LOCUS       NM_009155               2052 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus selenoprotein P (Selenop), transcript variant 1, mRNA.
ACCESSION   NM_009155
VERSION     NM_009155.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2052)
  AUTHORS   Ando,M., Suzuki,K., Kitamoto,R., Nakayama,A., Watanabe,N. and
            Kawahara,M.
  TITLE     Differences in serum selenoprotein P profile between C57BL/6 and
            BALB/c mice fed high-fat diet
  JOURNAL   J Trace Elem Med Biol 81, 127340 (2024)
   PUBMED   37984217
  REMARK    GeneRIF: Differences in serum selenoprotein P profile between
            C57BL/6 and BALB/c mice fed high-fat diet.
REFERENCE   2  (bases 1 to 2052)
  AUTHORS   Ye,X., Toyama,T., Taguchi,K., Arisawa,K., Kaneko,T., Tsutsumi,R.,
            Yamamoto,M. and Saito,Y.
  TITLE     Sulforaphane decreases serum selenoprotein P levels through
            enhancement of lysosomal degradation independent of Nrf2
  JOURNAL   Commun Biol 6 (1), 1060 (2023)
   PUBMED   37857700
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2052)
  AUTHORS   Pilat,J.M., Brown,R.E., Chen,Z., Berle,N.J., Othon,A.P.,
            Washington,M.K., Anant,S.A., Kurokawa,S., Ng,V.H., Thompson,J.J.,
            Jacobse,J., Goettel,J.A., Lee,E., Choksi,Y.A., Lau,K.S., Short,S.P.
            and Williams,C.S.
  TITLE     SELENOP modifies sporadic colorectal carcinogenesis and WNT
            signaling activity through LRP5/6 interactions
  JOURNAL   J Clin Invest 133 (13), e165988 (2023)
   PUBMED   37166989
  REMARK    GeneRIF: SELENOP modifies sporadic colorectal carcinogenesis and
            WNT signaling activity through LRP5/6 interactions.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2052)
  AUTHORS   Abuduwaili,H., Kamoshita,K., Ishii,K.A., Takahashi,K.,
            Abuduyimiti,T., Qifang,L., Isobe,Y., Goto,H., Nakano,Y.,
            Takeshita,Y., Takayama,H., Harada,K. and Takamura,T.
  TITLE     Selenoprotein P deficiency protects against immobilization-induced
            muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases
  JOURNAL   Am J Physiol Endocrinol Metab 324 (6), E542-E552 (2023)
   PUBMED   36947851
  REMARK    GeneRIF: Selenoprotein P deficiency protects against
            immobilization-induced muscle atrophy by suppressing
            atrophy-related E3 ubiquitin ligases.
REFERENCE   5  (bases 1 to 2052)
  AUTHORS   Dewing,A.S., Rueli,R.H., Robles,M.J., Nguyen-Wu,E.D., Zeyda,T.,
            Berry,M.J. and Bellinger,F.P.
  TITLE     Expression and regulation of mouse selenoprotein P transcript
            variants differing in non-coding RNA
  JOURNAL   RNA Biol 9 (11), 1361-1369 (2012)
   PUBMED   23064117
  REMARK    GeneRIF: results emphasize the importance of non-coding transcript
            variations as a regulatory means for Sepp1 expression in different
            tissues and stages of development; presence of a variant localized
            in the hippocampus and regulated by a microRNA may have
            implications for deficits in synaptic function caused by genetic
            deletion of Sepp1
REFERENCE   6  (bases 1 to 2052)
  AUTHORS   Mostert,V.
  TITLE     Selenoprotein P: properties, functions, and regulation
  JOURNAL   Arch Biochem Biophys 376 (2), 433-438 (2000)
   PUBMED   10775431
  REMARK    Review article
REFERENCE   7  (bases 1 to 2052)
  AUTHORS   Burk,R.F. and Hill,K.E.
  TITLE     Orphan selenoproteins
  JOURNAL   Bioessays 21 (3), 231-237 (1999)
   PUBMED   10333732
  REMARK    Review article
REFERENCE   8  (bases 1 to 2052)
  AUTHORS   Steinert,P., Bachner,D. and Flohe,L.
  TITLE     Analysis of the mouse selenoprotein P gene
  JOURNAL   Biol Chem 379 (6), 683-691 (1998)
   PUBMED   9687017
REFERENCE   9  (bases 1 to 2052)
  AUTHORS   Steinert,P., Ahrens,M., Gross,G. and Flohe,L.
