LOCUS       NM_027905               2446 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus selenoprotein O (Selenoo), mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_027905
VERSION     NM_027905.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2446)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   2  (bases 1 to 2446)
  AUTHORS   Han,S.J., Lee,B.C., Yim,S.H., Gladyshev,V.N. and Lee,S.R.
  TITLE     Characterization of mammalian selenoprotein o: a redox-active
            mitochondrial protein
  JOURNAL   PLoS One 9 (4), e95518 (2014)
   PUBMED   24751718
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2446)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AW060160.1, AK005048.1,
            BE864360.1 and BQ177186.1.
            
            On Jan 4, 2017 this sequence version replaced NM_027905.2.
            
            Summary: This gene encodes a selenoprotein that is localized to the
            mitochondria. It is the largest mammalian selenoprotein, containing
            the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA
            codon, which normally signals translation termination. The 3' UTRs
            of selenoprotein mRNAs contain a conserved stem-loop structure,
            designated the Sec insertion sequence (SECIS) element, that is
            necessary for the recognition of UGA as a Sec codon, rather than as
            a stop signal. The exact function of this selenoprotein is not
            known, but it is thought to have redox activity. [provided by
            RefSeq, Jan 2017].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141293.1, AK005048.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            protein contains selenocysteine    :: inferred from conservation
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-69                AW060160.1         285-353             c
            70-1926             AK005048.1         1-1857
            1927-2084           BE864360.1         1-158               c
            2085-2427           AK005048.1         2016-2358
            2428-2446           BQ177186.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2446
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="15"
                     /map="15 44.6 cM"
     gene            1..2446
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /note="selenoprotein O"
                     /db_xref="GeneID:223776"
                     /db_xref="MGI:MGI:1919007"
     exon            1..628
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     CDS             72..2075
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /EC_number="2.7.7.108"
                     /note="UGA stop codon recoded as selenocysteine"
                     /codon_start=1
                     /transl_except=(pos:2064..2066,aa:Sec)
                     /product="protein adenylyltransferase SelO, mitochondrial"
                     /protein_id="NP_082181.2"
                     /db_xref="CCDS:CCDS27738.1"
                     /db_xref="GeneID:223776"
                     /db_xref="MGI:MGI:1919007"
                     /translation="MASVRAAVGASLAVARTRPRCVGLALPSSAPRSAWAAAMEPTPR
                     WLAGLRFDNRALRELPVETPPPGPEDSLATPRPVPGACFSRARPAPLRRPRLVALSEP
                     ALALLGLEASEEAEVEAEAALFFSGNALLPGTEPAAHCYCGHQFGQFAGQLGDGAAMY
                     LGEVCTAAGERWELQLKGAGPTPFSRQADGRKVLRSSIREFLCSEAMFHLGIPTTRAG
                     ACVTSESTVMRDVFYDGNPKYEKCTVVLRIAPTFIRFGSFEIFKPPDEHTGRAGPSVG
                     RDDIRVQLLDYVISSFYPEIQAAHTCDTDNIQRNAAFFREVTQRTARMVAEWQCVGFC
                     HGVLNTDNMSIVGLTIDYGPFGFLDRYDPDHICNASDNAGRYTYSKQPQVCKWNLQKL
                     AEALEPELPLALAEAILKEEFDTEFQRHYLQKMRKKLGLIRVEKEEDGTLVAKLLETM
                     HLTGADFTNTFCVLSSFPADLSDSAEFLSRLTSQCASLEELRLAFRPQMDPRQLSMML
                     MLAQSNPQLFALIGTQANVTKELERVEHQSRLEQLSPSDLQRKNRDHWEAWLQEYRDR
                     LDKEKEGVGDTAAWQAERVRVMRANNPKYVLRNYIAQKAIEAAENGDFSEVRRVLKLL
