LOCUS       NM_001033166             694 bp    mRNA    linear   ROD 03-JUN-2024
DEFINITION  Mus musculus selenoprotein H (Selenoh), transcript variant 1, mRNA.
ACCESSION   NM_001033166
VERSION     NM_001033166.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 694)
  AUTHORS   Ma,Y.M., Guo,Y.Z., Ibeanu,G., Wang,L.Y., Dong,J.D., Wang,J.,
            Jing,L., Zhang,J.Z. and Li,P.A.
  TITLE     Overexpression of selenoprotein H prevents mitochondrial dynamic
            imbalance induced by glutamate exposure
  JOURNAL   Int J Biol Sci 13 (11), 1458-1469 (2017)
   PUBMED   29535592
  REMARK    GeneRIF: Overexpression of selenoprotein H can protect cells from
            glutamate toxicity by preserving mitochondrial morphology and
            suppressing autophagy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 694)
  AUTHORS   Gladyshev,V.N., Arner,E.S., Berry,M.J., Brigelius-Flohe,R.,
            Bruford,E.A., Burk,R.F., Carlson,B.A., Castellano,S., Chavatte,L.,
            Conrad,M., Copeland,P.R., Diamond,A.M., Driscoll,D.M., Ferreiro,A.,
            Flohe,L., Green,F.R., Guigo,R., Handy,D.E., Hatfield,D.L.,
            Hesketh,J., Hoffmann,P.R., Holmgren,A., Hondal,R.J., Howard,M.T.,
            Huang,K., Kim,H.Y., Kim,I.Y., Kohrle,J., Krol,A., Kryukov,G.V.,
            Lee,B.J., Lee,B.C., Lei,X.G., Liu,Q., Lescure,A., Lobanov,A.V.,
            Loscalzo,J., Maiorino,M., Mariotti,M., Sandeep Prabhu,K.,
            Rayman,M.P., Rozovsky,S., Salinas,G., Schmidt,E.E., Schomburg,L.,
            Schweizer,U., Simonovic,M., Sunde,R.A., Tsuji,P.A., Tweedie,S.,
            Ursini,F., Whanger,P.D. and Zhang,Y.
  TITLE     Selenoprotein Gene Nomenclature
  JOURNAL   J Biol Chem 291 (46), 24036-24040 (2016)
   PUBMED   27645994
REFERENCE   3  (bases 1 to 694)
  AUTHORS   Dikiy,A., Novoselov,S.V., Fomenko,D.E., Sengupta,A., Carlson,B.A.,
            Cerny,R.L., Ginalski,K., Grishin,N.V., Hatfield,D.L. and
            Gladyshev,V.N.
  TITLE     SelT, SelW, SelH, and Rdx12: genomics and molecular insights into
            the functions of selenoproteins of a novel thioredoxin-like family
  JOURNAL   Biochemistry 46 (23), 6871-6882 (2007)
   PUBMED   17503775
REFERENCE   4  (bases 1 to 694)
  AUTHORS   Novoselov,S.V., Kryukov,G.V., Xu,X.M., Carlson,B.A., Hatfield,D.L.
            and Gladyshev,V.N.
  TITLE     Selenoprotein H is a nucleolar thioredoxin-like protein with a
            unique expression pattern
  JOURNAL   J Biol Chem 282 (16), 11960-11968 (2007)
   PUBMED   17337453
REFERENCE   5  (bases 1 to 694)
  AUTHORS   Kryukov,G.V., Castellano,S., Novoselov,S.V., Lobanov,A.V.,
            Zehtab,O., Guigo,R. and Gladyshev,V.N.
  TITLE     Characterization of mammalian selenoproteomes
  JOURNAL   Science 300 (5624), 1439-1443 (2003)
   PUBMED   12775843
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BY239096.1, BC056177.1 and
            AV508490.1.
            
            On Mar 18, 2016 this sequence version replaced NM_001033166.2.
