LOCUS       NM_001033296            2488 bp    mRNA    linear   ROD 14-JUN-2024
DEFINITION  Mus musculus sel-1 suppressor of lin-12-like 2 (C. elegans)
            (Sel1l2), transcript variant 1, mRNA.
ACCESSION   NM_001033296 XM_130572 XM_894973 XM_918332 XM_925660
VERSION     NM_001033296.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2488)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2488)
  AUTHORS   Zambrowicz,B.P., Abuin,A., Ramirez-Solis,R., Richter,L.J.,
            Piggott,J., BeltrandelRio,H., Buxton,E.C., Edwards,J., Finch,R.A.,
            Friddle,C.J., Gupta,A., Hansen,G., Hu,Y., Huang,W., Jaing,C.,
            Key,B.W. Jr., Kipp,P., Kohlhauff,B., Ma,Z.Q., Markesich,D.,
            Payne,R., Potter,D.G., Qian,N., Shaw,J., Schrick,J., Shi,Z.Z.,
            Sparks,M.J., Van Sligtenhorst,I., Vogel,P., Walke,W., Xu,N.,
            Zhu,Q., Person,C. and Sands,A.T.
  TITLE     Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap
            screen to identify potential targets for therapeutic intervention
  JOURNAL   Proc Natl Acad Sci U S A 100 (24), 14109-14114 (2003)
   PUBMED   14610273
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL731795.11 and AL844528.13.
            
            On Mar 24, 2023 this sequence version replaced NM_001033296.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK132650.1, BC150948.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849384 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-150               AL731795.11        46361-46510
            151-206             AL731795.11        95928-95983
            207-375             AL731795.11        131308-131476
            376-478             AL731795.11        150779-150881
            479-641             AL731795.11        160522-160684
            642-695             AL731795.11        169672-169725
            696-755             AL731795.11        170160-170219
            756-837             AL731795.11        170306-170387
            838-992             AL731795.11        172562-172716
            993-1049            AL731795.11        173362-173418
            1050-1118           AL844528.13        128885-128953       c
            1119-1196           AL844528.13        127193-127270       c
            1197-1259           AL844528.13        120467-120529       c
            1260-1347           AL844528.13        119850-119937       c
            1348-1496           AL844528.13        117259-117407       c
            1497-1662           AL844528.13        116013-116178       c
            1663-1737           AL844528.13        115827-115901       c
            1738-1910           AL844528.13        112812-112984       c
            1911-2039           AL844528.13        102680-102808       c
            2040-2488           AL844528.13        101516-101964       c
FEATURES             Location/Qualifiers
     source          1..2488
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 69.2 cM"
     gene            1..2488
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /note="sel-1 suppressor of lin-12-like 2 (C. elegans)"
                     /db_xref="GeneID:228684"
                     /db_xref="MGI:MGI:2684964"
     exon            1..150
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..2159
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; protein sel-1 homolog 2; sel-1L2; suppressor of
                     lin-12-like protein 2"
                     /codon_start=1
                     /product="protein sel-1 homolog 2 isoform 1 precursor"
                     /protein_id="NP_001028468.1"
                     /db_xref="CCDS:CCDS50732.1"
                     /db_xref="GeneID:228684"
                     /db_xref="MGI:MGI:2684964"
                     /translation="MNPLALLVEILIIIEVTTKNTEAERYNRKQKEVNVTTQVSVSKV
                     KQFLLYLLEQGNANKITNKRENPLEKKKHQHKLKIKGIQNKNLLKRNQNYFKNPAKKS
                     ITDEGDELFKMGNKILQESKSQKQKTEAYTLFTRAANMGNLKAMEKMADAWLFGSFGM
                     QNITAAIQLYESLAKEGSYKAQNALGFLSSYGIGMEYDQAKALIYYTFGSAGGSMMSQ
                     MILGYRYLSGINVLQNCEVALNHYKKVADYIADKLEKSEGIPVEKVRLTERPENLSSN
                     SEILDWDIYQYYKFLAERGDVQIQVSLGQLHLIGRKGLDQDYSKALYYFLKAAKAGSA
                     NAMAFIGKMYFEGNAAAPQNNATAFKYFSMAASKGNAIGLHGLGLLYFHGKGVPVNYG
                     EALKYFQKAAEKGWPNAQFQLGFMYYSGSGVWKDYKLAFKYFYLASQSGQPLAIYYLA
                     EMYATGTGVLRSCRTAVELYKGVCELGHWAEKFLTAYFAYKDGDIDSSLIQYALLAEM
                     GYEVAQSNSAFILESKKAKILGKEKLYPMALLLWNRAAIQGNAFARVKIGDYHYYGYG
                     TKKDYETAATHYSIAADKHHSAQAMFNLAYMYEHGLGIAKDIHLARRLYDMAAQTSPD
                     AHIPVFFALMKLETMHLLHDILFFNFTMKWKWLKLDSTVGPYWDLLVIGLIVAMLIFL
                     LRNRHR"
     exon            151..206
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            207..375
