LOCUS       NM_029279               3327 bp    mRNA    linear   ROD 24-OCT-2024
DEFINITION  Mus musculus SECIS binding protein 2 (Secisbp2), transcript variant
            1, mRNA.
ACCESSION   NM_029279 XM_127336 XM_898257 XM_898266 XM_898273 XM_898283
            XM_914240 XM_923115 XM_923117 XM_923119 XM_923125 XM_980690
            XM_980725 XM_980761 XM_980790 XM_980820
VERSION     NM_029279.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3327)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3327)
  AUTHORS   Schoenmakers,E., Marelli,F., Jorgensen,H.F., Visser,W.E., Moran,C.,
            Groeneweg,S., Avalos,C., Jurgens,S.J., Figg,N., Finigan,A.,
            Wali,N., Agostini,M., Wardle-Jones,H., Lyons,G., Rusk,R.,
            Gopalan,D., Twiss,P., Visser,J.J., Goddard,M., Nashef,S.A.M.,
            Heijmen,R., Clift,P., Sinha,S., Pirruccello,J.P., Ellinor,P.T.,
            Busch-Nentwich,E.M., Ramirez-Solis,R., Murphy,M.P., Persani,L.,
            Bennett,M. and Chatterjee,K.
  TITLE     Selenoprotein deficiency disorder predisposes to aortic aneurysm
            formation
  JOURNAL   Nat Commun 14 (1), 7994 (2023)
   PUBMED   38042913
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3327)
  AUTHORS   Dai,Z.M., Guo,W., Yu,D., Zhu,X.J., Sun,S., Huang,H., Jiang,M.,
            Xie,B., Zhang,Z. and Qiu,M.
  TITLE     SECISBP2L-Mediated Selenoprotein Synthesis Is Essential for
            Autonomous Regulation of Oligodendrocyte Differentiation
  JOURNAL   J Neurosci 42 (30), 5860-5869 (2022)
   PUBMED   35760530
REFERENCE   4  (bases 1 to 3327)
  AUTHORS   Chellan,B., Zhao,L., Landeche,M., Carmean,C.M., Dumitrescu,A.M. and
            Sargis,R.M.
  TITLE     Selenocysteine insertion sequence binding protein 2 (Sbp2) in the
            sex-specific regulation of selenoprotein gene expression in mouse
            pancreatic islets
  JOURNAL   Sci Rep 10 (1), 18568 (2020)
   PUBMED   33122797
  REMARK    GeneRIF: Selenocysteine insertion sequence binding protein 2 (Sbp2)
            in the sex-specific regulation of selenoprotein gene expression in
            mouse pancreatic islets.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3327)
  AUTHORS   Fujisawa,H., Korwutthikulrangsri,M., Fu,J., Liao,X.H. and
            Dumitrescu,A.M.
  TITLE     Role of the Thyroid Gland in Expression of the Thyroid Phenotype of
            Sbp2-Deficient Mice
  JOURNAL   Endocrinology 161 (5) (2020)
   PUBMED   31826256
  REMARK    GeneRIF: Role of the Thyroid Gland in Expression of the Thyroid
            Phenotype of Sbp2-Deficient Mice.
REFERENCE   6  (bases 1 to 3327)
  AUTHORS   Seeher,S., Atassi,T., Mahdi,Y., Carlson,B.A., Braun,D., Wirth,E.K.,
            Klein,M.O., Reix,N., Miniard,A.C., Schomburg,L., Hatfield,D.L.,
            Driscoll,D.M. and Schweizer,U.
  TITLE     Secisbp2 is essential for embryonic development and enhances
            selenoprotein expression
  JOURNAL   Antioxid Redox Signal 21 (6), 835-849 (2014)
   PUBMED   24274065
  REMARK    GeneRIF: Secisbp2 is essential for embryonic development and
            enhances selenoprotein expression.
REFERENCE   7  (bases 1 to 3327)
  AUTHORS   Kossinova,O., Malygin,A., Krol,A. and Karpova,G.
