LOCUS       NM_053102               1515 bp    mRNA    linear   ROD 20-JUN-2024
DEFINITION  Mus musculus selenoprotein F (Selenof), mRNA.
ACCESSION   NM_053102
VERSION     NM_053102.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1515)
  AUTHORS   Wang,W., Miao,Z., Qi,X., Wang,B., Liu,Q., Shi,X. and Xu,S.
  TITLE     LncRNA Tug1 relieves the steatosis of SelenoF-knockout hepatocytes
            via sponging miR-1934-3p
  JOURNAL   Cell Biol Toxicol 39 (6), 3175-3195 (2023)
   PUBMED   37721623
  REMARK    GeneRIF: LncRNA Tug1 relieves the steatosis of SelenoF-knockout
            hepatocytes via sponging miR-1934-3p.
REFERENCE   2  (bases 1 to 1515)
  AUTHORS   Lee,T.J., Nettleford,S.K., McGlynn,A., Carlson,B.A.,
            Kirimanjeswara,G.S. and Prabhu,K.S.
  TITLE     The role of selenoproteins in neutrophils during inflammation
  JOURNAL   Arch Biochem Biophys 732, 109452 (2022)
   PUBMED   36336122
REFERENCE   3  (bases 1 to 1515)
  AUTHORS   Canter,J.A., Ernst,S.E., Peters,K.M., Carlson,B.A.,
            Thielman,N.R.J., Grysczyk,L., Udofe,P., Yu,Y., Cao,L., Davis,C.D.,
            Gladyshev,V.N., Hatfield,D.L. and Tsuji,P.A.
  TITLE     Selenium and the 15kDa Selenoprotein Impact Colorectal
            Tumorigenesis by Modulating Intestinal Barrier Integrity
  JOURNAL   Int J Mol Sci 22 (19), 10651 (2021)
   PUBMED   34638991
  REMARK    GeneRIF: Selenium and the 15kDa Selenoprotein Impact Colorectal
            Tumorigenesis by Modulating Intestinal Barrier Integrity.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1515)
  AUTHORS   Zheng,X., Ren,B., Li,X., Yan,H., Xie,Q., Liu,H., Zhou,J., Tian,J.
            and Huang,K.
  TITLE     Selenoprotein F knockout leads to glucose and lipid metabolism
            disorders in mice
  JOURNAL   J Biol Inorg Chem 25 (7), 1009-1022 (2020)
   PUBMED   32995962
  REMARK    GeneRIF: Selenoprotein F knockout leads to glucose and lipid
            metabolism disorders in mice.
REFERENCE   5  (bases 1 to 1515)
  AUTHORS   Irons,R., Tsuji,P.A., Carlson,B.A., Ouyang,P., Yoo,M.H., Xu,X.M.,
            Hatfield,D.L., Gladyshev,V.N. and Davis,C.D.
  TITLE     Deficiency in the 15-kDa selenoprotein inhibits tumorigenicity and
            metastasis of colon cancer cells
  JOURNAL   Cancer Prev Res (Phila) 3 (5), 630-639 (2010)
   PUBMED   20388823
  REMARK    GeneRIF: These data suggest tissue specificity in the
            cancer-protective effects of Sep15 downregulation, which are
            mediated, at least in part, by influencing the cell cycle.
REFERENCE   6  (bases 1 to 1515)
  AUTHORS   Labunskyy,V.M., Ferguson,A.D., Fomenko,D.E., Chelliah,Y.,
            Hatfield,D.L. and Gladyshev,V.N.
  TITLE     A novel cysteine-rich domain of Sep15 mediates the interaction with
            UDP-glucose:glycoprotein glucosyltransferase
  JOURNAL   J Biol Chem 280 (45), 37839-37845 (2005)
   PUBMED   16129668
  REMARK    GeneRIF: The cysteine-rich domain of Sep15 exclusively mediates
            protein-protein interactions with UDP-glucose:glycoprotein
            glucosyltransferase.
REFERENCE   7  (bases 1 to 1515)
  AUTHORS   Wu,H.J., Lin,C., Zha,Y.Y., Yang,J.G., Zhang,M.C., Zhang,X.Y.,
            Liang,X., Fu,M. and Wu,M.
