LOCUS       NP_694695                760 aa            linear   ROD 16-JUN-2024
DEFINITION  translocation protein SEC63 homolog isoform 1 [Mus musculus].
ACCESSION   NP_694695
VERSION     NP_694695.3
DBSOURCE    REFSEQ: accession NM_153055.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 760)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 760)
  AUTHORS   Ishikawa,Y., Fedeles,S., Marlier,A., Zhang,C., Gallagher,A.R.,
            Lee,A.H. and Somlo,S.
  TITLE     Spliced XBP1 Rescues Renal Interstitial Inflammation Due to Loss of
            Sec63 in Collecting Ducts
  JOURNAL   J Am Soc Nephrol 30 (3), 443-459 (2019)
   PUBMED   30745418
REFERENCE   3  (residues 1 to 760)
  AUTHORS   Hassan,H., Tian,X., Inoue,K., Chai,N., Liu,C., Soda,K., Moeckel,G.,
            Tufro,A., Lee,A.H., Somlo,S., Fedeles,S. and Ishibe,S.
  TITLE     Essential Role of X-Box Binding Protein-1 during Endoplasmic
            Reticulum Stress in Podocytes
  JOURNAL   J Am Soc Nephrol 27 (4), 1055-1065 (2016)
   PUBMED   26303067
REFERENCE   4  (residues 1 to 760)
  AUTHORS   Fedeles,S.V., So,J.S., Shrikhande,A., Lee,S.H., Gallagher,A.R.,
            Barkauskas,C.E., Somlo,S. and Lee,A.H.
  TITLE     Sec63 and Xbp1 regulate IRE1alpha activity and polycystic disease
            severity
  JOURNAL   J Clin Invest 125 (5), 1955-1967 (2015)
   PUBMED   25844898
  REMARK    GeneRIF: SEC63 function regulates IRE1alpha/XBP1 activation. SEC63
            and XBP1 are required for GPS cleavage and maturation of PC1,
            protecting against polycystic disease.
REFERENCE   5  (residues 1 to 760)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (residues 1 to 760)
  AUTHORS   Su,R.W., Sun,Z.G., Zhao,Y.C., Chen,Q.J., Yang,Z.M., Li,R.S. and
            Wang,J.
  TITLE     The uterine expression of SEC63 gene is up-regulated at
            implantation sites in association with the decidualization during
            the early pregnancy in mice
  JOURNAL   Reprod Biol Endocrinol 7, 12 (2009)
   PUBMED   19208265
  REMARK    GeneRIF: SEC63 gene expression is up-regulated and predominantly
            localized in mouse decidual cells during days 5-8 of pregnancy.
            Publication Status: Online-Only
REFERENCE   7  (residues 1 to 760)
  AUTHORS   Pierreux,C.E., Poll,A.V., Kemp,C.R., Clotman,F., Maestro,M.A.,
            Cordi,S., Ferrer,J., Leyns,L., Rousseau,G.G. and Lemaigre,F.P.
  TITLE     The transcription factor hepatocyte nuclear factor-6 controls the
            development of pancreatic ducts in the mouse
  JOURNAL   Gastroenterology 130 (2), 532-541 (2006)
   PUBMED   16472605
REFERENCE   8  (residues 1 to 760)
  AUTHORS   Chalhoub,N., Benachenhou,N., Rajapurohitam,V., Pata,M., Ferron,M.,
            Frattini,A., Villa,A. and Vacher,J.
  TITLE     Grey-lethal mutation induces severe malignant autosomal recessive
            osteopetrosis in mouse and human
  JOURNAL   Nat Med 9 (4), 399-406 (2003)
   PUBMED   12627228
REFERENCE   9  (residues 1 to 760)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (residues 1 to 760)
  AUTHORS   Chalhoub,N., Benachenhou,N. and Vacher,J.
  TITLE     Physical and transcriptional map of the mouse Chromosome 10
            proximal region syntenic to human 6q16-q21
  JOURNAL   Mamm Genome 12 (12), 887-892 (2001)
   PUBMED   11707774
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC059816.1, AY024346.1 and BF472596.1.
