LOCUS       NM_009156                722 bp    mRNA    linear   ROD 17-AUG-2024
DEFINITION  Mus musculus selenoprotein W (Selenow), mRNA.
ACCESSION   NM_009156
VERSION     NM_009156.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 722)
  AUTHORS   Ren,B., Situ,J., Huang,X., Tan,Q., Xiao,S., Li,N., Tian,J., Du,X.,
            Ni,J. and Liu,Q.
  TITLE     Selenoprotein W modulates tau homeostasis in an Alzheimer's disease
            mouse model
  JOURNAL   Commun Biol 7 (1), 872 (2024)
   PUBMED   39020075
  REMARK    GeneRIF: Selenoprotein W modulates tau homeostasis in an
            Alzheimer's disease mouse model.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 722)
  AUTHORS   Kim,H., Oh,J., Kim,M.K., Lee,K.H. and Jeong,D.
  TITLE     Selenoprotein W engages in overactive osteoclast differentiation in
            multiple myeloma
  JOURNAL   Mol Biol Rep 51 (1), 587 (2024)
   PUBMED   38683225
  REMARK    GeneRIF: Selenoprotein W engages in overactive osteoclast
            differentiation in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 722)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 722)
  AUTHORS   Misra,S., Lee,T.J., Sebastian,A., McGuigan,J., Liao,C., Koo,I.,
            Patterson,A.D., Rossi,R.M., Hall,M.A., Albert,I. and Prabhu,K.S.
  TITLE     Loss of selenoprotein W in murine macrophages alters the hierarchy
            of selenoprotein expression, redox tone, and mitochondrial
            functions during inflammation
  JOURNAL   Redox Biol 59, 102571 (2023)
   PUBMED   36516721
  REMARK    GeneRIF: Loss of selenoprotein W in murine macrophages alters the
            hierarchy of selenoprotein expression, redox tone, and
            mitochondrial functions during inflammation.
REFERENCE   5  (bases 1 to 722)
  AUTHORS   Loflin,J., Lopez,N., Whanger,P.D. and Kioussi,C.
  TITLE     Selenoprotein W during development and oxidative stress
  JOURNAL   J Inorg Biochem 100 (10), 1679-1684 (2006)
   PUBMED   16876868
  REMARK    GeneRIF: Selenoprotein W is involved in muscle growth and
            differentiation by protecting the developing myoblasts from
            oxidative stress
REFERENCE   6  (bases 1 to 722)
  AUTHORS   Jeong,Dw., Kim,T.S., Chung,Y.W., Lee,B.J. and Kim,I.Y.
  TITLE     Selenoprotein W is a glutathione-dependent antioxidant in vivo
  JOURNAL   FEBS Lett 517 (1-3), 225-228 (2002)
   PUBMED   12062442
REFERENCE   7  (bases 1 to 722)
  AUTHORS   Whanger,P.D.
  TITLE     Selenoprotein W: a review
  JOURNAL   Cell Mol Life Sci 57 (13-14), 1846-1852 (2000)
   PUBMED   11215511
  REMARK    Review article
REFERENCE   8  (bases 1 to 722)
  AUTHORS   Burk,R.F. and Hill,K.E.
  TITLE     Orphan selenoproteins
  JOURNAL   Bioessays 21 (3), 231-237 (1999)
   PUBMED   10333732
  REMARK    Review article
REFERENCE   9  (bases 1 to 722)
  AUTHORS   Whanger,P.D., Vendeland,S.C., Gu,Q.P., Beilstein,M.A. and Ream,L.W.
  TITLE     Selenoprotein W cDNAs from five species of animals
  JOURNAL   Biomed Environ Sci 10 (2-3), 190-197 (1997)
   PUBMED   9315310
REFERENCE   10 (bases 1 to 722)
  AUTHORS   Gu,Q.P., Beilstein,M.A., Vendeland,S.C., Lugade,A., Ream,W. and
            Whanger,P.D.
  TITLE     Conserved features of selenocysteine insertion sequence (SECIS)
            elements in selenoprotein W cDNAs from five species
  JOURNAL   Gene 193 (2), 187-196 (1997)
   PUBMED   9256076
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU604713.1 and AF015284.1.
