LOCUS       NP_001034178             790 aa            linear   ROD 10-FEB-2025
DEFINITION  protein sel-1 homolog 1 isoform a precursor [Mus musculus].
ACCESSION   NP_001034178
VERSION     NP_001034178.1
DBSOURCE    REFSEQ: accession NM_001039089.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 790)
  AUTHORS   Song,Z., Thepsuwan,P., Hur,W.S., Torres,M., Wu,S.A., Wei,X.,
            Tushi,N.J., Wei,J., Ferraresso,F., Paton,A.W., Paton,J.C.,
            Zheng,Z., Zhang,K., Fang,D., Kastrup,C.J., Jaiman,S., Flick,M.J.
            and Sun,S.
  TITLE     Regulation of hepatic inclusions and fibrinogen biogenesis by
            SEL1L-HRD1 ERAD
  JOURNAL   Nat Commun 15 (1), 9244 (2024)
   PUBMED   39455574
  REMARK    GeneRIF: Regulation of hepatic inclusions and fibrinogen biogenesis
            by SEL1L-HRD1 ERAD.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 790)
  AUTHORS   Correa-Medero,L.O., Jankowski,S.E., Hong,H.S., Armas,N.D.,
            Vijendra,A.I., Reynolds,M.B., Fogo,G.M., Awad,D., Dils,A.T.,
            Inoki,K.A., Williams,R.G., Ye,A.M., Svezhova,N., Gomez-Rivera,F.,
            Collins,K.L., O'Riordan,M.X., Sanderson,T.H., Lyssiotis,C.A. and
            Carty,S.A.
  TITLE     ER-associated degradation adapter Sel1L is required for CD8+ T cell
            function and memory formation following acute viral infection
  JOURNAL   Cell Rep 43 (5), 114156 (2024)
   PUBMED   38687642
  REMARK    GeneRIF: ER-associated degradation adapter Sel1L is required for
            CD8[+] T cell function and memory formation following acute viral
            infection.
REFERENCE   3  (residues 1 to 790)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   4  (residues 1 to 790)
  AUTHORS   Lin,L.L., Wang,H.H., Pederson,B., Wei,X., Torres,M., Lu,Y.,
            Li,Z.J., Liu,X., Mao,H., Wang,H., Zhou,L.E., Zhao,Z., Sun,S. and
            Qi,L.
  TITLE     SEL1L-HRD1 interaction is required to form a functional HRD1 ERAD
            complex
  JOURNAL   Nat Commun 15 (1), 1440 (2024)
   PUBMED   38365914
  REMARK    GeneRIF: SEL1L-HRD1 interaction is required to form a functional
            HRD1 ERAD complex.
            Erratum:[Nat Commun. 2024 Apr 15;15(1):3241. doi:
            10.1038/s41467-024-47251-2.. PMID: 38622165]
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 790)
  AUTHORS   Gao,Y., Li,W., Wang,Z., Zhang,C., He,Y., Liu,X., Tang,K., Zhang,W.,
            Long,Q., Liu,Y., Zhang,J., Zhang,B. and Zhang,L.
  TITLE     SEL1L preserves CD8+ T-cell survival and homeostasis by fine-tuning
            PERK signaling and the IL-15 receptor-mediated mTORC1 axis
  JOURNAL   Cell Mol Immunol 20 (10), 1232-1250 (2023)
   PUBMED   37644166
  REMARK    GeneRIF: SEL1L preserves CD8[+] T-cell survival and homeostasis by
            fine-tuning PERK signaling and the IL-15 receptor-mediated mTORC1
            axis.
REFERENCE   6  (residues 1 to 790)
  AUTHORS   Li,S., Francisco,A.B., Munroe,R.J., Schimenti,J.C. and Long,Q.
  TITLE     SEL1L deficiency impairs growth and differentiation of pancreatic
            epithelial cells
  JOURNAL   BMC Dev Biol 10, 19 (2010)
   PUBMED   20170518
  REMARK    GeneRIF: Data suggest that Sel1l is essential for the growth and
            differentiation of endoderm-derived pancreatic epithelial cells
            during mouse embryonic development.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 790)
  AUTHORS   Hart,A., Papadopoulou,S. and Edlund,H.
  TITLE     Fgf10 maintains notch activation, stimulates proliferation, and
            blocks differentiation of pancreatic epithelial cells
  JOURNAL   Dev Dyn 228 (2), 185-193 (2003)
   PUBMED   14517990
REFERENCE   8  (residues 1 to 790)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   9  (residues 1 to 790)
  AUTHORS   Biunno,I., Bernard,L., Dear,P., Cattaneo,M., Volorio,S.,
            Zannini,L., Bankier,A. and Zollo,M.
  TITLE     SEL1L, the human homolog of C. elegans sel-1: refined physical
            mapping, gene structure and identification of polymorphic markers
  JOURNAL   Hum Genet 106 (2), 227-235 (2000)
   PUBMED   10746565
REFERENCE   10 (residues 1 to 790)
  AUTHORS   Donoviel,D.B., Donoviel,M.S., Fan,E., Hadjantonakis,A. and
            Bernstein,A.
