LOCUS       NM_175033               1277 bp    mRNA    linear   ROD 05-AUG-2023
DEFINITION  Mus musculus selenoprotein V (Selenov), mRNA.
ACCESSION   NM_175033 XM_888279 XM_897972 XM_903171 XM_912870 XM_922528
VERSION     NM_175033.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1277)
  AUTHORS   Chen LL, Huang JQ, Wu YY, Chen LB, Li SP, Zhang X, Wu S, Ren FZ and
            Lei XG.
  TITLE     Loss of Selenov predisposes mice to extra fat accumulation and
            attenuated energy expenditure
  JOURNAL   Redox Biol 45, 102048 (2021)
   PUBMED   34167027
REFERENCE   2  (bases 1 to 1277)
  AUTHORS   Zhang X, Xiong W, Chen LL, Huang JQ and Lei XG.
  TITLE     Selenoprotein V protects against endoplasmic reticulum stress and
            oxidative injury induced by pro-oxidants
  JOURNAL   Free Radic Biol Med 160, 670-679 (2020)
   PUBMED   32846216
REFERENCE   3  (bases 1 to 1277)
  AUTHORS   Chen LL, Huang JQ, Xiao Y, Wu YY, Ren FZ and Lei XG.
  TITLE     Knockout of Selenoprotein V Affects Regulation of Selenoprotein
            Expression by Dietary Selenium and Fat Intakes in Mice
  JOURNAL   J Nutr 150 (3), 483-491 (2020)
   PUBMED   31773160
REFERENCE   4  (bases 1 to 1277)
  AUTHORS   Gladyshev VN, Arner ES, Berry MJ, Brigelius-Flohe R, Bruford EA,
            Burk RF, Carlson BA, Castellano S, Chavatte L, Conrad M, Copeland
            PR, Diamond AM, Driscoll DM, Ferreiro A, Flohe L, Green FR, Guigo
            R, Handy DE, Hatfield DL, Hesketh J, Hoffmann PR, Holmgren A,
            Hondal RJ, Howard MT, Huang K, Kim HY, Kim IY, Kohrle J, Krol A,
            Kryukov GV, Lee BJ, Lee BC, Lei XG, Liu Q, Lescure A, Lobanov AV,
            Loscalzo J, Maiorino M, Mariotti M, Sandeep Prabhu K, Rayman MP,
            Rozovsky S, Salinas G, Schmidt EE, Schomburg L, Schweizer U,
            Simonovic M, Sunde RA, Tsuji PA, Tweedie S, Ursini F, Whanger PD
            and Zhang Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   5  (bases 1 to 1277)
  AUTHORS   Miyata H, Castaneda JM, Fujihara Y, Yu Z, Archambeault DR, Isotani
            A, Kiyozumi D, Kriseman ML, Mashiko D, Matsumura T, Matzuk RM, Mori
            M, Noda T, Oji A, Okabe M, Prunskaite-Hyyrylainen R, Ramirez-Solis
            R, Satouh Y, Zhang Q, Ikawa M and Matzuk MM.
  TITLE     Genome engineering uncovers 54 evolutionarily conserved and
            testis-enriched genes that are not required for male fertility in
            mice
  JOURNAL   Proc Natl Acad Sci U S A 113 (28), 7704-7710 (2016)
   PUBMED   27357688
REFERENCE   6  (bases 1 to 1277)
  AUTHORS   Varlamova EG, Novoselov SV and Novoselov VI.
  TITLE     [cDNA cloning, expression and determination of substrate
            specificity of mice selenocysteine-containing protein SelV
            (Selenoprotein V)]
  JOURNAL   Mol Biol (Mosk) 49 (5), 785-789 (2015)
   PUBMED   26510596
  REMARK    GeneRIF: SelV posseses glutathione peroxidase and thioredoxin
            reductase activities.
REFERENCE   7  (bases 1 to 1277)
  AUTHORS   Mariotti M, Ridge PG, Zhang Y, Lobanov AV, Pringle TH, Guigo R,
            Hatfield DL and Gladyshev VN.
  TITLE     Composition and evolution of the vertebrate and mammalian
            selenoproteomes
  JOURNAL   PLoS One 7 (3), e33066 (2012)
   PUBMED   22479358
REFERENCE   8  (bases 1 to 1277)
  AUTHORS   Kryukov GV, Castellano S, Novoselov SV, Lobanov AV, Zehtab O, Guigo
            R and Gladyshev VN.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK077113.2 and BC089491.1.
            
            On Apr 24, 2017 this sequence version replaced NM_175033.3.
            
            Summary: This gene encodes a selenoprotein containing a
            selenocysteine (Sec) residue, which is encoded by the UGA codon
            that normally signals translation termination. The 3' UTRs of
            selenoprotein mRNAs contain a conserved stem-loop structure, the
            Sec insertion sequence (SECIS) element, which is necessary for the
            recognition of UGA as a Sec codon rather than as a stop signal.
