LOCUS       NM_016906               3039 bp    mRNA    linear   ROD 06-APR-2024
DEFINITION  Mus musculus SEC61 translocon subunit alpha 1 (Sec61a1), mRNA.
ACCESSION   NM_016906
VERSION     NM_016906.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3039)
  AUTHORS   Sebastien,M., Aubin,P., Brocard,J., Brocard,J., Marty,I. and
            Faure,J.
  TITLE     Dynamics of triadin, a muscle-specific triad protein, within
            sarcoplasmic reticulum subdomains
  JOURNAL   Mol Biol Cell 31 (4), 261-272 (2020)
   PUBMED   31877066
  REMARK    GeneRIF: Dynamics of triadin, a muscle-specific triad protein,
            within sarcoplasmic reticulum subdomains.
REFERENCE   2  (bases 1 to 3039)
  AUTHORS   Morel,J.D., Paatero,A.O., Wei,J., Yewdell,J.W., Guenin-Mace,L., Van
            Haver,D., Impens,F., Pietrosemoli,N., Paavilainen,V.O. and
            Demangel,C.
  TITLE     Proteomics Reveals Scope of Mycolactone-mediated Sec61 Blockade and
            Distinctive Stress Signature
  JOURNAL   Mol Cell Proteomics 17 (9), 1750-1765 (2018)
   PUBMED   29915147
  REMARK    GeneRIF: Sec61 blockade induces proteostatic stress in the cytosol
            and the endoplasmic reticulum.
REFERENCE   3  (bases 1 to 3039)
  AUTHORS   Weng,L., Jia,S., Xu,C., Ye,J., Cao,Y., Liu,Y. and Zheng,M.
  TITLE     Nogo-C regulates post myocardial infarction fibrosis through the
            interaction with ER Ca2+ leakage channel Sec61alpha in mouse hearts
  JOURNAL   Cell Death Dis 9 (6), 612 (2018)
   PUBMED   29795235
  REMARK    GeneRIF: Nogo-C regulates cardiac fibrosis through interacting with
            Sec61alpha to mediate the Ca(2+) leakage from endoplasmic
            reticulum.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3039)
  AUTHORS   Grotzke,J.E., Kozik,P., Morel,J.D., Impens,F., Pietrosemoli,N.,
            Cresswell,P., Amigorena,S. and Demangel,C.
  TITLE     Sec61 blockade by mycolactone inhibits antigen cross-presentation
            independently of endosome-to-cytosol export
  JOURNAL   Proc Natl Acad Sci U S A 114 (29), E5910-E5919 (2017)
   PUBMED   28679634
  REMARK    GeneRIF: The direct contribution of Sec61 to antigen
            cross-presentation, endosome-to-cytosol export, and endoplasmic
            reticulum-to-cytosol export.
REFERENCE   5  (bases 1 to 3039)
  AUTHORS   Bolar,N.A., Golzio,C., Zivna,M., Hayot,G., Van Hemelrijk,C.,
            Schepers,D., Vandeweyer,G., Hoischen,A., Huyghe,J.R., Raes,A.,
            Matthys,E., Sys,E., Azou,M., Gubler,M.C., Praet,M., Van Camp,G.,
            McFadden,K., Pediaditakis,I., Pristoupilova,A., Hodanova,K.,
            Vyletal,P., Hartmannova,H., Stranecky,V., Hulkova,H., Baresova,V.,
            Jedlickova,I., Sovova,J., Hnizda,A., Kidd,K., Bleyer,A.J.,
            Spong,R.S., Vande Walle,J., Mortier,G., Brunner,H., Van Laer,L.,
            Kmoch,S., Katsanis,N. and Loeys,B.L.
  TITLE     Heterozygous Loss-of-Function SEC61A1 Mutations Cause
            Autosomal-Dominant Tubulo-Interstitial and Glomerulocystic Kidney
            Disease with Anemia
  JOURNAL   Am J Hum Genet 99 (1), 174-187 (2016)
   PUBMED   27392076
REFERENCE   6  (bases 1 to 3039)
  AUTHORS   Hori,O., Miyazaki,M., Tamatani,T., Ozawa,K., Takano,K., Okabe,M.,
            Ikawa,M., Hartmann,E., Mai,P., Stern,D.M., Kitao,Y. and Ogawa,S.
  TITLE     Deletion of SERP1/RAMP4, a component of the endoplasmic reticulum
            (ER) translocation sites, leads to ER stress
  JOURNAL   Mol Cell Biol 26 (11), 4257-4267 (2006)
   PUBMED   16705175
REFERENCE   7  (bases 1 to 3039)
  AUTHORS   Houde,M., Bertholet,S., Gagnon,E., Brunet,S., Goyette,G.,
            Laplante,A., Princiotta,M.F., Thibault,P., Sacks,D. and
            Desjardins,M.
