LOCUS       NM_011345               3741 bp    mRNA    linear   ROD 26-JUN-2024
DEFINITION  Mus musculus selectin, endothelial cell (Sele), mRNA.
ACCESSION   NM_011345
VERSION     NM_011345.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3741)
  AUTHORS   Zheng,H., An,M., Luo,Y., Diao,X., Zhong,W., Pang,M., Lin,Y.,
            Chen,J., Li,Y., Kong,Y., Zhao,Y., Yin,Y., Ai,L., Huang,J., Chen,C.
            and Lin,T.
  TITLE     PDGFRalpha+ITGA11+ fibroblasts foster early-stage cancer
            lymphovascular invasion and lymphatic metastasis via ITGA11-SELE
            interplay
  JOURNAL   Cancer Cell 42 (4), 682-700 (2024)
   PUBMED   38428409
  REMARK    GeneRIF: PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage
            cancer lymphovascular invasion and lymphatic metastasis via
            ITGA11-SELE interplay.
REFERENCE   2  (bases 1 to 3741)
  AUTHORS   Zhang,J., Zhang,S., Xu,S., Zhu,Z., Li,J., Wang,Z., Wada,Y., Gatt,A.
            and Liu,J.
  TITLE     Oxidative Stress Induces E-Selectin Expression through Repression
            of Endothelial Transcription Factor ERG
  JOURNAL   J Immunol 211 (12), 1835-1843 (2023)
   PUBMED   37930129
  REMARK    GeneRIF: Oxidative Stress Induces E-Selectin Expression through
            Repression of Endothelial Transcription Factor ERG.
REFERENCE   3  (bases 1 to 3741)
  AUTHORS   Gullotta,G.S., De Feo,D., Friebel,E., Semerano,A., Scotti,G.M.,
            Bergamaschi,A., Butti,E., Brambilla,E., Genchi,A., Capotondo,A.,
            Gallizioli,M., Coviello,S., Piccoli,M., Vigo,T., Della Valle,P.,
            Ronchi,P., Comi,G., D'Angelo,A., Maugeri,N., Roveri,L., Uccelli,A.,
            Becher,B., Martino,G. and Bacigaluppi,M.
  TITLE     Age-induced alterations of granulopoiesis generate atypical
            neutrophils that aggravate stroke pathology
  JOURNAL   Nat Immunol 24 (6), 925-940 (2023)
   PUBMED   37188941
REFERENCE   4  (bases 1 to 3741)
  AUTHORS   Genduso,S., Freytag,V., Schetler,D., Kirchner,L., Schiecke,A.,
            Maar,H., Wicklein,D., Gebauer,F., Broker,K., Sturken,C.,
            Milde-Langosch,K., Oliveira-Ferrer,L., Ricklefs,F.L., Ewald,F.,
            Wolters-Eisfeld,G., Riecken,K., Unrau,L., Krause,L.,
            Bohnenberger,H., Offermann,A., Perner,S., Sebens,S., Lamszus,K.,
            Diehl,L., Linder,S., Jucker,M., Schumacher,U. and Lange,T.
  TITLE     Tumor cell integrin beta4 and tumor stroma E-/P-selectin
            cooperatively regulate tumor growth in vivo
  JOURNAL   J Hematol Oncol 16 (1), 23 (2023)
   PUBMED   36932441
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3741)
  AUTHORS   Dion-Albert,L., Cadoret,A., Doney,E., Kaufmann,F.N., Dudek,K.A.,
            Daigle,B., Parise,L.F., Cathomas,F., Samba,N., Hudson,N., Lebel,M.,
            Campbell,M., Turecki,G., Mechawar,N. and Menard,C.
  CONSRTM   Signature Consortium
  TITLE     Vascular and blood-brain barrier-related changes underlie stress
            responses and resilience in female mice and depression in human
            tissue
  JOURNAL   Nat Commun 13 (1), 164 (2022)
   PUBMED   35013188
  REMARK    GeneRIF: Vascular and blood-brain barrier-related changes underlie
            stress responses and resilience in female mice and depression in
            human tissue.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3741)
  AUTHORS   Weller,A., Isenmann,S. and Vestweber,D.