            
            On Jul 26, 2006 this sequence version replaced NM_009156.1.
            
            Summary: This gene encodes a selenoprotein containing a
            selenocysteine (Sec) residue, which is encoded by the UGA codon
            that normally signals translation termination. The 3' UTRs of
            selenoprotein mRNAs contain a conserved stem-loop structure, the
            Sec insertion sequence (SECIS) element that is necessary for the
            recognition of UGA as a Sec codon rather than as a stop signal.
            This protein is highly expressed in skeletal muscle and brain. It
            belongs to the SelWTH family, which possesses a thioredoxin-like
            fold and a conserved CxxU (C is cysteine, U is Sec) motif, and has
            been shown to function as a glutathione-dependent antioxidant in
            vivo. Studies in mouse suggest that this selenoprotein is involved
            in muscle growth and differentiation, and in the protection of
            neurons from oxidative stress during neuronal development.
            [provided by RefSeq, Apr 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF015284.1, BU524484.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: community standard
                                                (PMID:9256076)
            protein contains selenocysteine  :: PMID: 9256076, 12062442
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-45                BU604713.1         34-78
            46-722              AF015284.1         1-677
FEATURES             Location/Qualifiers
     source          1..722
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 8.62 cM"
     gene            1..722
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /note="selenoprotein W"
                     /db_xref="GeneID:20364"
                     /db_xref="MGI:MGI:1100878"
     exon            1..120
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..358
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /note="UGA stop codon recoded as selenocysteine;
                     selenoprotein W, muscle 1"
                     /codon_start=1
                     /transl_except=(pos:128..130,aa:Sec)
                     /product="selenoprotein W"
                     /protein_id="NP_033182.1"
                     /db_xref="CCDS:CCDS39778.1"
                     /db_xref="GeneID:20364"
                     /db_xref="MGI:MGI:1100878"
                     /translation="MALAVRVVYCGAUGYKPKYLQLKEKLEHEFPGCLDICGEGTPQV
                     TGFFEVTVAGKLVHSKKRGDGYVDTESKFRKLVTAIKAALAQCQ"
     exon            121..145
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /inference="alignment:Splign:2.1.0"
     exon            146..199
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /inference="alignment:Splign:2.1.0"
     exon            200..274
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /inference="alignment:Splign:2.1.0"
     exon            275..373
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /inference="alignment:Splign:2.1.0"
     exon            374..705
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      399..475
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      680..685
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /note="hexamer: AATAAA"
     polyA_site      705
                     /gene="Selenow"
                     /gene_synonym="selW; Sepw1"
                     /note="major polyA site"
ORIGIN      
        1 cggctgtgcg cacggcccca cgctcagagc ttgaggtcct tgttgcttgt gggtcgggtc
       61 ctcgtgttgt gcggggatgc gacgtgcagc tatggcgctc gccgttcgag tcgtgtattg
      121 tggagcttga ggctataagc ccaagtacct ccagctcaag gagaagctag aacatgagtt
      181 ccccggatgc ctggacattt gtggcgaggg gactccccag gtcaccgggt tctttgaagt
      241 gacagtagcc gggaagttgg tccactccaa gaagagaggt gatggctatg tggatacaga
      301 gagcaagttc cggaaactgg tgaccgccat caaagctgcc ttggctcagt gccagtgagc
      361 cctagaggca gggtcctgaa agctcctggc cggccttcct tggcagccgc ttcatgacag
      421 gaaggactga aatgtcttag acctgtggtc tttcctcgat gttcctgcgg ccaccaagtc
      481 aggccagaga tggattctgg ctgtgggtgc ctccccagaa tctacccgtg cacgcagcct
      541 gccctgcccc cctgccctct tccccacctc tctctctgaa ttcccccatt gtttcccacc
      601 caccctcctg ctttgctttc cctttccacc tcaagacttc aagaagacag gcagccatgt
      661 ttccaggtgt tcccggttga ataaagtttg gatgaggtaa cccaaaaaaa aaaaaaaaaa
      721 aa
//