  TITLE     [Redox reactions of Sep15 and its relationship with tumor
            development]
  JOURNAL   Ai Zheng 22 (2), 119-122 (2003)
   PUBMED   12600282
  REMARK    GeneRIF: Transfecting Sep15 gene did not influence the growth
            characteristics of BEL-7402 cell line and Sep15 may have redox
            function.
REFERENCE   8  (bases 1 to 1515)
  AUTHORS   Kumaraswamy,E., Korotkov,K.V., Diamond,A.M., Gladyshev,V.N. and
            Hatfield,D.L.
  TITLE     Genetic and functional analysis of mammalian Sep15 selenoprotein
  JOURNAL   Methods Enzymol 347, 187-197 (2002)
   PUBMED   11898406
  REMARK    GeneRIF: Genetic and functional analysis of mammalian Sep15
            selenoprotein.
REFERENCE   9  (bases 1 to 1515)
  AUTHORS   Korotkov,K.V., Kumaraswamy,E., Zhou,Y., Hatfield,D.L. and
            Gladyshev,V.N.
  TITLE     Association between the 15-kDa selenoprotein and
            UDP-glucose:glycoprotein glucosyltransferase in the endoplasmic
            reticulum of mammalian cells
  JOURNAL   J Biol Chem 276 (18), 15330-15336 (2001)
   PUBMED   11278576
REFERENCE   10 (bases 1 to 1515)
  AUTHORS   Kumaraswamy,E., Malykh,A., Korotkov,K.V., Kozyavkin,S., Hu,Y.,
            Kwon,S.Y., Moustafa,M.E., Carlson,B.A., Berry,M.J., Lee,B.J.,
            Hatfield,D.L., Diamond,A.M. and Gladyshev,V.N.
  TITLE     Structure-expression relationships of the 15-kDa selenoprotein
            gene. Possible role of the protein in cancer etiology
  JOURNAL   J Biol Chem 275 (45), 35540-35547 (2000)
   PUBMED   10945981
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CJ134973.1, AC123880.18,
            BY262067.1, AF288740.1 and AK159085.1.
            
            On Jul 28, 2006 this sequence version replaced NM_053102.1.
            
            Summary: The protein encoded by this gene belongs to the
            SEP15/selenoprotein M family. The exact function of this protein is
            not known; however, it has been found to associate with
            UDP-glucose:glycoprotein glucosyltransferase (UGTR), an endoplasmic
            reticulum(ER)-resident protein, which is involved in the quality
            control of protein folding. The association with UGTR retains this
            protein in the ER, where it may play a role in protein folding.
            Knockout studies in mice also suggest a role for this gene in
            cataract formation and colon carcinogenesis. This protein is a
            selenoprotein, containing the rare amino acid selenocysteine (Sec).
            Sec is encoded by the UGA codon, which normally signals translation
            termination. The 3' UTRs of selenoprotein mRNAs contain a conserved
            stem-loop structure, designated the Sec insertion sequence (SECIS)
            element, that is necessary for the recognition of UGA as a Sec
            codon, rather than as a stop signal. [provided by RefSeq, Nov
            2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF288740.1, AK159085.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            protein contains selenocysteine :: PMID: 10945981
            RefSeq Select criteria          :: based on single protein-coding
                                               transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                CJ134973.1         8-24
            18-19               AC123880.18        37758-37759         c
            20-52               BY262067.1         3-35
            53-971              AF288740.1         1-919
            972-1001            AK159085.1         699-728
            1002-1515           AF288740.1         950-1463
FEATURES             Location/Qualifiers
     source          1..1515
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 68.94 cM"
     gene            1..1515
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /note="selenoprotein F"
