LOCUS       NM_001039089            6300 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus sel-1 suppressor of lin-12-like (C. elegans) (Sel1l),
            transcript variant 1, mRNA.
ACCESSION   NM_001039089
VERSION     NM_001039089.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 6300)
  AUTHORS   Song,Z., Thepsuwan,P., Hur,W.S., Torres,M., Wu,S.A., Wei,X.,
            Tushi,N.J., Wei,J., Ferraresso,F., Paton,A.W., Paton,J.C.,
            Zheng,Z., Zhang,K., Fang,D., Kastrup,C.J., Jaiman,S., Flick,M.J.
            and Sun,S.
  TITLE     Regulation of hepatic inclusions and fibrinogen biogenesis by
            SEL1L-HRD1 ERAD
  JOURNAL   Nat Commun 15 (1), 9244 (2024)
   PUBMED   39455574
  REMARK    GeneRIF: Regulation of hepatic inclusions and fibrinogen biogenesis
            by SEL1L-HRD1 ERAD.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6300)
  AUTHORS   Correa-Medero,L.O., Jankowski,S.E., Hong,H.S., Armas,N.D.,
            Vijendra,A.I., Reynolds,M.B., Fogo,G.M., Awad,D., Dils,A.T.,
            Inoki,K.A., Williams,R.G., Ye,A.M., Svezhova,N., Gomez-Rivera,F.,
            Collins,K.L., O'Riordan,M.X., Sanderson,T.H., Lyssiotis,C.A. and
            Carty,S.A.
  TITLE     ER-associated degradation adapter Sel1L is required for CD8+ T cell
            function and memory formation following acute viral infection
  JOURNAL   Cell Rep 43 (5), 114156 (2024)
   PUBMED   38687642
  REMARK    GeneRIF: ER-associated degradation adapter Sel1L is required for
            CD8[+] T cell function and memory formation following acute viral
            infection.
REFERENCE   3  (bases 1 to 6300)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (bases 1 to 6300)
  AUTHORS   Lin,L.L., Wang,H.H., Pederson,B., Wei,X., Torres,M., Lu,Y.,
            Li,Z.J., Liu,X., Mao,H., Wang,H., Zhou,L.E., Zhao,Z., Sun,S. and
            Qi,L.
  TITLE     SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD
            complex
  JOURNAL   Nat Commun 15 (1), 1440 (2024)
   PUBMED   38365914
  REMARK    GeneRIF: SEL1L-HRD1 interaction is required to form a functional
            HRD1 ERAD complex.
            Erratum:[Nat Commun. 2024 Apr 15;15(1):3241. doi:
            10.1038/s41467-024-47251-2. PMID: 38622165]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 6300)
  AUTHORS   Gao,Y., Li,W., Wang,Z., Zhang,C., He,Y., Liu,X., Tang,K., Zhang,W.,
            Long,Q., Liu,Y., Zhang,J., Zhang,B. and Zhang,L.
  TITLE     SEL1L preserves CD8+ T-cell survival and homeostasis by fine-tuning
            PERK signaling and the IL-15 receptor-mediated mTORC1 axis
  JOURNAL   Cell Mol Immunol 20 (10), 1232-1250 (2023)
   PUBMED   37644166
  REMARK    GeneRIF: SEL1L preserves CD8[+] T-cell survival and homeostasis by
            fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1
            axis.
REFERENCE   6  (bases 1 to 6300)
  AUTHORS   Li,S., Francisco,A.B., Munroe,R.J., Schimenti,J.C. and Long,Q.
  TITLE     SEL1L deficiency impairs growth and differentiation of pancreatic
            epithelial cells
  JOURNAL   BMC Dev Biol 10, 19 (2010)
   PUBMED   20170518
  REMARK    GeneRIF: Data suggest that Sel1l is essential for the growth and
            differentiation of endoderm-derived pancreatic epithelial cells
            during mouse embryonic development.
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 6300)
  AUTHORS   Hart,A., Papadopoulou,S. and Edlund,H.
  TITLE     Fgf10 maintains notch activation, stimulates proliferation, and
            blocks differentiation of pancreatic epithelial cells
  JOURNAL   Dev Dyn 228 (2), 185-193 (2003)
   PUBMED   14517990
REFERENCE   8  (bases 1 to 6300)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (bases 1 to 6300)
  AUTHORS   Biunno,I., Bernard,L., Dear,P., Cattaneo,M., Volorio,S.,
            Zannini,L., Bankier,A. and Zollo,M.
