LOCUS       NM_027135               3881 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus SEC24 homolog D, COPII coat complex component
            (Sec24d), mRNA.
ACCESSION   NM_027135 XM_357344
VERSION     NM_027135.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3881)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3881)
  AUTHORS   Adams,E.J., Khoriaty,R., Kiseleva,A., Cleuren,A.C.A., Tomberg,K.,
            van der Ent,M.A., Gergics,P., Tang,V.T., Zhu,G., Hoenerhoff,M.J.,
            O'Shea,K.S., Saunders,T.L. and Ginsburg,D.
  TITLE     Murine SEC24D can substitute functionally for SEC24C during
            embryonic development
  JOURNAL   Sci Rep 11 (1), 21100 (2021)
   PUBMED   34702932
  REMARK    GeneRIF: Murine SEC24D can substitute functionally for SEC24C
            during embryonic development.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3881)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3881)
  AUTHORS   Wang,B., Joo,J.H., Mount,R., Teubner,B.J.W., Krenzer,A., Ward,A.L.,
            Ichhaporia,V.P., Adams,E.J., Khoriaty,R., Peters,S.T.,
            Pruett-Miller,S.M., Zakharenko,S.S., Ginsburg,D. and Kundu,M.
  TITLE     The COPII cargo adapter SEC24C is essential for neuronal
            homeostasis
  JOURNAL   J Clin Invest 128 (8), 3319-3332 (2018)
   PUBMED   29939162
REFERENCE   5  (bases 1 to 3881)
  AUTHORS   Bettigole,S.E., Lis,R., Adoro,S., Lee,A.H., Spencer,L.A.,
            Weller,P.F. and Glimcher,L.H.
  TITLE     The transcription factor XBP1 is selectively required for
            eosinophil differentiation
  JOURNAL   Nat Immunol 16 (8), 829-837 (2015)
   PUBMED   26147683
REFERENCE   6  (bases 1 to 3881)
  AUTHORS   Adams,E.J., Chen,X.W., O'Shea,K.S. and Ginsburg,D.
  TITLE     Mammalian COPII coat component SEC24C is required for embryonic
            development in mice
  JOURNAL   J Biol Chem 289 (30), 20858-20870 (2014)
   PUBMED   24876386
REFERENCE   7  (bases 1 to 3881)
  AUTHORS   Baines,A.C., Adams,E.J., Zhang,B. and Ginsburg,D.
  TITLE     Disruption of the Sec24d gene results in early embryonic lethality
            in the mouse
  JOURNAL   PLoS One 8 (4), e61114 (2013)
   PUBMED   23596517
  REMARK    GeneRIF: SEC24D is absolutely required for early embryonic
            development in the mouse, with complete deficiency resulting in
            uniform loss prior to the blastocyst stage.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3881)
  AUTHORS   Chen,X.W., Wang,H., Bajaj,K., Zhang,P., Meng,Z.X., Ma,D., Bai,Y.,
            Liu,H.H., Adams,E., Baines,A., Yu,G., Sartor,M.A., Zhang,B., Yi,Z.,
            Lin,J., Young,S.G., Schekman,R. and Ginsburg,D.
  TITLE     SEC24A deficiency lowers plasma cholesterol through reduced PCSK9
            secretion
  JOURNAL   Elife 2, e00444 (2013)
   PUBMED   23580231
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3881)
  AUTHORS   Wansleeben,C., Feitsma,H., Montcouquiol,M., Kroon,C., Cuppen,E. and
            Meijlink,F.
  TITLE     Planar cell polarity defects and defective Vangl2 trafficking in
            mutants for the COPII gene Sec24b
  JOURNAL   Development 137 (7), 1067-1073 (2010)
   PUBMED   20215345
REFERENCE   10 (bases 1 to 3881)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC067020.1.