  TITLE     A novel insight into the mechanism of mammalian selenoprotein
            synthesis
  JOURNAL   RNA 19 (8), 1147-1158 (2013)
   PUBMED   23788723
REFERENCE   8  (bases 1 to 3327)
  AUTHORS   Gonzalez-Flores,J.N., Gupta,N., DeMong,L.W. and Copeland,P.R.
  TITLE     The selenocysteine-specific elongation factor contains a novel and
            multi-functional domain
  JOURNAL   J Biol Chem 287 (46), 38936-38945 (2012)
   PUBMED   22992746
  REMARK    GeneRIF: SBP2/SECIS complex activates eEFSec by directing
            functional interactions between Domain IV and the ribosome to
            promote Sec-tRNA(Sec) binding and accommodation into the ribosomal
            A-site
REFERENCE   9  (bases 1 to 3327)
  AUTHORS   Caban,K. and Copeland,P.R.
  TITLE     Selenocysteine insertion sequence (SECIS)-binding protein 2 alters
            conformational dynamics of residues involved in tRNA accommodation
            in 80 S ribosomes
  JOURNAL   J Biol Chem 287 (13), 10664-10673 (2012)
   PUBMED   22308032
  REMARK    GeneRIF: Selenocysteine insertion sequence (SECIS)-binding protein
            2 alters conformational dynamics of residues involved in tRNA
            accommodation in 80 S ribosomes.
REFERENCE   10 (bases 1 to 3327)
  AUTHORS   Nishimura,M., Yokoi,N., Miki,T., Horikawa,Y., Yoshioka,H.,
            Takeda,J., Ohara,O. and Seino,S.
  TITLE     Construction of a multi-functional cDNA library specific for mouse
            pancreatic islets and its application to microarray
  JOURNAL   DNA Res 11 (5), 315-323 (2004)
   PUBMED   15747579
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC126547.4, AK168634.1,
            BP760396.1 and CA329104.1.
            
            On May 5, 2015 this sequence version replaced NM_029279.1.
            
            Summary: The incorporation of selenocysteine into a protein
            requires the concerted action of an mRNA element called a sec
            insertion sequence (SECIS), a selenocysteine-specific translation
            elongation factor and a SECIS binding protein. With these elements
            in place, a UGA codon can be decoded as selenocysteine. The gene
            described in this record encodes a nuclear protein that functions
            as a SECIS binding protein. Mutations in a similar gene in human
            have been associated with a reduction in activity of a specific
            thyroxine deiodinase, a selenocysteine-containing enzyme, and
            abnormal thyroid hormone metabolism. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, May 2015].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK168634.1, AK156076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                AC126547.4         60760-60793
            35-806              AK168634.1         6-777
            807-807             AC126547.4         66085-66085
            808-1506            AK168634.1         779-1477
            1507-1507           AC126547.4         83067-83067
            1508-2747           AK168634.1         1479-2718
            2748-2995           BP760396.1         365-612             c
            2996-3327           CA329104.1         1-332
FEATURES             Location/Qualifiers
     source          1..3327
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 26.12 cM"
     gene            1..3327
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /note="SECIS binding protein 2"
                     /db_xref="GeneID:75420"
                     /db_xref="MGI:MGI:1922670"
     exon            1..113
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             78..2654
