LOCUS       NM_011343                754 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus SEC61 translocon subunit gamma (Sec61g), transcript
            variant 1, mRNA.
ACCESSION   NM_011343
VERSION     NM_011343.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 754)
  AUTHORS   Zeng,K., Zeng,Y., Zhan,H., Zhan,Z., Wang,L., Xie,Y., Tang,Y.,
            Li,C., Chen,Y., Li,S., Liu,M., Chen,X., Liang,L., Deng,F., Song,Y.
            and Zhou,A.
  TITLE     SEC61G assists EGFR-amplified glioblastoma to evade immune
            elimination
  JOURNAL   Proc Natl Acad Sci U S A 120 (32), e2303400120 (2023)
   PUBMED   37523556
  REMARK    GeneRIF: SEC61G assists EGFR-amplified glioblastoma to evade immune
            elimination.
REFERENCE   2  (bases 1 to 754)
  AUTHORS   Xu,S., Li,X., Geng,J., Cao,Y., Yu,Y. and Qi,L.
  TITLE     Sec61gamma is a vital protein in the endoplasmic reticulum membrane
            promoting tumor metastasis and invasion in lung adenocarcinoma
  JOURNAL   Br J Cancer 128 (8), 1478-1490 (2023)
   PUBMED   36759724
  REMARK    GeneRIF: Sec61gamma is a vital protein in the endoplasmic reticulum
            membrane promoting tumor metastasis and invasion in lung
            adenocarcinoma.
REFERENCE   3  (bases 1 to 754)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   4  (bases 1 to 754)
  AUTHORS   Saito,K., Dubreuil,V., Arai,Y., Wilsch-Brauninger,M., Schwudke,D.,
            Saher,G., Miyata,T., Breier,G., Thiele,C., Shevchenko,A., Nave,K.A.
            and Huttner,W.B.
  TITLE     Ablation of cholesterol biosynthesis in neural stem cells increases
            their VEGF expression and angiogenesis but causes neuron apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 106 (20), 8350-8355 (2009)
   PUBMED   19416849
REFERENCE   5  (bases 1 to 754)
  AUTHORS   Gordon,H.M., Kucera,G., Salvo,R. and Boss,J.M.
  TITLE     Tumor necrosis factor induces genes involved in inflammation,
            cellular and tissue repair, and metabolism in murine fibroblasts
  JOURNAL   J Immunol 148 (12), 4021-4027 (1992)
   PUBMED   1602141
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CO808059.1 and AK012644.1.
            
            On Oct 19, 2007 this sequence version replaced NM_011343.2.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC019129.1, SRR1660811.272861.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164133, SAMN01164134
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-337               CO808059.1         16-352
            338-754             AK012644.1         2-418
FEATURES             Location/Qualifiers
     source          1..754
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 9.41 cM"
     gene            1..754
                     /gene="Sec61g"
                     /note="SEC61 translocon subunit gamma"
                     /db_xref="GeneID:20335"
                     /db_xref="MGI:MGI:1202066"
     exon            1..381
                     /gene="Sec61g"
                     /inference="alignment:Splign:2.1.0"
     CDS             292..594
                     /gene="Sec61g"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein transport protein Sec61 subunit gamma; SEC61,
                     gamma subunit"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit gamma
                     isoform 1"
                     /protein_id="NP_035473.2"
                     /db_xref="CCDS:CCDS48756.1"
                     /db_xref="GeneID:20335"
                     /db_xref="MGI:MGI:1202066"
                     /translation="MGGLWVASFRFRWARFSPELRVSTLSIRHPTNMDQVMQFVEPSR
                     QFVKDSIRLVKRCTKPDRKEFQKIAMATAIGFAIMGFIGFFVKLIHIPINNIIVGG"
     exon            382..481
                     /gene="Sec61g"
                     /inference="alignment:Splign:2.1.0"
     exon            482..584
                     /gene="Sec61g"
                     /inference="alignment:Splign:2.1.0"
     exon            585..754
                     /gene="Sec61g"
                     /inference="alignment:Splign:2.1.0"
     regulatory      731..736
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec61g"
     polyA_site      754
                     /gene="Sec61g"
ORIGIN      
        1 tatttgcatg cgcagcgggg agactcatag ctgtagcgca gacactcact cactaactaa
       61 ctagcgacac ttcgtggatt tacgttgagg ctgctggaga ggctgctgga gaggctgcgc
      121 ccgagaccgg gaggcgaaca atcgggaacc aagatcccac accgcccgcc cgttcagctg
      181 gagagacccg aatcgctcag gtcggcctct gctcgggaag ccgggagaaa cacacgtagc
      241 actgcgccgg cgtagtgacg tctctgcgtg aagagccaat tgaaaggagg aatgggcggg
      301 ctgtgggttg ccagcttccg gttccgttgg gctcggttct ctcctgagct acgtgtctct
      361 acgctctcaa tccgccatcc aacaaacatg gatcaggtaa tgcagtttgt ggagcccagc
      421 cggcagtttg taaaggactc aattcggctg gttaaaagat gcaccaaacc cgacagaaaa
      481 gaattccaga agattgccat ggctacagct ataggatttg ctatcatggg attcattggc
      541 ttcttcgtga aactgatcca tatacccatt aataacatta ttgtgggtgg ctgagtcctt
      601 ctcatcatgg gacgagtgag ccagagcggg ggaaagggca tgaagtaaag cgttgcctga
      661 atgctgtgtg gtgttttgtt tcttcctcct tcctatgagg ttttctactt ctcaattaaa
      721 ataatttcaa aataaacact ttttccataa caga
//
