LOCUS       NM_019414               1695 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus selenium binding protein 2 (Selenbp2), mRNA.
ACCESSION   NM_019414
VERSION     NM_019414.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1695)
  AUTHORS   Mattow,J., Demuth,I., Haeselbarth,G., Jungblut,P.R. and Klose,J.
  TITLE     Selenium-binding protein 2, the major hepatic target for
            acetaminophen, shows sex differences in protein abundance
  JOURNAL   Electrophoresis 27 (8), 1683-1691 (2006)
   PUBMED   16532517
  REMARK    GeneRIF: it was shown that the observed differences in SBP2
            abundance correlate with sex differences in transcription of the
            gene encoding SBP2, selenbp2, as revealed by RT-PCR and restriction
            digest as well as sequence analysis of the products.
REFERENCE   2  (bases 1 to 1695)
  AUTHORS   Karim,S.A., Johnson,K.J., Griffiths,I.R. and Vouyiouklis,D.A.
  TITLE     A physical map of the genomic region on mouse chromosome 3
            containing the hindshaker (hsh) mutation
  JOURNAL   Genomics 83 (2), 225-230 (2004)
   PUBMED   14706451
REFERENCE   3  (bases 1 to 1695)
  AUTHORS   Jin,W.H., Dai,J., Zhou,H., Xia,Q.C., Zou,H.F. and Zeng,R.
  TITLE     Phosphoproteome analysis of mouse liver using immobilized metal
            affinity purification and linear ion trap mass spectrometry
  JOURNAL   Rapid Commun Mass Spectrom 18 (18), 2169-2176 (2004)
   PUBMED   15378723
REFERENCE   4  (bases 1 to 1695)
  AUTHORS   Takenaka,M., Imai,E., Kaneko,T., Ito,T., Moriyama,T., Yamauchi,A.,
            Hori,M., Kawamoto,S. and Okubo,K.
  TITLE     Isolation of genes identified in mouse renal proximal tubule by
            comparing different gene expression profiles
  JOURNAL   Kidney Int 53 (3), 562-572 (1998)
   PUBMED   9507200
REFERENCE   5  (bases 1 to 1695)
  AUTHORS   Ellison,J.W., Wardak,Z., Young,M.F., Gehron Robey,P.,
            Laig-Webster,M. and Chiong,W.
  TITLE     PHOG, a candidate gene for involvement in the short stature of
            Turner syndrome
  JOURNAL   Hum Mol Genet 6 (8), 1341-1347 (1997)
   PUBMED   9259282
REFERENCE   6  (bases 1 to 1695)
  AUTHORS   Navarro,C.L., Cohen,S.D. and Khairallah,E.A.
  TITLE     Genes encoding the acetaminophen and selenium binding proteins map
            to mouse chromosome 3
  JOURNAL   Mamm Genome 7 (12), 919-920 (1996)
   PUBMED   8995767
REFERENCE   7  (bases 1 to 1695)
  AUTHORS   Lanfear,J., Fleming,J., Walker,M. and Harrison,P.
  TITLE     Different patterns of regulation of the genes encoding the closely
            related 56 kDa selenium- and acetaminophen-binding proteins in
            normal tissues and during carcinogenesis
  JOURNAL   Carcinogenesis 14 (3), 335-340 (1993)
   PUBMED   8453708
REFERENCE   8  (bases 1 to 1695)
  AUTHORS   Pumford,N.R., Martin,B.M. and Hinson,J.A.
  TITLE     A metabolite of acetaminophen covalently binds to the 56 kDa
            selenium binding protein
  JOURNAL   Biochem Biophys Res Commun 182 (3), 1348-1355 (1992)
   PUBMED   1540179
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC150033.2 and
            AC087903.27.