  TITLE     cDNA and deduced polypeptide sequence of a mouse selenoprotein P
  JOURNAL   Biofactors 6 (3), 311-319 (1997)
   PUBMED   9288402
REFERENCE   10 (bases 1 to 2052)
  AUTHORS   Kasik,J.W. and Rice,E.J.
  TITLE     Selenoprotein P expression in liver, uterus and placenta during
            late pregnancy
  JOURNAL   Placenta 16 (1), 67-74 (1995)
   PUBMED   7716129
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB231357.1, AK002450.1 and
            AA153204.1.
            
            On Feb 13, 2017 this sequence version replaced NM_009155.3.
            
            Summary: This gene encodes a selenoprotein that is predominantly
            expressed in the liver and secreted into the plasma. This
            selenoprotein is unique in that it contains multiple selenocysteine
            (Sec) residues per polypeptide (10 in mouse), and accounts for most
            of the selenium in plasma. It has been implicated as an
            extracellular antioxidant, and in the transport of selenium to
            extra-hepatic tissues via apolipoprotein E receptor-2 (apoER2).
            Mice lacking this gene exhibit neurological dysfunction, suggesting
            its importance in normal brain function. Sec is encoded by the UGA
            codon, which normally signals translation termination. The 3' UTRs
            of selenoprotein mRNAs contain a conserved stem-loop structure,
            designated the Sec insertion sequence (SECIS) element, that is
            necessary for the recognition of UGA as a Sec codon, rather than as
            a stop signal. The mRNA for this selenoprotein contains two SECIS
            elements. Alternatively spliced transcript variants differing in 5'
            non-coding region have been described for this gene. Expression of
            these variants varies in different tissues and developmental stages
            (PMID:23064117). [provided by RefSeq, Feb 2017].
            
            Transcript Variant: This variant (1, also known as Sepp1a)
            represents the predominant transcript. Variants 1, 2 and 3 encode
            the same protein containing 10 selenocysteine residues.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC001991.1, AK002450.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 9288402
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-19                CB231357.1         4-22
            20-2030             AK002450.1         2-2012
            2031-2052           AA153204.1         365-386
FEATURES             Location/Qualifiers
     source          1..2052
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 1.84 cM"
     gene            1..2052
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /note="selenoprotein P"
                     /db_xref="GeneID:20363"
                     /db_xref="MGI:MGI:894288"
     exon            1..76
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /inference="alignment:Splign:2.1.0"
     exon            77..292
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /inference="alignment:Splign:2.1.0"
     CDS             90..1232
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /note="UGA stop codons recoded as selenocysteine; seP;
                     plasma selenoprotein P; selenoprotein P, plasma, 1"
                     /codon_start=1
                     /transl_except=(pos:264..266,aa:Sec)
                     /transl_except=(pos:864..866,aa:Sec)
                     /transl_except=(pos:918..920,aa:Sec)
                     /transl_except=(pos:1041..1043,aa:Sec)
                     /transl_except=(pos:1077..1079,aa:Sec)
                     /transl_except=(pos:1143..1145,aa:Sec)
                     /transl_except=(pos:1185..1187,aa:Sec)
                     /transl_except=(pos:1191..1193,aa:Sec)
                     /transl_except=(pos:1212..1214,aa:Sec)
                     /transl_except=(pos:1218..1220,aa:Sec)
                     /product="selenoprotein P precursor"
                     /protein_id="NP_033181.3"