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            376..478
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            479..641
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            642..695
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            696..755
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            756..837
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            838..992
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1049
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1050..1118
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1196
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1197..1259
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1260..1347
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1348..1496
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1662
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1663..1737
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1738..1910
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            1911..2039
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     exon            2040..2488
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2214..2219
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /note="hexamer: AATAAA"
     polyA_site      2236
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /note="major polyA site"
     regulatory      2457..2462
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
                     /note="hexamer: AATAAA"
     polyA_site      2488
                     /gene="Sel1l2"
                     /gene_synonym="Gm118"
ORIGIN      
        1 gagtcttgaa tcccacagac ctgagaagag gaagcttgtg ggccagccac ctaattcagc
       61 ccgtgttaaa gtaaaaagga gctgcttagg agatgaatcc cttggctttg ttagtagaga
      121 tattgatcat tatcgaggtc acaaccaaaa atactgaagc agaaagatat aacagaaaac
      181 aaaaagaagt gaatgtcacc acacaggtat cagtgagcaa agtcaagcaa tttttattgt
      241 atctactgga acaaggaaac gcaaataaaa taaccaataa aagagaaaat cccttagaaa
      301 aaaagaagca tcaacataag ttaaaaataa aaggaattca aaataagaat ctcctgaaga
      361 gaaatcaaaa ctacttcaaa aacccagcca agaaaagtat cacagatgaa ggagatgagt
      421 tatttaaaat gggcaacaag attctccagg agtctaaaag ccaaaaacaa aaaacagaag
      481 cctacacact cttcaccaga gcagccaaca tgggaaattt gaaagctatg gaaaaaatgg
      541 ctgatgcttg gctatttgga agtttcggca tgcaaaacat aacagcagct attcagttat
      601 atgagtcctt ggctaaagaa ggatcataca aagcccaaaa tgcattagga tttttatctt
      661 catatggaat aggaatggaa tatgaccaag ccaaggcact gatatattat acctttggaa
      721 gtgctggagg aagcatgatg tcccagatga ttctggggta cagatacttg tcaggaatta
      781 acgttctgca aaattgtgaa gttgccctaa atcattacaa gaaagtggca gattatattg
      841 ctgataaatt ggaaaaaagt gaaggtattc ccgtggaaaa agtgaggcta accgagagac
      901 ctgagaatct gagttccaac agtgagattt tggattggga catataccaa tactataaat
      961 ttttggcaga aagaggagat gttcagatac aagtatctct tggacaatta catctaattg
     1021 ggagaaaggg actagatcaa gattacagta aggcgttata ctactttcta aaggcagcaa
     1081 aagccgggag tgcaaatgcc atggcattta taggaaagat gtattttgaa gggaatgctg
     1141 ctgcaccaca aaataacgcc actgccttca aatacttctc catggcggcc agcaagggca
     1201 acgcaattgg ccttcatgga cttggtctcc tttacttcca tggaaaaggt gttcctgtga
     1261 attatggtga agcacttaaa tacttccaga aagctgcgga gaagggatgg cctaatgcac
     1321 agttccagct gggcttcatg tactactctg gctctggagt atggaaggat tataagcttg
     1381 ccttcaaata cttttacttg gcatctcaga gtgggcagcc tcttgccatt tattatctag
     1441 ccgagatgta cgcaactggc actggagtgc tgagatcatg cagaacggcc gtggagcttt
     1501 acaaaggtgt ctgtgaacta ggccactggg ctgagaaatt cctaacggcc tatttcgcct
     1561 ataaggatgg ggacatagac tcttctctta ttcagtatgc attgcttgcc gaaatgggat
     1621 atgaagtagc tcaaagcaat tcagcattca ttttggaatc taaaaaagct aaaattctgg
     1681 ggaaagagaa gttgtatcca atggcacttc tgctatggaa ccgagccgcc attcaaggga
     1741 acgcttttgc tagagtaaaa attggagatt accattacta tggctacggg actaagaagg
     1801 actacgaaac agcagccaca cactacagca tcgcagcaga caagcatcac agtgcacaag
     1861 caatgttcaa cctggcatat atgtatgaac atggcttggg tattgcaaag gacattcact
     1921 tggccagaag attgtacgac atggctgctc agacaagccc agatgctcac atacctgtgt
     1981 tctttgccct tatgaaactg gaaaccatgc atctgctcca tgatatcctg ttttttaatt
     2041 ttaccatgaa atggaaatgg ctgaaactgg acagcactgt tggaccatac tgggatttat
     2101 tggtgattgg cctaattgtt gccatgctga tcttcctgct tagaaatcgc cataggtagg
     2161 ctctagacca tcagataacc tacttatagg ttcatgccaa gctatcctca ccaaataaag
     2221 aatttcctca tccaaattgc gagtctctac agatttccca cacaggcttt gatggagagt
     2281 ggacagagct taagaactac cctaaagaag caactccata cttcctactt ggtttaggga
     2341 ccatgggaag aatggtccct aaatgctgag gacaggtcat ctaagacatt gccacaaatt
     2401 tttcatcttg gtgatctaag tcctgacctc aataaaggtc accatctttg ggttataata
     2461 aaggtgccat ccccttttga gggaataa
//