  TITLE     Cloning of the mouse endothelial selectins. Expression of both E-
            and P-selectin is inducible by tumor necrosis factor alpha
  JOURNAL   J Biol Chem 267 (21), 15176-15183 (1992)
   PUBMED   1378846
REFERENCE   7  (bases 1 to 3741)
  AUTHORS   Becker-Andre,M., Hooft van Huijsduijnen,R., Losberger,C., Whelan,J.
            and Delamarter,J.F.
  TITLE     Murine endothelial leukocyte-adhesion molecule 1 is a close
            structural and functional homologue of the human protein
  JOURNAL   Eur J Biochem 206 (2), 401-411 (1992)
   PUBMED   1375914
REFERENCE   8  (bases 1 to 3741)
  AUTHORS   Singh,G., Kaur,S., Stock,J.L., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Potter,S.S.
  TITLE     Identification of 10 murine homeobox genes
  JOURNAL   Proc Natl Acad Sci U S A 88 (23), 10706-10710 (1991)
   PUBMED   1683707
REFERENCE   9  (bases 1 to 3741)
  AUTHORS   Bevilacqua,M., Butcher,E., Furie,B., Furie,B., Gallatin,M.,
            Gimbrone,M., Harlan,J., Kishimoto,K., Lasky,L., McEver,R. et al.
  TITLE     Selectins: a family of adhesion receptors
  JOURNAL   Cell 67 (2), 233 (1991)
   PUBMED   1717161
REFERENCE   10 (bases 1 to 3741)
  AUTHORS   Watson,M.L., Kingsmore,S.F., Johnston,G.I., Siegelman,M.H., Le
            Beau,M.M., Lemons,R.S., Bora,N.S., Howard,T.A., Weissman,I.L.,
            McEver,R.P. et al.
  TITLE     Genomic organization of the selectin family of leukocyte adhesion
            molecules on human and mouse chromosome 1
  JOURNAL   J Exp Med 172 (1), 263-272 (1990)
   PUBMED   1694218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC110499.19.
            
            On Aug 31, 2022 this sequence version replaced NM_011345.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M87862.1, BC119083.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            RefSeq Select criteria           :: based on conservation,
                                                expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-108               AC110499.19        117420-117527       c
            109-192             AC110499.19        116999-117082       c
            193-576             AC110499.19        116144-116527       c
            577-684             AC110499.19        115555-115662       c
            685-873             AC110499.19        114910-115098       c
            874-1059            AC110499.19        114020-114205       c
            1060-1248           AC110499.19        113729-113917       c
            1249-1437           AC110499.19        112589-112777       c
            1438-1626           AC110499.19        112018-112206       c
            1627-1803           AC110499.19        111748-111924       c
            1804-1914           AC110499.19        111015-111125       c
            1915-1936           AC110499.19        110167-110188       c
            1937-2009           AC110499.19        109993-110065       c
            2010-3741           AC110499.19        107255-108986       c
FEATURES             Location/Qualifiers
     source          1..3741
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 71.35 cM"
     gene            1..3741
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /note="selectin, endothelial cell"
                     /db_xref="GeneID:20339"
                     /db_xref="MGI:MGI:98278"
     exon            1..108
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            109..192
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     CDS             156..1994
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /note="CD62 antigen-like family member E; endothelial