  TITLE     SEL1L, the human homolog of C. elegans sel-1: refined physical
            mapping, gene structure and identification of polymorphic markers
  JOURNAL   Hum Genet 106 (2), 227-235 (2000)
   PUBMED   10746565
REFERENCE   10 (bases 1 to 6300)
  AUTHORS   Donoviel,D.B., Donoviel,M.S., Fan,E., Hadjantonakis,A. and
            Bernstein,A.
  TITLE     Cloning and characterization of Sel-1l, a murine homolog of the C.
            elegans sel-1 gene
  JOURNAL   Mech Dev 78 (1-2), 203-207 (1998)
   PUBMED   9858735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK220502.1 and AC157658.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220502.1, SRR1660813.80432.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5723              AK220502.1         1-5723
            5724-6300           AC157658.2         191177-191753
FEATURES             Location/Qualifiers
     source          1..6300
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 45.02 cM"
     gene            1..6300
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /note="sel-1 suppressor of lin-12-like (C. elegans)"
                     /db_xref="GeneID:20338"
                     /db_xref="MGI:MGI:1329016"
     exon            1..199
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            200..237
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            238..454
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            455..622
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            623..728
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            729..891
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            892..945
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            946..1005
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1006..1087
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1242
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1243..1299
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1300..1368
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1369..1446
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1447..1509
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1510..1597
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1598..1746
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1747..1912
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1913..1987
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            1988..2160
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2161..2289
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     exon            2290..6300
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      4006
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
     regulatory      6278..6283
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /note="hexamer: AATAAA"
     polyA_site      6300
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /note="major polyA site"
ORIGIN      
        1 gggaaggggc gaagaaggaa cctgagcagg aagagcggct gcgaggcggc ggcacagagg
       61 cagcggctga gttggtcgcg gcgacggcga cggcgacggc gagggctctc gaccttcgag
      121 agcaggatgc aggtccgcgt caggctgtcg ttgctgctgc tctgcgcggt gctcctgggc
      181 tcggcagccg cgacctcgga tgacaaaact aaccaggatg actccttaga ttccaagagt
      241 tctttgccca cagatgagtc agtgaaggac cacaccacca cgggcaaagt agttgctggc
      301 cagatatttg ttgattctga agaagcagaa gtggaatccc ttcttcagga cgaggaagat
      361 agctccaaga cccaggagga agagatcagc tttttagaat ctccgaatcc aagcagcaag
      421 acctacgaag aactaaagag agtgcggaag ccagtcttga ctgccattga aggtacggcg
      481 cacggggagc cctgccactt ccctttcctt ttcctggata aggagtatga tgagtgcacc