            This protein is specifically expressed in the testis. It belongs to
            the SelWTH family, which possesses a thioredoxin-like fold and a
            conserved CxxU (C is cysteine, U is Sec) motif, suggesting a redox
            function for this gene. [provided by RefSeq, Apr 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089491.1, AK077113.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            NMD candidate                   :: translation inferred from
                                               conservation
            protein contains selenocysteine :: PMID: 12775843
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1266              AK077113.2         2-1267
            1267-1277           BC089491.1         1214-1224
FEATURES             Location/Qualifiers
     source          1..1277
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 16.67 cM"
     gene            1..1277
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /note="selenoprotein V"
                     /db_xref="GeneID:280621"
                     /db_xref="MGI:MGI:3608324"
     exon            1..864
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /inference="alignment:Splign:2.1.0"
     CDS             110..1096
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /note="UGA stop codon recoded as selenocysteine"
                     /codon_start=1
                     /transl_except=(pos:872..874,aa:Sec)
                     /product="selenoprotein V"
                     /protein_id="NP_778198.2"
                     /db_xref="CCDS:CCDS39855.1"
                     /db_xref="GeneID:280621"
                     /db_xref="MGI:MGI:3608324"
                     /translation="MNNKARVPAPSSVRANTPARTPAPIRTATPVRAPNPAHNSTPVR
                     TSIRVRAPAQVPNPVPIRFPTPAPVPAPTLTPAPTPAPVRHAAPVRTPAPVRAPNLGR
                     VFPKISPGRFFPSLASPTAQPLSSRAASALLKDPTLAQNQKPSIHSLAEAIQGPLPVL
                     TPSSSKTQGSIPDTASPIDSLASTAMASSTLGPIPGPNPTLEFLASPLKETPGLGKLS
                     TISPAPSFGSTKEIPSTSEDVPTPNRILIRVMYCGLUSYGLRYIILKRTLEHQFPNLL
                     EFEEERATQVTGEFEVFVDGKLIHSKKKGDGFVDESGLKKLVGAIDEEIKKR"
     exon            865..889
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            890..943
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            944..1018
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..1155
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /inference="alignment:Splign:2.1.0"
     exon            1156..1267
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1156..1228
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenov"
                     /gene_synonym="Selv"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     polyA_site      1267
                     /gene="Selenov"
                     /gene_synonym="Selv"
ORIGIN      
        1 gtggttgctt cggtttttag aatcctcggg tgcgaaagct ctcctcgctc aaggaagcag
       61 ggcgaggcgg gacgcttagc ctggggtacc cgggtctcac ctggtcccca tgaataacaa
      121 ggcgcgggtc cccgctccct cctcagtccg ggcaaacacc ccggcccgga cacccgctcc
      181 catccgaacc gcgaccccag tcagggcccc gaacccagcg cacaactcga ctccagtccg
      241 aacttccatc cgggtccggg ctcctgccca agtccctaac cctgttccaa tccggttccc
      301 aactccagcc ccagtccctg ccccaaccct aaccccagcc ccaactccag ctccagtccg
      361 gcatgcagca ccggtgcgga ctccagcacc agtccgggcc ccgaatctag gtcgggtctt
      421 tcctaagatc tctccaggca ggttcttccc gagcttggcc tcgcccacgg cacagcccct
      481 ttcttccagg gctgctagcg ctctcttgaa ggatcccaca ctcgctcaaa atcagaaacc
      541 ctcgatccac agcctagcgg aggccatcca ggggcccctt ccagtgctca ctccctcgtc
      601 ctccaagaca caaggctcca taccggacac cgcctctccc atagactcct tggcttctac
      661 tgccatggcc tccagtacat tgggccccat tccgggcccc aaccctacac tagagttctt
      721 ggcctccccg ctgaaggaaa cccctggtct gggtaagctc tccacgattt ccccagcacc
      781 cagcttcggt tccactaagg agatcccatc caccagcgag gacgtcccaa cgcccaacag
      841 aatcttgatc cgtgtgatgt actgtggcct ctgaagctat ggccttcggt acattatact
      901 gaaaaggacc ctggagcatc aattcccaaa ccttctggag tttgaggagg aaagagctac
      961 ccaggttaca ggggagtttg aagtgtttgt ggatgggaag ctgatccatt ccaagaagaa
     1021 aggtgatggc tttgtggatg agtccggtct gaagaaactt gtgggtgcta ttgacgaaga
     1081 gatcaagaag aggtagcagc agcaacggag gggacatgag tgaggtgctg tggagggcca
     1141 ggaggaagca tgcaagagcc tcagcaggat gatgagaagg gctgaaatgc tgccaaacca
     1201 ggtccttttc tgatggtggc tggggcttgg gtggggcttg ggagagtaaa gaaaaatgta
     1261 aactgctaaa aaaaaaa
//
