LOCUS       NM_145373               1615 bp    mRNA    linear   ROD 21-AUG-2024
DEFINITION  Mus musculus secreted and transmembrane 1A (Sectm1a), mRNA.
ACCESSION   NM_145373
VERSION     NM_145373.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1615)
  AUTHORS   Wang,X., Du,W., Li,Y., Yang,H.H., Zhang,Y., Akbar,R., Morgan,H.,
            Peng,T., Chen,J., Sadayappan,S., Hu,Y.C., Fan,Y., Huang,W. and
            Fan,G.C.
  TITLE     Macrophage-enriched Sectm1a promotes efficient efferocytosis to
            attenuate ischemia/reperfusion-induced cardiac injury
  JOURNAL   JCI Insight 9 (5), e173832 (2024)
   PUBMED   38456501
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1615)
  AUTHORS   Mu,X., Fan,H., Wang,P., Li,Y., Domenico,K., Li,Q., Wang,X.,
            Essandoh,K., Chen,J., Peng,T. and Fan,G.C.
  TITLE     Sectm1a Facilitates Protection against Inflammation-Induced Organ
            Damage through Promoting TRM Self-Renewal
  JOURNAL   Mol Ther 29 (3), 1294-1311 (2021)
   PUBMED   33279722
  REMARK    GeneRIF: Sectm1a Facilitates Protection against
            Inflammation-Induced Organ Damage through Promoting TRM
            Self-Renewal.
REFERENCE   3  (bases 1 to 1615)
  AUTHORS   Li,Y., Deng,S., Wang,X., Huang,W., Chen,J., Robbins,N., Mu,X.,
            Essandoh,K., Peng,T., Jegga,A.G., Rubinstein,J., Adams,D.E.,
            Wang,Y., Peng,J. and Fan,G.C.
  TITLE     Sectm1a deficiency aggravates inflammation-triggered cardiac
            dysfunction through disruption of LXRalpha signalling in
            macrophages
  JOURNAL   Cardiovasc Res 117 (3), 890-902 (2021)
   PUBMED   32170929
  REMARK    GeneRIF: Sectm1a deficiency aggravates inflammation-triggered
            cardiac dysfunction through disruption of LXRalpha signalling in
            macrophages.
REFERENCE   4  (bases 1 to 1615)
  AUTHORS   Mu,X., Wang,P., Wang,X., Li,Y., Zhao,H., Li,Q., Essandoh,K.,
            Deng,S., Peng,T. and Fan,G.C.
  TITLE     Identification of a Novel Antisepsis Pathway: Sectm1a Enhances
            Macrophage Phagocytosis of Bacteria through Activating GITR
  JOURNAL   J Immunol 205 (6), 1633-1643 (2020)
   PUBMED   32769121
REFERENCE   5  (bases 1 to 1615)
  AUTHORS   Kamata,H., Yamamoto,K., Wasserman,G.A., Zabinski,M.C., Yuen,C.K.,
            Lung,W.Y., Gower,A.C., Belkina,A.C., Ramirez,M.I., Deng,J.C.,
            Quinton,L.J., Jones,M.R. and Mizgerd,J.P.
  TITLE     Epithelial Cell-Derived Secreted and Transmembrane 1a Signals to
            Activated Neutrophils during Pneumococcal Pneumonia
  JOURNAL   Am J Respir Cell Mol Biol 55 (3), 407-418 (2016)
   PUBMED   27064756
  REMARK    GeneRIF: Sectm1a is an epithelial product that sustains a positive
            feedback loop amplifying neutrophilic inflammation during
            pneumococcal pneumonia.
REFERENCE   6  (bases 1 to 1615)
  AUTHORS   Gu,Z., Imai,F., Kim,I.J., Fujita,H., Katayama,Ki., Mori,K.,
            Yoshihara,Y. and Yoshida,Y.
  TITLE     Expression of the immunoglobulin superfamily cell adhesion
            molecules in the developing spinal cord and dorsal root ganglion
  JOURNAL   PLoS One 10 (3), e0121550 (2015)
   PUBMED   25826454
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 1615)
  AUTHORS   Harrow,J.L., Steward,C.A., Frankish,A., Gilbert,J.G.,
            Gonzalez,J.M., Loveland,J.E., Mudge,J., Sheppard,D., Thomas,M.,
            Trevanion,S. and Wilming,L.G.
  TITLE     The Vertebrate Genome Annotation browser 10 years on
  JOURNAL   Nucleic Acids Res 42 (Database issue), D771-D779 (2014)
   PUBMED   24316575
REFERENCE   8  (bases 1 to 1615)
  AUTHORS   Howie,D., Garcia Rueda,H., Brown,M.H. and Waldmann,H.
  TITLE     Secreted and transmembrane 1A is a novel co-stimulatory ligand
  JOURNAL   PLoS One 8 (9), e73610 (2013)
   PUBMED   24039998
  REMARK    GeneRIF: Data indicate the tissue ligand SECTM1A (Secreted and
            transmembrane1A) as an alternative CD7 ligand.
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1615)
  AUTHORS   Tachikawa,K., Sasaki,S., Maeda,T. and Nakajima,K.