                     /db_xref="CCDS:CCDS27357.1"
                     /db_xref="GeneID:20363"
                     /db_xref="MGI:MGI:894288"
                     /translation="MWRSLGLALALCLLPYGGAESQGQSSACYKAPEWYIGDQNPMLN
                     SEGKVTVVALLQASUYLCLLQASRLEDLRIKLESQGYFNISYIVVNHQGSPSQLKHSH
                     LKKQVSEHIAVYRQEEDGIDVWTLLNGNKDDFLIYDRCGRLVYHLGLPYSFLTFPYVE
                     EAIKIAYCEERCGNCNLTSLEDEDFCKTVTSATANKTAEPSEAHSHHKHHNKHGQEHL
                     GSSKPSENQQPGPSETTLPPSGLHHHHRHRGQHRQGHLESUDTTASEGLHLSLAQRKL
                     URRGCINQLLCKLSKESEAAPSSCCCHCRHLIFEKSGSAIAUQCAENLPSLCSUQGLF
                     AEEKVTESCQCRSPPAAUQNQPMNPMEANPNUSUDNQTRKUKUHSN"
     exon            293..505
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /inference="alignment:Splign:2.1.0"
     exon            506..623
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /inference="alignment:Splign:2.1.0"
     exon            624..2032
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1504..1575
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1883..1948
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      2006..2011
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /note="hexamer: AATAAA"
     polyA_site      2029
                     /gene="Selenop"
                     /gene_synonym="D15Ucla1; Se-P; selp; Sepp1"
                     /note="major polyA site"
ORIGIN      
        1 agtgtcagcc tgtggctttg gggagctgct ctaactagag caaagagaca ggacgaagct
       61 agtccgaagg ggttgcgaca acctcagcaa tgtggagaag cctagggctt gccctggctc
      121 tctgtctcct cccctatgga ggagcagaga gccaaggcca aagctctgct tgttacaaag
      181 ccccggagtg gtacatagga gatcaaaatc caatgctaaa ctcagagggc aaagtgacag
      241 tggttgctct tcttcaagcc agctgatact tgtgtcttct gcaggcatcc agattggaag
      301 acctgcgcat aaaactagaa agccaaggat attttaacat ctcttacatt gttgttaacc
      361 atcaaggatc tccttcccaa ttaaaacact cacatcttaa aaagcaggtg tcagaacaca
      421 tcgcagtgta cagacaagaa gaagatggca tagatgtctg gactctctta aatggaaaca
      481 aagatgactt cctcatctat gacagatgtg gccgtcttgt gtatcacctt ggtttgcctt
      541 actccttcct cacattccca tatgttgaag aagccattaa gatcgcttac tgtgaggaga
      601 ggtgcggaaa ctgcaatctc acgagtcttg aagatgaaga cttctgtaaa actgtgacct
      661 cagctactgc caataaaact gcggagccct cagaggctca tagccaccac aaacaccaca
      721 acaaacatgg gcaggagcat cttggcagca gtaagccttc agagaatcag caaccagggc
      781 catcagagac gactctgcct ccttcaggct tgcaccacca ccacaggcat aggggccagc
      841 acaggcaggg tcacttagag agctgagaca ccacagcaag tgaaggcttg cacctttcac
      901 ttgcccagag gaagctctga cgaagggggt gcatcaacca gctcctgtgt aagttgtcta
      961 aggagtccga ggcagccccc agcagctgct gctgtcactg ccgccacctc atatttgaga
     1021 agtcagggtc tgcaattgct tgacagtgtg cggaaaacct cccatcctta tgtagctgac
     1081 aggggctttt cgcggaggag aaagtcactg aatcctgtca gtgtaggtca cctccagctg
     1141 cctgacaaaa tcagcccatg aaccccatgg aagccaaccc caactgaagc tgagataatc
     1201 agaccaggaa gtgaaaatga cattcaaact aaattattta aaacaaggca tacctctccc
     1261 caactcagtc taaagacaca atttcatttt gagaatgttt acagcccatt taattaatca
     1321 gtgaactaaa agtcatagaa attggatttg tgcaaatgta gagaaatcta ccatattggc
     1381 ttccaaaatt taaaaatttt atgccacaga acatttcatc caaatcagat ttgtacaata
     1441 gggcacctga aaagtgactg cagcctttgg ttaatatgtc tttctttttc ctttttccag
     1501 tgttctagtt acattaatga gaacagaaac ataaactatg acctaggggt ttctgttgga
     1561 tagcttgtaa ttaagaacgg agaaagaaca acaaagacat attttccagt tttttttttc
     1621 tttacttaaa ctctgaaaac aacagaaact ttgtcttcct actcttacat tctaaaccga
     1681 tgaaatcttt aacagattac actttaaata tctactcatc attttctctc tcagagtcct
     1741 agcttgagtt gcactgcatg tatctgtgca tcttgttctc ttcatttaat gctgtactgt
     1801 tctgctgagc tctgagggac tatcttgaga gatgtaatgg aaggaaagcg tggtgttaat
     1861 ctgcgtactg cttaagacag tatttccata atcaatgatg gtttcataga gaaactaagt
     1921 cctatgaacc tgacctcttt tatggctaat acgactaagc aagaatggag tacagaatta
     1981 agtggctaca gtacacactt atcaaaataa atgcaatttt aaaacctttc aaaaaaaaaa
     2041 aaaaaaaaaa aa
//