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     selenocysteine insertion sequence-binding protein 2"
                     /codon_start=1
                     /product="selenocysteine insertion sequence-binding
                     protein 2 isoform 1"
                     /protein_id="NP_083555.1"
                     /db_xref="CCDS:CCDS36665.1"
                     /db_xref="GeneID:75420"
                     /db_xref="MGI:MGI:1922670"
                     /translation="MASERPREPDGEDSIKLSADVKPFVPKFAGLNVAWSESSETRVF
                     PGCAATYYPFVQEPPAAEQKMYPEDMAFGAPTFPAQYVSSEIALHPFAYPTYTLESAQ
                     SVCSVPTLQYDYSQARCHPGFRTAKPRHEHVCPPPQEAKGVFKKKPSDERRACEEQKS
                     SSRRADNAVPCEARPARGSSHLSSRTESSLKSDGYHKRPDRKSRILAKSASTSKPEFE
                     FSRLDFPELQSPKNSNMPETQKPPRWGPLGPAASNMPLLGDVGKPVADMVEGKMVKSD
                     HTDGAVTSNATTSSPSCTQELSWTPMGYIVRQTVSSDSAAATENVTSMINLKKTTSSA
                     DAKNVSVTSEALSSNPSYNREKRVYPAPKAKASQGGELEQNESSKKNKKKKEKSKPSY
                     EVLTVQEPPRIEDAEEFPNLSVASERRHRGQSPKLHSKQQTQNEFKTSGKKSQVPVQL
                     DLGGMLAALEKQQQQQHASHAKPSSRPVVFSVGAVPVLSKDASSSERGRRSSQMKTPH
                     NPLDSSAPLMKKGKQREIPKAKKPTSLKKIILKERQERMQQRLQESAVSLTVASDDSQ
                     DVESGASNQTPSQDNPTGPEKTEESVSSTPVVEGESEEPAGTEFQRDPEACQPAPDSA
                     TFPKIHSRRFRDYCSQMLSKEVDACVTGLLKELVRFQDRMYQKDPVKAKTKRRLVLGL
                     REVLKHLKLRKLKCIIISPNCEKTQSKGGLDDTLHTIIDCACEQNIPFVFALNRKALG
                     RSLNKAVPVSIVGIFSYDGAQDQFHKMVELTMAARQAYKTMLETMRQEQAGEPGPQSP
                     PSPPMQDPIPSTEEGTLPSTGEEPHYIEIWKKHLEAYSQRALELEDSLEASTSQMMNL
                     NL"
     exon            114..262
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            263..512
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            513..654
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            655..884
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            885..963
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            964..1166
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1167..1289
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1290..1379
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1521
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1522..1688
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1689..1827
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1828..1984
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            1985..2205
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2206..2360
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2361..2550
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..3317
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3293..3298
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /note="hexamer: AATAAA"
     polyA_site      3317
                     /gene="Secisbp2"
                     /gene_synonym="2210413N07Rik; 2810012K13Rik; SBP2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcaggaag gcggaaacgc tgagtcgttg gttaggcgcg ccgctagctt cacggcgcgg
       61 gctcttccgt ggccgccatg gcgtcggagc ggccgcggga gccggacggc gaggatagca
      121 tcaagttgtc agctgatgtc aaaccattcg tccctaagtt tgctgggctc aacgtggcgt
      181 ggtcagagtc ctcagagaca cgtgtcttcc caggctgtgc ggccacctac tatccatttg
      241 tacaggaacc accagcagct gaacagaaaa tgtatcccga agacatggct ttcggagccc
      301 ccacctttcc agcacagtac gtgtcttctg agatagcgct gcatcctttt gcctatccca
      361 cttacaccct agagtccgca cagagtgttt gctcagtgcc aaccctgcag tacgactaca
      421 gccaagcacg gtgtcaccca ggctttcgga cagcaaagcc ccggcatgag cacgtgtgcc