                     leukocyte adhesion molecule 1; leukocyte-endothelial cell
                     adhesion molecule 2"
                     /codon_start=1
                     /product="E-selectin precursor"
                     /protein_id="NP_035475.2"
                     /db_xref="CCDS:CCDS15432.1"
                     /db_xref="GeneID:20339"
                     /db_xref="MGI:MGI:98278"
                     /translation="MNASRFLSALVFVLLAGESTAWYYNASSELMTYDEASAYCQRDY
                     THLVAIQNKEEINYLNSNLKHSPSYYWIGIRKVNNVWIWVGTGKPLTEEAQNWAPGEP
                     NNKQRNEDCVEIYIQRTKDSGMWNDERCNKKKLALCYTASCTNASCSGHGECIETINS
                     YTCKCHPGFLGPNCEQAVTCKPQEHPDYGSLNCSHPFGPFSYNSSCSFGCKRGYLPSS
                     METTVRCTSSGEWSAPAPACHVVECEALTHPAHGIRKCSSNPGSYPWNTTCTFDCVEG
                     YRRVGAQNLQCTSSGIWDNETPSCKAVTCDAIPQPQNGFVSCSHSTAGELAFKSSCNF
                     TCEQSFTLQGPAQVECSAQGQWTPQIPVCKAVQCEALSAPQQGNMKCLPSASGPFQNG
                     SSCEFSCEEGFELKGSRRLQCGPRGEWDSKKPTCSAVKCDDVPRPQNGVMECAHATTG
                     EFTYKSSCAFQCNEGFSLHGSAQLECTSQGKWTQEVPSCQVVQCPSLDVPGKMNMSCS
                     GTAVFGTVCEFTCPDDWTLNGSAVLTCGATGRWSGMPPTCEAPVSPTRPLVVALSAAG
                     TSLLTSSSLLYLLMRYFRKKAKKFVPASSCQSLQSFENYHVPSYNV"
     exon            193..576
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            577..684
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..873
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            874..1059
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1060..1248
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1249..1437
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1438..1626
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1803
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1914
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1915..1936
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            1937..2009
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     exon            2010..3741
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2409..2414
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /note="hexamer: AATAAT"
     polyA_site      2437
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /note="major polyA site"
     regulatory      3722..3727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /note="hexamer: AATAAA"
     polyA_site      3741
                     /gene="Sele"
                     /gene_synonym="CD62E; E-selectin; Elam; ELAM-1; LECAM2"
                     /note="major polyA site"
ORIGIN      
        1 agtggtcctc gactgactac acagcaaaac tgcgagaaga acggatagag agaagcagga
       61 gcaatacacc taagggatcc aacgccagaa caacaattcc actgaacaga aagtttctcc
      121 agtctagcgc ctggatgaaa gcaactgctg gagtcatgaa tgcctcgcgc tttctctctg
      181 ctcttgtttt tgttctcctc gctggagaga gcacagcttg gtactacaat gcctccagtg
      241 agctcatgac gtatgatgaa gccagtgcat actgtcagcg ggactacaca catctggtgg
      301 caattcagaa caaggaagag atcaactacc ttaactccaa tctgaaacat tcaccgagtt
      361 actactggat tggaatcaga aaagtcaata acgtatggat ctgggtgggg acggggaagc
      421 ctctgacaga ggaagctcag aactgggctc caggtgaacc aaacaacaaa caaagaaatg
      481 aggactgtgt agagatttac atccaacgaa ccaaagactc gggcatgtgg aatgacgaga
      541 gatgtaacaa aaagaagctg gctctgtgct acacagcttc gtgtaccaat gcatcctgca
      601 gtggtcatgg tgaatgcata gagaccatca atagttacac ctgcaagtgc caccctggct
      661 tcctgggacc caactgtgag caagctgtga cttgcaaacc acaggaacac cctgactatg
      721 gaagcctgaa ctgctcccac ccgttcggcc ccttcagcta taattcctcc tgctcctttg
      781 gctgtaaaag gggctacctg cccagcagca tggagaccac cgtgcggtgt acgtcctctg