            
            On or before Sep 30, 2004 this sequence version replaced
            XM_357344.2, NM_027135.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC067020.1, SRR7652917.388279.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3881              BC067020.1         1-3881
FEATURES             Location/Qualifiers
     source          1..3881
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 53.82 cM"
     gene            1..3881
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /note="SEC24 homolog D, COPII coat complex component"
                     /db_xref="GeneID:69608"
                     /db_xref="MGI:MGI:1916858"
     exon            1..41
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            42..201
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     CDS             84..3182
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /note="Sec24 related gene family, member D"
                     /codon_start=1
                     /product="protein transport protein Sec24D"
                     /protein_id="NP_081411.2"
                     /db_xref="CCDS:CCDS38621.1"
                     /db_xref="GeneID:69608"
                     /db_xref="MGI:MGI:1916858"
                     /translation="MSQQGYVATPPYSQSQPGMGISPPHYGHYGDPSHASSPPGVMKP
                     LGPSAAPSGMLPPGPLPPGPPQFGPNGAHTPGHPPQRFPGPPPVNSVAPSYASGQTLP
                     QSSYPGPGSTSSVTQLGSQFSSMQINSYGVGATPQSQGPPGPQSAGAFQGPPQPAQPS
                     ILQPGHQVPPPPPTALNGPGASPMSPPTHRQDGLPGPAPLNAQYQPPPPPGQTLGPGY
                     PPQQATNYGPQMGGAQMSYPGGFPGGPAQMAGPAPQLQRKLDPDSIPSPIQVIENDRA
                     TRGGQVYTTNTRGQVPPLVTTECVIQDQGHSSPRYIRCTTYCFPCTSDMAKQAQIPLA
                     AVIKPFADIPPNETPLYLVNHGESGPVRCNRCKAYMCPFMQFIEGGRRYQCGFCSCVN
                     EVPPFYFQHLDHIGRRLDHYEKPELSLGSYEYVATLDYCRKNKPPSPPAFIFMIDVSY
                     SNIKNGLVKLICEELKTALKRLPKEEHEETSAIRVGFITYNKVLHFFNVKSNLAQPQM
                     MVVTDVGEVFVPLLDGFLVNYEESQSVIHNLLDQIPEMFADSNENETVFAPVIQAGME
                     ALKAAECPGKLFIFHSSLPTAEAPGKLKNRDDKKLVNTDKEKILFQPQTAVYESLAKD
                     CVANSCSVTLFLFPSQFVDVASLGLVPLLTGGTLYKYNVFQIHSDSQRFLTDLRNDIE
                     KKIGFDAIMRVRTSTGFRATDFFGGIFMNNTTDVEMAAIDCDKAVTVEFKHDDKLSED
                     VGALIQCAVLYTTISGQRRLRIHNLALNCSTQLADLYKSCETDALINFFAKSAFKAVL
                     NQPLKAIREILVNQTAHMLACYRKHCASPSAASQLILPDSMKVLPVYMNSLLKNCVLL
                     SRSEISPDERAYQRQLVMTMGVADSQLFFYPLLLPIHTLDVKSAALPPAVRCSESRLS
                     EEGIFLLANGLNMFLWFGVGSPPELIQGIFNVPSFAHINTDMTSLPEVGSPHSQQLRM
                     IMNNIQQKKPYSMKLIVVKQREQREMAFRQFLVEDKGLYGGSSYVDFLCCVHKEICQL
                     LN"
     exon            202..325
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            326..474
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            475..750
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            751..884
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            885..996
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            997..1124
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            1125..1263
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            1264..1379
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            1380..1504
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            1505..1696
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1790
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            1791..1907
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            1908..2078
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            2079..2175
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            2176..2321
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2460
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            2461..2579
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            2580..2759
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            2760..2951
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            2952..3041
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     exon            3042..3857
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3840..3845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /note="hexamer: AATAAA"
     polyA_site      3857
                     /gene="Sec24d"
                     /gene_synonym="2310020L09Rik; Gm1349"
                     /note="major polyA site"
ORIGIN      
        1 actcggcggc ggcggcgcgg ggcgcggagc gtgcagagca gggttattct gcagtagctc
       61 ttctttggaa tgatattttc atcatgagcc aacaaggcta tgtggcgaca cccccttatt
      121 ctcagtccca gcctggaatg ggtatctctc cccctcacta cggacactat ggggacccgt