      541 tcagacggga gggaagatgg cagactgtgg tgtgccacaa cctatgacta caagacagat
      601 gagaagtggg gcttctgcga aactgaagaa gatgctgcca aaagacgaca gatgcaggaa
      661 gcagagatga tctatcaggc cgggatgaag atactgaatg gaagcaatag gaagagccaa
      721 aagagagaag catatcggta ccttcagaag gcagcaggca tgaatcacac caaagccctg
      781 gagagagtgt cctatgctct cttgtttggt gattacctca cacagaatat ccaggcagcc
      841 aaagagatgt ttgagaaact gactgaggaa gggtctccca aaggacagac tggtcttggc
      901 tttctctacg cttctgggct tggtgttaat tcaagtcagg caaaggctct tgtatattat
      961 actttcggag ctcttggagg caacctgata gcccatatga ttttgggtta ccgctactgg
     1021 gctggcatcg gagtcctcca gagttgtgag tcggcactga cccattatcg tcttgttgcc
     1081 aatcatgttg ctagtgatat ctccctaact ggaggctctg tagtccagag aatacggctg
     1141 cccgatgaag tggaaaaccc ggggatgaac agtgggatgc tggaagaaga cctgattcag
     1201 tattaccagt tcctagctga gaagggtgac gtccaagcac aggttggcct gggacagctg
     1261 catctgcatg gagggcgtgg agtagaacag aatcaccaga gagcgtttga ctacttcaac
     1321 ttagcagcaa atgctggcaa ttcacatgct atggccttcc tgggaaagat gtattctgaa
     1381 ggaagtgaca tcgtacctca gagtaatgag acggcacttc actactttaa gaaagctgct
     1441 gacatgggca accccgtggg acagagcggg cttggaatgg cctacctcta cggaagaggc
     1501 gttcaagtta attatgacct ggccctcaag tatttccaga aagctgctga gcaaggctgg
     1561 gtggacgggc agctgcagct cggctctatg tactacaatg gcattggagt caagagagat
     1621 tataagcagg ccttgaagta ttttaatctg gcttctcaag gaggccatat cttggctttc
     1681 tataacctcg cacagatgca cgccagcggc acaggggtga tgcggtcctg tcacactgca
     1741 gtggagttgt ttaagaatgt gtgtgagcga ggtcgctggt cagagagact gatgactgcc
     1801 tacaacagct ataaggatga ggactacaat gctgcagtgg tccagtacct cctgctggct
     1861 gagcagggct acgaggtggc gcagagcaac gcagccttca tcctcgacca gagagaagca
     1921 accattgtag gtgagaatga aacttacccc agagctttac tgcattggaa cagggccgcc
     1981 tcccaaggtt acactgtggc tagaattaag cttggagact accacttcta tggctttggc
     2041 actgatgtgg attatgagac cgcatttatt cattaccgcc tggcttctga gcagcagcac
     2101 agcgcccaag ctatgtttaa cctgggctac atgcacgaga agggcctagg cattaaacag
     2161 gacattcacc ttgcaaaacg cttttatgac atggcagccg aagctagccc agatgcacaa
     2221 gtacctgtgt tcctcgcact ctgcaaatta ggtgtcgtct atttcttaca gtacatacgg
     2281 gaagcaaaca ttcgagatct attcacacaa ctggatatgg accagctttt gggacccgag
     2341 tgggaccttt acctcatgac catcattgca ctgctcttgg gtacagtcat agcttacagg
     2401 cagcgacagc accaggacat accagttccc aggcccccag ggccacggcc ggctcctccc
     2461 cagcaggaag gaccaccaga gcagcagcca ccacagtagc agccacacac tcaccttggt
     2521 cggtgaccac tggggagctg cttgctgaga acgcttgcat ttgatgtagg gctctggatg
     2581 gtggcaccgc ctggaagagg cgtgaggcgt gttgaatccc agaagctgct tagaacctgc
     2641 tgccttcctt ttcagggatg cgcggctctc ggcagagctg cagtgaatgt ttgtttcagt
     2701 gccatacgga atgacaactc tcagtggctt tcctctttcc tttttctttc ttcgttctgc
     2761 aaacatacac aagacactcg agtcatgtct actgtaccct gtctttcctg agagaccttt
     2821 cgtcatcctg ttgatgtgca taacttctta cctgtcttct aaggtcctga gcattgacaa
     2881 cctggggaaa cccagttagt tgcaagttta accctaaaaa catgcttaag tctgagacta
     2941 gaacttgcca ttaagtcaaa agcaaaacaa gccaagcagg acgtcttcag ggtgtttggg
     3001 aaatgcagta actgggaaat tttaccagtc tacatgccag gtcatatgtt cggcactctt
     3061 attttaaaag ggattattga tcggattcct gtactgtgac tctgacactt cctagcaaac
     3121 ttctcttcct caaagactga aaggctttgc taaagacttc ttcgtgatgt cacatccctg
     3181 ccatggagta gaagtcaaac tcagtcagct gactccgtgc tcccacagag gactttgccc
     3241 cagctactca tgtgagttgc atatacagag ccctagtcca gacgccagag gatgatctaa
     3301 atggagaaat cagaaaacag ccttaaccaa cttgaggtgg gacctgggac atgccctccc
     3361 tcgggtagat tcgttgcttc ccggatctca ttttacttca catttcttat ggcacagaga