      481 ctccacctca ggaagcaaaa ggtgtattta agaaaaaacc ctctgatgag agaagagcat
      541 gtgaagagca aaagtcaagc agcagaaggg ctgacaatgc ggtgccctgt gaggcgagac
      601 cagccagggg gtccagtcac ctgtcctctc gaactgagag cagtttgaaa tctgatggtt
      661 accacaagcg acccgaccgc aagtccagaa tccttgcgaa gagtgcatct acctctaaac
      721 ctgaatttga gtttagtagg ttagactttc ctgaactgca gagtccaaag aacagtaaca
      781 tgccagagac acagaagccg cccaggtggg ggcctcttgg ccctgctgcc agtaacatgc
      841 ctctcctagg agacgtcggc aagcccgtcg cagatatggt agagggcaaa atggtgaaga
      901 gcgatcacac tgatggagct gtgaccagta atgccactac cagttcccct tcatgtaccc
      961 aagagttgtc ttggacacca atgggttata ttgttcggca gacagtgtct tcagattcag
     1021 cagcagccac tgaaaatgtg acttccatga taaacctaaa gaagactact tcatcagctg
     1081 atgctaaaaa tgttagtgtg acatctgagg ctttatcttc aaatccttcc tacaacagag
     1141 aaaagcgtgt ttatcctgct ccaaaggcca aagcatcaca aggaggtgaa cttgaacaaa
     1201 acgaaagctc caaaaagaat aagaaaaaga aagagaagtc taaaccgagt tatgaagtcc
     1261 tgacggttca ggagccgcca aggattgaag atgcagagga attccccaac ctgtcagttg
     1321 cgtcggaaag aagacacaga gggcaatcac cgaagcttca cagtaaacag cagacgcaga
     1381 atgaatttaa aacaagtggg aagaagagcc aggtcccagt gcagctggac ctggggggca
     1441 tgctggccgc gctggagaag cagcagcagc agcagcacgc ctcgcacgcc aagccatcct
     1501 ccagacccgt cgtgttctca gttggagcag tgccagtcct gtccaaggat gcctcctcca
     1561 gtgagagggg acgccgctcc agtcagatga agaccccaca caaccccctg gactccagtg
     1621 cccccctgat gaagaagggg aagcagaggg agatacctaa ggccaagaag cccacctcac
     1681 tgaagaagat aattttgaaa gaacggcaag agaggatgca gcagcgactc caagaaagtg
     1741 ctgtgagcct gacggtggcc agtgatgact cacaggatgt ggagagtggc gccagtaacc
     1801 aaacccccag tcaggacaac cccacaggtc cagagaagac agaagaatca gtgtcttcta
     1861 cacctgtggt tgagggtgag tcagaggagc cagctggcac agagttccag agggacccag
     1921 aggcttgcca gcctgcccct gacagtgcca ccttccccaa gatccacagc cggaggttcc
     1981 gggactactg cagccagatg cttagtaaag aagtagatgc ttgtgtcacg ggtctgctca
     2041 aggagctggt gcgcttccaa gaccgcatgt accagaagga tcccgtcaag gccaagacaa
     2101 aacggcggct cgtgctgggg ctgagggagg tcctgaaaca cctgaagctc aggaagctga
     2161 agtgcatcat catctctccc aactgtgaga agacccagtc taaaggtggg ctggacgaca
     2221 cgctgcacac catcatcgac tgcgcctgcg agcagaacat ccccttcgtg tttgcactca
     2281 atcgcaaggc tctggggcgg agcctgaata aagctgttcc tgtcagcatt gtagggatct
     2341 tcagctacga tggggcccag gaccagttcc acaagatggt tgagctgacc atggcagccc
     2401 gtcaggcata caagaccatg ttggagacaa tgcggcagga acaggcagga gaacctggac
     2461 ctcagtcccc tcccagccca cccatgcaag accccatccc atccacggaa gaaggcaccc
     2521 tcccttccac tggagaagag ccacactaca ttgagatttg gaaaaagcac ctggaagcgt
     2581 acagtcagcg tgccctggag ctggaagact cactggaggc gtcaacctct cagatgatga
     2641 acttgaattt ataagaagag ttcttgcctg tgtgtctgtg tattgggtaa ggatgggaga
     2701 ggcaggaaaa gacttccttc tcagttcttt actgacatga tgtatttatg tgactgtaga
     2761 gttggaaatt cactgggcct cagggcaaag gaagcacctg gttgtagcac tgagtccatc
     2821 agatgggcac tcagatgcgc ccgtgggcac ctttccttaa gagcctattg atcagcttcg
     2881 gttctttctc tctgcactct ggatctggaa aacgctggag aacgtggtcc tgggtaccgt
     2941 ggctgcctag gacccactat tacagtgctg ctcaaccaag tttggggatg gtgaaccagg
     3001 agctgtgctc cggggtgtgc agggcccttc ctcgggggtg gagtcctgcc attgtgctgc
     3061 caaggatttg ctaagatgag cctcagaaga aaattagttt ctaacatgac tttttgacat
     3121 aaattaatgc ttttagtttt tattttccaa agaagcagta tatatcaaat ttgtagattt
     3181 cagtttggtg tctacaaatc tttttaatga acataggatg aatgtgtttc tgtcctagag
     3241 gacagagctt actaacatat tttcctgcaa gcaagagggc ttatttgttt tgaataaaga
     3301 gtgattattt aatttcaaaa aaaaaaa
//
