LOCUS       NM_053267                906 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus selenoprotein M (Selenom), mRNA.
ACCESSION   NM_053267 XM_987202
VERSION     NM_053267.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 906)
  AUTHORS   Zhang,X., Gai,X., Xu,L., Ma,W., Liu,Q., Shi,B., Fang,C., Cai,J. and
            Zhang,Z.
  TITLE     Role of selenoprotein M knockdown in the melatonin antagonism of
            nickel-induced apoptosis and endoplasmic reticulum stress in mouse
            heart
  JOURNAL   J Zhejiang Univ Sci B 24 (5), 406-417 (2023)
   PUBMED   37190890
  REMARK    GeneRIF: Role of selenoprotein M knockdown in the melatonin
            antagonism of nickel-induced apoptosis and endoplasmic reticulum
            stress in mouse heart.
REFERENCE   2  (bases 1 to 906)
  AUTHORS   Lin,S., Chen,C., Ouyang,P., Cai,Z., Liu,X., Abdurahman,A., Peng,J.,
            Li,Y., Zhang,Z. and Song,G.L.
  TITLE     SELENOM Knockout Induces Synaptic Deficits and Cognitive
            Dysfunction by Influencing Brain Glucose Metabolism
  JOURNAL   J Agric Food Chem 71 (3), 1607-1619 (2023)
   PUBMED   36635091
  REMARK    GeneRIF: SELENOM Knockout Induces Synaptic Deficits and Cognitive
            Dysfunction by Influencing Brain Glucose Metabolism.
REFERENCE   3  (bases 1 to 906)
  AUTHORS   Gong,T., Hashimoto,A.C., Sasuclark,A.R., Khadka,V.S., Gurary,A. and
            Pitts,M.W.
  TITLE     Selenoprotein M Promotes Hypothalamic Leptin Signaling and
            Thioredoxin Antioxidant Activity
  JOURNAL   Antioxid Redox Signal 35 (10), 775-787 (2021)
   PUBMED   30648404
  REMARK    GeneRIF: Selenoprotein M Promotes Hypothalamic Leptin Signaling and
            Thioredoxin Antioxidant Activity.
REFERENCE   4  (bases 1 to 906)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   5  (bases 1 to 906)
  AUTHORS   Pitts,M.W., Reeves,M.A., Hashimoto,A.C., Ogawa,A., Kremer,P.,
            Seale,L.A. and Berry,M.J.
  TITLE     Deletion of selenoprotein M leads to obesity without cognitive
            deficits
  JOURNAL   J Biol Chem 288 (36), 26121-26134 (2013)
   PUBMED   23880772
  REMARK    GeneRIF: SelM plays an important role in the regulation of body
            weight and energy metabolism.
REFERENCE   6  (bases 1 to 906)
  AUTHORS   Lai,H.C., Klisch,T.J., Roberts,R., Zoghbi,H.Y. and Johnson,J.E.
  TITLE     In vivo neuronal subtype-specific targets of Atoh1 (Math1) in
            dorsal spinal cord
  JOURNAL   J Neurosci 31 (30), 10859-10871 (2011)
   PUBMED   21795538
REFERENCE   7  (bases 1 to 906)
  AUTHORS   Reeves,M.A., Bellinger,F.P. and Berry,M.J.
  TITLE     The neuroprotective functions of selenoprotein M and its role in
            cytosolic calcium regulation
  JOURNAL   Antioxid Redox Signal 12 (7), 809-818 (2010)
   PUBMED   19769485
  REMARK    GeneRIF: These results suggest that selenoprotein M may have an
            important role in protecting against oxidative damage in the brain
            and may potentially function in calcium regulation.
REFERENCE   8  (bases 1 to 906)
  AUTHORS   Ferguson,A.D., Labunskyy,V.M., Fomenko,D.E., Arac,D., Chelliah,Y.,
            Amezcua,C.A., Rizo,J., Gladyshev,V.N. and Deisenhofer,J.
  TITLE     NMR structures of the selenoproteins Sep15 and SelM reveal redox
            activity of a new thioredoxin-like family
  JOURNAL   J Biol Chem 281 (6), 3536-3543 (2006)
   PUBMED   16319061
  REMARK    GeneRIF: Sep15 and SelM have roles as thiol-disulfide
            oxidoreductases
REFERENCE   9  (bases 1 to 906)
  AUTHORS   Hwang,D.Y., Cho,J.S., Oh,J.H., Shim,S.B., Jee,S.W., Lee,S.H.,
            Seo,S.J., Lee,S.K., Lee,S.H. and Kim,Y.K.
  TITLE     Differentially expressed genes in transgenic mice carrying human
            mutant presenilin-2 (N141I): correlation of selenoprotein M with
            Alzheimer's disease
  JOURNAL   Neurochem Res 30 (8), 1009-1019 (2005)
   PUBMED   16258850
  REMARK    GeneRIF: mouse SelM had significantly suppressed on its
            transcriptional products in transgenic brains
REFERENCE   10 (bases 1 to 906)
  AUTHORS   Korotkov,K.V., Novoselov,S.V., Hatfield,D.L. and Gladyshev,V.N.
  TITLE     Mammalian selenoprotein in which selenocysteine (Sec) incorporation
            is supported by a new form of Sec insertion sequence element
  JOURNAL   Mol Cell Biol 22 (5), 1402-1411 (2002)
   PUBMED   11839807
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BB589016.2, BC147333.1 and
            AW049879.1.
            
