LOCUS       NM_024171                552 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus SEC61 translocon subunit beta (Sec61b), mRNA.
ACCESSION   NM_024171
VERSION     NM_024171.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 552)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 552)
  AUTHORS   Morishita,H., Zhao,Y.G., Tamura,N., Nishimura,T., Kanda,Y.,
            Sakamaki,Y., Okazaki,M., Li,D. and Mizushima,N.
  TITLE     A critical role of VMP1 in lipoprotein secretion
  JOURNAL   Elife 8, e48834 (2019)
   PUBMED   31526472
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 552)
  AUTHORS   Yi,K., Rubinstein,B., Unruh,J.R., Guo,F., Slaughter,B.D. and Li,R.
  TITLE     Sequential actin-based pushing forces drive meiosis I chromosome
            migration and symmetry breaking in oocytes
  JOURNAL   J Cell Biol 200 (5), 567-576 (2013)
   PUBMED   23439682
REFERENCE   4  (bases 1 to 552)
  AUTHORS   Lang,S., Benedix,J., Fedeles,S.V., Schorr,S., Schirra,C.,
            Schauble,N., Jalal,C., Greiner,M., Hassdenteufel,S., Tatzelt,J.,
            Kreutzer,B., Edelmann,L., Krause,E., Rettig,J., Somlo,S.,
            Zimmermann,R. and Dudek,J.
  TITLE     Different effects of Sec61alpha, Sec62 and Sec63 depletion on
            transport of polypeptides into the endoplasmic reticulum of
            mammalian cells
  JOURNAL   J Cell Sci 125 (Pt 8), 1958-1969 (2012)
   PUBMED   22375059
REFERENCE   5  (bases 1 to 552)
  AUTHORS   Kuang,E., Okumura,C.Y., Sheffy-Levin,S., Varsano,T., Shu,V.C.,
            Qi,J., Niesman,I.R., Yang,H.J., Lopez-Otin,C., Yang,W.Y.,
            Reed,J.C., Broday,L., Nizet,V. and Ronai,Z.A.
  TITLE     Regulation of ATG4B stability by RNF5 limits basal levels of
            autophagy and influences susceptibility to bacterial infection
  JOURNAL   PLoS Genet 8 (10), e1003007 (2012)
   PUBMED   23093945
  REMARK    Erratum:[PLoS Genet. 2020 May 11;16(5):e1008795. doi:
            10.1371/journal.pgen.1008795.. PMID: 32392217]
REFERENCE   6  (bases 1 to 552)
  AUTHORS   Kondratyev,M., Avezov,E., Shenkman,M., Groisman,B. and
            Lederkremer,G.Z.
  TITLE     PERK-dependent compartmentalization of ERAD and unfolded protein
            response machineries during ER stress
  JOURNAL   Exp Cell Res 313 (16), 3395-3407 (2007)
   PUBMED   17707796
REFERENCE   7  (bases 1 to 552)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   8  (bases 1 to 552)
  AUTHORS   Kamhi-Nesher,S., Shenkman,M., Tolchinsky,S., Fromm,S.V., Ehrlich,R.
            and Lederkremer,G.Z.
  TITLE     A novel quality control compartment derived from the endoplasmic
            reticulum
  JOURNAL   Mol Biol Cell 12 (6), 1711-1723 (2001)
   PUBMED   11408579
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK004505.1.
            
            On Apr 6, 2007 this sequence version replaced NM_024171.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK004505.1, BU524945.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-552               AK004505.1         2-553
FEATURES             Location/Qualifiers
     source          1..552
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 26.03 cM"
     gene            1..552
                     /gene="Sec61b"
                     /gene_synonym="1190006C12Rik"
                     /note="SEC61 translocon subunit beta"
                     /db_xref="GeneID:66212"
                     /db_xref="MGI:MGI:1913462"
     exon            1..93
                     /gene="Sec61b"
                     /gene_synonym="1190006C12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             91..381
                     /gene="Sec61b"
                     /gene_synonym="1190006C12Rik"
                     /note="Sec61 beta subunit"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit beta"
                     /protein_id="NP_077133.1"
                     /db_xref="CCDS:CCDS38759.1"
                     /db_xref="GeneID:66212"
                     /db_xref="MGI:MGI:1913462"
                     /translation="MPGPTPSGTNVGSSGRSPSKAVAARAAGSTVRQRKNASCGTRSA
                     GRTTSAGTGGMWRFYTEDSPGLKVGPVPVLVMSLLFIAAVFMLHIWGKYTRS"
     exon            94..191
                     /gene="Sec61b"
                     /gene_synonym="1190006C12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            192..293
                     /gene="Sec61b"
                     /gene_synonym="1190006C12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            294..552
                     /gene="Sec61b"
                     /gene_synonym="1190006C12Rik"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      552
                     /gene="Sec61b"
                     /gene_synonym="1190006C12Rik"
                     /note="putative"
ORIGIN      
        1 agagcctgta tctacgagag ttctgagtgc tcggcaactt cacgacttcc ctcttcctgc
       61 ctcctgtgcc caccgttctt aggcatcagc atgccgggtc caacgcccag tggcaccaac
      121 gtgggctcct ctggccgctc tcccagcaaa gcggtggccg cacgggctgc gggatccact
      181 gttcggcaga gaaaaaatgc cagctgtggg acccggagcg caggccgcac cacctctgca
      241 gggactgggg ggatgtggcg attctacacg gaagattccc cagggctcaa agtgggccct
      301 gtcccagtgc tggtgatgag tcttctgttc atcgctgctg tatttatgct gcacatttgg
      361 ggcaagtaca cgcgatcata gattgggcta catccatctg tcatctgaag aagaagaaga
      421 aggaaaaaaa cccaacatat cttggaccaa aagtgtagtg attttctgtt cacgtgtatt
      481 attttacaga gaataagaat tgactttgag aaatcagttt tttctatggc taataaactt
      541 tggaattgct tt
//
