LOCUS       NM_021305               2476 bp    mRNA    linear   ROD 25-APR-2023
DEFINITION  Mus musculus SEC61 translocon subunit alpha 2 (Sec61a2), transcript
            variant 1, mRNA.
ACCESSION   NM_021305
VERSION     NM_021305.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2476)
  AUTHORS   Hori O, Miyazaki M, Tamatani T, Ozawa K, Takano K, Okabe M, Ikawa
            M, Hartmann E, Mai P, Stern DM, Kitao Y and Ogawa S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK161316.1, AK160602.1, AL928924.12 and BQ033332.1.
            
            [WARNING] On May 25, 2023 this sequence was replaced by
            NM_021305.5.
            
            On Oct 4, 2017 this sequence version replaced NM_021305.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK077701.1, AK160602.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164142 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-95                AK161316.1         1-95
            96-641              AK160602.1         3-548
            642-643             AL928924.12        91943-91944         c
            644-2457            AK160602.1         549-2362
            2458-2476           BQ033332.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2476
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2"
     gene            1..2476
                     /gene="Sec61a2"
                     /note="SEC61 translocon subunit alpha 2"
                     /db_xref="GeneID:57743"
                     /db_xref="MGI:MGI:1931071"
     exon            1..176
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     CDS             170..1600
                     /gene="Sec61a2"
                     /note="isoform 1 is encoded by transcript variant 1; Sec61
                     alpha; protein transport protein Sec61 subunit alpha;
                     sec61 alpha-2; Sec61, alpha subunit 2"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit alpha
                     isoform 2 isoform 1"
                     /protein_id="NP_067280.1"
                     /db_xref="CCDS:CCDS15668.1"
                     /db_xref="GeneID:57743"
                     /db_xref="MGI:MGI:1931071"
                     /translation="MGIKFLEVIKPFCAVLPEIQKPERKIQFREKVLWTAITLFIFLV
                     CCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEV
                     GDTPKDRALFNGAQKLFGMIITIGQAIVYVMTGMYGDPAEMGAGICLLIIIQLFVAGL
                     IVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTINTGRGTEFEGAVIALFH
                     LLATRTDKVRALREAFYRQNLPNLMNLIATVFVFAVVIYFQGFRVDLPIKSARYRGQY
                     SSYPIKLFYTSNIPIILQSALVSNLYVISQMLSVRFSGNFLVNLLGQWADVSGGGPAR
                     SYPVGGLCYYLSPPESMGAIFEDPVHVVVYIIFMLGSCAFFSKTWIEVSGSSAKDVAK
                     QLKEQQMVMRGHRDTSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLA
                     VTIIYQYFEIFVKEQAEVGGMGALFF"
     exon            177..244
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            245..310
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            311..389
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            390..521
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            522..631
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            632..785
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            786..946
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1144
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1145..1336
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1413
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
     exon            1414..2458
                     /gene="Sec61a2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aggtctggga ggagcctaga gcgcatgtca catgactctg tgggcggagc ttgtgcgggg
       61 acggccagag cgtgtcccca gcctccgccg cctaggccag agtcgtgagg aacggagcgg
      121 aggcagctgc gaggccgcgg gtgcccgccg ggtgtgctga gccgccgcca tgggcatcaa
      181 gtttttagaa gttattaaac ctttctgtgc agttctacca gaaattcaga agcctgaaag
      241 gaaaattcag tttagagaga aggtactatg gactgctata acactcttca ttttcttagt
      301 atgctgtcag attccgctgt ttgggatcat gtcatcggac tctgcagatc ccttctactg
      361 gatgagagtt attcttgcat ccaacagagg aacattgatg gaattgggta tttccccaat
      421 tgtaacgtct ggtttgatta tgcagttgtt agctggagcc aaaatcattg aagttggaga
      481 cacacccaaa gatagagctc tgttcaatgg agcccagaaa ttatttggta tgatcattac
      541 cattgggcaa gccattgtgt atgtcatgac ggggatgtac ggggaccctg cggaaatggg
      601 tgctgggatc tgtctcctta tcattattca gttgtttgtt gctggtttga ttgtgctgct
      661 gttagatgag ctgctacaga agggttacgg cttggggtct gggatttccc tctttattgc
      721 caccaacatc tgtgaaacca ttgtctggaa ggcctttagt cccactacca ttaacactgg
      781 cagaggtacg gagtttgaag gtgcagtcat agctctgttt catttgctgg ccaccaggac
      841 agacaaggtg cgagccttga gggaggcttt ctataggcag aacctcccca acctcatgaa
      901 cctcatcgcc acagtgttcg tgtttgctgt cgtcatctat tttcaggggt ttcgtgttga
      961 cttgcccatt aagtcggcac ggtatcgtgg acagtacagt agctatccta tcaagctctt
     1021 ctacacgtcg aatattccca taatcctcca gtctgcccta gtttcaaact tgtacgtcat
     1081 ttcccagatg ctgtctgttc gatttagtgg caacttctta gtaaacttac taggacagtg
     1141 ggccgatgtc agtgggggag ggcctgctcg ctcctaccct gttggcggcc tttgttacta
     1201 tctgtctcct cctgagtcta tgggagccat atttgaggat cctgttcatg tagttgtata
     1261 tattatcttc atgttggggt catgtgcatt cttttctaag acgtggatag aagtttctgg
     1321 ttcttcagcc aaagatgtgg ccaagcaact taaagaacag cagatggtga tgaggggtca
     1381 cagagatacc tccatggtcc atgagctgaa caggtacatc cccacagcag ctgcctttgg
     1441 gggtctgtgc atcggtgccc tgtcagtact agcagacttc cttggggcca ttggctctgg
     1501 tactggaatt ctgcttgcag tcactattat ttatcagtat tttgaaatat ttgttaagga
     1561 acaggctgaa gttggtggaa tgggtgcttt gtttttctaa atgttcatct atttctttgt
     1621 gtgtgtgaaa gggaaaatat tttgacatac tgtttctgtc aaataatgct ggttcccctt
     1681 tcttccctca gtttgttgtt ttcagtgctc actgtcccat ttctgaagtg ggcacagagc
     1741 taagcctgtg tgcagcatca gtaccagctg ccttaaaact gaagtttaca ttatttgttg
     1801 acactgtcca tctagtgtta gccatgacgc tgggaagcag tgtatctgcc tcgctgttgg
     1861 tcagacagca agacagtgat gtggattagc ttcgcacaca acattcagaa cactgaatat
     1921 tcccttgttt aaaaataagt gcagtgcaga ttgccacttt ccagtatttt gagcttccct
     1981 aatgagttat ggagcattta tatctaatgt atattttaga taatttttat acttttttaa
     2041 ctcatcagcc ccacccctac ttgattcatc ctatccccaa actgccactc agcctggatg
     2101 ggcaaaaatc aagcattgaa gttatttctg tcactggaca caattgcttc caattccctt
     2161 ttctgctttt catttgtcct cttttcctgg tgacagctac gagtgctgtc cagctgtatt
     2221 ggccatgcct tctactccaa tgcccccaag tatttcctct ctcccctcgt ccccaaagca
     2281 agacccagtt ctcaagcagt gtctgtagtt gagtggaagt gagcaatgag tattcatgca
     2341 aggacttcat gtctgtgata tgcatagcag gacccaagtg taaacagtag acaataaact
     2401 ttatttaaga aaactgttgc agttgtgatg aaaaataaag agattcctat taagtgttaa
     2461 aaaaaaaaaa aaaaaa
//