  TITLE     Phagosomes are competent organelles for antigen cross-presentation
  JOURNAL   Nature 425 (6956), 402-406 (2003)
   PUBMED   14508490
REFERENCE   8  (bases 1 to 3039)
  AUTHORS   Guermonprez,P., Saveanu,L., Kleijmeer,M., Davoust,J., Van Endert,P.
            and Amigorena,S.
  TITLE     ER-phagosome fusion defines an MHC class I cross-presentation
            compartment in dendritic cells
  JOURNAL   Nature 425 (6956), 397-402 (2003)
   PUBMED   14508489
REFERENCE   9  (bases 1 to 3039)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 3039)
  AUTHORS   Dudek,J., Volkmer,J., Bies,C., Guth,S., Muller,A., Lerner,M.,
            Feick,P., Schafer,K.H., Morgenstern,E., Hennessy,F., Blatch,G.L.,
            Janoscheck,K., Heim,N., Scholtes,P., Frien,M., Nastainczyk,W. and
            Zimmermann,R.
  TITLE     A novel type of co-chaperone mediates transmembrane recruitment of
            DnaK-like chaperones to ribosomes
  JOURNAL   EMBO J 21 (12), 2958-2967 (2002)
   PUBMED   12065409
  REMARK    Erratum:[EMBO J 2002 Jul 15;21(14):3917]
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC154038.1.
            
            [WARNING] On Apr 9, 2024 this sequence was replaced by NM_016906.5.
            
            On Apr 28, 2007 this sequence version replaced NM_016906.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088473.1, AK153055.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-115               AC154038.1         92683-92797         c
            116-183             AC154038.1         92368-92435         c
            184-249             AC154038.1         89501-89566         c
            250-328             AC154038.1         89341-89419         c
            329-460             AC154038.1         88310-88441         c
            461-570             AC154038.1         86493-86602         c
            571-724             AC154038.1         86099-86252         c
            725-885             AC154038.1         82559-82719         c
            886-1083            AC154038.1         81169-81366         c
            1084-1275           AC154038.1         80738-80929         c
            1276-1352           AC154038.1         80142-80218         c
            1353-3039           AC154038.1         77604-79290         c
FEATURES             Location/Qualifiers
     source          1..3039
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 39.51 cM"
     gene            1..3039
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /note="SEC61 translocon subunit alpha 1"
                     /db_xref="GeneID:53421"
                     /db_xref="MGI:MGI:1858417"
     exon            1..115
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     CDS             109..1539
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /note="transport protein sec61 alpha subunit; protein
                     transport protein Sec61 subunit alpha; sec61 alpha-1;
                     SEC61, alpha subunit; Sec61 alpha 1 subunit"
                     /codon_start=1
                     /product="protein transport protein Sec61 subunit alpha
                     isoform 1"
                     /protein_id="NP_058602.1"
                     /db_xref="CCDS:CCDS39553.1"
                     /db_xref="GeneID:53421"
                     /db_xref="MGI:MGI:1858417"
                     /translation="MAIKFLEVIKPFCVILPEIQKPERKIQFKEKVLWTAITLFIFLV
                     CCQIPLFGIMSSDSADPFYWMRVILASNRGTLMELGISPIVTSGLIMQLLAGAKIIEV
                     GDTPKDRALFNGAQKLFGMIITIGQSIVYVMTGMYGDPSEMGAGICLLITIQLFVAGL
                     IVLLLDELLQKGYGLGSGISLFIATNICETIVWKAFSPTTVNTGRGMEFEGAIIALFH
                     LLATRTDKVRALREAFYRQNLPNLMNLIATIFVFAVVIYFQGFRVDLPIKSARYRGQY
                     NTYPIKLFYTSNIPIILQSALVSNLYVISQMLSARFSGNLLVSLLGTWSDTSSGGPAR
                     AYPVGGLCYYLSPPESFGSVLEDPVHAVVYIVFMLGSCAFFSKTWIEVSGSSAKDVAK
                     QLKEQQMVMRGHRETSMVHELNRYIPTAAAFGGLCIGALSVLADFLGAIGSGTGILLA
                     VTIIYQYFEIFVKEQSEVGSMGALLF"
     exon            116..183
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            184..249
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            250..328
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            329..460
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            461..570
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            571..724