  TITLE     Identification of molecules preferentially expressed beneath the
            marginal zone in the developing cerebral cortex
  JOURNAL   Neurosci Res 60 (2), 135-146 (2008)
   PUBMED   18055048
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK082020.1, AW985540.1 and AL662887.13.
            
            On Sep 8, 2006 this sequence version replaced NM_145373.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010462.1, BI558904.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-213               AK082020.1         2-214
            214-554             AW985540.1         214-554
            555-739             AK082020.1         247-431
            740-1615            AL662887.13        100544-101419       c
FEATURES             Location/Qualifiers
     source          1..1615
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 84.89 cM"
     gene            1..1615
                     /gene="Sectm1a"
                     /note="secreted and transmembrane 1A"
                     /db_xref="GeneID:209588"
                     /db_xref="MGI:MGI:2384805"
     exon            1..57
                     /gene="Sectm1a"
                     /inference="alignment:Splign:2.1.0"
     exon            58..213
                     /gene="Sectm1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             123..701
                     /gene="Sectm1a"
                     /note="secreted and transmembrane protein 1A"
                     /codon_start=1
                     /product="secreted and transmembrane protein 1A precursor"
                     /protein_id="NP_663348.2"
                     /db_xref="CCDS:CCDS25766.1"
                     /db_xref="GeneID:209588"
                     /db_xref="MGI:MGI:2384805"
                     /translation="MMTCPSVPAIPTLWLFSILLLVVSLNAQNKSWDNPICTEGILSV
                     PRGNPAVMTCNISNTFTDVTIQLSANGKDKTIFDKKPQGNFSWRGWELQVQGGLAQLV
                     IKDTQDDHTGIYLWQLHGRQRCYKNITLNILEPSNEDKVPDTTLFTSFPDHAKSSPIE
                     GKPGTLVGVITVIFILGVAGFITFIYYRHRRS"
     exon            214..522
                     /gene="Sectm1a"
                     /inference="alignment:Splign:2.1.0"
     exon            523..576
                     /gene="Sectm1a"
                     /inference="alignment:Splign:2.1.0"
     exon            577..739
                     /gene="Sectm1a"
                     /inference="alignment:Splign:2.1.0"
     exon            740..1615
                     /gene="Sectm1a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtcatcca gggcagcagt ggaggtaaca ttggagagct tgctggagaa gggacaggga
       61 gtgtttccag acagctagag ggtacaacgg tctcctaagg cctcctgtcc caccagccgg
      121 ccatgatgac ctgcccttca gtgcctgcta tccctaccct ctggctgttc agcatcctgc
      181 tcctggtggt ctccctgaat gctcagaata aaagctggga caaccctatc tgcacggagg
      241 gcatcctgtc tgtgcctcga ggcaatcctg cagtgatgac ctgtaacatc tctaacacct
      301 tcaccgatgt caccatccag ctgtctgcca atggaaagga caagaccatc ttcgataaaa
      361 agccccaagg aaacttctct tggcgtgggt gggagctcca agttcaaggg gggctggcac
      421 agcttgtgat caaagacacc caggacgacc acacagggat atacttgtgg cagctgcatg
      481 gacgccagag atgctacaaa aacatcaccc tgaatatctt agagccttcc aacgaggaca
      541 aggtcccaga cactacgctc tttacatcct tcccagatca cgcgaagagc tctccaatag
      601 agggcaagcc tgggaccctt gtgggagtca tcactgtcat cttcatcttg ggagtcgccg
      661 gattcattac gtttatctac tacaggcacc gtcgttccta gaagccccag atggaatgta
      721 cctcagtgcc tgacttgagg taaggtggtt ccaggtctgt ggccagtgga agctgaaggg
      781 agctgcctgc agggttgagt ccagagtgag accaccagca tgggcttatg ttctaagccc
      841 taggagacct ctgggactgc agacaccatg gaagtcatca ttacgcgctt ggcagagcac
      901 atggctttgt tcagtctgct gggcacaaag tcctttccct gagggcaatg gaacccttgg
      961 ctctgtacag atcaggggac agtgattcac tgaagaagga ccttggaagc tggaaaacaa
     1021 tttaggcatc ttttggtcac atgaacaaga gtacagcctc ctgactatgg tcttcagaca
     1081 tctgatccat tcctcaactc ttccccaaat tgggaattcc cagccgcaca gctcttgacg
     1141 atcggcatag gcttcattat ttctgctaaa cctctgaggt tagggtctca ctaccaccca
     1201 aagagctcca gtgtaagcct gatgctgcac caagatttgc ttcaggtaca acttgggggc
     1261 gtacctgatt tctgactcac aacagaaacg agttcgggaa gcccagatgt caggttccag
     1321 gggccaaaat agggagctaa gactttcaga tgaatcatct ccccactccc acccctgcaa
     1381 ggcagagtgc tgtcaggaac aggggtctgt ggaaggatgt agtgttggtt ggcaggcatt
     1441 gctctcctga ggatcataga gcatcttggg attccctggg ggcttctctt cagcagactc
     1501 ctgagcccca actccctgat tcaacagcca ctacccactg ttcttttcta aacttttgtc
     1561 ctagttacaa tgttattttt tcttacaatt aaaaaatgat ttttgtagaa acttc
//