     3421 acagacaacc ctcccaaagt cttcaaatat gaaatgctat tgtcaagatt ggcaggtggt
     3481 gacttccttt gtaatactaa aatactaaaa tactcagaca atggaggatg ggttagaccc
     3541 aatgcatggc aaaaccaaag gcctgggtgc accgttgtgt atgctgcggg agctttttat
     3601 ttctgacggt ttgatgtggc tgtagaaagt cagccactga gtagctgttg tgttatcgcc
     3661 cttctgttgt aaacattagg aaattaaagc agttacaccc agcattgcct gcttcagtaa
     3721 gaggcgaaaa caacgactga gagcttcaca taatcacccc aaagcccaag ctgaatttgt
     3781 ggtctgtgta atcagatctg tggatggtag cgttgggtag ccagcacccc atgggagctc
     3841 acgcccctgt tcattatcgc ctttccattg ttttctgtaa tccttgtctg caatgaaacg
     3901 actttatcac ttgtggagtt tggaaagctt tgagtttgaa tgttgggatt gtcatgagaa
     3961 ttcaatgtag ttcatctgta ttgaacatga aggctttaag tgtgaagttg tgtacatttg
     4021 tgtgtgctca cagtattatg ggaaacccag gaagcaaaaa ttttcctcga agatatttgc
     4081 ctccaaattt gaagacatgg ccacagagag gcagatcttt gagaggcagc cagcattcct
     4141 ctcaaaaatg taatgttgct ttgggcttgt aaatagtaag gctcatttgg tgtcctgtgc
     4201 tgaaagacta gattgtgagc ggtgcagtaa acagggtcct tagccctgcc tcctctccca
     4261 gcccctccct cagcccagga aaggaaatac gctacggccc ggcccgtctc tgccgtctct
     4321 cttcctttag aaggcaggtt ttacatgatt cacaggaact gggcacagtg gtgtgtagct
     4381 gcagtctcct gtcactcaca gtaggctggg gggttaagac cagcttaggc aatacaacaa
     4441 gacccagtct ctacaaataa ataaataaaa agatgggaaa ctctaagatg ccactggctt
     4501 ctgtggtttt cctgtgccat ccacctcagg cctccttgga tggcagcagt tttgcctcca
     4561 tctttacttc ccacagaaag tacttgaaga aaatatctct taaaatagca tacactacct
     4621 aaggctggac gggacagtct aggtttgttc ttcatgtagc agacttgccc cttgctgtcc
     4681 ttttacgaac ggtcactaca gcagatgccc ttcccgagac ttttaccctc tgtttccagc
     4741 ctgcggcgtc tactgcgaga actcagttct cgctgctgct ttcctagatg atctcaagcg
     4801 ctttgctctg ttctcttacc tagagtctgt gggacgtggg accgaagcaa ataggcactg
     4861 ggttcggtgg ttctcttaaa aataatgcac agtacttact aatggcatcc atttgaataa
     4921 agtggcaata aagctagttg atgtcagtga cattaagcca actccaggat tcgggagttt
     4981 tagcattagg atttagattt accagctaga gcgtggcttc cttcctccct gtagcccatc
     5041 cctactgctg cctttcgtgg tctgtctcgc aggtctgtct tgcggcctac caaggctctc
     5101 tgacgagcct ctgttctcct gcgccccgcc ccgttgggca accagctaca tcagagtcta
     5161 gagaacacaa attttacttc tgtggcggtg tacaaaagtg gagtttttgt ttttgaagtt
     5221 tttgtttctg atttctgggt tttcttagtt actagccgat aatacagaaa aaggtctgac
     5281 aggggcttta ttttccccca aatttattaa tacctaaact agattaatgt aaaagtacaa
     5341 gtcctaaatc ttggtactcc tgaaggcttg tagttcttct gaagatatat atagatagat
     5401 agattaactt ctgaacatat taccactcac catctctacc ttggagaagc gttagaaccc
     5461 tgctccaggg gtctggtgag gagcgggtgg ctgggggttc tctacacaga atttggtttc
     5521 gtctggctgc ttggttgggt tttctctctc tcctctgctc cccaggtttg ctctctggtg
     5581 cttaggagca gccatggcag cctccacatg cagacctcaa ccccttgtgt gtgtggcatt
     5641 tgcaaccagt gaccaaccac atctgcaaaa cacgcaagaa gatacgcaag aagtaaccgg
     5701 aacaaaggaa aactatttta tgcaaaaaaa aaaaaaaaaa aactattttc atcagttatt
     5761 gcctcagata cgagagaaac tatttctgga tgctgtattg tcaggttttt aagtgggtat
     5821 ttttctttga aaaagaagct aagtgtcttc acccactagg gacttgaaga aaatttgaaa
     5881 taaccccata taccaatgat ttctatgtta aagagcctgt ttacacatca gaaagccgat
     5941 tttgtatgca tatgaagggc cctttggtta tgagcaggga gccatccaga tgttctttgt
     6001 ttactattta ttggtgaacg atctgacact atttctcttt tatttaagaa acaacgttga
     6061 tatgatcaaa gtatgaccac tagagatgtt gagggacatg cttaaagagc ataagctgac
     6121 gtcatgaagg aacaccatac tagacttttt gtaaatttat tttgtattta atggaatgca
     6181 gtataacggc tggtgacgtg tattataatt gtgtaaacaa atcctgttaa tagagagatg
     6241 tacagattca ttttgtactg tatctggaaa cttgtgaaat aaagaccccc tctctggtta
//