                     /db_xref="GeneID:93684"
                     /db_xref="MGI:MGI:1927947"
     exon            1..373
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..787
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /note="UGA stop codon recoded as selenocysteine; 15 kDa
                     selenoprotein; selenoprotein 15"
                     /codon_start=1
                     /transl_except=(pos:575..577,aa:Sec)
                     /product="selenoprotein F precursor"
                     /protein_id="NP_444332.1"
                     /db_xref="CCDS:CCDS17884.1"
                     /db_xref="GeneID:93684"
                     /db_xref="MGI:MGI:1927947"
                     /translation="MAAGQGGWLRPALGLRLLLATAFQAASALGAEFASEACRELGFS
                     SNLLCSSCDLLGQFNLLPLDPVCRGCCQEEAQFETKKLYAGAILEVCGUKLGRFPQVQ
                     AFVRSDKPKLFRGLQIKYVRGSDPVLKLLDDNGNIAEELSILKWNTDSVEEFLSEKLE
                     RI"
     exon            374..541
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /inference="alignment:Splign:2.1.0"
     exon            542..605
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /inference="alignment:Splign:2.1.0"
     exon            606..655
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /inference="alignment:Splign:2.1.0"
     exon            656..1510
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1336..1415
                     /regulatory_class="recoding_stimulatory_region"
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /note="SECIS_element"
                     /function="essential for recoding UGA to specify
                     selenocysteine"
     regulatory      1479..1484
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /note="hexamer: AATAAA"
     polyA_site      1510
                     /gene="Selenof"
                     /gene_synonym="9430015P09Rik; Sep15"
                     /note="major polyA site"
ORIGIN      
        1 gcggggctac tgatggccga gctggggctt cgtggatagc cgattgaatg tcgtgaataa
       61 gaagccccgg tgtggggagt ttaggaaaat gcctaatttg aatctctaaa agaacctgag
      121 gactgtttaa caatcgatca cttacaggct cccatggtcg cctaactaac actcgtcttt
      181 gtgggataat aggcttgtag cagtggcctt tcgcggcggg tttcgcgtca ggcagtgcag
      241 tggacgtccc cggcacaggg gtcctcagac ccctgaagat tgacggcaga ccgcagggat
      301 ggcggcaggg cagggtgggt ggctgcggcc cgctctgggg ctgcgcttgc tgctggcgac
      361 tgcgtttcaa gcggcgtctg ctctgggggc agagtttgcg tcagaggcat gcagagagtt
      421 gggtttctcc agcaacttgc tctgcagctc ttgcgatctt cttggacagt ttaatctgct
      481 cccactggat cctgtttgca gagggtgctg tcaggaagaa gcacaatttg aaaccaaaaa
      541 gctgtatgca ggagccatcc ttgaagtctg cggatgaaaa ttggggaggt tccctcaagt
      601 ccaagctttt gtcagaagtg ataaacccaa actcttcaga ggtctacaga tcaagtatgt
      661 tcgaggctca gaccctgtac taaagctttt ggacgacaac gggaacattg ctgaagaact
      721 aagcatcctc aagtggaaca cagacagtgt ggaagagttc ctgagcgaga agttggaacg
      781 catataaaca tgcttagtag tttttatact aatcaaatga attatcacag cacctagaca
      841 ataacttagt tttgcatgct tacattggtc atccttttta tgtacatcat taatcttctg
      901 acaagaagct gaagtagcac cacagtccat aatatatcag gatctggcaa gcttaaggaa
      961 cccagctctt agaaatttct cttcttctac acttgttgct ctcaccagtg aaacgctttg
     1021 taaggaggca tctgggtaat tatgcaaata agtttgtgat aattgctcca gttctacaaa
     1081 caacagaatt ttaaatagag gaagtggata aaggagacac ctcccttgct gtgtgctctt
     1141 tgaaagtaat tgacagaaaa ctacaaacac gtaggatgcc ctgcgcctca gcagcaccca
     1201 ccccagagcc tcttggcatg cccagctttc ttttcagtac aagtatttgt agtttgtaat
     1261 gaatgtgcca catacaggtt ttgtagctta ttattatgga acagactgaa gatctgcagt
     1321 acgaatttaa tacttataaa ggtttgcatt aatgaggatt acacagaaaa cctttgttaa
     1381 ggacttgtgt agatctgata attggcaaat ttttatttta aaagtattct tacagaagag
     1441 ttccatttaa gaatgttcac ttataggacc aaaatataaa taaaaacttt caaatatgtt
     1501 tgattttaaa aaaaa
//