                     ESPYHSEEEATGPEAVARSTEEQSSYSNRPPLWAAELCVTUSS"
     exon            629..832
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            833..1019
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1020..1150
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1151..1431
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1432..1576
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1577..1762
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1919
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     exon            1920..2428
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2156..2232
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      2407..2412
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
     polyA_site      2428
                     /gene="Selenoo"
                     /gene_synonym="1300018J18Rik; Selo"
ORIGIN      
        1 ctcccaccag cccctaactg ggtgggggaa aacttccggt cggggcgagc aggcttccgg
       61 cgaggcggcg aatggcctct gtcagggccg cggtcggggc ctcgctcgcg gttgcccgaa
      121 cccggccacg gtgcgtcggt ctcgcgcttc cgtcgtccgc gccccggtcc gcctgggctg
      181 cagctatgga gcccacgccg cgttggctgg cagggctgcg ctttgacaac cgcgccctgc
      241 gtgagctgcc ggtggagacg ccgccgcctg ggccggagga ctccctggcc accccgcggc
      301 cggtgcccgg agcctgcttc agccgtgcgc ggccggcccc gctacggcgg ccgcgcctgg
      361 tggcgctgtc agagcccgcg ctggccttgc tggggctcga ggccagcgag gaggccgagg
      421 tcgaggccga agctgcgctc ttcttcagcg gcaatgcgct gctgccgggc accgagcccg
      481 ccgcgcactg ctactgtgga caccagttcg gtcagttcgc tgggcagttg ggcgacggtg
      541 ccgccatgta cctgggcgag gtgtgcacag cggccggcga gcgctgggag ctgcagctca
      601 aaggcgccgg ccccacgccc ttctccagac aagccgatgg tcgcaaagtc ctgcggtcaa
      661 gcatccgtga gttcctgtgc agcgaagcca tgtttcacct gggaatcccc accacgaggg
      721 ccggggcctg cgtcacgtct gagtctacag tgatgcgaga cgtgttctat gatggtaatc
      781 caaaatatga aaagtgcacg gttgtgttgc gtatagctcc cactttcata agattcggct
      841 cctttgaaat ttttaagcct cctgatgagc acacagggcg tgcaggcccc agcgtgggac
      901 gagatgatat ccgagtccaa ttgcttgact atgtcatcag ctctttctac cctgagatcc
      961 aggctgccca tacctgtgac acggacaaca tacagaggaa cgcggccttt ttcagagagg
     1021 tgacacagcg aacagcacgg atggttgctg aatggcagtg tgttggcttt tgccatggcg
     1081 tgctcaacac tgacaacatg agcattgtgg ggctcactat cgactatgga ccctttggct
     1141 tcctggacag gtacgaccct gaccatatat gtaatgcctc tgacaatgct gggcgctaca
     1201 catacagtaa gcagccccag gtatgcaagt ggaatctgca gaaactagct gaagcattgg
     1261 agcctgaact gccacttgcg ctggctgagg ccattctaaa agaggagttt gacactgagt
     1321 tccaaaggca ctatctacag aagatgcgta aaaagctggg ccttattcga gtggagaagg
     1381 aagaagatgg gacacttgtg gccaaacttc tggagaccat gcatctgact ggtgctgact
     1441 tcactaacac cttctgtgtt ctgagctcct ttccggctga cctgtcggac tcagcagagt
     1501 tcctgagcag gctgacctcc cagtgtgcct ctctggaaga gctaaggctc gccttcagac
     1561 cacagatgga tccccggcag ctctctatga tgctgatgct tgcacagtcg aacccacagc
     1621 tctttgcact cattggtact caagccaatg tcacaaagga gctagaacgt gtggagcatc
     1681 agtctcggct agaacagctg agcccctctg acctgcagcg caagaacaga gaccactggg
     1741 aagcctggct acaggaatac agagaccgtc tcgacaagga gaaggagggt gttggagaca
     1801 ctgctgcctg gcaggcagaa cgtgtacgtg tcatgcgtgc caacaacccc aagtacgtcc
     1861 tgaggaacta tattgcacag aaagccattg aagctgctga aaatggagac ttttcagagg
     1921 tgcggcgtgt cctgaagctg ctagagtctc cttaccacag tgaagaggag gccacaggcc
     1981 ctgaagcagt ggcaaggagc actgaggagc aatcttccta cagtaacagg ccacccctct
     2041 gggcagcaga actctgtgta acatgatcct cataaaggcc tcggtgtcct ccacttgtct
     2101 ggagtctccc gaggcctccc cagtgctgct gagttgctga gaccgctggg atgcctgtcc
     2161 tcagtctctc catgacggca gaggtctcca gtcaaaacct gacccatctc tgtctgatac
     2221 taccttagca gtactaccct ggcctagcat tcaacacgcc cttagcacac agtgcttcat
     2281 gctagaatat cagtctcatg tttttaagta atgcaaacag gcctaagtaa gtaagccttg
     2341 tggcctgtgt gtgcattttg ccccaaaggg cagggcttca cacctgttga atctcctggg
     2401 cctctaaata aagcagcttc ttcaggtcaa aaaaaaaaaa aaaaaa
//