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            725..885
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            886..1083
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            1084..1275
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            1276..1352
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
     exon            1353..3039
                     /gene="Sec61a1"
                     /gene_synonym="Sec61a"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cactgacgtg tctctcggtc gaggaagcgc gctccggagc tagcagcgcc tcctcactcg
       61 aagtggagcg cagtcggggc cgggcgtgta gtcggatcag ccgccgccat ggcgatcaaa
      121 tttctggaag tcatcaagcc attctgtgtc atcttgccgg aaattcagaa gccagagaga
      181 aagattcagt ttaaggagaa agttctgtgg acagccatca ccctcttcat cttcttagta
      241 tgctgtcaga tccccctgtt tggcatcatg tcttcagact cagctgaccc gttctactgg
      301 atgcgagtga ttctggcctc taacagaggt accttaatgg agctgggcat ctctcctatt
      361 gtcacctccg gtcttatcat gcagctctta gctggtgcca agataattga agttggggac
      421 accccgaaag accgagctct cttcaatgga gcccagaagt tgtttggaat gatcattact
      481 atcggtcagt ccattgtgta tgtgatgacg ggcatgtacg gggacccttc ggagatgggt
      541 gctggaatct gcctgctgat caccattcag ctctttgttg ctggcttaat tgtcctactt
      601 ttggatgaac ttctgcaaaa agggtacggc ttgggctctg gcatttctct cttcattgcg
      661 actaacatct gtgagaccat tgtgtggaag gcattcagcc ccaccactgt caacactggc
      721 cgagggatgg aattcgaagg cgccatcata gcgctattcc acctgctggc cacccgcaca
      781 gacaaggtcc gagcccttcg agaggcattc taccgccaga acctccccaa cctcatgaac
      841 ctgattgcca ccatcttcgt ctttgccgtt gtcatctatt tccagggctt ccgagtggac
      901 cttccaatca agtcggcgcg ttaccgaggc cagtacaaca cctatcccat caagctcttc
      961 tacacctcca acatccccat catcttgcag tctgctctgg tgtccaacct gtatgtcatc
     1021 tcccagatgc tgtcagcacg cttcagtggc aacctgctgg ttagcctgct gggcacctgg
     1081 tcggatacat catctggggg cccagcccga gcttaccccg ttggtggcct gtgttactac
     1141 ctgtctcctc cggaatcgtt cggctcagtg ctggaggacc ctgtccatgc ggtcgtgtac
     1201 atcgtgttca tgctgggctc ctgtgcattc ttctccaaaa catggatcga agtctcaggt
     1261 tcttctgcca aagatgttgc aaagcagctg aaggagcagc agatggtgat gaggggccac
     1321 agggagacct ccatggtgca tgagctcaac cggtacatcc ccacagccgc agcctttggt
     1381 gggctgtgca ttggggccct ctctgtcctg gctgacttcc tgggtgctat cgggtctgga
     1441 actgggatcc tgcttgcggt caccatcatc taccagtact ttgagatctt cgtcaaggaa
     1501 cagagcgagg tgggcagcat gggagccctt ctcttctgag ccttgcgtgc ccgtggacca
     1561 gggtgagggc acaggctcca gaactgccca ggaagggtgc tcttactgct ggagcatgct
     1621 actgtggcat agggacttta attttttttt ttaatttttt ttaaaatttc atatcttttc
     1681 attccactgt gtaaagtgct aggaaatttc caatttgaaa ttttgctttt tctggcattg
     1741 gcaaaaaacc agtagaagtg aattgttagc tgatggccag ggggtgtgat aacaaattgt
     1801 cctcaagtat cccatgtaat ttttatttaa acccttgcac ttctcagtgc ctggcagctg
     1861 caagggtccc agctgccccg aggcagtctg tggccctggt tgaaggaagc acaaactaga
     1921 tgtctgcatc tcatctgggc gtgcagacag gtgaggatca gcagggtcca cgtgtctgct
     1981 gttgccagca aagggggtca ctggctttac ctggagcctg gccagctagg tagctggacg
     2041 tatataaagg gtcctcgtgc ttgttctttg ccagttccca ctagaaaagg cgctcctgtg
     2101 gtggccacct ctgtcttcct actgagaact tcctgttcca ggttttagaa ttttcttatt
     2161 gtcgttagga ccaaatgtag actggctcag gacctgtaag gaaatcacag gttcagagat
     2221 ctcttaggga agttgctcaa aatcctgttt gtagttaagg tgtctggggt aacagataac
     2281 atgggcctga gggagccctc aggtctatag gaaaggcccc tcttaagaca gaaacggttt
     2341 aacagcaagg gtacaaaggc tgtagtttga ggccagagca attagcgctt gtcagcttac
     2401 cttacaacac agagggtcca gctgttcaca caagggggca ggagctctgg tgggtgtgca
     2461 gccatgtggt cacagcctgc cagcagcaag acacctgggt ccaccacacc tcagtggaag
     2521 tagcagaatg cctccctgac ccggggctct tagggactct tgctgctatg cttgccagca
     2581 aatggcaatc aagggacaat tagccacttg ccccgacaca ggtcagcatc agggccagat
     2641 cccttgcaca cagcccaggg cgcacaccat atcacacgtg gccttgtcta gacccagtcc
     2701 tgagcagagg agcctggtgc cctcccagtc cacagggtct tcccactgcc cctcctctgc
     2761 cactgccaca gagcagcttc ccacctaccc tagggactcc acagcttctg gcaagcaggt
     2821 gcagagtccc cagctctggg ctgtgctggg gagtgtcagg cctggagtcc acagcctcac
     2881 ctgctgctgt agctgtcagc tggacctggt ggcttgtggt tgatggtcac tattagtggg
     2941 tgagtgggga tgacctggct tccaagagga ctgtcactgt ggacaccaaa atggcttaac
     3001 tgagatacag tgaaaacatg acaaataaac caacttttt
//