            
            On Nov 17, 2006 this sequence version replaced NM_019414.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: S56599.1, BC024106.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-90                AC150033.2         100611-100700
            91-147              AC150033.2         103832-103888
            148-260             AC150033.2         104030-104142
            261-446             AC150033.2         104343-104528
            447-567             AC150033.2         105081-105201
            568-750             AC150033.2         106568-106750
            751-929             AC150033.2         106976-107154
            930-1008            AC087903.27        23858-23936
            1009-1130           AC087903.27        24019-24140
            1131-1223           AC087903.27        25025-25117
            1224-1342           AC087903.27        25260-25378
            1343-1695           AC087903.27        25592-25944
FEATURES             Location/Qualifiers
     source          1..1695
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 40.74 cM"
     gene            1..1695
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /note="selenium binding protein 2"
                     /db_xref="GeneID:20342"
                     /db_xref="MGI:MGI:104859"
     exon            1..90
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     CDS             87..1505
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /note="56 kDa acetaminophen-binding protein"
                     /codon_start=1
                     /product="selenium-binding protein 2"
                     /protein_id="NP_062287.1"
                     /db_xref="CCDS:CCDS38539.1"
                     /db_xref="GeneID:20342"
                     /db_xref="MGI:MGI:104859"
                     /translation="MATKCTKCGPGYPTPLEAMKGPREEIVYLPCIYRNTGTEAPDYL
                     ATVDVDPKSPQYSQVIHRLPMPYLKDELHHSGWNTCSSCFGDSTKSRNKLILPGLMSS
                     RIYVVDVGSEPRAPKLHKVIEASEIQAKCNVSNTHTSHCLASGEVMVNTLGDLQGNGK
                     GSFVLLDGETFEVKGTWEKPGGASPMGYDFWYQPRHNVMVSTEWAAPNVFKDGFNPAH
                     VEAGLYGSRIFVWDWQRHEIIQTLQMTDGLIPLEIRFLHDPSATQGFVGCALSSNIQR
                     FYKNEEGTWSVEKVIQVPSKKVKGWMLPEMPGLITDILLSLDDRFLYFSNWLHGDIRQ
                     YDISNPQKPRLTGQIFLGGSIVRGGSVQVLEDQELTCQPEPLVVKGKRIPGGPQMIQL
                     SLDGKRLYATTSLYSDWDKQFYPDLIREGSVMLQVDVDTVNGGLKLNPNFLVDFGKEP
                     LGPALAHELRYPGGDCSSDIWI"
     exon            91..147
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            148..260
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            261..446
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            447..567
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            568..750
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..929
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            930..1008
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1130
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1131..1223
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1342
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     exon            1343..1695
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1677..1682
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /note="hexamer: AATAAA"
     polyA_site      1695
                     /gene="Selenbp2"
                     /gene_synonym="AP56; Lpsb2"
                     /note="major polyA site"
ORIGIN      
        1 gcacttaata ccagcactgg tctctgctga gcctctgctc attcctggca aatcctgcag
       61 gacccgagtg tcagccagcc agcagcatgg ctacaaaatg cacaaagtgt ggtccaggtt
      121 accccacccc tctggaggcc atgaaaggac cccgagagga gattgtctac ttgccctgca
      181 tttaccggaa cacaggcacc gaagccccgg attatttggc cactgtggat gtagacccta
      241 agtctcccca gtatagccag gtcatccaca ggttgcccat gccctacctg aaggacgagc
      301 tgcaccactc aggatggaac acctgcagca gctgctttgg ggacagcacg aagtcacgca
      361 acaagctgat actgcctggt ctcatgtcct cccgcatcta cgtggtggat gtgggctctg
      421 agcctcgtgc cccgaagttg cacaaggtca ttgaagccag tgaaatccaa gccaagtgca
      481 acgtgagcaa tacgcacacc agccactgcc tggccagtgg agaagtcatg gtcaacacct
      541 tgggggatct ccagggtaat ggcaaaggga gttttgtgct gctggatggg gagaccttcg
      601 aggtgaaagg gacatgggag aagcctgggg gtgcatctcc aatgggctac gacttctggt
      661 accagcctcg acacaatgtc atggtcagca ctgaatgggc agctcccaat gtcttcaaag
      721 atggcttcaa cccggctcat gtggaggctg ggctgtatgg gagccgcata tttgtgtggg
      781 actggcagcg ccatgagatt atccagaccc tgcaaatgac agatgggctg atacccctgg
      841 agatccgttt cctgcacgac ccaagtgcca cccagggttt tgtaggctgt gccctcagct
      901 ccaacatcca gcgcttctac aagaatgagg aaggcacttg gtcagtggag aaggtgatcc
      961 aagtgccctc caagaaagtg aagggctgga tgttgccaga aatgcctggt ttgatcaccg
     1021 acatcctgct gtccctggat gaccgcttcc tttacttcag caactggctg catggggaca
     1081 ttcggcagta tgacatctct aacccacaga agccccgcct cactgggcag atcttccttg
     1141 ggggcagcat tgttagagga ggctctgtgc aagtgctgga ggaccaagag ttaacctgtc
     1201 agccggagcc cctagtggtc aagggaaaac gaattcctgg aggccctcag atgatccagc
     1261 tcagcttaga tggcaagcgt ctttacgcca ctacatcact gtacagcgac tgggacaagc
     1321 agttttaccc tgacctcatt agggaaggct ccgtgatgct tcaagttgat gtagacacag
     1381 taaatggagg gctgaagttg aaccccaact ttctggtgga ctttgggaag gagccccttg
     1441 ggccagcact ggctcacgag cttcgttacc cagggggtga ctgcagttct gatatctgga
     1501 tctgaaggct cacactaggg gcccccctcc acattctgag cctgcctggc ttcactctgc
     1561 tctcagcccc aactctccaa ggccactctg agaccagcga gatctgtaga gcagcatctc
     1621 tgtaccgttg cttgttgttt gtacttttct taagtgagct cctggaagca cctggaaata
     1681 aaatgctgaa acttc
//