      841 gagagtggag tgcgcctgct ccagcctgcc atgtggttga atgtgaagct ttgacccacc
      901 ctgcccacgg tatcaggaaa tgttcctcaa atcctgggag ctacccatgg aacacgacat
      961 gcacgtttga ctgtgtggaa gggtacaggc gagttggagc tcagaatcta cagtgtacct
     1021 catctggcat ctgggataac gagacgccat catgcaaagc tgtgacctgt gacgccatcc
     1081 ctcagcctca gaatggcttt gtgagctgca gccactcaac agctggagaa cttgcgttta
     1141 agtcatcctg taacttcacc tgtgagcaga gtttcacgtt gcaggggcca gcgcaggttg
     1201 aatgcagcgc acaagggcag tggacaccac aaatcccagt ctgcaaagct gtccagtgtg
     1261 aagccttatc tgcgccacag cagggcaaca tgaaatgtct tcccagtgct tctggacctt
     1321 tccaaaatgg gtccagttgt gagttctcct gcgaagaagg atttgaactg aagggatcaa
     1381 gaagacttca gtgtggtcca agaggggaat gggatagcaa gaagcccacg tgttcagctg
     1441 tgaaatgtga tgatgtccct cggccccaga atggcgtcat ggagtgtgct catgctacta
     1501 ctggagaatt cacctacaag tcctcatgtg cctttcaatg caatgagggc tttagcttgc
     1561 atggctcagc tcaacttgag tgcacatctc agggaaagtg gacccaggaa gtcccctcct
     1621 gccaagtggt acaatgtcca agccttgacg tcccgggaaa gatgaacatg agctgcagcg
     1681 gaacagcagt tttcggcaca gtgtgtgagt ttacatgtcc tgatgattgg acactcaatg
     1741 gatctgcagt tctgacgtgt ggtgccacgg gacgctggtc tgggatgccg cctacctgtg
     1801 aagccccagt cagccccacc cgtcccttgg tagttgcact ttctgcggca ggaacctcac
     1861 tcctgacatc gtcctcattg ctctacttgt tgatgagata ctttcggaag aaagcaaaga
     1921 aatttgttcc tgctagcagc tgccaaagcc ttcaatcgtt tgaaaactac catgtgcctt
     1981 cttacaacgt ctaggttcaa aacaatcagg aacacaaatg catcgtggga aatagaatga
     2041 taagctgaag acagcaggaa atgaactgtc tacagaatcc tggttcctct tgcctgctta
     2101 aaaactggga tcccgactcc atggatcaaa actgagtgac aaggccagcc ctctactaga
     2161 atgactcagt ttcctctttc ctagttagtg acagtatgaa gaacatgctg ccacagaagg
     2221 tggaggtgct ctcttcaaaa gagagtgaat ggacggggga gagcgcgagc tggaatagca
     2281 gaatccattc tgactcttag tcatgctaga atttgggaac agaaacagcg ttttattgct
     2341 ttgtttcttt ctcttgttcc ccacacagtg tgtcaacagc taattccagt attgttgtca
     2401 caggcgtaaa taatatttat cagcagtttt gagcaaatga ttttctattt ctatcttgaa
     2461 aaacaaaaaa ggcagaattg ccatattctc aggttatggc ctaggagtgt cattacgggt
     2521 acaaggtgca gttcctggtg aatataacat gttaagactg ctaggcagac atattggctt
     2581 tatccccatg ggattcagtg gctgccgaag tattcttgaa cattgtgttc tgtgtcctgg
     2641 cactgaagcc agcatgagat ccatcattct tatgtcagct caagggtcaa aaggacttaa
     2701 aaaaaaatca gaatcctgtg gcctatcaca tggcaaaagt tatcctaaat ctttttttta
     2761 attagaaaat ccctaaatct aaaattaatg ttatatctgc agcccactta ttttcaaaat
     2821 gagaaattaa taatcagtgt gaaatcctga gtatttaacg gtagctggtt ttaagacatg
     2881 gtactatcag aagaatagaa agtgaagaga gagtttagat atttgatccc cccctgccct
     2941 gccaaggttt ttttttttct ggaagagaga ccatccttga agctaaatgt tctgatttaa
     3001 taaaagcata aatgataaaa agtacatttt aatgtattta agagcatgtc aaaatgtgaa
     3061 catgctgtga ttcctaaaag agtggttctt ttacacgaca aacacgtgat tcttatacct
     3121 tgtatctaat tctaaatcca cgatgaggtg tcaccctgta atcaatgcag acaatggact
     3181 tttaaagagt aaaggtgtcc agtggttatt ctagttcata tgttctagag gaggggaaag
     3241 ctggtgaaca cagtgattat gttatgttac agagaataaa actcctaagc aatttcatct
     3301 gcaactggca atgacataca cttggtctgt aaatgccagc tctgttcctg ccaaaagtgt
     3361 cccaagttcc aaattaacat attagagaaa gaaaattttt gggaggtcct cgctgattgg
     3421 tggcggtgga aaagccaaca gggaacagga agtgtgatag gcattaggat gagagaggag
     3481 tgacagagag agagagagag agagagagag agagagagag agagagactg tgagaaactg
     3541 cacaatgtaa atggttgtat attttgtatc agaaattact gtgtgaaata taagtgtggt
     3601 ctgtatctaa gtcctgattg agtattttaa attatgattt aaaatatttt atggtgtaag
     3661 agtatgtatt tatttaaata tgttaaactt attgtattca catatgagta taatgttttg
     3721 caataaacgc gtttctactt a
//