      181 cccatgcatc ctctccacca ggcgtgatga agccattggg gccttcagct gctccttcag
      241 ggatgctgcc cccaggtcct ttacctcctg gacccccaca gtttggcccc aatggagccc
      301 atactccagg ccatcctcct caaagatttc caggaccccc acctgtcaat agtgtggcac
      361 cctcttatgc gtcaggccag accctgccac agtcatctta cccaggccct gggtccactt
      421 cctctgtcac ccagctgggc agtcagttca gctccatgca gatcaacagc tatggtgtgg
      481 gcgcgactcc tcagagccag ggtccgcctg gcccccagtc agcaggcgcc ttccaggggc
      541 ctccacaacc tgcacagcca tctattctgc agccaggaca tcaggttccg ccgccacccc
      601 ccactgccct gaacggccct ggtgcctctc ctatgtctcc accaactcac aggcaagatg
      661 gccttcctgg gccagctcct ctgaacgccc agtatcagcc cccacctcca ccaggccaga
      721 ccctgggtcc tggctaccct ccacagcaag caaccaacta tggaccgcag atgggaggtg
      781 cacagatgtc ttacccagga gggttccctg gaggtcctgc ccagatggct gggccggcac
      841 cacagctcca gaggaagctg gatccggact ccatccccag ccctattcaa gtgatcgaga
      901 atgacagggc caccagaggt ggacaagtct atacgaccaa taccaggggc caggtacctc
      961 cactggtcac caccgagtgt gtgattcaag accaaggcca ctcgagcccc cgctatatcc
     1021 gctgcactac gtattgcttt ccgtgcacgt ccgacatggc caagcaagct cagatcccac
     1081 tggctgccgt catcaaaccc ttcgctgaca ttccgcccaa cgagaccccc ttgtacttgg
     1141 taaaccatgg ggagagtgga ccagtgaggt gcaacaggtg caaagcctac atgtgcccgt
     1201 tcatgcaatt catcgaaggc ggacggcgct atcagtgcgg attctgcagc tgtgtgaatg
     1261 aagtcccacc attctatttc caacatctgg accacattgg aaggagattg gaccactatg
     1321 agaagccaga gctgtcgctg ggatcctatg aatatgttgc tacattggat tactgcagaa
     1381 agaataaacc tcccagccca ccagccttca tcttcatgat tgatgtctca tatagtaaca
     1441 taaagaatgg cctcgtcaag ctcatatgtg aagagctgaa gaccgcgctg aagcggctac
     1501 ccaaggagga gcatgaggag acgtctgcaa tccgagttgg tttcatcaca tacaacaaag
     1561 ttctccactt ctttaacgtg aagagtaatc tggcccagcc tcagatgatg gtggtgacgg
     1621 atgtcggaga ggtctttgtt cctttgttgg atgggttcct tgtcaactat gaagaatctc
     1681 aatctgtgat ccacaattta ttggaccaga ttcctgagat gtttgctgac tctaatgaaa
     1741 acgagacagt ctttgccccg gtcatccagg ccggcatgga ggccctgaag gcagcagagt
     1801 gcccggggaa gctcttcatc ttccattcct ctttgcctac tgccgaagca ccggggaagc
     1861 tcaagaacag agacgacaaa aagctggtga acacagacaa agagaagata cttttccagc
     1921 cccaaacagc tgtctacgaa tctctggcca aagactgtgt ggccaacagc tgctcagtga
     1981 ctctgttcct cttccccagt cagtttgtgg atgtggcttc cttgggtctg gttcctctgc
     2041 tcacgggagg aactctttac aaatacaacg ttttccagat acattcagat agccaaaggt
     2101 ttctgaccga cctccggaat gatattgaga agaaaatagg cttcgatgct atcatgaggg
     2161 ttcggaccag cacaggtttc agggccactg atttctttgg tggaatattc atgaacaaca
     2221 ccacagatgt ggaaatggcg gccatcgact gcgataaagc cgtgacagtg gagttcaagc
     2281 acgatgacaa gctcagtgaa gatgtcgggg ccctgatcca gtgtgctgtg ctctacacga
     2341 ccatcagtgg tcagcgaaga ctccggattc acaatctcgc cttaaactgc agcacccagc
     2401 tagcggatct gtacaagagc tgtgaaactg atgcccttat caacttcttt gccaagtcag
     2461 cttttaaagc agttttgaac cagcccttga aggccatccg ggaaattcta gtcaatcaga
     2521 ctgcccatat gctggcgtgt taccggaagc actgtgcgag tccgtctgca gcaagccagc
     2581 ttatactgcc agattccatg aaggtgctgc ctgtgtacat gaacagtttg ttgaaaaact
     2641 gtgtgctgct cagcagatcg gagatctccc ctgatgagcg ggcttaccag cggcagctgg
     2701 tcatgaccat gggcgtggct gactcccagc tcttcttcta tccactgctc ctgccaatcc
     2761 acacgttaga tgtgaagagt gcagcgctgc caccagccgt ccgctgctcc gagtcccgac
     2821 tctctgaaga aggaatattc ctgctggcta acggtctgaa catgttctta tggtttggag
     2881 tgggcagccc accagagctg attcagggaa tatttaatgt gccatcgttt gcacatatca
     2941 acacagatat gacatcgctg cctgaggtgg gaagtccaca ctctcaacaa ctcagaatga
     3001 taatgaataa tatccagcaa aagaagccat actcaatgaa gctcatcgtg gttaaacagc
     3061 gagagcagcg ggagatggct ttccgacagt tcctggtgga agataaaggg ctctatggag
     3121 gatcttcgta cgtggatttc ctctgctgtg ttcacaagga gatctgtcaa ctgcttaact
     3181 gagccctcgg ctctccctct gaggtcacat tcctgaggag acagtctcca acttggtgcc
     3241 taattttctg atgatagtag gctagtttta atttcttgat cactttcagg acagcttgcc
     3301 tggacagcac acagaccttc agctcggagt gctcaggtgg caagcccgtg gaggtgtggg
     3361 ggtactgtaa agggaagagt ccattactgg ctgtccagct tctaatttct aaagctgaca
     3421 caatttgcat ttcataaata catagtttac agaaccattt gcagcctcaa ttttctttgt
     3481 gcttgttata taaattattt ttcaaactgt atagattcat gataaaatta tcttggttcc
     3541 tctctctttt accgtgagag gaaaagactt catttttatc ttatacctaa tttttttaaa
     3601 accccgtgat gacattaaac agaatttttt ttccaacata agatctgcac agcagacttt
     3661 taaaaagcct gaaatctgtc tggtagaaca atttgtgttc tccttttttc ataattatat
     3721 attgtctgtt taaaatattt tccagttgtt ttgtctataa aacggtatct atattcttaa
     3781 tggttctttg tacaattttg atggtttcta cctgtatata atggatctta accaatatca
     3841 ataaattact tcatgtaaaa aaaaaaaaaa aaaaaaaaaa a
//