            On Dec 13, 2016 this sequence version replaced NM_053267.2.
            
            Summary: The protein encoded by this gene belongs to the
            selenoprotein M/SEP15 family. The exact function of this protein is
            not known. It is localized in the perinuclear region, is highly
            expressed in the brain, and may be involved in neurodegenerative
            disorders. Transgenic mice with targeted deletion of this gene
            exhibit increased weight gain, suggesting a role for this gene in
            the regulation of body weight and energy metabolism. This protein
            is a selenoprotein, containing the rare amino acid selenocysteine
            (Sec). Sec is encoded by the UGA codon, which normally signals
            translation termination. The 3' UTRs of selenoprotein mRNAs contain
            a conserved stem-loop structure, designated the Sec insertion
            sequence (SECIS) element, that is necessary for the recognition of
            UGA as a Sec codon, rather than as a stop signal. [provided by
            RefSeq, Dec 2016].
            
            ##Evidence-Data-START##
            Transcript exon combination :: BQ939285.1, AK018791.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 11839807
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               BB589016.2         2-107
            107-794             BC147333.1         1-688
            795-906             AW049879.1         1-112               c
FEATURES             Location/Qualifiers
     source          1..906
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 2.47 cM"
     gene            1..906
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /note="selenoprotein M"
                     /db_xref="GeneID:114679"
                     /db_xref="MGI:MGI:2149786"
     exon            1..390
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /inference="alignment:Splign:2.1.0"
     exon            391..426
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /inference="alignment:Splign:2.1.0"
     exon            427..461
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /inference="alignment:Splign:2.1.0"
     exon            462..540
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /inference="alignment:Splign:2.1.0"
     exon            541..890
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /inference="alignment:Splign:2.1.0"
     regulatory      732..820
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      872..877
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /note="hexamer: ACTAAA"
     polyA_site      890
                     /gene="Selenom"
                     /gene_synonym="1500040L08Rik; A230103K18; Selm; Sepm"
                     /note="major polyA site"
ORIGIN      
        1 agtgggcaaa tgcaatatgg agattgtgag aactgggaac atgaagtctg gaggaccaga
       61 gagtagctga gacagggatg ggggttagtg ggaggcaacc acccgatttg ggtgggatgt
      121 cagtggggct gtttctagct ctgggggcgt ggtttatggc tgggcggagc ttttggcttg
      181 ggcggggcca gcttgcgggc cagacgtggc gcagcggccg agtttgggtg cagcctgcgg
      241 aacgtctcct gccaggcaca gatgagcatc ctactgtcgc cgccgtcgct gctgctgctt
      301 cttgcagccc ttgtggctcc agccacctcc accaccaact accgaccgga ttggaaccgt
      361 cttcgaggcc tggccagggg gcgggtggag acctgtggag gatgacagtt gaatcgccta
      421 aaggaggtga aggcctttgt caccgaggac attcaactgt accacaacct ggtgatgaag
      481 cacctccctg gggcagaccc cgaactcgtg ctgttaagcc gaaattacca ggaactagag
      541 cgaatcccac tcagccaaat gacccgggac gagatcaatg cgctggtaca ggagctcggc
      601 ttctaccgca agtcggcgcc ggaagctcag gtgccccccg agtacctgtg ggcgcccgct
      661 aagccccccg aggaagcttc agaacacgac gacctgtagc cccgagccac agtggagctg
      721 ggaccccccc ctgccagcgc cccggagaca gaatgaagcg ctcagtatcc cgggagcatc
      781 tcccttgctg agggccgacg ccagtctcca aagcaacgga aatggggtgt gtggggggaa
      841 tctcaatcct ccctttcctc tccccagctc tactaaatct tcttccttca aaaaaaaaaa
      901 aaaaaa
//
