1381 gaccaacagc tcctcctaat ttcccctcgc tcattcatcc cattaaccct atcccataat
     1441 gtgtgtctat acagagtagt attttatcat cttttctgtg gaggaacaag caaaagtgtt
     1501 actgtagaat ataaagacag ctgcttttac tctttcctaa ctcttgtttc ctagttcaat
     1561 tcagcacaga agctaatgcc aaacacagtg aaaatatgat ccatgagtaa ttggaaactc
     1621 agactccttg cgcatagtac gtaccctatg taacatcgac aaaaatcttt catttccacc
     1681 tccaaagaac agtgctctat tcaagttggg aaagtcctac ttcctctgta gacccactat
     1741 ctgtgagtga cagccactgt agctgttcac attaaccttc cccatctcct tttcctagga
     1801 gaataattcc acacactgca ccccatgatg gccaccaaac atcaaagaag ggaaaatctc
     1861 ctgcattgag ttttagtttt gagttttccc ttctctttat tagatctctc taggttcctt
     1921 gaagtcagtg ttctgatgat tattaatagt taatgataac acaacccact ctcttggagc
     1981 tgatgttatg aagacaacag gtagaaaaat tcctgggctc aggctggagt gacacccttt
     2041 tctttcccta acatcttcta ctcagatacc taaatttaag attcaggaca gctgtcccca
     2101 actcttacca tgtcttttat aacttgctcc ttaacttgcc caacctgtag gctatctcat
     2161 tttctcgctt cactctgcaa ggtttataac atgatgaatt taaatacagc ctgttttttg
     2221 ttttttttta aatgttactt agtctatttg tataccagaa tatgtgttgt ttttttccta
     2281 gataaaattg tacccttctt gaggggagag actgtgtcag aaaaaaaaaa aaaaaaaaaa
     2341 a
//