            
            Summary: This gene encodes a nucleolar protein, which belongs to
            the SelWTH family. It functions as an oxidoreductase, and has been
            shown to protect neurons against UVB-induced damage by inhibiting
            apoptotic cell death pathways, promote mitochondrial biogenesis and
            mitochondrial function, and suppress cellular senescence through
            genome maintenance and redox regulation. This protein is a
            selenoprotein, containing the rare amino acid selenocysteine (Sec)
            at its active site. Sec is encoded by the UGA codon, which normally
            signals translation termination. The 3' UTRs of selenoprotein mRNAs
            contain a conserved stem-loop structure, designated the Sec
            insertion sequence (SECIS) element, that is necessary for the
            recognition of UGA as a Sec codon, rather than as a stop signal.
            Alternatively spliced transcript variants have been found for this
            gene. [provided by RefSeq, May 2016].
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC056177.1, SRR1660819.207428.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 17337453
            RefSeq Select criteria          :: based on conservation,
                                               expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 BY239096.1         63-69
            8-676               BC056177.1         1-669
            677-694             AV508490.1         163-180
FEATURES             Location/Qualifiers
     source          1..694
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 49.45 cM"
     gene            1..694
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /note="selenoprotein H"
                     /db_xref="GeneID:72657"
                     /db_xref="MGI:MGI:1919907"
     exon            1..226
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..473
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /note="UGA stop codon recoded as selenocysteine"
                     /codon_start=1
                     /transl_except=(pos:234..236,aa:Sec)
                     /product="selenoprotein H"
                     /protein_id="NP_001028338.1"
                     /db_xref="CCDS:CCDS16187.1"
                     /db_xref="GeneID:72657"
                     /db_xref="MGI:MGI:1919907"
                     /translation="MAPHGRKRKAGAAPMETVDKREKLAEGATVVIEHCTSURVYGRH
                     AAALSQALQLEAPELPVQVNPSKPRRGSFEVTLLRSDNSRVELWTGIKKGPPRKLKFP
                     EPQEVVEELKKYLS"
     exon            227..372
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /inference="alignment:Splign:2.1.0"
     exon            373..502
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /inference="alignment:Splign:2.1.0"
     exon            503..685
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /inference="alignment:Splign:2.1.0"
     regulatory      512..585
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      656..661
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /note="hexamer: AATAAA"
     polyA_site      679
                     /gene="Selenoh"
                     /gene_synonym="2700094K13Rik; Selh"
                     /note="major polyA site"
ORIGIN      
        1 ccgcacattt ccctttgctg cgagatttga actttgcatc tgtgattccc ggctgctggt
       61 ttgtctctcc ggagttgcat cgccccttat tccaccaacg cgccatcccc gaaatccgtg
      121 ccatggcccc ccacggaaga aagcgtaagg cgggggccgc gcctatggag acggtggaca
      181 agcgcgagaa actggcggag ggcgcgaccg tggtcattga gcattgtacg agctgacgcg
      241 tgtacggccg ccatgctgct gccttgagcc aggctctgca actggaggcc ccagagctac
      301 ctgtgcaagt gaacccgtcc aaaccgcgga ggggcagctt cgaggtgacg ctgctgcgct
      361 cggacaacag ccgtgttgaa ctctggactg gtattaagaa gggccctcca cgaaagctca
      421 aatttcctga gcctcaagag gtggttgaag aattgaagaa gtacctttca taaagaggtt
      481 gggaaagagt cctcatgttg agctttcagt ccctggagat gttgaagcat ttatgatggt
      541 gcatggccaa acttaagcta tgcacctgaa gccatagttt cttcctcacc agaagtgatg
      601 gttcagttgt gaggcagccc tccagcaaga cattgtaaaa gtgtttcaat tgtttaataa
      661 aaggtcaagt atctgagaat aaggaaaaaa aaaa
//