  TITLE     Cloning and characterization of Sel-1l, a murine homolog of the C.
            elegans sel-1 gene
  JOURNAL   Mech Dev 78 (1-2), 203-207 (1998)
   PUBMED   9858735
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK220502.1 and AC157658.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK220502.1, SRR1660813.80432.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..790
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="12"
                     /map="12 45.02 cM"
     Protein         1..790
                     /product="protein sel-1 homolog 1 isoform a precursor"
                     /note="protein sel-1 homolog 1; sel-1L; suppressor of
                     lin-12-like protein 1; Sel1 (suppressor of lin-12) 1
                     homolog"
                     /calculated_mol_wt=86132
     sig_peptide     1..21
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2G6.2)"
                     /calculated_mol_wt=2227
     mat_peptide     22..790
                     /product="Protein sel-1 homolog 1. /id=PRO_0000022296"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
                     /calculated_mol_wt=86132
     Region          22..51
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          23..733
                     /region_name="Interaction with ERLEC1, OS9 and SYVN1.
                     /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Site            64
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UBV2; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          67..98
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          116..164
                     /region_name="FN2"
                     /note="Fibronectin type 2 domain; smart00059"
                     /db_xref="CDD:128373"
     Site            order(127,129,134,148,155,161,163)
                     /site_type="active"
                     /note="putative gelatin-binding site [active]"
                     /db_xref="CDD:238019"
     Site            191
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          201..227
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Site            213
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          234..263
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          251..286
                     /region_name="SEL1"
                     /note="Sel1-like repeats; smart00671"
                     /db_xref="CDD:214772"
     Site            268
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          270..299
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          348..533
                     /region_name="Important for homodimerization and
                     oligomerization. /evidence=ECO:0000269|PubMed:27064360"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          <359..548
                     /region_name="TPR"
                     /note="TPR repeat [General function prediction only];
                     COG0790"
                     /db_xref="CDD:440553"
     Region          389..418
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          426..455
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Site            427
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          462..491
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          566..595
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          602..635
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Site            604
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          625..658
                     /region_name="SEL1"
                     /note="Sel1-like repeats; smart00671"
                     /db_xref="CDD:214772"
     Region          639..719
                     /region_name="Interaction with SYVN1.
                     /evidence=ECO:0000269|PubMed:27064360"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          642..672
                     /region_name="SLR repeat"
                     /note="SLR repeat [structural motif]"
                     /db_xref="CDD:276807"
     Region          660..693
                     /region_name="Sel1"
                     /note="Sel1 repeat; pfam08238"
                     /db_xref="CDD:429881"
     Region          734..790
                     /region_name="Mediates retention in the endoplasmic
                     reticulum. /evidence=ECO:0000250"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Site            735..755
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     Region          763..790
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9Z2G6.2)"
     CDS             1..790
                     /gene="Sel1l"
                     /gene_synonym="mKIAA4137; Sel1h"
                     /coded_by="NM_001039089.1:127..2499"
                     /note="isoform a precursor is encoded by transcript
                     variant 1"
                     /db_xref="CCDS:CCDS26091.1"
                     /db_xref="GeneID:20338"
                     /db_xref="MGI:MGI:1329016"
ORIGIN      
        1 mqvrvrlsll llcavllgsa aatsddktnq ddsldskssl ptdesvkdht ttgkvvagqi
       61 fvdseeaeve sllqdeedss ktqeeeisfl espnpsskty eelkrvrkpv ltaiegtahg
      121 epchfpflfl dkeydectsd gredgrlwca ttydyktdek wgfceteeda akrrqmqeae
      181 miyqagmkil ngsnrksqkr eayrylqkaa gmnhtkaler vsyallfgdy ltqniqaake
      241 mfeklteegs pkgqtglgfl yasglgvnss qakalvyytf galggnliah milgyrywag
      301 igvlqscesa lthyrlvanh vasdisltgg svvqrirlpd evenpgmnsg mleedliqyy
      361 qflaekgdvq aqvglgqlhl hggrgveqnh qrafdyfnla anagnshama flgkmysegs
      421 divpqsneta lhyfkkaadm gnpvgqsglg maylygrgvq vnydlalkyf qkaaeqgwvd
      481 gqlqlgsmyy ngigvkrdyk qalkyfnlas qgghilafyn laqmhasgtg vmrschtave
      541 lfknvcergr wserlmtayn sykdedynaa vvqylllaeq gyevaqsnaa fildqreati
      601 vgenetypra llhwnraasq gytvariklg dyhfygfgtd vdyetafihy rlaseqqhsa
      661 qamfnlgymh ekglgikqdi hlakrfydma aeaspdaqvp vflalcklgv vyflqyirea
      721 nirdlftqld mdqllgpewd lylmtiiall lgtviayrqr qhqdipvprp pgprpappqq
      781 egppeqqppq
//