            
            On Oct 31, 2007 this sequence version replaced NP_694695.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC059816.1, SRR1660815.259420.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..760
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 22.89 cM"
     Protein         1..760
                     /product="translocation protein SEC63 homolog isoform 1"
                     /note="translocation protein SEC63 homolog; SEC63-like;
                     dnaJ homolog subfamily C member 23"
                     /calculated_mol_wt=87739
     Site            15..35
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHE0.4)"
     Site            70..90
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHE0.4)"
     Region          104..162
                     /region_name="DnaJ"
                     /note="DnaJ domain; pfam00226"
                     /db_xref="CDD:395170"
     Site            order(132..134,139,142..143,146..147)
                     /site_type="other"
                     /note="HSP70 interaction site [polypeptide binding]"
                     /db_xref="CDD:99751"
     Site            189..209
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHE0.4)"
     Region          209..715
                     /region_name="SEC63"
                     /note="Domain of unknown function in Sec63p, Brr2p and
                     other proteins; smart00611"
                     /db_xref="CDD:214744"
     Region          492..617
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHE0.4)"
     Site            537
                     /site_type="phosphorylation"
                     /note="Phosphothreonine.
                     /evidence=ECO:0000250|UniProtKB:Q9UGP8; propagated from
                     UniProtKB/Swiss-Prot (Q8VHE0.4)"
     Region          564..>633
                     /region_name="SEEEED"
                     /note="Serine-rich region of AP3B1, clathrin-adaptor
                     complex; pfam14797"
                     /db_xref="CDD:434218"
     Region          720..760
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8VHE0.4)"
     Site            742
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UGP8; propagated from
                     UniProtKB/Swiss-Prot (Q8VHE0.4)"
     Site            748
                     /site_type="phosphorylation"
                     /note="Phosphoserine.
                     /evidence=ECO:0000250|UniProtKB:Q9UGP8; propagated from
                     UniProtKB/Swiss-Prot (Q8VHE0.4)"
     CDS             1..760
                     /gene="Sec63"
                     /gene_synonym="5730478J10Rik"
                     /coded_by="NM_153055.3:270..2552"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /db_xref="CCDS:CCDS23815.1"
                     /db_xref="GeneID:140740"
                     /db_xref="MGI:MGI:2155302"
ORIGIN      
        1 magqqfqydd sgntffyflt sfvglivipa tyylwprdqn aeqirlknir kvygrcmwyr
       61 lrllkpqpni iptvkkivll agwalflfla ykvsktdrey qeynpyevln ldpgatvaei
      121 kkqyrllslk yhpdkggdev mfmriakaya altdeesrkn weefgnpdgp qatsfgialp
      181 awivdqknsi lvllvyglaf mvilpvvvgs wwyrsirysg dqilirttqi ytyfvyktrn
      241 mdmkrlimvl agasefdpqy nkdstsrptd nilipqlire igsinlkkne ppltcpyslk
      301 arvlllshla rmkipetlee dqqfmlkkcp allqemvnvi cqliimarsr eerefraptl
      361 aslencmkls qmavqglqqf kspllqlphi eednlrrvsn hkkykiktiq dlvslkesdr
      421 hsllhflede kyeevmavlg sfpyvtmdik sqvlddedsn nitvgslvtv lvkltrqtma
      481 evfekeqsic aaeeqptedg qsdankikak ggwqqknkgp kkmpkskkkk plkkkpttvp
      541 lpqakqqkqk qangvvgsea aikeeeddis dkgsdseeee tnrdsqseke dgsdresdre
      601 qdekqskdde aewqelqqsi qrkerallet kskithpvys lyfpeekqew wwlyiadrke
      661 qtlismpyhv ctlkdteeve lkfpapgkpg nyqytvflrs dsymgldqik plklevheak
      721 pvpenhpqwd taiegdedqe dsegfedsfe eeeeeeeggd
//
